The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
A dissipative pathway for the structural evolution of DNA fibres
Abstract
Biochemical networks interconnect, grow and evolve to express new properties as different chemical pathways are selected during a continuous cycle of energy consumption and transformation. In contrast, synthetic systems that push away from equilibrium usually return to the same self-assembled state, often generating waste that limits system recyclability and prevents the formation of adaptable networks. Here we show that annealing by slow proton dissipation selects for otherwise inaccessible morphologies of fibres built from DNA and cyanuric acid. Using single-molecule fluorescence microscopy, we observe that proton dissipation influences the growth mechanism of supramolecular polymerization, healing gaps within fibres and converting highly branched, interwoven networks into nanocable superstructures. Just as the growth kinetics of natural fibres determine their structural attributes to modulate function, our system of photoacid-enabled depolymerization and repolymerization selects for healed materials to yield organized, robust fibres. Our method provides a chemical route for error-checking, distinct from thermal annealing, that improves the morphologies and properties of supramolecular materials using out-of-equilibrium systems.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Because of the noncovalent nature of DNA nanostructures, they can be reconfigured using established strategies, including strand displacement,26 thermal annealing,105 and pH changes.106”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [106]
Citations
Cites
Functional Supramolecular Polymers
Aida, T., Meijer, E. W., & Stupp, S. I. (2012) · Science · doi:10.1126/science.1205962 · Cited by 3,703
Seeman, N. C., & Sleiman, H. F. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.68 · Cited by 1,875
Self-citationSupramolecular systems chemistry
Mattia, E., & Otto, S. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2014.337 · Cited by 1,023
Molecular mechanisms of protein aggregation from global fitting of kinetic models
Meisl, G., Kirkegaard, J. B., Arosio, P., Michaels, T. C. T., Vendruscolo, M., Dobson, C. M., Linse, S. S., & Knowles, T. P. J. (2016) · Nature Protocols · doi:10.1038/nprot.2016.010 · Cited by 771
A rational strategy for the realization of chain-growth supramolecular polymerization
Kang, J., Miyajima, D., Mori, T., Inoue, Y., Itoh, Y., & Aida, T. (2015) · Science · doi:10.1126/science.aaa4249 · Cited by 662
Structural DNA Nanotechnology: State of the Art and Future Perspective
Zhang, F., Nangreave, J., Liu, Y., & Yan, H. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505101a · Cited by 574
Dissipative out-of-equilibrium assembly of man-made supramolecular materials
van Rossum, S. A. P., Tena‐Solsona, M., van Esch, J. H., Eelkema, R., & Boekhoven, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00246g · Cited by 573
How to Distinguish Isodesmic from Cooperative Supramolecular Polymerisation
Smulders, M. M. J., Nieuwenhuizen, M. M. L., de Greef, T. F. A., van der Schoot, P., Schenning, A. P. H. J., & Meijer, E. W. (2009) · Chemistry - A European Journal · doi:10.1002/chem.200902415 · Cited by 569
A Discrete Self-Assembled Metal Array in Artificial DNA
Tanaka, K., Tengeiji, A., Kato, T., Toyama, N., & Shionoya, M. (2003) · Science · doi:10.1126/science.1080587 · Cited by 565
Thubagere, A. J., Li, W., Johnson, R. F., Chen, Z., Doroudi, S., Lee, Y. L., Izatt, G., Wittman, S., Srinivas, N., Woods, D., et al. (2017) · Science · doi:10.1126/science.aan6558 · Cited by 559
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 547
Light-controlled self-assembly of non-photoresponsive nanoparticles
Kundu, P. K., Samanta, D., Leizrowice, R., Margulis, B., Zhao, H., Börner, M., Udayabhaskararao, T., Manna, D., & Klajn, R. (2015) · Nature Chemistry · doi:10.1038/nchem.2303 · Cited by 542
Hachimoji DNA and RNA: A genetic system with eight building blocks.
Hoshika, S., Leal, N. A., Kim, M.-J., Kim, M.-S., Karalkar, N. B., Kim, H.-J., Bates, A. M., Watkins, N. E., SantaLucia, H. A., Meyer, A. J., et al. (2019) · Science · doi:10.1126/science.aat0971 · Cited by 494
Nucleation–elongation: a mechanism for cooperative supramolecular polymerization
Zhao, D., & Moore, J. S. (2003) · Organic & Biomolecular Chemistry · doi:10.1039/b308788c · Cited by 479
Chemistries for DNA Nanotechnology
Madsen, M., & Gothelf, K. V. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00570 · Cited by 459
Revising Complex Supramolecular Polymerization under Kinetic and Thermodynamic Control
Matern, J., Dorca, Y., Sánchez, L., & Fernández, G. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201905724 · Cited by 456
The nanotechnology of life-inspired systems
Grzybowski, B. A., & Huck, W. T. S. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.116 · Cited by 453
Role of nanoscale antigen organization on B-cell activation probed using DNA origami
Veneziano, R., Moyer, T. J., Stone, M. B., Wamhoff, E., Read, B. J., Mukherjee, S., Shepherd, T. R., Das, J., Schief, W. R., Irvine, D. J., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0719-0 · Cited by 439
Non-Centrosymmetric Cylindrical Micelles by Unidirectional Growth
Rupar, P. A., Chabanne, L., Winnik, M. A., & Manners, I. (2012) · Science · doi:10.1126/science.1221206 · Cited by 374
Weisel, J. W., & Nagaswami, C. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81594-1 · Cited by 347
DNA-based communication in populations of synthetic protocells
Joesaar, A., Yang, S., Bögels, B. W. A., van der Linden, A. J., Pieters, P. A., Kumar, B. V. V. S. P., Dalchau, N., Phillips, A., Mann, S., & de Greef, T. F. A. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0399-9 · Cited by 334
Long-Lived Photoacid Based upon a Photochromic Reaction
Shi, Z., Peng, P., Strohecker, D., & Liao, Y. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203851c · Cited by 327
McLaughlin, C. K., Hamblin, G. D., & Sleiman, H. F. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15253j · Cited by 281
Self-citationThe Design of Dissipative Molecular Assemblies Driven by Chemical Reaction Cycles
Rieß, B., Grötsch, R. K., & Boekhoven, J. (2019) · Chem · doi:10.1016/j.chempr.2019.11.008 · Cited by 265
Autonomous dynamic control of DNA nanostructure self-assembly
Green, L. N., Subramanian, H. K. K., Mardanlou, V., Kim, J., Hariadi, R. F., & Franco, E. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0251-8 · Cited by 262
A metallo-DNA nanowire with uninterrupted one-dimensional silver array
Kondo, J., Tada, Y., Dairaku, T., Hattori, Y., Saneyoshi, H., Ono, A. M., & Tanaka, Y. (2017) · Nature Chemistry · doi:10.1038/nchem.2808 · Cited by 239
Zhu, S., Yuan, Q., Yin, T., You, J., Gu, Z., Xiong, S., & Hu, Y. (2018) · Journal of Materials Chemistry B · doi:10.1039/c7tb02999c · Cited by 214
Biomimetic temporal self-assembly via fuel-driven controlled supramolecular polymerization
Mishra, A., Korlepara, D. B., Kumar, M., Jain, A., Jonnalagadda, N., Bejagam, K. K., Balasubramanian, S., & George, S. J. (2018) · Nature Communications · doi:10.1038/s41467-018-03542-z · Cited by 203
Programmable dynamic steady states in ATP-driven nonequilibrium DNA systems
Heinen, L., & Walther, A. (2019) · Science Advances · doi:10.1126/sciadv.aaw0590 · Cited by 188
Re-programming Hydrogel Properties Using a Fuel-Driven Reaction Cycle
Singh, N., Lainer, B., Formon, G. J. M., Piccoli, S. D., & Hermans, T. M. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b11503 · Cited by 159
The poly dA helix: a new structural motif for high performance DNA-based molecular switches
Chakraborty, S., Sharma, S., Maiti, P. K., & Krishnan, Y. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp133 · Cited by 152
Reprogramming the assembly of unmodified DNA with a small molecule
Avakyan, N., Greschner, A. A., Aldaye, F., Serpell, C. J., Toader, V., Petitjean, A., & Sleiman, H. F. (2016) · Nature Chemistry · doi:10.1038/nchem.2451 · Cited by 148
Self-citationFuel-Controlled Reassembly of Metal–Organic Architectures
Wood, C. S., Browne, C., Wood, D. M., & Nitschke, J. R. (2015) · ACS Central Science · doi:10.1021/acscentsci.5b00279 · Cited by 109
A transient self-assembling self-replicator
Colomer, I., Morrow, S. M., & Fletcher, S. P. (2018) · Nature Communications · doi:10.1038/s41467-018-04670-2 · Cited by 107
A poly(thymine)–melamine duplex for the assembly of DNA nanomaterials
Li, Q., Zhao, J., Liu, L., Jonchhe, S., Rizzuto, F. J., Mandal, S., He, H., Wei, S., Sleiman, H. F., Mao, H., et al. (2020) · Nature Materials · doi:10.1038/s41563-020-0728-2 · Cited by 101
Self-citationDissipative Synthetic DNA‐Based Receptors for the Transient Loading and Release of Molecular Cargo
Grosso, E. D., Amodio, A., Ragazzon, G., Prins, L. J., & Ricci, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801318 · Cited by 97
The Growing Development of DNA Nanostructures for Potential Healthcare‐Related Applications
Mathur, D., & Medintz, I. L. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801546 · Cited by 85
Efficient One-Step PEG-Silane Passivation of Glass Surfaces for Single-Molecule Fluorescence Studies
Gidi, Y., Bayram, S. S., Ablenas, C. J., Blum, A. S., & Cosa, G. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b15796 · Cited by 73
Self-citationDeng, J., & Walther, A. (2020) · Nature Communications · doi:10.1038/s41467-020-17479-9 · Cited by 70
Responsive DNA-Based Supramolecular Hydrogels
Shi, J., Shi, Z., Dong, Y., Wu, F., & Liu, D. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00081 · Cited by 65
Self-assembling outside equilibrium: emergence of structures mediated by dissipation
Arango-Restrepo, A., Barragán, D., & Rubí, J. M. (2019) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp01088b · Cited by 62
Transient dormant monomer states for supramolecular polymers with low dispersity
Jalani, K., Das, A. D., Sasmal, R., Agasti, S. S., & George, S. J. (2020) · Nature Communications · doi:10.1038/s41467-020-17799-w · Cited by 58
Single-molecule methods in structural DNA nanotechnology
Platnich, C. M., Rizzuto, F. J., Cosa, G., & Sleiman, H. F. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00776h · Cited by 52
Self-citationAmyloid assembly is dominated by misregistered kinetic traps on an unbiased energy landscape
Jia, Z., Schmit, J. D., & Chen, J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911153117 · Cited by 51
Fragmentation and Coagulation in Supramolecular (Co)polymerization Kinetics
Markvoort, A. J., ten Eikelder, H. M. M., Hilbers, P. A. J., & de Greef, T. F. A. (2016) · ACS Central Science · doi:10.1021/acscentsci.6b00009 · Cited by 50
Molecular Printing with DNA Nanotechnology
Rizzuto, F. J., Trinh, T., & Sleiman, H. F. (2020) · Chem · doi:10.1016/j.chempr.2020.06.012 · Cited by 31
Self-citationRapid and inefficient kinetics of sickle hemoglobin fiber growth
Castle, B. T., Odde, D. J., & Wood, D. K. (2019) · Science Advances · doi:10.1126/sciadv.aau1086 · Cited by 25
Noncovalent Helicene Structure between Nucleic Acids and Cyanuric Acid
Alenaizan, A., Fauché, K., Krishnamurthy, R., & Sherrill, C. D. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202004390 · Cited by 25
Cited by
Sorted by citations
Photoresponsive Supramolecular Polymers: From Light‐Controlled Small Molecules to Smart Materials
Xu, F., & Feringa, B. L. (2022) · Advanced Materials · doi:10.1002/adma.202204413 · Cited by 331
Emerging Approaches to DNA Data Storage: Challenges and Prospects
Doricchi, A., Platnich, C. M., Gimpel, A., Horn, F., Earle, M., Lanzavecchia, G., Cortajarena, A. L., Liz-Marzán, L. M., Liu, N., Heckel, R., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c06748 · Cited by 235
Self-citationDissipative DNA nanotechnology
Grosso, E. D., Franco, E., Prins, L. J., & Ricci, F. (2022) · Nature Chemistry · doi:10.1038/s41557-022-00957-6 · Cited by 184
Photocleavable Ortho -Nitrobenzyl-Protected DNA Architectures and Their Applications
O’Hagan, M., Duan, Z., Huang, F., Laps, S., Dong, J., Xia, F., & Willner, I. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00016 · Cited by 148
Large, Tunable, and Reversible pH Changes by Merocyanine Photoacids
Wimberger, L., Prasad, S. K. K., Peeks, M. D., Andréasson, J., Schmidt, T. W., & Beves, J. E. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c08810 · Cited by 136
Metadata
- Authors
- Rizzuto, F. J., Platnich, C. M., Luo, X., Shen, Y., Dore, M. D., Lachance-Brais, C., Guarné, A., Cosa, G., & Sleiman, H. F.
- Affiliations
- McGill University (CA)
- Corresponding author
- Sleiman, Hanadi F.
- ORCID
- Venue
- Nature Chemistry
- Published
- 2021-08-09
- Volume
- 13
- Issue
- 9
- Pages
- 843-849
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W3192049880
- Cited by
- 120
- References
- 48
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 19 · 2023: 29 · 2022: 22 · 2021: 8
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
- Keywords
- cyanuric acid, dissipative systems, supramolecular polymerization, repolymerization, hierarchical assembly, error detection, single-molecule fluorescence microscopy
- MeSH terms
- DNA, Hydrogen-Ion Concentration, Indoles, Light, Triazines, Polymerization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
