The DOI matches its Crossref record; 81 of the 82 references it cites were found in a registry or an index.
p120-catenin-dependent collective brain infiltration by glioma cell networks
Open accessAbstract
Diffuse brain infiltration by glioma cells causes detrimental disease progression, but its multicellular coordination is poorly understood. We show here that glioma cells infiltrate the brain collectively as multicellular networks. Contacts between moving glioma cells are adaptive epithelial-like or filamentous junctions stabilized by N-cadherin, β-catenin and p120-catenin, which undergo kinetic turnover, transmit intercellular calcium transients and mediate directional persistence. Downregulation of p120-catenin compromises cell-cell interaction and communication, disrupts collective networks, and both the cadherin and RhoA binding domains of p120-catenin are required for network formation and migration. Deregulating p120-catenin further prevents diffuse glioma cell infiltration of the mouse brain with marginalized microlesions as the outcome. Transcriptomics analysis has identified p120-catenin as an upstream regulator of neurogenesis and cell cycle pathways and a predictor of poor clinical outcome in glioma patients. Collective glioma networks infiltrating the brain thus depend on adherens junctions dynamics, the targeting of which may offer an unanticipated strategy to halt glioma progression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interstitial compartments are organized into various 3D architectures, including fibrillar porous networks or aligned bundles, heterogeneous in density, topology, and stiffness [11,12].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Stupp, R., Hegi, M. E., Mason, W. P., van den Bent, M. J., TAPHOORN, M. J. B., Janzer, R. C., Ludwin, S. K., Allgeier, A., Fisher, B., Bélanger, K., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70025-7 · Cited by 7,980
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735
Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.020 · Cited by 7,575
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel, A. P., Tirosh, I., Trombetta, J. J., Shalek, A. K., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., et al. (2014) · Science · doi:10.1126/science.1254257 · Cited by 5,063
Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments
Grauer, O. M., Wesseling, P., & Adema, G. J. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00315.x · Cited by 4,023
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
The Cancer Genome Atlas Research Network (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402121 · Cited by 3,148
GMAP: A genomic mapping and alignment program for mRNA and EST sequences
Wu, T. D., & Watanabe, C. K. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti310 · Cited by 2,354
Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L. M., deCarvalho, A. C., Lyu, S., Li, P., Li, Y., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.06.003 · Cited by 2,039
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
Glutamatergic synaptic input to glioma cells drives brain tumour progression
Venkataramani, V., Tanev, D. I., Strahle, C., Studier-Fischer, A., Fankhauser, L., Kessler, T., Körber, C., Kardorff, M., Ratliff, M., Xie, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1564-x · Cited by 1,197
Brain tumour cells interconnect to a functional and resistant network
Osswald, M., Jung, E., Sahm, F., Solecki, G. M., Venkataramani, V., Blaes, J., Heuer, S., Horstmann, H., Wiestler, B., Syed, M., et al. (2015) · Nature · doi:10.1038/nature16071 · Cited by 1,180
Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial
Gilbert, M. R., Wang, M., Aldape, K. D., Stupp, R., Hegi, M. E., Jaeckle, K. A., Armstrong, T. S., Wefel, J. S., Won, M., Blumenthal, D. T., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.6968 · Cited by 1,063
Adherens junctions: from molecules to morphogenesis
Harris, T., & Tepass, U. (2010) · Nature reviews. Molecular cell biology · doi:10.1038/nrm2927 · Cited by 983
Classifying collective cancer cell invasion
Friedl, P., Locker, J. D., Sahai, E. A., & Segall, J. E. (2012) · Nature Cell Biology · doi:10.1038/ncb2548 · Cited by 966
A neurocentric perspective on glioma invasion
Cuddapah, V. A., Robel, S., Watkins, S., & Sontheimer, H. W. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3765 · Cited by 877
Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program
Cheung, K. J., Gabrielson, E. W., Werb, Z., & Ewald, A. J. (2013) · Cell · doi:10.1016/j.cell.2013.11.029 · Cited by 859
WHO 2016 Classification of gliomas
Wesseling, P., & Capper, D. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12432 · Cited by 829
E-cadherin is required for metastasis in multiple models of breast cancer
Padmanaban, V., Krol, I., Suhail, Y., Szczerba, B. M., Aceto, N., Bader, J. S., & Ewald, A. J. (2019) · Nature · doi:10.1038/s41586-019-1526-3 · Cited by 818
Building the Neuronal Microtubule Cytoskeleton
Kapitein, L. C., & Hoogenraad, C. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.046 · Cited by 684
Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology
Gravendeel, L. A. M., Kouwenhoven, M. C. M., Gevaert, O., de Rooi, J. J., Stubbs, A., Duijm, J. E., Daemen, A., Bleeker, F. E., Bralten, L. B. C., Kloosterhof, N. K., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2307 · Cited by 678
Mechanisms and Molecules of Neuronal Wiring: A PrimerPreprint
Kolodkin, A. L., & Tessier‐Lavigne, M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001727 · Cited by 641
Collective cell durotaxis emerges from long-range intercellular force transmission
Sunyer, R., Conte, V., Escribano, J. M. G., Elósegui-Artola, A., Labernadie, A., Valon, L., Navajas, D., García‐Aznar, J. M., Muñoz, J. J., Roca‐Cusachs, P., et al. (2016) · Science · doi:10.1126/science.aaf7119 · Cited by 632
Weissman, T. A., Riquelme, P. A., Ivic, L., Flint, A. C., & Kriegstein, A. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.015 · Cited by 586
Korff, T., & Augustin, H. G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1341 · Cited by 557
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
Sawamiphak, S., Seidel, S., Essmann, C. L., Wilkinson, G. A., Pitulescu, M. E., Acker, T., & Acker‐Palmer, A. (2010) · Nature · doi:10.1038/nature08995 · Cited by 551
The integrated landscape of driver genomic alterations in glioblastoma
Frattini, V., Trifonov, V., Chan, J. M., Castano, A., Lia, M., Abate, F., Keir, S. T., Ji, A. X., Zoppoli, P., Niola, F., et al. (2013) · Nature Genetics · doi:10.1038/ng.2734 · Cited by 524
Inhibition of RhoA by p120 catenin
Anastasiadis, P. Z., Moon, S. Y., Thoreson, M. A., Mariner, D. J., Crawford, H. C., Zheng, Y., & Reynolds, A. B. (2000) · Nature Cell Biology · doi:10.1038/35023588 · Cited by 472
Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L. M., deCarvalho, A. C., Lyu, S., Li, P., Li, Y., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.12.012 · Cited by 390
Ishiyama, N., Lee, S.-H., Liu, S., Li, G., Smith, M. J., Reichardt, L. F., & Ikura, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.017 · Cited by 372
Interstitial guidance of cancer invasion
Gritsenko, P. G., Ilina, O., & Friedl, P. (2011) · The Journal of Pathology · doi:10.1002/path.3031 · Cited by 368
Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells
Reffay, M., Parrini, M. C., Cochet‐Escartin, O., Ladoux, B., Buguin, A., Coscoy, S., Amblard, F., Camonis, J., & Silberzan, P. (2014) · Nature Cell Biology · doi:10.1038/ncb2917 · Cited by 355
Cadherins in Brain Morphogenesis and Wiring
Hirano, S., & Takeichi, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00014.2011 · Cited by 320
Mir, S. E., Hamer, P. C. D. W., Krawczyk, P. M., Balaj, L., Claes, A., Niers, J. M., van Tilborg, A. A. G., Zwinderman, A. H., Geerts, D., Kaspers, G. J. L., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.011 · Cited by 299
A secreted luciferase for ex vivo monitoring of in vivo processes
Wurdinger, T. D., Badr, C. E., Pike, L. S., de Kleine, R. H. J., Weissleder, R., Breakefield, X. O., & Tannous, B. A. (2008) · Nature Methods · doi:10.1038/nmeth.1177 · Cited by 284
Axon growth inhibition by RhoA/ROCK in the central nervous system
Fujita, Y., & Yamashita, T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00338 · Cited by 279
Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders
Sloan, S. A., & Barres, B. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.03.005 · Cited by 260
Bradykinin Promotes the Chemotactic Invasion of Primary Brain Tumors
Montana, V., & Sontheimer, H. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3825-10.2011 · Cited by 214
Elia, L. P., Yamamoto, M. P., Zang, K., & Reichardt, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.018 · Cited by 210
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
Chan, C.-H., Lee, S.-W., Li, C.-F., Wang, J., Yang, W.-L., Wu, C.-Y., Wu, J., Nakayama, K. I., Kang, H.-Y., Huang, H.-Y., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2047 · Cited by 209
Wnt Signaling in the Vertebrate Central Nervous System: From Axon Guidance to Synaptic FunctionPreprint
Salinas, P. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008003 · Cited by 195
Cadherins in collective cell migration of mesenchymal cells
Théveneau, E., & Mayor, R. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.002 · Cited by 186
Rho GTPases in collective cell migration
Zegers, M. M., & Friedl, P. (2014) · Small GTPases · doi:10.4161/sgtp.28997 · Cited by 184
Adherens junction treadmilling during collective migration
Péglion, F., Llense, F., & Etienne‐Manneville, S. (2014) · Nature Cell Biology · doi:10.1038/ncb2985 · Cited by 175
Wu, Y., Siadaty, M. S., Berens, M. E., Hampton, G. M., & Theodorescu, D. (2008) · Oncogene · doi:10.1038/onc.2008.264 · Cited by 172
Serres, É., Debarbieux, F. C., Stanchi, F., Maggiorella, L., Grall, D., Turchi, L., Burel‐Vandenbos, F., Figarella‐Branger, D., Virolle, T., Rougon, G., et al. (2013) · Oncogene · doi:10.1038/onc.2013.305 · Cited by 169
Camand, E., Péglion, F., Osmani, N., Sanson, M., & Etienne‐Manneville, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.087668 · Cited by 153
Schackmann, R. C. J., van Amersfoort, M., Haarhuis, J. H. I., Vlug, E. J., Halim, V. A., Roodhart, J. M. L., Vermaat, J. S. P., Voest, E. E., van der Groep, P., van Diest, P. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41695 · Cited by 143
Faber‐Elman, A., Solomon, A., Abraham, J. A., Marikovsky, M., & Schwartz, M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118385 · Cited by 142
Hydrodynamic Cellular Volume Changes Enable Glioma Cell Invasion
Watkins, S., & Sontheimer, H. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3938-11.2011 · Cited by 138
Cheng, W., Kandel, J. J., Yamashiro, D. J., Canoll, P., & Anastassiou, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034705 · Cited by 132
Fujii, Y., Maékawa, S., & Morita, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-13243-0 · Cited by 129
Beyond β-catenin: prospects for a larger catenin network in the nucleus
McCrea, P. D., & Gottardi, C. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.3 · Cited by 128
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer
Bajrami, I., Marlow, R., van de Ven, M., Brough, R., Pemberton, H. N., Frankum, J. R., Song, F., Rafiq, R., Konde, A., Krastev, D. B., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0603 · Cited by 125
Chu, Y., Hughes, S., & Chan‐Ling, T. (2001) · The FASEB Journal · doi:10.1096/fj.00-0868fje · Cited by 112
p120-catenin in cancer – mechanisms, models and opportunities for intervention
Schackmann, R. C. J., Tenhagen, M., van de Ven, R. A. H., & Derksen, P. W. B. (2013) · Journal of Cell Science · doi:10.1242/jcs.134411 · Cited by 106
Molecules and mechanisms that regulate multipolar migration in the intermediate zone
Cooper, J. A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00386 · Cited by 102
Laminins containing the β2 and γ3 chains regulate astrocyte migration and angiogenesis in the retina
Gnanaguru, G., Bachay, G., Biswas, S., Pinzón‐Duarte, G., Hunter, D. D., & Brunken, W. J. (2013) · Development · doi:10.1242/dev.087817 · Cited by 98
Plasticity of Cancer Cell Invasion—Mechanisms and Implications for Therapy
Boekhorst, V. T., & Friedl, P. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.07.005 · Cited by 89
Gritsenko, P. G., Leenders, W. P. J., & Friedl, P. (2017) · Histochemistry and Cell Biology · doi:10.1007/s00418-017-1604-2 · Cited by 85
An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth
Dohn, M. R., Brown, M. V., & Reynolds, A. B. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200807096 · Cited by 84
Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion
Deborah, H., Lewis‐Tuffin, L. J., Carlson, B. L., Schroeder, M. A., Rodríguez, F. J., Giannini, C., Galanis, E., Sarkaria, J. N., & Anastasiadis, P. Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056505 · Cited by 81
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
Depner, C., Buttel, H. Z., Böğürcü, N., Cuesta, Á. M., Aburto, M. R., Seidel, S., Finkelmeier, F., Foss, F., Hofmann, J., Kaulich, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms12329 · Cited by 78
Claes, A., Schuuring, J., Boots‐Sprenger, S., Hendriks-Cornelissen, S. J. B., Dekkers, M. M. G., van der Kogel, A. J., Leenders, W. P. J., Wesseling, P., & Jeuken, J. W. M. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00141.x · Cited by 72
Hensel, N., Rademacher, S., & Claus, P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00198 · Cited by 71
Wesseling, P. (2012) · Springer eBooks · doi:10.1007/978-0-85729-458-6_1 · Cited by 57
Nestin expression in astrocytic tumors delineates tumor infiltration
Kitai, R., Horita, R., Sato, K., Yoshida, K., Arishima, H., Higashino, Y., Hashimoto, N., Takeuchi, H., Kubota, T., & Kikuta, K. (2010) · Brain Tumor Pathology · doi:10.1007/s10014-009-0261-0 · Cited by 55
Skalli, O., Wilhelmsson, U., Örndahl, C., Fekete, B., Malmgren, K., Rydenhag, B., & Pekny, M. (2013) · Human Pathology · doi:10.1016/j.humpath.2013.03.013 · Cited by 54
Intercellular protein–protein interactions at synapses
Yang, X., Hou, D., Jiang, W., & Zhang, C. (2014) · Protein & Cell · doi:10.1007/s13238-014-0054-z · Cited by 51
Neuronal polarization in the developing cerebral cortex
Sakakibara, A., & Hatanaka, Y. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00116 · Cited by 49
Muramatsu, T., Kozaki, K., Imoto, S., Yamaguchi, R., Tsuda, H., Kawano, T., Fujiwara, N., Morishita, M., Miyano, S., & Inazawa, J. (2016) · Oncogene · doi:10.1038/onc.2016.71 · Cited by 43
van de Ven, R. V. D., Tenhagen, M., Meuleman, W., van Riel, J. J. G., Schackmann, R., & Derksen, P. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.018648 · Cited by 38
Adaptive adhesion systems mediate glioma cell invasion in complex environments
Gritsenko, P. G., & Friedl, P. (2018) · Journal of Cell Science · doi:10.1242/jcs.216382 · Cited by 38
Barriga, E. H., & Mayor, R. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.023 · Cited by 35
Phosphorylation and isoform use in p120-catenin during development and tumorigenesis
Hong, J. Y., Oh, I., & McCrea, P. D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.008 · Cited by 35
van de Ven, R. A. H., de Groot, J. S., Park, D., van Domselaar, R., de Jong, D., Szuhai, K., van der Wall, E., Rueda, O. M., Ali, H. R., Caldas, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13874 · Cited by 35
Ozaki, C., Yoshioka, M., Tominaga, S., Osaka, Y., Obata, S., & Suzuki, S. (2010) · Cell Structure and Function · doi:10.1247/csf.10009 · Cited by 16
The function of p120 catenin in filopodial growth and synaptic vesicle clustering in neurons
Cheng Ann, C. H. E. N., Li, P. P., Madhavan, R., & Peng, H. B. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-01-0004 · Cited by 7
Cited by
Sorted by citations
Glioblastoma hijacks neuronal mechanisms for brain invasion
Venkataramani, V., Yang, Y., Schubert, M. C., Reyhan, E., Tetzlaff, S. K., Wißmann, N., Botz, M., Soyka, S. J., Beretta, C. A., Pramatarov, R. L., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.054 · Cited by 673
Cancer neuroscience: State of the field, emerging directions
Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T. T., Demir, İ. E., Deneen, B., Gutmann, D. H., Hervey‐Jumper, S. L., Kuner, T., Mabbott, D., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.002 · Cited by 602
Towards targeting of shared mechanisms of cancer metastasis and therapy resistance
Weiß, F., Lauffenburger, D. A., & Friedl, P. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-021-00427-0 · Cited by 295
Autonomous rhythmic activity in glioma networks drives brain tumour growth
Hausmann, D., Hoffmann, D. C., Venkataramani, V., Jung, E., Horschitz, S., Tetzlaff, S. K., Jabali, A., Hai, L., Keßler, T., Azorín, D. D., et al. (2022) · Nature · doi:10.1038/s41586-022-05520-4 · Cited by 278
Jiang, D., Christ, S., Correa‐Gallegos, D., Ramesh, P., Gopal, S. K., Wannemacher, J., Mayr, C. H., Lupperger, V., Yu, Q., Ye, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19425-1 · Cited by 144
Metadata
- Authors
- Gritsenko, P. G., Atlasy, N., Dieteren, C. E. J., Navis, A. C., Venhuizen, J.-H., Veelken, C., Schubert, D., Acker-Palmer, A., Westerman, B. A., Wurdinger, T., Leenders, W., Wesseling, P., Stunnenberg, H. G., & Friedl, P.
- Affiliations
- Radboud University Medical Center (NL)
- Radboud University Nijmegen (NL)
- Karolinska Institutet (SE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Princess Máxima Center (NL)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Friedl, Peter
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2020-01
- Volume
- 22
- Issue
- 1
- Pages
- 97-107
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC6952556
- OpenAlex
- W2997878069
- Cited by
- 112
- References
- 82
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 19 · 2023: 17 · 2022: 23 · 2021: 15 · 2020: 16
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Brain Tumour Charity (GN-000429)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (918.11.626, 863.13.019)
- National Cancer Institute (U54CA210184, P30CA016672)
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- p120 catenin, glioma, brain infiltration, collective cell migration, multicellular networks, N-cadherin, β-catenin, adherens junctions, intercellular calcium signaling, RhoA, directional persistence, intercellular communication, neurogenesis, cell cycle, clinical outcome prediction
- MeSH terms
- Delta Catenin, Animals, Brain, Cell Adhesion, Glioma, Phosphoproteins, Phosphorylation, Down-Regulation, Cadherins, Adherens Junctions, Cell Line, Tumor, Catenins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
