The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Early lineage segregation of multipotent embryonic mammary gland progenitors
Open accessAbstract
The mammary gland is composed of basal cells and luminal cells. It is generally believed that the mammary gland arises from embryonic multipotent progenitors, but it remains unclear when lineage restriction occurs and what mechanisms are responsible for the switch from multipotency to unipotency during its morphogenesis. Here, we perform multicolour lineage tracing and assess the fate of single progenitors, and demonstrate the existence of a developmental switch from multipotency to unipotency during embryonic mammary gland development. Molecular profiling and single cell RNA-seq revealed that embryonic multipotent progenitors express a unique hybrid basal and luminal signature and the factors associated with the different lineages. Sustained p63 expression in embryonic multipotent progenitors promotes unipotent basal cell fate and was sufficient to reprogram adult luminal cells into basal cells by promoting an intermediate hybrid multipotent-like state. Altogether, this study identifies the timing and the mechanisms mediating early lineage segregation of multipotent progenitors during mammary gland development. Wuidart et al. show that the mammary gland develops from embryonic multipotent progenitors that switch from multipotency to unipotency and express a unique gene signature. ΔNp63 promotes their basal fate and also reprograms adult luminal cells.
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Scenic: single-cell regulatory network inference and clustering.
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Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
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Distinct stem cells contribute to mammary gland development and maintenance
Van Keymeulen, A., Rocha, A. S., Ousset, M., Beck, B., Bouvencourt, G., Rock, J., Sharma, N., Dekoninck, S., & Blanpain, C. (2011) · Nature · doi:10.1038/nature10573 · Cited by 854
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Li, C. M.-C., Shapiro, H., Tsiobikas, C., Selfors, L. M., Chen, H., Rosenbluth, J., Moore, K., Gupta, K. P., Gray, G. K., Oren, Y., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108566 · Cited by 184
Metadata
- Authors
- Wuidart, A., Sifrim, A., Fioramonti, M., Matsumura, S., Brisebarre, A., Brown, D., Centonze, A., Dannau, A., Dubois, C., Van Keymeulen, A., Voet, T., & Blanpain, C.
- Venue
- Nature Cell Biology
- Published
- 2018-05-21
- Volume
- 20
- Issue
- 6
- Pages
- 666-676
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2804088280
- Cited by
- 160
- References
- 8
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Wuidart, A., Sifrim, A., Fioramonti, M., Matsumura, S., Brisebarre, A., Brown, D., Centonze, A., Dannau, A., Dubois, C., Van Keymeulen, A., Voet, T., & Blanpain, C. (2018). Early lineage segregation of multipotent embryonic mammary gland progenitors. Nature Cell Biology. https://doi.org/10.1038/s41556-018-0095-2
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