The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure
Abstract
Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer immunotherapy. However, the currently available ICD inducers are still very limited and photosensitizer‐based ones can hardly induce sufficient ICD to achieve satisfactory cancer immunotherapy by themselves. Herein, an organic photosensitizer (named TPE‐DPA‐TCyP) with a twisted molecular structure, strong aggregation‐induced emission activity, and specific ability is reported for effectively inducing focused mitochondrial oxidative stress of cancer cells, which can serve as a much superior ICD inducer to the popularly used ones, including chlorin e6 (Ce6), pheophorbide A, and oxaliplatin. Furthermore, more effective in vivo ICD immunogenicity of TPE‐DPA‐TCyP than Ce6 is also demonstrated using a prophylactic tumor vaccination model. The underlying mechanism of the effectiveness and robustness of TPE‐DPA‐TCyP in inducing antitumor immunity and immune‐memory effect in vivo is verified by immune cell analyses. This study thus reveals that inducing focused mitochondrial oxidative stress is a highly effective strategy to evoke abundant and large‐scale ICD.
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Cites
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Calreticulin exposure dictates the immunogenicity of cancer cell death
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Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
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Regulatory T cells in tumor immunity
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Self-citationThe EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death
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Cited by
Zhang, Z., Xu, W., Kang, M., Wen, H., Guo, H., Zhang, P., Xi, L., Li, K., Wang, L., Wang, D., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003210 · Cited by 436
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Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
Self-citationEngineered algae: A novel oxygen-generating system for effective treatment of hypoxic cancer
Qiao, Y., Yang, F., Xie, T., Du, Z., Zhong, D., Qi, Y., Li, Y., Li, W., Lu, Z., Rao, J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba5996 · Cited by 282
Tang, Y., Bisoyi, H. K., Chen, X., Liu, Z., Chen, X., Zhang, S., & Li, Q. (2023) · Advanced Materials · doi:10.1002/adma.202300232 · Cited by 214
Metadata
- Authors
- Chen, C., Ni, X., Jia, S., Liang, Y., Wu, X., Kong, D., & Ding, D.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-11-07
- Volume
- 31
- Issue
- 52
- Pages
- e1904914-e1904914
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2982753862
- Cited by
- 503
- References
- 10
- FWCI
- 24.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, C., Ni, X., Jia, S., Liang, Y., Wu, X., Kong, D., & Ding, D. (2019). Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure. Advanced Materials. https://doi.org/10.1002/adma.201904914
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