The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy
Open accessAbstract
Patients with acute myeloid leukaemia who relapse following therapy have few treatment options and face poor outcomes. Immune checkpoint inhibition, for example, by antibody-mediated programmed death-1 (PD-1) blockade, is a potent therapeutic modality that improves treatment outcomes in acute myeloid leukaemia. Here, we show that systemically delivered blood platelets decorated with anti-PD-1 antibodies (aPD-1) and conjugated to haematopoietic stem cells (HSCs) suppress the growth and recurrence of leukaemia in mice. Following intravenous injection into mice bearing leukaemia cells, the HSC–platelet–aPD-1 conjugate migrated to the bone marrow and locally released aPD-1, significantly enhancing anti-leukaemia immune responses, and increasing the number of active T cells, production of cytokines and chemokines, and survival time of the mice. This cellular conjugate also promoted resistance to re-challenge with leukaemia cells. Taking advantage of the homing capability of HSCs and in situ activation of platelets for the enhanced delivery of a checkpoint inhibitor, this cellular combination-mediated drug delivery strategy can significantly augment the therapeutic efficacy of checkpoint blockade. The systemic administration of haematopoietic stem cells conjugated to anti-PD-1-decorated platelets in leukaemic mice promotes the delivery of the checkpoint inhibitor to the bone marrow and suppresses the growth and recurrence of leukaemia.
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Zhang, F., Li, F., Lu, G.-H., Nie, W., Zhang, L., Lv, Y., Bao, W., Gao, X., Wei, W., Pu, K., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00892 · Cited by 357
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Metadata
- Authors
- Hu, Q., Sun, W., Wang, J., Ruan, H., Zhang, X., Ye, Y., Shen, S., Wang, C., Lu, W., Cheng, K., Dotti, G., Zeidner, J. F., Wang, J., & Gu, Z.
- Venue
- Nature Biomedical Engineering
- Published
- 2018-10-29
- Volume
- 2
- Issue
- 11
- Pages
- 831-840
- ISSN
- 2157-846X (ISSN-L)
- OpenAlex
- W2897826078
- Cited by
- 310
- References
- 7
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy. https://app.cochat.ai/papers/10.1038/s41551-018-0310-2
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- Hu, Q., Sun, W., Wang, J., Ruan, H., Zhang, X., Ye, Y., Shen, S., Wang, C., Lu, W., Cheng, K., Dotti, G., Zeidner, J. F., Wang, J., & Gu, Z. (2018). Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-018-0310-2
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