Shared genetic architectures of subjective well-being in East Asian and European ancestry populations
Open accessAbstract
Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.
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The result that cross-population PGS outperformed ancestry-matched PGSs replicated previous studies showing that multi-ancestry PGS demonstrated improved prediction performance relative to ancestry-matched PGSs.
“This result replicated previous studies showing that multi-ancestry PGS demonstrated an improved prediction performance relative to ancestry-matched PGSs41,42.”
From Shared genetic architectures of educational attainment in East Asian and European populations (2024) · cites this paper as [42]
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Self-citation
- Authors
- Kim, S., Kim, K., Hwang, M. Y., Ko, H., Jung, S.-H., Shim, I., Cha, S., Lee, H., Kim, B., Yoon, J., Ha, T. H., Kim, D. K., Kim, J., Park, W.-Y., Okbay, A., Kim, B.-J., Kim, Y. J., Myung, W., & Won, H.-H.
- Affiliations
- Seoul National University (KR)
- Hallym University (KR)
- Korea National Institute of Health (KR)
- Samsung Medical Center (KR)
- Soonchunhyang University (KR)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Kim, Young Jin
- Myung, Woojae
- Won, Hong-Hee
- ORCID
- Venue
- Nature Human Behaviour
- Published
- 2022-05-19
- Volume
- 6
- Issue
- 7
- Pages
- 1014-1026
- ISSN
- 2397-3374 (ISSN-L)
- OpenAlex
- W4280508570
- Cited by
- 18
- References
- 0
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 2
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Human Behaviour (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Korea Health Industry Development Institute (HI19C1328000020, HI19C1132)
- Ministry of Health, Welfare and Family Affairs | Korea National Institute of Health (2019-NG-053-01)
- National Research Foundation of Korea (2021R1A2C4001779, 2018R1C1B6001708, 2019R1A2C4070496)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Social Psychology › Psychological Well-being and Life Satisfaction
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- subjective well-being, major depressive disorder, HMGA2, heritability, East Asian ancestry, European ancestry, Korean population
- MeSH terms
- Major Depressive Disorder, Depressive Disorder, Major, Humans, Mental Health, Multifactorial Inheritance, Polymorphism, Single Nucleotide, White People, Asian People, Genome-Wide Association Study
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