The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
A dissipative pathway for the structural evolution of DNA fibres
Abstract
Biochemical networks interconnect, grow and evolve to express new properties as different chemical pathways are selected during a continuous cycle of energy consumption and transformation. In contrast, synthetic systems that push away from equilibrium usually return to the same self-assembled state, often generating waste that limits system recyclability and prevents the formation of adaptable networks. Here we show that annealing by slow proton dissipation selects for otherwise inaccessible morphologies of fibres built from DNA and cyanuric acid. Using single-molecule fluorescence microscopy, we observe that proton dissipation influences the growth mechanism of supramolecular polymerization, healing gaps within fibres and converting highly branched, interwoven networks into nanocable superstructures. Just as the growth kinetics of natural fibres determine their structural attributes to modulate function, our system of photoacid-enabled depolymerization and repolymerization selects for healed materials to yield organized, robust fibres. Our method provides a chemical route for error-checking, distinct from thermal annealing, that improves the morphologies and properties of supramolecular materials using out-of-equilibrium systems.
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“Because of the noncovalent nature of DNA nanostructures, they can be reconfigured using established strategies, including strand displacement,26 thermal annealing,105 and pH changes.106”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [106]
Citations
Cites
Functional Supramolecular Polymers
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Self-citationSupramolecular systems chemistry
Mattia, E., & Otto, S. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2014.337 · Cited by 1,023
Molecular mechanisms of protein aggregation from global fitting of kinetic models
Meisl, G., Kirkegaard, J. B., Arosio, P., Michaels, T. C. T., Vendruscolo, M., Dobson, C. M., Linse, S. S., & Knowles, T. P. J. (2016) · Nature Protocols · doi:10.1038/nprot.2016.010 · Cited by 771
A rational strategy for the realization of chain-growth supramolecular polymerization
Kang, J., Miyajima, D., Mori, T., Inoue, Y., Itoh, Y., & Aida, T. (2015) · Science · doi:10.1126/science.aaa4249 · Cited by 662
Structural DNA Nanotechnology: State of the Art and Future Perspective
Zhang, F., Nangreave, J., Liu, Y., & Yan, H. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505101a · Cited by 574
Dissipative out-of-equilibrium assembly of man-made supramolecular materials
van Rossum, S. A. P., Tena‐Solsona, M., van Esch, J. H., Eelkema, R., & Boekhoven, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00246g · Cited by 573
How to Distinguish Isodesmic from Cooperative Supramolecular Polymerisation
Smulders, M. M. J., Nieuwenhuizen, M. M. L., de Greef, T. F. A., van der Schoot, P., Schenning, A. P. H. J., & Meijer, E. W. (2009) · Chemistry - A European Journal · doi:10.1002/chem.200902415 · Cited by 569
A Discrete Self-Assembled Metal Array in Artificial DNA
Tanaka, K., Tengeiji, A., Kato, T., Toyama, N., & Shionoya, M. (2003) · Science · doi:10.1126/science.1080587 · Cited by 565
Thubagere, A. J., Li, W., Johnson, R. F., Chen, Z., Doroudi, S., Lee, Y. L., Izatt, G., Wittman, S., Srinivas, N., Woods, D., et al. (2017) · Science · doi:10.1126/science.aan6558 · Cited by 559
Cited by
Sorted by citations
Photoresponsive Supramolecular Polymers: From Light‐Controlled Small Molecules to Smart Materials
Xu, F., & Feringa, B. L. (2022) · Advanced Materials · doi:10.1002/adma.202204413 · Cited by 331
Emerging Approaches to DNA Data Storage: Challenges and Prospects
Doricchi, A., Platnich, C. M., Gimpel, A., Horn, F., Earle, M., Lanzavecchia, G., Cortajarena, A. L., Liz-Marzán, L. M., Liu, N., Heckel, R., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c06748 · Cited by 235
Self-citationDissipative DNA nanotechnology
Grosso, E. D., Franco, E., Prins, L. J., & Ricci, F. (2022) · Nature Chemistry · doi:10.1038/s41557-022-00957-6 · Cited by 184
Photocleavable Ortho -Nitrobenzyl-Protected DNA Architectures and Their Applications
O’Hagan, M., Duan, Z., Huang, F., Laps, S., Dong, J., Xia, F., & Willner, I. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00016 · Cited by 148
Large, Tunable, and Reversible pH Changes by Merocyanine Photoacids
Wimberger, L., Prasad, S. K. K., Peeks, M. D., Andréasson, J., Schmidt, T. W., & Beves, J. E. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c08810 · Cited by 136
Metadata
- Authors
- Rizzuto, F. J., Platnich, C. M., Luo, X., Shen, Y., Dore, M. D., Lachance-Brais, C., Guarné, A., Cosa, G., & Sleiman, H. F.
- Affiliations
- McGill University (CA)
- Corresponding author
- Sleiman, Hanadi F.
- ORCID
- Venue
- Nature Chemistry
- Published
- 2021-08-09
- Volume
- 13
- Issue
- 9
- Pages
- 843-849
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W3192049880
- Cited by
- 120
- References
- 48
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 19 · 2023: 29 · 2022: 22 · 2021: 8
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
- Keywords
- cyanuric acid, dissipative systems, supramolecular polymerization, repolymerization, hierarchical assembly, error detection, single-molecule fluorescence microscopy
- MeSH terms
- DNA, Hydrogen-Ion Concentration, Indoles, Light, Triazines, Polymerization
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