The DOI matches its Crossref record; 82 of the 83 references it cites were found in a registry or an index.
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration
Open accessAbstract
Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that ductal cells clonally expand as self-renewing liver organoids that retain their differentiation capacity into both hepatocytes and ductal cells. However, the molecular mechanisms by which adult ductal-committed cells acquire cellular plasticity, initiate organoids and regenerate the damaged tissue remain largely unknown. Here, we describe that ductal cells undergo a transient, genome-wide, remodelling of their transcriptome and epigenome during organoid initiation and in vivo following tissue damage. TET1-mediated hydroxymethylation licences differentiated ductal cells to initiate organoids and activate the regenerative programme through the transcriptional regulation of stem-cell genes and regenerative pathways including the YAP-Hippo signalling. Our results argue in favour of the remodelling of genomic methylome/hydroxymethylome landscapes as a general mechanism by which differentiated cells exit a committed state in response to tissue damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Through coordination of this and other epigenetics pathways42, YAP activity is able to be amplified robustly to ensure a timely adjustment during liver injury and regeneration.”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [42]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Pooling together different cells and/or organoids for bulk analysis can lead to inaccurate results3,70,100,204,207,208.”
From Organoids (2022) · cites this paper as [208]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications
Krueger, F., & Andrews, S. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr167 · Cited by 5,324
GREAT improves functional interpretation of cis-regulatory regions
McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., & Bejerano, G. (2010) · Nature Biotechnology · doi:10.1038/nbt.1630 · Cited by 4,502
Full-length RNA-seq from single cells using Smart-seq2
Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137
Organoid Models and Applications in Biomedical Research
Xinaris, C., Brizi, V., & Remuzzi, G. (2015) · The Nephron journals/Nephron journals · doi:10.1159/000433566 · Cited by 3,519
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
TET enzymes, TDG and the dynamics of DNA demethylation
Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623
Cited by
Sorted by citations
Items 101–160 of 160
CD133‐Src‐TAZ signaling stimulates ductal fibrosis following DDC diet‐induced liver injury
Oh, H. T., Heo, W., Yoo, G. D., Kim, K. M., Hwang, J., Hwang, E. S., Ko, J., Ko, Y., & Hong, J. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30899 · Cited by 7
“…liver function and it was revealed that the gene expression signature of growing cholangiocyte organoids is similar to that of DDC diet‐damaged cholangiocytes, thus validating organoids as a model system to study the molecular mechanisms of liver regeneration after damage (Aloia et al., 2019).”
BackgroundTang, J. L. Y., Hakes, A. E., Krautz, R., Suzuki, T., Contreras, E. G., Fox, P. M., & Brand, A. H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.07.447332 · Cited by 9
“We drove expression of NanoDam in embryonic NSCs with worniu-GAL4 and compared our results to those we obtained using TaDa.”
InfluentialSelf-citationYuan, W.-C., Earl, A. S., Ma, S., Alcedo, K., Russell, J. O., Duarte, F. M., Chu, Y.-T., Chang, P.-C., Chen, H.-Y., Chi, H.-H., et al. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.04.010 · Cited by 7
Hepatobiliary organoid research: the progress and applications
Zou, R.-Q., Dai, Y.-S., Liu, F., Yang, S., Hu, H., & Li, F. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1473863 · Cited by 9
Influencing factors and mechanism of hepatocyte regeneration
Zhang, X., Li, S., Hao, L., Jia, F., Yu, F., & Hu, X. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06278-9 · Cited by 6
“In addition, as the downstream effector of Hippo transducer YAP, Notch signaling pathway is also very important in hepatocyte regeneration [104].”
Using different zebrafish models to explore liver regeneration
Mo, D., Lv, M., & Mao, X. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1485773 · Cited by 6
Haaker, M. W., Chang, J., Chung, B. K., Pieper, T. S., Noé, F., Wang, T., Geijsen, N., Houweling, M., Wolfrum, C., Vaandrager, A. B., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101472 · Cited by 7
“11 The expansion of Lgr5 þ liver stem cells is induced by Wnt-driven regeneration, mediated by the leucine rich repeat containing G protein-coupled receptor 5 (LGR5) , a receptor for R-spondins.”
Galanakis, V., Gribben, C., Munteanu, A., Cagna, M., Roos, F. J. M., Bulgaru, C., Ciortuz, L., Allison, M., Mohorianu, I. I., & Vallier, L. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.09.021 · Cited by 7
Human liver cholangiocyte organoids capture the heterogeneity of in vivo liver ductal epithelium
Bregante, J., Don, F. K., Rost, F., Gohr, A., Belenguer, G., Baenke, F., Liabeuf, D., Pöche, J., Schafmayer, C., Wilsch‐Bräuninger, M., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116786 · Cited by 6
Self-citationMastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges
Jiao, C., Karakaya, O. F., Dadgar, N., Wehrle, C. J., Massoud, Z., Hong, H., Fairchild, R. L., Leipzig, N. D., Aucejo, F., Ma, W. W., et al. (2026) · MedComm · doi:10.1002/mco2.70571 · Cited by 9
Huang, Y. G., Zhang, S., Weng, J., Huang, D., & Gu, W. (2022) · Open Medicine · doi:10.1515/med-2022-0481 · Cited by 6
“Based on transcriptional profiles, Aloia and colleagues found that cells in organoids underwent genome-wide remodelling as a result of DDC-induced biliary damage, which may be crucial in transdifferentiation and liver regeneration [98].”
BackgroundInfluentialChi, K. Y., & Kim, J. (2022) · Organoid · doi:10.51335/organoid.2022.2.e6 · Cited by 6
“Similar protocols [37] have been used for the large-scale production of liver organoids [38] to investigate the basic mechanisms underlying liver development and regeneration [39] and”
MethodOrganoids as tools for fundamental discovery and translation—a Keystone Symposia report
Cable, J., Lütolf, M. P., Fu, J., Park, S. E., Apostolou, A. P., Chen, S., Song, C. J., Spence, J. R., Liberali, P., Lancaster, M. A., et al. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14874 · Cited by 6
Self-citationLiver regeneration: metabolic and epigenetic regulation
Verma, S., Purohit, J. S., Arora, A., Sinha, S., & Chaturvedi, M. M. (2021) · Hepatoma Research · doi:10.20517/2394-5079.2020.122 · Cited by 5
“Summary of epigenetic modifications associated with liver regeneration([84,86,112,126-129]).”
BackgroundInfluentialTen-eleven translocation-2-mediated macrophage activation promotes liver regeneration
Chen, Y., Meng, L., Xu, N., Chen, H., Wei, X., Lu, D., Wang, S., & Xu, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01407-7 · Cited by 5
“Epigenetic regulation also affects liver regeneration after PHx [50–52], and mice transplanted with Tet2-deficient hematopoietic cells display heightened macrophage cytokines [51].”
BackgroundCholangiocyte Organoids in Liver Transplantation; a Comprehensive Review
Rejas, C., & Junger, H. H. G. (2024) · Transplant International · doi:10.3389/ti.2024.12708 · Cited by 5
“Interestingly, these cells can modify their epigenetic imprinting to adapt to different stimuli [25].”
BackgroundXu, Z.-Y., Wang, M., Shi, J.-Y., Liu, Y., Yu, C., Zhang, X.-Y., Zhang, C.-W., He, Q.-F., Pan, C., Zhou, J., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101700 · Cited by 5
“2C) [41,42].”
Lian, J., An, Y., Wei, W., Lu, Y., Zhang, X., Sun, G., Guo, H., Xu, L., Chen, X., & Hu, H. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115633 · Cited by 5
Rao, S., Romal, S., Torenvliet, B., Slotman, J. A., Huijs, T. T. G., & Mahmoudi, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30740 · Cited by 4
“…used in this study [18], the liver organoids are derived from adult resident ductal cells that undergo Tet1-mediated epigenetic reprogramming to assume a stem cell state [44], with some cholangiocyte markers still being expressed upon differentiation into the hepatocyte-like cell fate [21,45].”
BackgroundTissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair
Jiang, Y., Przybilla, M. J., Bakker, L. V., Jacobs, F. C., Mckeon, D., van der Sluijs, R., Sato, K., Wezenbeek, J., van Strien, J., Willems, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67072-1 · Cited by 5
Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation
Zhong, S., Zheng, L., Wu, Y., Shujin, S., Luo, Q., Song, G., Lü, D., & Long, M. (2024) · BMC Biology · doi:10.1186/s12915-024-02062-1 · Cited by 5
Pour une bonne compréhension et un bon usage du terme « organoïdes »
Chneiweiss, H., Dubart‐Kupperschmitt, A., Duclos‐Vallée, J., Clément, B., Flacher, V., Galzi, J., Gidrol, X., Goureau, O., Guasch, G., Haiech, J., et al. (2023) · médecine/sciences · doi:10.1051/medsci/2023155 · Cited by 5
Epigenetic regulation in liver regeneration
Li, Z., & Sun, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122924 · Cited by 5
Update on Hepatobiliary Plasticity
Kim, M., Rizvi, F., Shin, D., & Gouon–Evans, V. (2023) · Seminars in Liver Disease · doi:10.1055/s-0042-1760306 · Cited by 5
“The Notch – IGF1 axis 76 and Tet1 77 have been reported to control LPC proliferation during the conversion, thereby affecting the number of BEC-derived hepatocytes.”
BackgroundAnfuso, B., Velnati, S., Selvestrel, D., Garlant, C., Ferracci, E., Baj, G., Parisse, P., Overi, D., Bertolio, R., Bulla, R., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116681 · Cited by 3
Shen, Z., Dai, W., Guo, Y., Wang, J., Shen, B., Li, B., Lu, L., & Cai, X. (2023) · The FASEB Journal · doi:10.1096/fj.202201919r · Cited by 3
The influence of tissue spatial geometry and functional organisation on liver regeneration
Aloia, L. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.09.011 · Cited by 4
“ICOs express stem-cell genes defining bipotent adult liver progenitors in vivo (e.g. Trop2 ) [53,58,59] and recapitulate the transcriptional and epigenetic profiles of regenerative cholangiocytes in the mouse injured liver in vivo [53].”
InfluentialSelf-citationNOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocyte reprogramming into intrahepatic cholangiocarcinomaPreprint
Hu, S., Molina, L. M., Tao, J., Liu, S., Hassan, M., Singh, S., Poddar, M., Bell, A. W., Sia, D., Oertel, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.03.410993 · Cited by 3
“cell fate switches including HC-to-BEC conversion (29-32).”
Lo, E. K. W., Velazquez, J. J., Peng, D., Kwon, C., Ebrahimkhani, M. R., & Cahan, P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.07.506886 · Cited by 3
Exploiting the plasticity of cholangiocytes to repair the biliary tree
Frau, C., & Vallier, L. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102257 · Cited by 2
“Cholangio-cyte activation and their re-entry in the cell cycle are likely to involve epigenetic regulations, as mouse COs can rapidly change their DNA methylation during deri-vation in vitro thereby demonstrating a unique capacity to remodel their epigenome [18].”
Schwayer, C., Barbiero, S., Brückner, D. B., Oost, K. C., Baader, C., Repina, N. A., Kim, J., Diaz, O. E., Uccelli, I., Capolupo, L., et al. (2026) · Cell · doi:10.1016/j.cell.2026.06.009 · Cited by 3
Function-oriented design: A novel strategy for advanced biomedical materials
Zhou, Z., Wang, W., Wang, J., Wang, H., Xia, Y., Zhang, W., Lai, Y., Lin, X. Y., Huang, Y., Zou, X., et al. (2022) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2022.09.066 · Cited by 2
In toto biological framework: Modeling interconnectedness during human development
Yoneyama, Y., Wu, Y., Mori, K., & Takebe, T. (2025) · Developmental Cell · doi:10.1016/j.devcel.2024.09.027 · Cited by 2
Controlling cellular plasticity to improve in vitro models for kidney regeneration
Casellas, C. P., Rookmaaker, M. B., & Verhaar, M. C. (2021) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2021.100345 · Cited by 2
Once upon a dish: the next frontier in engineering multicellular systems
Huch, M., & Gouti, M. (2022) · Development · doi:10.1242/dev.200744 · Cited by 2
Self-citationKANSL3 directs transcriptional programs essential for hepatic metabolism and differentiation
Wiese, M., Rodrigues, C. P., Akbas, M. E., Sun, Y., Holz, H., Greene, J. A. M., Tsang, T. H., Bella, C., Ganter, K., Stehle, T., et al. (2025) · Life Science Alliance · doi:10.26508/lsa.202503238 · Cited by 1
“For example, transitions to liver progenitor states are facilitated by active histone modifications that increase chromatin accessibility through ARID1A, a key component of the SWI/SNF complex (Li et al, 2019), or by the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine mediated by TET1 (Aloia et al, 2019).”
Maehara, H., Hatano, A., Shirai, M., Kokaji, T., Suzuki, Y., Matsumoto, M., Egami, R., Kubota, H., Araki, H., Miura, F., et al. (2025) · npj Systems Biology and Applications · doi:10.1038/s41540-025-00606-x · Cited by 1
“Hepatocytesexhibitdistinctmetabolicandtranscriptional programsdependingontheirpositionalongtheportal-centralaxis 48,49 , and recentsingle-cellandspatialtranscriptomicsstudieshaverevealedthatboth transcriptionfactorbindingandDNAmethylationexhibitzonated patterns 49,50 .”
Capturing complex epigenetic phenomena through human multicellular systems
Sen, D., & Keung, A. J. (2020) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2020.05.008 · Cited by 1
Vasko Popa a diez años de su muerte
Prenz, J. O. (2001) · Cuadernos hispanoamericanos · Cited by 1
Waddell, S. H., Yao, Y., Olaizola, P., Jarman, E. J., Gournopanos, K., Christodoulou, E., Gautier, P. E., Drenth, J. P. H., Kendall, T. J., Bañales, J. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.08.487546 · Cited by 1
“The FASEB Journal, 33(5):6667–6681, may 2019.”
BackgroundMethodInfluentialHepatic lipid overload potentiates biliary epithelial cell activation via E2FsPreprint
Yıldız, E., Alam, G. E., Perino, A., Jalil, A., Denechaud, P., Huber, K., Lluis Fajas, A., Auwerx, J. H., Sorrentino, G., & Schoonjans, K. (2022) · doi:10.7554/elife.81926.1 · Cited by 1
Collective dynamics of DNA methylation during ageingPreprint
Hashtroud, A. M., Bonder, M. J., Stegle, O., von Meyenn, F., Reik, W., & Rulands, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.15.628564 · Cited by 1
Cordero-Espinoza, L., Kohler, T. N., Dowbaj, A. M., Strauss, B., Sarlidou, O., Pacini, C., Dobie, R., Wilson‐Kanamori, J. R., Butler, R., Serup, P., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.21.306258
“35 References Aloia, L. et al. (2019) ‘Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration’, Nature Cell Biology, 21(11), pp. 1321–1333. doi: 10.1038/s41556-019-04026. Alvaro, D. et al. (2005) ‘The intrahepatic biliary epithelium is a target of the growth hormone/insulinl…”
BackgroundResultInfluentialSelf-citationChen, S.-J., Zhang, J., Ma, W., & Ye, H. (2021) · Research Square · doi:10.21203/rs.3.rs-136553/v2
Science shines in a new virtual SY-Stem
Buecker, C., & Merkle, F. T. (2021) · Development · doi:10.1242/dev.188367
Yamada, M., Okada, H., Ema, M., Kikkawa, Y., Miyajima, A., & Itoh, T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.25.477619
Chen, S.-J., Zhang, J., Ma, W., & Ye, H. (2020) · Research Square · doi:10.21203/rs.3.rs-136553/v1
Tet2-mediated macrophage activation promotes liver regeneration
Chen, Y., Meng, L., Xu, N., Chen, H., Wei, X., Lu, D., Wang, S., & Xu, X. (2023) · Korean Journal of Transplantation · doi:10.4285/atw2023.f-8988
Author Response: Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs
Yıldız, E., Alam, G. E., Perino, A., Jalil, A., Denechaud, P., Huber, K., Fajas, L., Auwerx, J. H., Sorrentino, G., & Schoonjans, K. (2022) · doi:10.7554/elife.81926.1.sa3
Zheng, Q., Li, X., Xu, Z., Cai, Y., Li, F., Xue, X., Li, S., Sun, R., Fan, G., Wu, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.07.602368
Fu, W., Pan, J., Yang, X., Zhang, Y., Mo, J., Tang, X., & Liu, H. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5170674
Genetically modified cell membrane proteins in tissue engineering and regenerative medicine
Bao, Y., Hu, Y., Hao, M., Zhang, Q., Yang, G., & Jiang, Z. (2025) · Biofabrication · doi:10.1088/1758-5090/add625 · Cited by 1
“When combined with gene editing techniques, organoids can be applied in cancer research and treatment [231], the creation of in vitro disease diagnostic models [232], gene correction [233], organ development [234], and tissue repair and regeneration [235].”
An interview with Meritxell (Meri) Huch
(2025) · Development · doi:10.1242/dev.205227
Chen, Y., Meng, L., Xu, N., Chen, H., Wei, X., Lu, D., Wang, S., & Xu, X. (2024) · Figshare · doi:10.6084/m9.figshare.25138050
Chen, Y., Meng, L., Xu, N., Chen, H., Wei, X., Lu, D., Wang, S., & Xu, X. (2024) · Figshare · doi:10.6084/m9.figshare.25137935
Rojo, C., Vila, J. J., Guembe, L., Arrubla-Gamboa, A., Jusue-Irurita, V., Carrascosa-Gil, J., Rullan, M., Rández-Garbayo, J., Fernández-Barrena, M. G., Huch, M., et al. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1812445
“In the dissociated workflow, we followed the protocol described in Aloia et al. (2019).”
Self-citationLiver organoids: modelling complexity in homeostasis and disease
Dowbaj, A. M., & Huch, M. (2026) · FEBS Letters · doi:10.1002/1873-3468.70432 · Cited by 1
Self-citation
Metadata
- Authors
- Aloia, L., McKie, M. A., Vernaz, G., Cordero-Espinoza, L., Aleksieva, N., van den Ameele, J., Antonica, F., Font-Cunill, B., Raven, A., Aiese Cigliano, R., Belenguer, G., Mort, R. L., Brand, A. H., Zernicka-Goetz, M., Forbes, S. J., Miska, E. A., & Huch, M.
- Affiliations
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
- MRC Centre for Regenerative Medicine (GB)
- Lancaster University (GB)
- Corresponding author
- Huch, Meritxell
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2019-11
- Volume
- 21
- Issue
- 11
- Pages
- 1321-1333
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC6940196
- OpenAlex
- W2986073722
- Cited by
- 160
- References
- 83
- Citations by year
- 2026: 6 · 2025: 26 · 2024: 21 · 2023: 22 · 2022: 42 · 2021: 24 · 2020: 18
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Lancaster EPrints (Lancaster University) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Iris (University of Trento) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Wellcome Trust (104640/Z/14/Z, 104151/Z/14/Z, 092096/Z/10/Z, 105839, 104151, C6946/A14492, 103792/Z/14/Z, 105839/Z/14/Z, 104640, 092096, 103792)
- Cancer Research UK (A18583, C13474/A18583, C6946 /A14492, 092096, C6946, 18583, A14492)
- Royal Society (RP150061)
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/R001162/1)
- Cambridge Trust
- National Centre for the Replacement Refinement and Reduction of Animals in Research (NC/R001162/1)
- Darwin Trust of Edinburgh
- Horizon 2020 Framework Programme (MSCA-IF-2016, 668350)
- Medical Research Council (MR/P016839/1, MC_PC_12009, MR/K017047/1, MR/K50127X/1)
- Cancer Research UK Cambridge Institute, University of Cambridge (C6946/A14492)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- cholangiocytes, liver regeneration, liver organoids, epigenetic remodeling, TET1, DNA hydroxymethylation, cellular plasticity, stemness genes, hepatocyte differentiation, tissue damage
- MeSH terms
- Epigenome, Hippo Signaling Pathway, YAP-Signaling Proteins, Animals, Bile Ducts, DNA-Binding Proteins, Epithelial Cells, Female, Liver, Liver Regeneration, Male, Mice, Transgenic, Organoids, Proto-Oncogene Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Cell Cycle Proteins, DNA Methylation, Gene Expression Profiling, Epigenesis, Genetic, Adaptor Proteins, Signal Transducing, Transcriptome, Primary Cell Culture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
