Cited by 204Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsAutophagy in Disease and Therapy

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence

Open access

Choi, Insup, Wang, Minghui, Yoo, Seungyeul, Xu, Peng, Seegobin, Steven P., Li, Xianting, Han, Xian, Wang, Qian, Peng, Junmin, Zhang, Bin, Yue, Zhenyu·2023·Nature Cell Biology

DOI 10.1038/s41556-023-01158-0PMC PMC10950302

Open this paper in CoChat — free account Open PDF

Abstract

Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer's disease (AD). Previous evidence suggested disruptions of multiple stages of the autophagy-lysosomal pathway in affected neurons. However, whether and how deregulated autophagy in microglia, a cell type with an important link to AD, contributes to AD progression remains elusive. Here we report that autophagy is activated in microglia, particularly of disease-associated microglia surrounding amyloid plaques in AD mouse models. Inhibition of microglial autophagy causes disengagement of microglia from amyloid plaques, suppression of disease-associated microglia, and aggravation of neuropathology in AD mice. Mechanistically, autophagy deficiency promotes senescence-associated microglia as evidenced by reduced proliferation, increased Cdkn1a/p21 Cip1, dystrophic morphologies and senescence-associated secretory phenotype. Pharmacological treatment removes autophagy-deficient senescent microglia and alleviates neuropathology in AD mice. Our study demonstrates the protective role of microglial autophagy in regulating the homeostasis of amyloid plaques and preventing senescence; removal of senescent microglia is a promising therapeutic strategy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41556-023-01158-0

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
Martinez, J., Malireddi, R. K. S., Lu, Q., Cunha, L. D., Pelletier, S., Gingras, S., Orchard, R., Guan, J.-L., Tan, H., Peng, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3192 · Cited by 758
Self-citation
Retracted
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
Kim, D., Paggi, J. M., Park, C., Bennett, C., & Salzberg, S. L. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0201-4 · Cited by 15,022
The Molecular Signatures Database Hallmark Gene Set Collection
Liberzon, A., Birger, C., Thorvaldsdóttir, H., Ghandi, M., Mesirov, J. P., & Tamayo, P. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.004 · Cited by 13,807
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Show all 76 references

Sorted by citations

Items 101–200 of 204

Alterations of Mitophagy (BNIP3), Apoptosis (CASP3), and Autophagy (BECN1) Genes in the Frontal Cortex in an Ischemic Model of Alzheimer's Disease with Long-Term Survival
Pluta, R. M., Kocki, J., Bogucka‐Kocka, A., Bogucki, J., & Czuczwar, S. J. (2025) · Current Alzheimer Research · doi:10.2174/0115672050385480250619045022 · Cited by 6
Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
Lane, R. M., Darreh‐Shori, T., Junge, C., Li, D. X., Yang, Q., Edwards, A., Graham, D. L., Moore, K. M., & Mummery, C. J. (2024) · BMC Neurology · doi:10.1186/s12883-024-03611-5 · Cited by 5
Exploring Iron Deposition Patterns Using Light and Electron Microscopy in the Mouse Brain Across Aging and Alzheimer's Disease Pathology Conditions
Lau, V. Z., VanderZwaag, J., Murray, C. J., & Tremblay, M. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70086 · Cited by 6
Mammalian innate antiviral defenses: beyond interferon
Rex, E. A., Shaffer, J., Deng, D. M., & Gammon, D. B. (2025) · Journal of Virology · doi:10.1128/jvi.01707-24 · Cited by 7
Entwined processes in Alzheimer's disease: Brain cellular senescence and Alzheimer's disease pathology
Li, W., Han, Y., Wang, P., & Qiao, S. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70803 · Cited by 6
A senolysis-targeting bioenergetic nanoplatform for diabetic wound healing
Zheng, Z., Wei, X., Jiang, Z., Xie, D., Shi, P., Ma, J., Yu, Q., He, Y., Pang, A., Zeng, J., et al. (2025) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-025-01509-5 · Cited by 6
Evolving insights into the identity and function of dark microglia
Flury, A. G., St‐Pierre, M., Ayata, P., & Tremblay, M. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.11.002 · Cited by 7
Programmable CAR immunotherapies for neurodegenerative proteinopathies
Pesce, G., Estivill-Alonso, M., & Ventura, S. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.02.009 · Cited by 5
Zi Shen Wan Fang repaired blood–brain barrier integrity in diabetic cognitive impairment mice via preventing cerebrovascular cells senescence
Yin, Q., Yang, G., Su, R., Bu, J., Li, Y., Zhang, H., Zhang, Y., & Zhuang, P. (2024) · Chinese Medicine · doi:10.1186/s13020-024-01041-6 · Cited by 5
miRNA375-3p/rapamycin mediates the mTOR pathway by decreasing PS1, enhances microglial cell activity to regulate autophagy in Alzheimer's disease
Wang, Y., Xiao, Z., Yin, H., Ren, Z., Ma, X., Wang, Y., Zhang, Y., Fu, X., Zhang, F., & Zeng, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37589 · Cited by 5
A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s DiseasePreprint
Jin, M., Ma, Z., Dang, R., Zhang, H., Kim, R., Xue, H., Pascual, J. R., Finkbeiner, S., Head, E., Liu, Y., et al. (2024) · bioRxiv · doi:10.1101/2024.03.12.584646 · Cited by 5
MicroRNA-21-5p regulates autophagy and apoptosis via the activation of the PI3K/AKT/mTOR signaling pathway and reducing H 2 O 2 -induced damage in primary AEC-II
Liu, X., Dai, Q., Zheng, J., Qin, S., Ren, Y., Yu, K., Feng, B., Chen, M., & Mei, H. (2025) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320251343369 · Cited by 4
Redox regulation of neuroinflammatory pathways contributes to damage in Alzheimer’s disease brain
Carnevale, L. N., Banerjee, P., Zhang, X., Navarro, J., Raspur, C. K., Patel, P. R., Nakamura, T., Schahrer, E., Scott, H. R., Lang, N., et al. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.03.017 · Cited by 5
ATOX1 overexpression mitigates copper homeostasis in microglia: Implications for Alzheimer's disease therapy
Zhong, F., Wu, J., Deng, Z., Yu, W., Song, J., Chen, Y., Yu, W., & Lü, Y. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101888 · Cited by 4
Mitochondria beyond boundaries: from cellular powerhouses to intercellular messengers in health and disease
Zhuang, H., Mo, W., Xie, J., Zhang, T., Qiu, K., Wu, W., Tan, W., Jiang, X., Chen, X., Hu, Y., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-3069-3 · Cited by 5
TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury
Han, L., Wang, C., Guo, X., Luo, Y., Zhang, J., He, F., Zeng, Z., Jiang, L., Ouyang, W., Gong, Y. Q., et al. (2025) · Advanced Science · doi:10.1002/advs.202509973 · Cited by 4
Cancer and aging: complex associations and therapeutic targets
Liang, J., Zang, S., Zhe, W. A. N. G., & Zhang, R. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00423-6 · Cited by 4
Diosgenin alleviates neuropathic pain based on the enhancement of autophagy and promotion of M2 polarization
Man, S., Zhou, Y., Zhang, X., Tang, X., Xie, L., Ma, L., & Gao, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114936 · Cited by 5
Genetic model of selective COX2 inhibition improve learning and memory ability and brain pathological changes in 5xFAD mouse
Yang, Y., Wang, J., Ni, H., Ding, H., Wei, L., & Ke, Z. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148566 · Cited by 4
Neuroinflammation-targeted magnetic resonance imaging nanoprobes for the early diagnosis of Alzheimer's disease
Jiang, Y., Li, W., Ma, Y., & Hou, Y. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb02210f · Cited by 4
Axonal Organelle Buildup from Loss of AP-4 Complex Function Causes Exacerbation of Amyloid Plaque Pathology and Gliosis in Alzheimer's Disease Mouse Model
Orlowski, A., Karippaparambil, J., Paumier, J., Ghanta, S., Pallares, E., Chandran, R., Edmison, D., Tandukar, J., Gao, R., & Gowrishankar, S. (2024) · eNeuro · doi:10.1523/eneuro.0445-24.2024 · Cited by 4
Atg5 in microglia regulates sex-specific effects on postnatal neurogenesis in Alzheimer’s disease
Walter, E. M., Angst, G., Bollinger, J. L., Truong, L., Ware, E., Wohleb, E. S., Fan, Y., & Wang, C. (2025) · npj Aging · doi:10.1038/s41514-025-00209-0 · Cited by 4
Dynamic interplay of cellular senescence, chronic neuroinflammation and synaptic plasticity in age-related neurodegeneration
Li, N., Huang, X., Zou, T., Wu, X., Yang, S., Xu, Z., Dai, J., Wang, K., & Zhao, J. (2025) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2025.9610011 · Cited by 3
Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases
Huang, X.-Y., Fang, Y., Song, J., Hao, Y., Cai, Y., Wei, P., & Zhang, N. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400186 · Cited by 5
The emerging role and therapeutic targeting of autophagy-lysosome pathway in the pathogenesis of Parkinson’s disease
Shimizu, T., Isik, S., Kamath, N., & Yue, Z. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00555-3 · Cited by 3
Self-citation
Telmisartan Reduces LPS-Mediated Inflammation and Induces Autophagy of Microglia
Affram, K. O., Janatpour, Z. C., Shanbhag, N. C., Villapol, S., & Symes, A. J. (2024) · Neuroglia · doi:10.3390/neuroglia5020014 · Cited by 3
Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice
Ning, Z., Zhong, X., Wang, Y., Hu, D., Tang, X., & Deng, M. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113581 · Cited by 3
Liquid-liquid phase separation of RBM33 facilitates hippocampus aging by inducing microglial senescence by activating CDKN1A
Yang, X., Lin, W., Zhong, S., Wang, Q., Zhang, Y., Zhang, Y., & Yu, A. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142986 · Cited by 3
Self-citation
Top 100 most-cited articles on tau protein: a bibliometric analysis and evidence mapping
Chen, Z., Shan, G., Wang, X., Zuo, Y., Song, X., Ma, Y., Zhao, X., & Jin, Y. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1345225 · Cited by 3
Microglial autophagy in neurogenesis: a new player in Alzheimer’s disease
Tang, X., Nagayach, A., & Wang, C. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01962 · Cited by 3
Chromatin and transcriptional adaptation accompany monocyte engraftment in the injured retinaPreprint
Liu, J., Lei, F., Romano, C., Yan, B., Cao, T., Cui, N., Sharma, J., Correa, V., Roach, L., Kikolaou, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.09.612126 · Cited by 3
Microglial Regulation of Neural Networks in Neuropsychiatric Disorders
Cao, Z.-L., Zhu, L., Wang, H., & Zhu, L. (2025) · The Neuroscientist · doi:10.1177/10738584251316558 · Cited by 2
Age-Related Differences in Lipopolysaccharide-Induced Delirium-like Behavior Implicate the Distinct Microglial Composition in the Hippocampus
Sun, C., Kang, X., Jia, X., Wang, Y., Zhao, L., Sun, X., Abula, A., & Liu, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052055 · Cited by 2
Obesity impact on leukocyte telomere shortening and immune aging assessed by Mendelian randomization and transcriptomics analysis
Feng, Z., Li, J., Zhang, H., Liu, S., Wang, Y., Zhou, M., Ding, Z., & Xiao, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-16817-5 · Cited by 3
Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1
Palmer, J. E., Puri, C., O’Rourke, R., Son, S. M., Sang, C., Huang, Y. A., & Rubinsztein, D. C. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116266 · Cited by 5
Dual Signals of Chiral and Fluorescent Copper Sulphide Nanoparticles Boost Tumor Cell Autophagy
Song, L., Chen, P., Shi, B., Qu, A., Xu, C., Kuang, H., & Sun, M. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202506926 · Cited by 3
Bioinformatic analysis and experimental validation of hub autophagy-related genes as novel biomarkers for type 2 diabetes mellitus and Alzheimer’s disease
Zhang, R., Wang, R., Zhai, S., Shen, C., An, Y., & Liu, Q. (2025) · PeerJ · doi:10.7717/peerj.20143 · Cited by 2
Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination
Yan, W., Xiang, D., Du, L., Zhu, D., Jia, Q., Liu, Y., Wang, S., Liu, L., Guan, H., Zhao, Y., et al. (2026) · iScience · doi:10.1016/j.isci.2026.114718 · Cited by 2
Da-Bu-Yin-Wan rescues cognitive deficits in aging and Alzheimer’s disease models by Wnt/β-catenin-dependent restoration of lysosomal acidification
Zhang, H., Zhang, H., Zhao, M., Luo, W., Chen, S., Wang, P., Liu, X., & Xu, S. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157916 · Cited by 2
Inflammatory Mediators of Alzheimer’s Disease Characterized in a Mouse Model (APP/PS1)
Jorda, A., Alvarez-Gamez, K., Campo-Palacio, I., Campos-Campos, J., Colmena, C., Singh, S. K., Miralles, M. J. C., Aldasoro, C., Aldasoro, M., & Vallés, S. L. (2026) · NeuroSci · doi:10.3390/neurosci7010023 · Cited by 2
PYGL-driven glycogenolysis impairs microglial autophagic flux via SNAP29 O-GlcNAcylation in Alzheimer's disease
Ding, Y., Li, S.-Y., Zhang, W.-F., Chu, M.-M., Wang, X.-J., Zhang, Y., Zhang, H., Zhang, Y., Xu, L., Liu, X., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.04.017 · Cited by 2
Microglial senescence and epigenetic reprogramming in alzheimer's disease: An immunometabolic perspective
Ma, J., Yang, B., Jiang, X., Wang, L., Wei, W., Cao, Y., & Li, H. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113177 · Cited by 4
Neuroinflammation in Alzheimer’s and Parkinson’s diseases: pathogenic mechanisms and therapeutic strategies
Wang, Q.-Q., Sun, Q.-Q., Guo, Y.-S., Yin, S., & Zhou, J. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00571-3 · Cited by 2
Self-citation
Comparative Analysis of Human Brain RNA-seq Reveals the Combined Effects of Ferroptosis and Autophagy on Alzheimer’s Disease in Multiple Brain Regions
Ye, K., Zhao, X. L., Liu, L., Ge, F., Zheng, F., Liu, Z., Tian, M., Han, X., Gao, X., Xia, Q. H., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04642-2 · Cited by 1
Self-citation
Unlocking the therapeutic promise of miRNAs in promoting amyloid-β clearance for Alzheimer's disease
Kaur, V., & Sunkaria, A. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115505 · Cited by 1
Hydrogen-rich water alleviates neuropathic pain through the modulation of bile acid/Takeda G-protein-coupled receptor 5–mediated autophagy
Zeng, X., Lin, J., Liu, B., Su, Z. Z., Yu, Y., Li, X., Duan, W., Liu, C., Hou, Q., Zhang, J., et al. (2025) · Pain · doi:10.1097/j.pain.0000000000003830 · Cited by 1
Self-citation
Advanced immunology in aging population: unveiling the complexities of vaccine responsiveness
Han, Y., Huang, Y., Zhou, Y., He, W., Luo, G., Yang, L., Chen, Y., Zhu, Y., Jiang, W., Xiao, C., et al. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1682763 · Cited by 1
Targeting innovative therapeutic approaches to the hallmarks of aging to combat Alzheimer’s disease
Izrael, M., & Frenkel, O. M. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00966 · Cited by 1
The dual role of TRPC channel-mediated dysregulation of calcium signaling in regulating mitophagy in early brain injury after subarachnoid hemorrhage
Yang, J. F., Zou, Y., & Zhao, X. (2026) · Reviews in the Neurosciences · doi:10.1515/revneuro-2025-0115 · Cited by 1
Microglial Senescence in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives
Liu, Y., Hu, Z., Xiao, Y., Han, X., Cheng, X., & Ye, T. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00016 · Cited by 1
Self-citation
PACells identifies phenotype-associated cell states from single-cell chromatin accessibility profiles
Hua, J., Sheng, Q., Xiao, S., Yang, Z., Qi, J., & Jin, S. (2026) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2026.03.012 · Cited by 1
Microglial state transitions are constrained by developmental and metabolic checkpoints
Mesaoudi, A. E., & Kim, D. W. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1852176 · Cited by 1
Neuroinflammation in Alzheimer’s disease: glial crosstalk, pathological modulation, and therapeutic implications
Li, E., Zhang, P., & Feng, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1783786 · Cited by 1
Supramolecular Integration of 18-Crown-6 and an N-Capped Short Peptide Enables Multivalent Recognition and Modulation of Amyloid-β Proteotoxicity
Chatterjee, A., Roy, R., Sarkar, S., Sarkar, S., Chaini, A., Roy, A. N., Jana, B., Ethirajan, A., Pal, U., Barman, S., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c03780 · Cited by 1
Macrophage senescence and programmed cell death in atherosclerosis: Mechanisms, cross-talk, and emerging therapeutic strategies
Xu, C., Ke, C., Zhong, Y.-L., Yang, X.-H., Wang, M.-M., Cao, Y., & Chen, J. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103225 · Cited by 1
Self-citation
The autophagy-senescence-inflammasome axis: A novel triad in neurodegenerative diseases?
Ellappan, S., Kujur, P. P., & Mondal, A. C. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103248 · Cited by 1
Oral exposure to non-brain-penetrable microplastics induces neurotoxicity via disrupting the gut microbiota−tryptophan metabolism−microglial autophagy cascade
Wu, Y., Dong, Z., Wang, D., Dong, J., Jiang, X., Fu, G., & Cheng, M. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.143127 · Cited by 1
Roles of autophagy in brain homeostasis and disease
Kim, H., Wickstead, E. S., Zhou, X., Choi, I., & Yue, Z. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02426-6 · Cited by 1
Self-citation
Withaferin A Modulation of Microglia Autophagy Mitigates Neuroinflammation and Enhances Cognitive Function in POCDPreprint
Zhu, H. B., Wei, G., Huang, D. A., Lin, Y., Zhou, B., Yin, J., Hua, F., & Zhang, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3508591/v1 · Cited by 1
Correction to “Unlocking the Therapeutic Potential of Natural Products for Alzheimer’s Disease”
Li, Z., Zhang, Z., & Yu, B. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00926 · Cited by 1
Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous SystemPreprint
Liu, J., Lei, F., Yan, B., Cao, T., Cui, N., Sharma, J., Correa, V., Roach, L., Nicolaou, S., Pitts, K. M., et al. (2025) · eLife · doi:10.7554/elife.108641.1 · Cited by 1
Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease
Miao, J., Wang, J., Li, Y., Zhang, H., Zhang, Y., Li, Q., Xiao, B., Zhou, W., & Guo, J. (2026) · Advanced Science · doi:10.1002/advs.77929
The Microglial Response to Inhibition of Colony-Stimulating-Factor-1 Receptor Differs by Sex in Adult MicePreprint
Le, L., Eliseeva, S. I., Kara-Pabani, K., Li, H., Yarovinsky, F., & Majewska, A. K. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4795163
Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in MPS VIIPreprint
Mandal, N., Das, A., & Datta, R. (2024) · bioRxiv · doi:10.1101/2024.08.23.609363
References
(2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23565-8.09996-8
Inflammatory Roads to Parkinson’s Disease
Anisman, H., Hayley, S. P., & Kusnecov, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23565-8.00015-6
TREM2 expression is differentially associated with microglia and hematogenous monocyte/macrophages proximally and distally located to amyloid plaquesPreprint
Kozyrev, N., Ibáñez, F. G., McKee, C., Traetta, M. E., Tellios, V., Nygard, K. L., Rylett, R. J., Tremblay, M., & Dekaban, G. A. (2025) · Research Square · doi:10.21203/rs.3.rs-6222217/v1
Autophagy and Neurodegenerative Diseases
Barbosa, A. D., Palmer, J. E., Li, X., & Rubinsztein, D. C. (2025) · Learning materials in biosciences · doi:10.1007/978-3-031-88121-3_6
Self-citation
Impact Induces Phagocytic Defect in Reactive MicrogliaPreprint
Yu, R., Rogers, E. A., Manchanda, P., Beveridge, C. H., Randolph, C. E., Beauclair, T., Jethava, K. P., Shi, R., & Chopra, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.14.676171
The Neuroimmune Landscape of the Lysosomal Storage Disorder Sanfilippo Syndrome
Badell‐Grau, R. A., & Schlachetzki, J. C. M. (2025) · BioEssays · doi:10.1002/bies.70083
Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous SystemPreprint
Liu, J., Lei, F., Yan, B., Cao, T., Cui, N., Sharma, J., Correa, V., Roach, L., Nicolaou, S., Pitts, K. M., et al. (2025) · eLife · doi:10.7554/elife.108641
Additional file 2 of Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
Lane, R. M., Darreh-Shori, T., Junge, C., Li, D., Yang, Q., Edwards, A., Graham, D. L., Moore, K. M., & Mummery, C. J. (2024) · Figshare · doi:10.6084/m9.figshare.25572641
Additional file 1 of Profiling of long non-coding RNAs in hippocampal–entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease
Liu, H., Li, J., Wang, X., Luo, S., Luo, D., Ge, W., & Ma, C. (2024) · Figshare · doi:10.6084/m9.figshare.26703235
Additional file 1 of Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
Lane, R. M., Darreh-Shori, T., Junge, C., Li, D., Yang, Q., Edwards, A., Graham, D. L., Moore, K. M., & Mummery, C. J. (2024) · Figshare · doi:10.6084/m9.figshare.25572515
Additional file 2 of Profiling of long non-coding RNAs in hippocampal–entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease
Liu, H., Li, J., Wang, X., Luo, S., Luo, D., Ge, W., & Ma, C. (2024) · Figshare · doi:10.6084/m9.figshare.26703238
Additional file 3 of Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
Lane, R. M., Darreh-Shori, T., Junge, C., Li, D., Yang, Q., Edwards, A., Graham, D. L., Moore, K. M., & Mummery, C. J. (2024) · Figshare · doi:10.6084/m9.figshare.26703981
Additional file 1 of Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
Wang, C., Wang, X., Sun, S., Chang, Y., Lian, P., Guo, H., Zheng, S., Ma, R., & Li, G. (2024) · Figshare · doi:10.6084/m9.figshare.25824768
Mitigation of Aβ neurotoxicity in Alzheimer's disease using a non-toxic platinum complex derived from retinamide
Qian, C., Shang, Y., Cai, L., Zhang, Y., Chu, C., Guo, Z., & Wang, X. (2025) · Inorganic Chemistry Frontiers · doi:10.1039/d5qi01746g
In vivo imaging of autophagy dynamics in the intact mammalian brain using a fluorescence lifetime-based sensorPreprint
Maman, M., Ando, K., Fisher, N., Thomas, C., Levy, Y., Bond, G., Kagan, T., Malchenko, N., Desbois, M., Zaken, S. B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.25.693346
CCL18 binding to MAPT promotes chronic obstructive pulmonary disease by inhibiting autophagy and triggering cell senescence
Chen, H., Wang, L., Liu, J., & Zhang, Y. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103415
The effects of bacterial and viral infections on microglia
Ermolina, S., & Bowdish, D. M. E. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27340-7.00001-2
Transcription factor EB as a therapeutic target for intracerebral hemorrhage: A review
Wang, X., He, K., Xia, L., Xie, Y., Qi, E., Wan, L., Hua, X., Wang, S., & Jing, C. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152121
The modifier matrix: emerging roles of ubiquitin-like proteins in Alzheimer’s disease
颜亭祥, Vaquer, J., Springer, W., & Fiesel, F. C. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00031-2
From infection to dysfunction: viral triggers and antiviral immune factors in Alzheimer’s disease pathology
Oh, S. J., Shin, O. S., & Hur, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1839357
Neuroinflammation-targeted natural products for the therapy of Alzheimer’s disease
Chaweewan, S., Cui, K., Zhang, Y., Mao, J., Zheng, J., & Wan, Y. (2026) · Model Organisms Research · doi:10.1016/j.mores.2026.100004 · Cited by 1
Structural characterization of a branched α-glucan from Pseudostellaria heterophylla and its neuroprotective effect against Alzheimer's disease via regulating the microbiota-gut-brain axis
Chen, L., Kang, X., Deng, W., Zhang, Y., Zhao, Y., Song, C., & Yang, Z. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153352
STAT6 Targets the Autophagy Pathway to Regulate Microglial Senescence in Cognitive Impairment Caused by Cerebral Small-Vessel Disease
Liu, X., Liu, Q., Yang, J., Hu, X., Zhu, X., Zhang, Z., Zuo, Y., Huang, J., Lz, W., Fan, Y., et al. (2026) · NeuroMolecular Medicine · doi:10.1007/s12017-026-08944-7
Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction
Liu, B., Mahoney, M., Feng, Y., Telpoukhovskaia, M. A., Giani, A. M., Torres, E. R., Zhan, L., Ye, P., Zhu, J., Foxe, N. R., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.07.021
Neuron-derived SPP1 instructs microglia to limit degeneration
Li, S., & Jakobs, T. (2026) · Science Advances · doi:10.1126/sciadv.aee4940
Selenoprotein I deficiency disrupts iron homeostasis in brain
Wurlitzer, K., Ma, C., Nunes, L. G. A., Watanabe, M., Griffin, C., Khadka, V. S., Soares, A. G., Hoffmann, F. W., Hoffmann, P. R., & Pitts, M. W. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107588
A study on comprehensive bibliometric analysis of natural medicines for Alzheimer's disease (1999–2025)
Chen, Y., Shi, H., Chen, S., & Zhu, L. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261478276
Lysosomal Dysfunction Is Associated With Intervertebral Disc Degeneration: Multiomics and Machine Learning Identify Molecular Subtypes and Hub Genes
Yang, Y., Li, H., Ou, Y., Yu, Y., Sun, K., Chen, S., & Ji, C. (2026) · The Journal of Gene Medicine · doi:10.1002/jgm.70109
Mitochondria–endoplasmic reticulum contact sites (MERCS/MAM): Multi-layered upstream regulators of microglial senescence in Alzheimer’s disease
Liu, A., Xing, L., Li, J., Gao, W., Yao, M., Song, J., & Li, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103352
Sleep Deprivation Induces Glial Dysfunction, Synaptic Loss, Metabolic Imbalance, and Cognitive Impairment in 12‐Month‐Old Mice: Protective Effects of D30
Liu, X., Lin, H., Zhong, J., Chen, X., Wang, Z., Shi, M., Shi, H., Zhang, H., Chen, P., & Ye, Z. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71134
Border-Associated Macrophage Migrasomes in Alzheimer’s Disease: An Emerging Aβ–Senescence–Microglia Axis?
Chmiel, J., & Kopańska, M. (2026) · Cells · doi:10.3390/cells15181671
Compartment-Specific Lysosomal Heterogeneity in Microglia Is Regulated by Adaptor Protein Complex-4Preprint
Somodji, E. A., & Gowrishankar, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.17.752408
Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
Šimončičová, E., & Tremblay, M. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1884230
Telomeric autophagy in human health, aging, and diseases
Li, X., & Wu, X. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1922188
Self-citation
Dynamic remodeling of microglial responses in Alzheimer’s disease: heterogeneous states, spatiotemporal progression, and immunometabolic dysregulation
Han, S., Wang, S., Liu, J., Liu, X., Wang, Q., & Meng, C. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1929282
Self-citation
Exercise promotes lipophagy and mitigates cognitive impairment in Alzheimer’s disease through downregulating microglial TMEM9
Zhang, L., Li, S., Ma, X., Cheng, S., Ye, Z., Liu, S., Qin, L., Dong, H., Feng, Y., Li, M., et al. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00583-z · Cited by 1

Authors: Choi, I., Wang, M., Yoo, S., Xu, P., Seegobin, S. P., Li, X., Han, X., Wang, Q., Peng, J., Zhang, B., & Yue, Z.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Sema4 (United States) (US)
St. Jude Children's Research Hospital (US)
Corresponding author: Yue, Zhenyu
ORCID: Choi, Insup
Wang, Minghui
Yoo, Seungyeul
Xu, Peng
Seegobin, Steven P.
Li, Xianting
Han, Xian
Wang, Qian
Peng, Junmin
Zhang, Bin
Yue, Zhenyu
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2023-05-25
Volume: 25
Issue: 7
Pages: 963-974
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/s41556-023-01158-0
PMC: PMC10950302
OpenAlex: W4378212353
Cited by: 202
References: 76
Citations by year: 2026: 49 · 2025: 75 · 2024: 69 · 2023: 9
FWCI: 20.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: autophagy, microglia, Alzheimer's disease, amyloid plaques, microglial senescence, disease-associated microglia, senescence-associated secretory phenotype, autophagy-lysosome pathway, senolytic therapy, microglial proliferation
MeSH terms: Alzheimer Disease, Animals, Autophagy, Disease Models, Animal, Mice, Transgenic, Neurons, Microglia, Mice, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks