Nanocarriers as an emerging platform for cancer therapy

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works

Multidrug resistance in cancer: role of ATP–dependent transporters

Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536 · see citing works

Recent advances with liposomes as pharmaceutical carriers

Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282 · see citing works

Cancer nanotechnology: opportunities and challenges

Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance

Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,961 · see citing works

Nanoparticles in cancer therapy and diagnosis

Brigger, I., Dubernet, C., & Couvreur, P. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00044-3 · Cited by 3,040 · see citing works

Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment

Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4607 · Cited by 2,438 · see citing works

World Cancer Report

Stewart, B. W., & Kleihues, P. (2003) · Cited by 2,389 · see citing works

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

Arap, W., Pasqualini, R., & Ruoslahti, E. I. (1998) · Science · doi:10.1126/science.279.5349.377 · Cited by 2,040 · see citing works

Polymer conjugates as anticancer nanomedicines

Duncan, R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1958 · Cited by 1,956 · see citing works

Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910 · see citing works

Immunotargeted Nanoshells for Integrated Cancer Imaging and Therapy

Loo, C. H., Lowery, A. R., Halas, N. J., West, J. L., & Drezek, R. A. (2005) · Nano Letters · doi:10.1021/nl050127s · Cited by 1,792 · see citing works

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,706 · see citing works

Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo

Farokhzad, O. C., Cheng, J., Teply, B. A., Sherifi, I., Jon, S., Kantoff, P. W., Richie, J. P., & Langer, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601755103 · Cited by 1,667 · see citing works

Ligand-targeted therapeutics in anticancer therapy

Allen, T. M. (2002) · Nature reviews. Cancer · doi:10.1038/nrc903 · Cited by 1,648 · see citing works

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

Papahadjopoulos, D., Allen, T. M., Gabizón, A., Mayhew, E. G., Matthay, K. K., Huang, S. K., Lee, K. D., Woodle, M. C., Lasiç, D. D., & Redemann, C. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11460 · Cited by 1,621 · see citing works

Dendrimers and dendritic polymers in drug delivery

Gillies, E. R., & Fréchet, J. M. J. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03276-3 · Cited by 1,361 · see citing works

Small-scale systems for in vivo drug delivery

LaVan, D. A., McGuire, T., & Langer, R. (2003) · Nature Biotechnology · doi:10.1038/nbt876 · Cited by 1,301 · see citing works

Dendrimers:

Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J.-W., Meijer, E. W., Paulus, W., & Duncan, R. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00246-1 · Cited by 1,228 · see citing works

Barriers to Drug Delivery in Solid Tumors

Jain, R. K. (1994) · Scientific American · doi:10.1038/scientificamerican0794-58 · Cited by 1,074 · see citing works

Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents

Chen, J., Saeki, F., Wiley, B. J., Cang, H., Cobb, M. J., Li, Z., Au, L., Zhang, H., Kimmey, M. B., Li, X. D., et al. (2005) · Nano Letters · doi:10.1021/nl047950t · Cited by 977 · see citing works

Nanotechnology: Intelligent Design to Treat Complex Disease

Couvreur, P., & Vauthier, C. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0284-8 · Cited by 950 · see citing works

Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system

Sengupta, S., Eavarone, D. A., Capila, I., Zhao, G., Watson, N., Kiziltepe, T., & Sasisekharan, R. (2005) · Nature · doi:10.1038/nature03794 · Cited by 946 · see citing works

Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases.

Haran, G., Cohen, R., Bar, L. K., & Barenholz, Y. (1993) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(93)90105-9 · Cited by 934 · see citing works

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer

Kukowska‐Latallo, J. F., Candido, K. A., Cao, Z., Nigavekar, S. S., Majoros, I., Thomas, T. P., Balogh, L. P., Khan, M. K., & Baker, J. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3921 · Cited by 912 · see citing works

Polymersomes

Discher, D. E., & Ahmed, F. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095838 · Cited by 844 · see citing works

Cancer Facts & Figures 2004

Betts, P., Mokry, B., Risser, D. R., Weiss, N. S., Williams, M. A., Sjoberg, E., Clanton, M. S., Frankel, L. S., Foxhall, L. E., Hancock, L. E., et al. (2004) · Cited by 841 · see citing works

Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles.

Sokolov, K., Follen, M. M., Aaron, J., Pavlova, I., Malpica, A. L., Lotan, R., & Richards-Kortum, R. R. (2003) · PubMed · Cited by 838 · see citing works

Improving the efficacy of antibody-based cancer therapies

Carter, P. M. (2001) · Nature reviews. Cancer · doi:10.1038/35101072 · Cited by 833 · see citing works

Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines

Calvo, P., Remuñán‐López, C., Vila-Jato, J. L., et al. (1997) · Pharmaceutical Research · doi:10.1023/a:1012128907225 · Cited by 820 · see citing works

Nanomedicine: Developing smarter therapeutic and diagnostic modalities☆

Farokhzad, O. C., & Langer, R. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.011 · Cited by 801 · see citing works

Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain

Nord, K., Gunneriusson, E., Ringdahl, J., Ståhl, S., Uhlén, M., & Nygren, P. (1997) · Nature Biotechnology · doi:10.1038/nbt0897-772 · Cited by 663 · see citing works

Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery.

Park, J. W., Hong, K., Kirpotin, D. B., Colbern, G. T., Shalaby, R., Baselga, J. M., Shao, Y. Y., Nielsen, U. B., Marks, J. D., Moore, D. H., et al. (2002) · PubMed · Cited by 647 · see citing works

Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin

Matsumura, Y., Hamaguchi, T., Ura, T., Muro, K., Yamada, Y., Shimada, Y., Shirao, K., Okusaka, T., Ueno, H., Ikeda, M., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602204 · Cited by 623 · see citing works

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.

Adams, G. P., Schier, R., McCall, A. M., Simmons, H. H., Horak, E. M., Alpaugh, R. K., Marks, J. D., & Weiner, L. M. (2001) · PubMed · Cited by 623 · see citing works

Pegylated liposomal doxorubicin (doxil): Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2

Safra, T., Muggia, F. M., Jeffers, S., Tsao-Wei, D. D., Groshen, S. G., Lyass, O., Henderson, R., Berry, G. J., & Gabizón, A. (2000) · Annals of Oncology · doi:10.1023/a:1008365716693 · Cited by 618 · see citing works

The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform

Hong, S., Leroueil, P. R., Majoros, I., Orr, B. G., Baker, J. R., & Holl, M. M. B. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.11.015 · Cited by 585 · see citing works

VEGF as a Therapeutic Target in Cancer

Ferrara, N. (2005) · Oncology · doi:10.1159/000088479 · Cited by 577 · see citing works

Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor

Lee, E. S., Na, K., & Bae, Y. H. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.018 · Cited by 577 · see citing works

Development of the polymer micelle carrier system for doxorubicin

Nakanishi, T., Fukushima, S., Okamoto, K., Suzuki, M., Matsumura, Y., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00341-8 · Cited by 570 · see citing works

Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy

Gabizón, A. (2001) · Cancer Investigation · doi:10.1081/cnv-100103136 · Cited by 569 · see citing works

Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates

Trail, P. A., Willner, D., Lasch, S. J., Henderson, A. J., Hofstead, S. J., Casazza, A. M., Firestone, R. A., Hellström, I., & Hellström, K. E. (1993) · Science · doi:10.1126/science.8327892 · Cited by 557 · see citing works

Systematic Review: Efficacy and Safety of Rituximab for Adults with Idiopathic Thrombocytopenic Purpura

Arnold, D. M., Dentali, F., Crowther, M. A., Meyer, R. M., Cook, R. J., Sigouin, C. S., Fraser, G. A. M., Lim, W., & Kelton, J. G. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-1-200701020-00006 · Cited by 551 · see citing works

Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer

Lee, K. S., Chung, H. C., Im, S. A., Park, Y. H., Kim, C. S., Kim, S.-B., Rha, S. Y., Lee, M. Y., & Ro, J. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9591-y · Cited by 541 · see citing works

Immunotoxin therapy of cancer

Pastan, I. H., Hassan, R., FitzGerald, D. J., & Kreitman, R. J. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1891 · Cited by 529 · see citing works

Metal Nanoshells

Hirsch, L. R., Gobin, A. M., Lowery, A. R., Tam, F., Drezek, R. A., Halas, N. J., & West, J. L. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-9001-8 · Cited by 516 · see citing works

The biological chemistry of folate receptors

Antony, A. (1992) · Blood · doi:10.1182/blood.v79.11.2807.2807 · Cited by 477 · see citing works

Facile Synthesis of Gold−Silver Nanocages with Controllable Pores on the Surface

Chen, J., McLellan, J. M., Siekkinen, A. R., et al. (2006) · Journal of the American Chemical Society · doi:10.1021/ja066023g · Cited by 450 · see citing works

Long-circulating (sterically stabilized) liposomes for targeted drug delivery

Allen, T. M. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90314-x · Cited by 447 · see citing works

Ligand-targeted liposomal anticancer drugs

Sapra, P., & Allen, T. M. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00032-8 · Cited by 438 · see citing works

Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.

Goren, D., Horowitz, A. T., Tzemach, D., Tarshish, M., Zalipsky, S., & Gabizón, A. (2000) · PubMed · Cited by 402 · see citing works

Efficient Cancer Therapy with a Nanobody-Based Conjugate

Cortez‐Retamozo, V., Backmann, N., Senter, P. D., Wernery, U., BAETSELIER, P. D., Muyldermans, S., & Revets, H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3935 · Cited by 383 · see citing works

Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer

Danson, S., Ferry, D., Alakhov, V, Margison, J., Kerr, D., Jowle, D., Brampton, M., Halbert, G., & Ranson, M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601856 · Cited by 382 · see citing works

Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470

Satchi‐Fainaro, R., Puder, M., Davies, J. W., Tran, H. T., Sampson, D. A., Greene, A. K., Corfas, G., & Folkman, J. (2004) · Nature Medicine · doi:10.1038/nm1002 · Cited by 345 · see citing works

Advancing the field of drug delivery

Moses, M. A., Brem, H., & Langer, R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00276-9 · Cited by 344 · see citing works

Shrinkage of a Rapidly Growing Tumor by Drug-Loaded Polymersomes: pH-Triggered Release through Copolymer Degradation

Ahmed, F., Pakunlu, R. I., Srinivas, G., Brannan, A. K., Bates, F. S., Klein, M. L., Minko, T., & Discher, D. E. (2006) · Molecular Pharmaceutics · doi:10.1021/mp050103u · Cited by 330 · see citing works

Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells.

Eliaz, R. E., & Szoka, F. C. (2001) · PubMed · Cited by 330 · see citing works

Nanomedicines for overcoming biological barriers

Alonso, M. J. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2004.01.007 · Cited by 312 · see citing works

A New Polymer–Lipid Hybrid Nanoparticle System Increases Cytotoxicity of Doxorubicin Against Multidrug-Resistant Human Breast Cancer Cells

Wong, H. L., Rauth, A. M., Bendayan, R., Manias, J. L., Ramaswamy, M., Liu, Z., Erhan, S. Z., & Wu, X. Y. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0282-x · Cited by 303 · see citing works

Developing aptamers into therapeutics

White, R. R., Sullenger, B. A., & Rusconi, C. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11325 · Cited by 297 · see citing works

Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1

Peer, D., Zhu, P., Carman, C. V., Lieberman, J., & Shimaoka, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608491104 · Cited by 276 · see citing works

Pros and Cons of the Liposome Platform in Cancer Drug Targeting

Gabizón, A., Shmeeda, H., & Zalipsky, S. (2006) · Journal of Liposome Research · doi:10.1080/08982100600848769 · Cited by 272 · see citing works

Randomized Phase II Study of BR96-Doxorubicin Conjugate in Patients With Metastatic Breast Cancer

Tolcher, A. W., Sugarman, S. M., Gelmon, K. A., Cohen, R., Saleh, M. N., Isaacs, C. J., Young, L., Healey, D. I., Onetto-Pothier, N., & Slichenmyer, W. J. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.2.478 · Cited by 271 · see citing works

Pegylated liposomal doxorubicin-related palmar-plantar erythrodysesthesia (‘hand-foot’ syndrome)

Lorusso, D., Stefano, A. D., Carone, V., Fagotti, A., Pisconti, S., & Scambia, G. (2007) · Annals of Oncology · doi:10.1093/annonc/mdl477 · Cited by 263 · see citing works

In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma.

de Menezes, D. E. L., Pilarski, L. M., & Allen, T. M. (1998) · PubMed · Cited by 260 · see citing works

Liposomes Bearing Polyethyleneglycol-Coupled Transferrin with Intracellular Targeting Property to the Solid Tumors In Vivo

Ishida, O., Maruyama, K., Tanahashi, H., Iwatsuru, M., Sasaki, K., Eriguchi, M., & Yanagië, H. (2001) · Pharmaceutical Research · doi:10.1023/a:1010960900254 · Cited by 258 · see citing works

Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature

Halin, C., Rondini, S., Nilsson, F., Berndt, A., Kosmehl, H., Zardi, L., & Neri, D. (2002) · Nature Biotechnology · doi:10.1038/nbt0302-264 · Cited by 249 · see citing works

Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs.

Sapra, P., & Allen, T. M. (2002) · PubMed · Cited by 242 · see citing works

Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet.

Gabizón, A. (2001) · PubMed · Cited by 236 · see citing works

Loading mitomycin C inside long circulating hyaluronan targeted nano‐liposomes increases its antitumor activity in three mice tumor models

Peer, D., & Margalit, R. (2003) · International Journal of Cancer · doi:10.1002/ijc.11615 · Cited by 229 · see citing works

Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity

Batrakova, E., Dorodnych, T. Y., Klinskii, E., Kliushnenkova, E., Шемчукова, О. Б., Goncharova, O., Arjakov, S., Alakhov, V., & Kabanov, A. V. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.587 · Cited by 228 · see citing works

Targeted contrast agents for magnetic resonance imaging and ultrasound

Morawski, A. M., Lanza, G., & Wickline, S. A. (2004) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2004.11.001 · Cited by 223 · see citing works

Toxicity of Polyalkylcyanoacrylate Nanoparticles II: Doxorubicin-Loaded Nanoparticles

Couvreur, P., Kante, B., Grislain, L., Roland, M., & Speiser, P. P. (1982) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600710717 · Cited by 217 · see citing works

Intracellular targeting therapy of cisplatin‐encapsulated transferrin‐polyethylene glycol liposome on peritoneal dissemination of gastric cancer

Iinuma, H., Maruyama, K., Okinaga, K., Sasaki, K., Sekine, T., Ishida, O., Ogiwara, N., Johkura, K., & Yonemura, Y. (2002) · International Journal of Cancer · doi:10.1002/ijc.10242 · Cited by 216 · see citing works

Tumor-Targeted Hyaluronan Nanoliposomes Increase the Antitumor Activity of Liposomal Doxorubicin in Syngeneic and Human Xenograft Mouse Tumor Models

Peer, D., & Margalit, R. (2004) · Neoplasia · doi:10.1593/neo.03460 · Cited by 214 · see citing works

Human Antibody Fragments Specific for Human Blood Group Antigens from a Phage Display Library

Marks, J. D., Ouwehand, W. H., Bye, J. M., et al. (1993) · Nature Biotechnology · doi:10.1038/nbt1093-1145 · Cited by 202 · see citing works

Nanotechnology for biomaterials engineering: structural characterization of amphiphilic polymeric nanoparticles by 1H NMR spectroscopy

Hrkach, J. S., Peracchia, M. T., Bomb, A., Lotan, N., & Langer, R. (1997) · Biomaterials · doi:10.1016/s0142-9612(96)00077-4 · Cited by 201 · see citing works

A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats

Garcion, E., Lamprecht, A., Heurtault, B., Paillard, A., Aubert‐Pouëssel, A., Denizot, B., Meneï, P., & Benoît, J. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0289 · Cited by 198 · see citing works

Monoclonal Antibody Therapy for Cancer

von Mehren, M., Adams, G. P., & Weiner, L. M. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152442 · Cited by 191 · see citing works

Adsorption of Antineoplastic Drugs to Polyalkylcyanoacrylate Nanoparticles and Their Release in Calf Serum

Couvreur, P., Kante, B., Roland, M., et al. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600681215 · Cited by 186 · see citing works

Polymer–drug conjugates: towards a novel approach for the treatment of endrocine-related cancer

Duncan, R., Vicent, M. J., Greco, F., & Nicholson, R. I. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.01045 · Cited by 179 · see citing works

The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteremia and complications of sepsis

Lucas, K. G., Brown, A. E., Armstrong, D., Chapman, D. S., & Heller, G. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960215)77:4 · Cited by 174 · see citing works

Tissue Distribution of Antitumor Drugs Associated with Polyalkylcyanoacrylate Nanoparticles

Couvreur, P., Kante, B., Lenaerts, V., et al. (1980) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600690222 · Cited by 152 · see citing works

Trastuzumab, a humanized anti-HER2 monoclonal antibody, for the treatment of breast cancer

Albanell, J., & Baselga, J. (1999) · Drugs of today · doi:10.1358/dot.1999.35.12.564040 · Cited by 142 · see citing works

Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains

Silverman, J., Lu, Q., Bakker, A., To, W., Duguay, A. N., Alba, B. M., Smith, R., Rivas, A., Li, P., Le, H., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1166 · Cited by 137 · see citing works

The intratumoral expression of vascular endothelial growth factor and interleukin-8 associated with angiogenesis in nonsmall cell lung carcinoma patients

Masuya, D., Huang, C., Liu, D., Kameyama, K., Hayashi, E., Yamauchi, A., Kobayashi, S., Haba, R., & Yokomise, H. (2001) · Cancer · doi:10.1002/1097-0142(20011115)92:10 · Cited by 122 · see citing works

Targeting tumor vasculature endothelial cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft model

Hu, Z., Sun, Y. H., & Garen, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8161 · Cited by 100 · see citing works

Mapping Tumor Epitope Space by Direct Selection of Single-Chain Fv Antibody Libraries on Prostate Cancer Cells

Liu, B., Conrad, F., Cooperberg, M. R., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2732 · Cited by 96 · see citing works

Immunoliposomes for cancer therapy.

Kontermann, R. E. (2006) · PubMed · Cited by 91 · see citing works

New approaches to antibody therapy

Weiner, L. M., & Adams, G. P. (2000) · Oncogene · doi:10.1038/sj.onc.1204000 · Cited by 89 · see citing works

Fluoxetine and reversal of multidrug resistance

Peer, D., & Margalit, R. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.06.003 · Cited by 83 · see citing works

Recent Developments in Polymeric Nanoparticle Engineering and Their Applications in Experimental and Clinical Oncology

Moghimi, S. M. (2006) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152006778699130 · Cited by 74 · see citing works

Targeting of RGD‐modified proteins to tumor vasculature: A pharmacokinetic and cellular distribution study

Schraa, A. J., Kok, R. J., Moorlag, H. E., Bos, E. J., Proost, J. H., Meijer, D. K. F., de Leij, L. F. M. H., & Molema, G. (2002) · International Journal of Cancer · doi:10.1002/ijc.10727 · Cited by 73 · see citing works

Reconstituted collagen nanoparticles, a novel drug carrier delivery system

El-Samaligy, M. S., & Rohdewald, P. J. (1983) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1983.tb04831.x · Cited by 70 · see citing works

Polymer Therapeutics II

Satchi‐Fainaro, R., & Duncan, R. (2005) · Advances in polymer science · doi:10.1007/11547785 · Cited by 56 · see citing works

Possibility of the reversal of multidrug resistance and the avoidance of side effects by liposomes modified with MRK-16, a monoclonal antibody to P-glycoprotein

Matsuo, H., Wakasugi, M., Takanaga, H., et al. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00460-6 · Cited by 48 · see citing works

Distribution of the transferrin receptor in normal human fibroblasts and fibrosarcoma cells

Ekblom, P., Thesleff, I., Lehto, V., & Virtanen, I. (1983) · International Journal of Cancer · doi:10.1002/ijc.2910310118 · Cited by 48 · see citing works

Synthesis of Alginic Acid−Poly[2-(diethylamino)ethyl methacrylate] Monodispersed Nanoparticles by a Polymer−Monomer Pair Reaction System

Guo, R., Zhang, L., Jiang, Z., Cao, Y., Ding, Y., & Jiang, X. (2007) · Biomacromolecules · doi:10.1021/bm060906i · Cited by 47 · see citing works

Differential transferrin receptor density in human colorectal cancer: A potential probe for diagnosis and therapy.

Prost, A., Ménégaux, F., Langlois, P., Vidal, J. M., Koulibaly, M., Jost, J. L., Duron, J. J., Jp, C., Vayre, P., Aurengo, A., et al. (1998) · International Journal of Oncology · doi:10.3892/ijo.13.4.871 · Cited by 46 · see citing works

Attempted targeting of a monoclonal antibody in a human tumour xenograft system

Warenius, H. M., Galfré, G., Bleehen, N. M., et al. (1981) · European Journal of Cancer and Clinical Oncology · doi:10.1016/s0277-5379(81)80006-5 · Cited by 41 · see citing works

Fusion protein from RGD peptide and Fc fragment of mouse immunoglobulin G inhibits angiogenesis in tumor

Li, J., Ji, J., Holmes, L. M., Burgin, K. E., Barton, L. B., Yu, X., Wagner, T. E., & Wei, Y. (2004) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700707 · Cited by 34 · see citing works

Improved Delivery of Methoxsalen

Kreuter, J., & Higuchi, T. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600680415 · Cited by 24 · see citing works

Cell adhesion and tumor metastasis.

Ruoslahti, E. I. (1994) · PubMed · Cited by 23 · see citing works

Phase I study of NK105, a paclitaxel-incorporating micellar nanoparticle, in patients with advanced cancer

Kato, K., Hamaguchi, T., Yasui, H., Okusaka, T., Ueno, H., Ikeda, M., Shirao, K., Shimada, Y., Nakahama, H., Muro, K., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.24.18_suppl.2018 · Cited by 19 · see citing works

Polymer therapeutics : polymers as drugs, conjugates and gene delivery systems

Duncan, R., Satchi‐Fainaro, R., Alakhov, V. Y., et al. (2006) · Springer eBooks · Cited by 14 · see citing works

Selection of Internalizing Antibodies for Drug Delivery

Marks, J. D. (2004) · Humana Press eBooks · doi:10.1385/1-59259-666-5:201 · Cited by 14 · see citing works

Cancer nanomedicine: progress, challenges and opportunities

Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works

Analysis of nanoparticle delivery to tumours

Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218 · see citing works

Clinical development and potential of photothermal and photodynamic therapies for cancer

Li, X., Lovell, J. F., Yoon, J., & Chen, X. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0410-2 · Cited by 3,456 · see citing works

Progress and challenges towards targeted delivery of cancer therapeutics

Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220 · see citing works

Endocytosis of nanomedicines

Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181 · see citing works

Engineered Nanoparticles for Drug Delivery in Cancer Therapy

Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164 · see citing works

Nanoparticles in the clinic: an update

Anselmo, A. C., & Mitragotri, S. (2019) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10143 · Cited by 1,766 · see citing works

The entry of nanoparticles into solid tumours

Sindhwani, S., Syed, A. M., Ngai, J., Kingston, B. R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N. U., Hoang, T., et al. (2020) · Nature Materials · doi:10.1038/s41563-019-0566-2 · Cited by 1,732 · see citing works

Liposomes: Structure, composition, types, and clinical applications

Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09394 · Cited by 1,561 · see citing works

Multifunctional wearable devices for diagnosis and therapy of movement disorders

Son, D., Lee, J., Qiao, S., Ghaffari, R., Kim, J., Lee, J. E., Song, C., Kim, S. J., Lee, D. J., Jun, S. W., et al. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.38 · Cited by 1,462 · see citing works

Block copolymer micelles in nanomedicine applications

Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309 · see citing works

Nanoparticles in the clinic

Anselmo, A. C., & Mitragotri, S. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10003 · Cited by 1,321 · see citing works

Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery

Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270 · see citing works

BioMOFs: Metal–Organic Frameworks for Biological and Medical Applications

McKinlay, A. C., Morris, R. E., Horcajada, P., Férey, G., Gref, R., Couvreur, P., & Serre, C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000048 · Cited by 1,256 · see citing works

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.45 · Cited by 1,101 · see citing works

Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Gavas, S., Quazi, S., & Karpiński, T. M. (2021) · Nanoscale Research Letters · doi:10.1186/s11671-021-03628-6 · Cited by 1,069 · see citing works

Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review

Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998 · see citing works

Targeting drugs to tumours using cell membrane-coated nanoparticles

Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980 · see citing works

Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells

Wang, F., Wang, Y.-C., Dou, S., Xiong, M.-H., Sun, T.-M., & Wang, J. (2011) · ACS Nano · doi:10.1021/nn200007z · Cited by 813 · see citing works

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Yong, T., Zhang, X., Bie, N., Zhang, H., Zhang, X., Li, F., Hakeem, A., Hu, J., Gan, L., Santos, H. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11718-4 · Cited by 806 · see citing works

Design considerations for tumour-targeted nanoparticles

Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754 · see citing works

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

Diop-Frimpong, B., Chauhan, V. P., Krane, S., Boucher, Y., & Jain, R. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018892108 · Cited by 733 · see citing works

Nanomedicine therapeutic approaches to overcome cancer drug resistance

Markman, J. L., Rekechenetskiy, A., Holler, E., & Ljubimova, J. Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.019 · Cited by 733 · see citing works

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: In vitro and in vivo evaluations

Kim, M. S., Haney, M. J., Zhao, Y., Yuan, D., Deygen, I., Klyachko, N. L., Kabanov, A. V., & Batrakova, E. V. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.09.011 · Cited by 663 · see citing works

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works

Recent advances of cocktail chemotherapy by combination drug delivery systems

Hu, Q., Sun, W., Wang, C., & Gu, Z. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.022 · Cited by 625 · see citing works

Self‐assembled DNA nanoclews for the efficient delivery of CRISPR–Cas9 for genome editing

Sun, W., Ji, W., Hall, J. M., Hu, Q., Wang, C., Beisel, C. L., & Gu, Z. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506030 · Cited by 629 · see citing works

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

Kim, O. Y., Park, H. T., Dinh, N. T. H., Choi, S. J., Lee, J., Kim, J. H., Lee, S.-W., & Gho, Y. S. (2017) · Nature Communications · doi:10.1038/s41467-017-00729-8 · Cited by 616 · see citing works

CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery

Wang, H.-X., Li, M., Lee, C. M., Chakraborty, S., Kim, H.-W., Bao, G., & Leong, K. W. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00799 · Cited by 560 · see citing works

Redox-responsive polymers for drug delivery: from molecular design to applications

Huo, M., Yuan, J., Tao, L., & Wei, Y. (2014) · Polym. Chem. · doi:10.1039/c3py01192e · Cited by 561 · see citing works

Emerging flexible and wearable physical sensing platforms for healthcare and biomedical applications

Kenry, Yeo, J. C., & Lim, C. T. (2016) · Microsystems & Nanoengineering · doi:10.1038/micronano.2016.43 · Cited by 550 · see citing works

Tailoring nanocarriers for intracellular protein delivery

Gu, Z., Biswas, A., Zhao, M., & Tang, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00227e · Cited by 543 · see citing works

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

Li, H.-J., Du, J.-Z., Liu, J., Du, X.-J., Shen, S., Zhu, Y.-H., Wang, X., Ye, X., Nie, S., & Wang, J. (2016) · ACS Nano · doi:10.1021/acsnano.6b02326 · Cited by 537 · see citing works

A Review of Clinical Translation of Inorganic Nanoparticles

Anselmo, A. C., & Mitragotri, S. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9780-2 · Cited by 509 · see citing works

Mechanisms of drug release in nanotherapeutic delivery systems

Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507 · see citing works

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506 · see citing works

Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances

Karimi, M., Sahandi Zangabad, P., Ghasemi, A., Amiri, M., Bahrami, M., Malekzad, H., Ghahramanzadeh Asl, H., Mahdieh, Z., Bozorgomid, M., Ghasemi, A., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00371 · Cited by 500 · see citing works

Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Zhen, X., Cheng, P., & Pu, K. (2019) · Small · doi:10.1002/smll.201804105 · Cited by 483 · see citing works

Multifunctional polymeric micelles for delivery of drugs and siRNA

Jhaveri, A. M., & Torchilin, V. P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00077 · Cited by 466 · see citing works

Magnetic nanoparticle-based drug delivery for cancer therapy

Tietze, R., Zaloga, J., Unterweger, H., Lyer, S., Friedrich, R. P., Janko, C., Pöttler, M., Dürr, S., & Alexiou, C. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.022 · Cited by 425 · see citing works

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works

Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities

Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415 · see citing works

Cloaking nanoparticles with protein corona shield for targeted drug delivery.

Oh, J. Y., Kim, H. S., Palanikumar, L., Go, E. M., Jana, B., Park, S. A., Kim, H. Y., Kim, K., Seo, J. K., Kwak, S. K., et al. (2018) · Nature communications · doi:10.1038/s41467-018-06979-4 · Cited by 409 · see citing works

Biomaterials and emerging anticancer therapeutics: engineering the microenvironment

Gu, L., & Mooney, D. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.3 · Cited by 407 · see citing works

Stimuli-responsive nanomaterials for therapeutic protein delivery

Lu, Y., Sun, W., & Gu, Z. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.015 · Cited by 415 · see citing works

Nanotechnology for protein delivery: Overview and perspectives

Yu, M., Wu, J., Shi, J., & Farokhzad, O. C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.012 · Cited by 410 · see citing works

Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles

Arvizo, R. R., Miranda, O. R., Moyano, D. F., Walden, C. A., Giri, K., Bhattacharya, R., Robertson, J. D., Rotello, V. M., Reid, J. M., & Mukherjee, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024374 · Cited by 403 · see citing works

Triggered release from liposomes through magnetic actuation of iron oxide nanoparticle containing membranes

Amstad, E., Kohlbrecher, J., Müller, E., Schweizer, T., Textor, M., & Reimhult, E. (2011) · Nano Letters · doi:10.1021/nl2001499 · Cited by 397 · see citing works

Nanotheranostics and image-guided drug delivery: current concepts and future directions

Lammers, T., Kiessling, F., Hennink, W. E., & Storm, G. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100228v · Cited by 397 · see citing works

Nanomedicine of synergistic drug combinations for cancer therapy – Strategies and perspectives

Zhang, R. X., Wong, H. L., Xue, H. Y., Eoh, J. Y., & Wu, X. Y. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.012 · Cited by 380 · see citing works

Advancement of the emerging field of RNA nanotechnology

Jasinski, D., Haque, F., Binzel, D. W., & Guo, P. (2017) · ACS Nano · doi:10.1021/acsnano.6b05737 · Cited by 352 · see citing works

Ligand-installed nanocarriers toward precision therapy

Mi, P., Cabral, H., & Kataoka, K. (2020) · Advanced Materials · doi:10.1002/adma.201902604 · Cited by 350 · see citing works

Breaking Down the Barriers to Precision Cancer Nanomedicine

von Roemeling, C., Jiang, W., Chan, C. K., Weissman, I. L., & Kim, B. Y. S. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.07.006 · Cited by 330 · see citing works

Ph-responsive polymer–drug conjugates: design and progress

Pang, X., Jiang, Y., Xiao, Q., Leung, A. W., Hua, H., & Xu, C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.024 · Cited by 317 · see citing works

Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles

Li, L., Gu, W., Chen, J., Chen, W., & Xu, Z. P. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.095 · Cited by 304 · see citing works

Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J. (2012) · Advanced Materials · doi:10.1002/adma.201202847 · Cited by 299 · see citing works

Positioning metal-organic framework nanoparticles within the context of drug delivery – A comparison with mesoporous silica nanoparticles and dendrimers

Wuttke, S., Lismont, M., Escudero, A., Rungtaweevoranit, B., & Parak, W. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.025 · Cited by 286 · see citing works

Visualization of the Cellular Uptake and Trafficking of DNA Origami Nanostructures in Cancer Cells

Wang, P., Rahman, M. A., Zhao, Z., Weiss, K., Zhang, C., Chen, Z., Hurwitz, S. J., Chen, Z. G., Shin, D. M., & Ke, Y. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b09024 · Cited by 269 · see citing works

Metallodrugs in cancer nanomedicine

Peña, Q., Wang, A., Zaremba, O., Shi, Y., Scheeren, H. W., Metselaar, J. M., Kiessling, F., Pallares, R. M., Wuttke, S., & Lammers, T. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00468a · Cited by 259 · see citing works

A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery

Chai, Z., Hu, X., Wei, X., Zhan, C., Lu, L., Jiang, K., Su, B., Ruan, H., Ran, D., Fang, R. H., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.027 · Cited by 253 · see citing works

Evolution in Lithography Techniques: Microlithography to Nanolithography

Sharma, E., Rathi, R., Misharwal, J., Sinhmar, B., Kumari, S., Dalal, J., & Kumar, A. (2022) · Nanomaterials · doi:10.3390/nano12162754 · Cited by 257 · see citing works

Synthesis of Size‐Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single‐Layer Microchannels

Rhee, M., Valencia, P. M., Rodriguez, M. I., Langer, R., Farokhzad, O. C., & Karnik, R. (2011) · Advanced Materials · doi:10.1002/adma.201004333 · Cited by 236 · see citing works

The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen

Jain, A. K., Swarnakar, N. K., Godugu, C., Singh, R. P., & Jain, S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.037 · Cited by 232 · see citing works

Cell membrane coated-nanoparticles for cancer immunotherapy

Zeng, Y., Li, S., Zhang, S., Wang, L., Yuan, H., & Hu, F. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.02.023 · Cited by 238 · see citing works

Non-genetic engineering of cells for drug delivery and cell-based therapy

Wang, Q., Cheng, H., Peng, H., Zhou, H., Li, P. Y., & Langer, R. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.003 · Cited by 225 · see citing works

Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment

Martínez-Carmona, M., Lozano, D., Colilla, M., & Vallet-Regí, M. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.11.007 · Cited by 220 · see citing works

Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation‐Induced Emission

Xue, X., Zhao, Y., Dai, L., Zhang, X., Hao, X., Zhang, C., Huo, S., Liu, J., Liu, C., Kumar, A., et al. (2014) · Advanced Materials · doi:10.1002/adma.201302365 · Cited by 206 · see citing works

Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy

Gao, J., Wang, W.-Q., Pei, Q., Lord, M. S., & Yu, H.-J. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0400-z · Cited by 203 · see citing works

Enhancing tumor penetration of nanomedicines

Sun, Q., Ojha, T., Kiessling, F., Lammers, T., & Shi, Y. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00068 · Cited by 198 · see citing works

Actively targeted delivery of anticancer drug to tumor cells by redox-responsive star-shaped micelles

Shi, C., Guo, X., Qu, Q., Tang, Z., Wang, Y., & Zhou, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.036 · Cited by 189 · see citing works

Aptamer-guided nanomedicines for anticancer drug delivery

Alshaer, W., Hillaireau, H., & Fattal, E. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.011 · Cited by 187 · see citing works

Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles

Cohen, Z. R., Ramishetti, S., Peshes-Yaloz, N., Goldsmith, M., Wohl, A., Zibly, Z., & Peer, D. (2015) · ACS Nano · doi:10.1021/nn506248s · Cited by 182 · see citing works

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

Ioannidis, J. P. A., Kim, B. Y. S., & Trounson, A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0314-y · Cited by 175 · see citing works

Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells

Sun, R., Liu, Y., Li, S.-Y., Shen, S., Du, X.-J., Xu, C.-F., Cao, Z.-T., Bao, Y., Zhu, Y.-H., Li, Y.-P., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.018 · Cited by 172 · see citing works

Nanoparticle shape improves delivery: rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles

Loverde, S. M., Klein, M. L., & Discher, D. E. (2012) · Advanced Materials · doi:10.1002/adma.201103192 · Cited by 162 · see citing works

Polymeric Micelles for Multi-Drug Delivery in Cancer

Cho, H., Lai, T. C., Tomoda, K., & Kwon, G. S. (2015) · AAPS PharmSciTech · doi:10.1208/s12249-014-0251-3 · Cited by 159 · see citing works

Recent Advances in Nanomicelles Delivery Systems.

Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works

NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

Li, M., Sun, X., Zhang, N., Wang, W., Yang, Y., Jia, H., & Liu, W. (2018) · Advanced Science · doi:10.1002/advs.201800155 · Cited by 153 · see citing works

Modulating the Tumor Microenvironment to Enhance Tumor Nanomedicine Delivery

Zhang, B., Hu, Y., & Pang, Z. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00952 · Cited by 152 · see citing works

Targeted Delivery of Nanoparticles to Ischemic Muscle for Imaging and Therapeutic Angiogenesis

Kim, J., Cao, L., Shvartsman, D., Silva, E. A., & Mooney, D. J. (2011) · Nano Letters · doi:10.1021/nl103812a · Cited by 150 · see citing works

Near-infrared light sensitive polypeptide block copolymer micelles for drug delivery

Kumar, S., Allard, J.-F., Morris, D., Dory, Y. L., Lepage, M., & Zhao, Y. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm16380b · Cited by 146 · see citing works

PEGylated nanomedicines: recent progress and remaining concerns

Vllasaliu, D., Fowler, R., & Stolnik, S. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.866651 · Cited by 137 · see citing works

The Fluid Mechanics of Cancer and Its Therapy

Koumoutsakos, P., Pivkin, I., & Milde, F. (2013) · Annual Review of Fluid Mechanics · doi:10.1146/annurev-fluid-120710-101102 · Cited by 129 · see citing works

Polypeptide-based combination of paclitaxel and cisplatin for enhanced chemotherapy efficacy and reduced side-effects

Song, W., Tang, Z., Li, M., Lv, S., Sun, H., Deng, M., Liu, H., & Chen, X. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.11.026 · Cited by 126 · see citing works

Iron oxide-loaded nanotheranostics: major obstacles to in vivo studies and clinical translation

Schleich, N., Danhier, F., & Préat, V. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.024 · Cited by 124 · see citing works

MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

Chen, W.-H., Luo, G.-F., Lei, Q., Jia, H.-Z., Hong, S., Wang, Q.-R., Zhuo, R.-X., & Zhang, X.-Z. (2015) · Chemical Communications · doi:10.1039/c4cc07563c · Cited by 115 · see citing works

pH-Responsive PDMS- <i>b</i> -PDMAEMA Micelles for Intracellular Anticancer Drug Delivery

Car, A., Baumann, P., Duskey, J. T., Chami, M., Bruns, N., & Meier, W. (2014) · Biomacromolecules · doi:10.1021/bm500919z · Cited by 113 · see citing works

PEG-Graft Density Controls Polymeric Nanoparticle Micelle Stability

Logie, J., Owen, S. C., McLaughlin, C. K., & Shoichet, M. S. (2014) · Chemistry of Materials · doi:10.1021/cm500448x · Cited by 110 · see citing works

Nano-assemblies of J-aggregates based on a NIR dye as a multifunctional drug carrier for combination cancer therapy

Song, X., Zhang, R., Liang, C., Chen, Q., Gong, H., & Liu, Z. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.001 · Cited by 101 · see citing works

Thermo-triggered Drug Release from Actively Targeting Polymer Micelles

Guo, X., Li, D., Yang, G., Shi, C., Tang, Z., Wang, J., & Zhou, S. (2014) · ACS Applied Materials &amp; Interfaces · doi:10.1021/am501422r · Cited by 97 · see citing works

Capillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment

Yokoi, K., Kojic, M., Milosevic, M., Tanei, T., Ferrari, M., & Ziemys, A. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3494 · Cited by 95 · see citing works

Targeting cell adhesion molecules with nanoparticles using <i>in vivo</i> and flow-based <i>in vitro</i> models of atherosclerosis

Khodabandehlou, K., Masehi-Lano, J. J., Poon, C., Wang, J., & Chung, E. J. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217693116 · Cited by 91 · see citing works

A mini review on the functional biomaterials based on poly (lactic acid) stereocomplex

Jing, Y., Quan, C., Liu, B., Jiang, Q., & Zhang, C. (2016) · Polymer Reviews · doi:10.1080/15583724.2015.1111380 · Cited by 92 · see citing works

Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles

Sayour, E. J., De Leon, G., Pham, C., Grippin, A., Kemeny, H., Chua, J., Huang, J., Sampson, J. H., Sanchez-Perez, L., Flores, C., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1256527 · Cited by 93 · see citing works

Ultrasonically triggered drug delivery: Breaking the barrier

Husseini, G. A., Pitt, W. G., & Martins, A. M. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2014.07.051 · Cited by 87 · see citing works

Noninvasive Fluorescence Resonance Energy Transfer Imaging of <i>in Vivo</i> Premature Drug Release from Polymeric Nanoparticles

Zou, P., Chen, H., Paholak, H. J., & Sun, D. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4002393 · Cited by 88 · see citing works

Redox-Responsive Core-Cross-Linked Block Copolymer Micelles for Overcoming Multidrug Resistance in Cancer Cells

Maiti, C., Parida, S., Kayal, S., Maiti, S., Mandal, M., & Dhara, D. (2018) · ACS Applied Materials &amp; Interfaces · doi:10.1021/acsami.7b18245 · Cited by 75 · see citing works

Chloroquine in combination with aptamer-modified nanocomplexes for tumor vessel normalization and efficient erlotinib/Survivin shRNA co-delivery to overcome drug resistance in EGFR-mutated non-small cell lung cancer

Lv, T., Li, Z., Xu, L., Zhang, Y., Chen, H., & Gao, Y. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.06.034 · Cited by 74 · see citing works

Imaging-assisted anticancer nanotherapy

Dasgupta, A., Biancacci, I., Kiessling, F., & Lammers, T. (2020) · Theranostics · doi:10.7150/thno.38288 · Cited by 74 · see citing works

pH-sensitive nanocarriers for curcumin delivery in cancer therapy

Mohammadzadeh, V., Zirak, M. R., Hosseinikhah, S. M., Kamali, H., & Jaafari, M. R. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102879 · Cited by 21 · see citing works

Reduction-sensitive polymeric nanocarriers in cancer therapy: a comprehensive review

Deng, B., Ma, P., & Xie, Y. (2015) · Nanoscale · doi:10.1039/c5nr02878g · Cited by 138 · see citing works

Recent advances in near-infrared light-responsive nanocarriers for cancer therapy

Saneja, A., Kumar, R., Arora, D., Kumar, S., Panda, A. K., & Jaglan, S. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.02.005 · Cited by 111 · see citing works

Pharmaceutical Nanocarriers (Liposomes and Micelles) in Cancer Therapy

Vaze, O. S. (2016) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.1000e138 · Cited by 18 · see citing works

Polymeric nanocarriers incorporating near-infrared absorbing agents for potent photothermal therapy of cancer

Zhang, Y., Ang, C. Y., & Zhao, Y. (2015) · Polymer Journal · doi:10.1038/pj.2015.117 · Cited by 81 · see citing works