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Cited by 447

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury

Open access
Jiang, Dawei, Ge, Zhilei, Im, Hyung-Jun, England, Christopher G., Ni, Dalong, Hou, Junjun, Zhang, Luhao, Kutyreff, Christopher J., Yan, Yongjun, Liu, Yan, Cho, Steve Y., Engle, Jonathan W., Shi, Jiye, Huang, Peng, Fan, Chunhai, Yan, Hao, Cai, Weibo·2018·Nature Biomedical Engineering
DOI 10.1038/s41551-018-0317-8
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Abstract

Patients with acute kidney injury (AKI) frequently require kidney transplantation and supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled DNA origami nanostructures (DONs) with rectangular, triangular and tubular shapes accumulate preferentially in the kidneys of healthy mice and mice with rhabdomyolysis-induced AKI, and that rectangular DONs have renal-protective properties, with efficacy similar to the antioxidant N-acetylcysteine—a clinically used drug that ameliorates contrast-induced AKI and protects kidney function from nephrotoxic agents. We evaluated the biodistribution of DONs non-invasively via positron emission tomography, and the efficacy of rectangular DONs in the treatment of AKI via dynamic positron emission tomography imaging with 68Ga-EDTA, blood tests and kidney tissue staining. DNA-based nanostructures could become a source of therapeutic agents for the treatment of AKI and other renal diseases. DNA origami nanostructures with different shapes can accumulate preferentially in the kidney, with some being renal-protective, as shown in healthy mice and in a mouse model of acute kidney injury.

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Metadata

Authors
Jiang, D., Ge, Z., Im, H.-J., England, C. G., Ni, D., Hou, J., Zhang, L., Kutyreff, C. J., Yan, Y., Liu, Y., Cho, S. Y., Engle, J. W., Shi, J., Huang, P., Fan, C., Yan, H., & Cai, W.
Venue
Nature Biomedical Engineering
Publisher
Springer Science and Business Media LLC
Published
2018-11-08
Volume
2
Issue
11
Pages
865-877
ISSN
2157-846X (ISSN-L)
DOI
10.1038/s41551-018-0317-8
OpenAlex
W2899124834
Cited by
447
References
68
FWCI
26.97
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury. https://app.cochat.ai/papers/10.1038/s41551-018-0317-8
The paper
Jiang, D., Ge, Z., Im, H.-J., England, C. G., Ni, D., Hou, J., Zhang, L., Kutyreff, C. J., Yan, Y., Liu, Y., Cho, S. Y., Engle, J. W., Shi, J., Huang, P., Fan, C., Yan, H., & Cai, W. (2018). DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-018-0317-8

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.