The DOI matches its Crossref record; 248 of the 248 references it cites were found in a registry or an index.
Stem Cells and the Differentiation Hierarchy in Mammary Gland Development
Abstract
The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproductive cycle. These changes are fueled by dedicated stem and progenitor cells. Both short- and long-lived lineage-restricted progenitors have been identified in adult tissue as well as a small pool of multipotent mammary stem cells (MaSCs), reflecting intrinsic complexity within the epithelial hierarchy. While unipotent progenitor cells predominantly execute day-to-day homeostasis and postnatal morphogenesis during puberty and pregnancy, multipotent MaSCs have been implicated in coordinating alveologenesis and long-term ductal maintenance. Nonetheless, the multipotency of stem cells in the adult remains controversial. The advent of large-scale single-cell molecular profiling has revealed striking changes in the gene expression landscape through ontogeny and the presence of transient intermediate populations. An increasing number of lineage cell-fate determination factors and potential niche regulators have now been mapped along the hierarchy, with many implicated in breast carcinogenesis. The emerging diversity among stem and progenitor populations of the mammary epithelium is likely to underpin the heterogeneity that characterizes breast cancer.
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Cites
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Cited by
Breast milk, a source of beneficial microbes and associated benefits for infant health
Lyons, K. E., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Nutrients · doi:10.3390/nu12041039 · Cited by 613
Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing
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Metadata
- Authors
- Fu, N. Y., Nolan, E., Lindeman, G. J., & Visvader, J. E.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2020-04-01
- Volume
- 100
- Issue
- 2
- Pages
- 489-523
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2974150138
- Cited by
- 267
- References
- 248
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fu, N. Y., Nolan, E., Lindeman, G. J., & Visvader, J. E. (2020). Stem Cells and the Differentiation Hierarchy in Mammary Gland Development. Physiological Reviews. https://doi.org/10.1152/physrev.00040.2018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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