Cited by 175Pancreatic function and diabetesDiabetes and associated disordersT-cell and B-cell Immunology

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

Open access

Headen, Devon M., Woodward, Kyle B., Coronel, María M., Shrestha, Pradeep, Weaver, Jessica D., Zhao, Hong, Tan, Min, Hunckler, Michael D., Bowen, William S., Johnson, Christopher T., Shea, Lonnie, Yolcu, Esma S., García, Andrés J., Shirwan, Haval·2018·Nature Materials

DOI 10.1038/s41563-018-0099-0PMC PMC6060019

Open this paper in CoChat — free account

Abstract

Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function. T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results in prolonged survival of allogeneic islet grafts in diabetic mice. A short course of rapamycin treatment boosted the immunomodulatory efficacy of SA-FasL microgels, resulting in acceptance and function of allografts over 200 days. Survivors generated normal systemic responses to donor antigens, implying immune privilege of the graft, and had increased CD4+CD25+FoxP3+ T regulatory cells in the graft and draining lymph nodes. Deletion of T regulatory cells resulted in acute rejection of established islet allografts. This localized immunomodulatory biomaterial-enabled approach may provide an alternative to chronic immunosuppression for clinical islet transplantation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41563-018-0099-0

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990
International trial of the Edmonton protocol for islet transplantation
Shapiro, A. M. J., Ricordi, C., Hering, B. J., Auchincloss, H., Lindblad, R., Robertson, R. P., Secchi, A., Brendel, M. D., Berney, T., Brennan, D. C., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061267 · Cited by 1,942
Lethal effect of the anti-Fas antibody in mice
Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
Kim, J. M., Rasmussen, J. P., & Rudensky, A. Y. (2006) · Nature Immunology · doi:10.1038/ni1428 · Cited by 1,827
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
Ju, S., Panka, D., Cui, H., Ettinger, R., EI-Khatib, M., Sherr, D., Stanger, B., & Marshak-Rothstein, A. (1995) · Nature · doi:10.1038/373444a0 · Cited by 1,709
mTOR regulates memory CD8 T-cell differentiation
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.
Battaglia, M., Stabilini, A., & Roncarolo, M. (2005) · Blood · doi:10.1182/blood-2004-10-3932 · Cited by 1,203
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
Lahl, K., Loddenkemper, C., Drouin, C. E., Freyer, J., Arnason, J. E., Eberl, G., Hamann, A., Wagner, H., Huehn, J., & Sparwasser, T. D. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061852 · Cited by 951
The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
Rao, R. R., Li, Q., Odunsi, K., & Shrikant, P. A. (2010) · Immunity · doi:10.1016/j.immuni.2009.10.010 · Cited by 656

Show all 44 references

Sorted by citations

Items 101–174 of 174

Advancements and Challenges in Immune Protection Strategies for Islet Transplantation
Wang, X., Zeng, Z., Li, D., Wang, K., Zhang, W., Yu, Y., & Wang, X. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70048 · Cited by 18
Cell Membrane-Coated Electrospun Fibers Enhance Keratinocyte Growth through Cell-Type Specific Interactions
Chooi, W. H., Dong, Q., Low, J. Z. Y., Yuen, C., Chin, J. S., Lin, J., Ong, W., Liu, Q., & Chew, S. Y. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00303 · Cited by 15
Single-Cell Landscape of Mouse Islet Allograft and Syngeneic Graft
Chen, P., Yao, F., Lu, Y., Peng, Y., Zhu, S., Deng, J., Wu, Z., Chen, J., Deng, K., Li, Q., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.853349 · Cited by 16
Fas Ligand-Modified Scaffolds Protect Stem Cell Derived β-Cells by Modulating Immune Cell Numbers and Polarization
Li, F., Crumley, K. M., Bealer, E. J., King, J. L., Saito, E., Grimany-Nuno, O., Yolcu, E. S., Shirwan, H., & Shea, L. D. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c12939 · Cited by 14
Self-citation
Analyzing the scaffold immune microenvironment using flow cytometry: practices, methods and considerations for immune analysis of biomaterials
Sadtler, K., & Elisseeff, J. H. (2019) · Biomaterials Science · doi:10.1039/c9bm00349e · Cited by 16
Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap
Naaz, A., Turnquist, H. R., Gorantla, V. S., & Little, S. R. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115429 · Cited by 15
Biomaterial Applications in Islet Encapsulation and Transplantation
Caserto, J. S., Bowers, D. T., Shariati, K., & Ma, M. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01235 · Cited by 14
Biomimetic Vascularized iPSC‐Hepatocyte Spheroids for Liver Regeneration
Wang, J., Huang, D., Ren, H., & Zhao, Y. (2025) · Advanced Science · doi:10.1002/advs.202405662 · Cited by 13
Controlling placental spheroid growth and phenotype using engineered synthetic hydrogel matrices
Slaby, E. M., Plaisier, S. B., Brady, S. R., Hiremath, S. C., & Weaver, J. D. (2024) · Biomaterials Science · doi:10.1039/d3bm01393f · Cited by 12
Self-citation
Conjugation of IL‐33 to Microporous Annealed Particle Scaffolds Enhances Type 2‐Like Immune Responses In Vitro and In Vivo
Roosa, C., Lempke, S. L., Hannan, R. T., Nicklow, E., Sturek, J. M., Ewald, S. E., & Griffin, D. R. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400249 · Cited by 12
Biomaterial-based approaches to engineering immune tolerance
Emerson, A. E., Slaby, E. M., Hiremath, S. C., & Weaver, J. D. (2020) · Biomaterials Science · doi:10.1039/d0bm01171a · Cited by 12
Self-citation
Shear-thinning hydrogel for allograft cell transplantation and externally controlled transgene expression
Bezold, M. G., Dollinger, B. R., DeJulius, C. R., Keech, M. C., Hanna, A. R., Kittel, A. R., Yu, F., Gupta, M. K., d’Arcy, R., Brunger, J. M., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122812 · Cited by 11
STAT3 inhibition in combination with CD47 blockade inhibits osteosarcoma lung metastasis
Shrestha, P., Shrestha, R., Zhou, Y. L., Zielinski, R. J., Priebe, W., & Kleinerman, E. S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1608375 · Cited by 13
Self-citation
Translation of cell therapies to treat autoimmune disorders
Mehta, J. M., Hiremath, S. C., Chilimba, C., Ghasemi, A., & Weaver, J. D. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115161 · Cited by 11
Self-citation
Islet Transplantation: Microencapsulation, Nanoencapsulation, and Hypoimmune Engineering
Lee, K., Vargas, A. A., Bottino, R., & Wang, Y. (2025) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.70016 · Cited by 12
Engineering Strategies for Allogeneic Solid Tissue Acceptance
Sousa, A. R., Mano, J. F., & Oliveira, M. B. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.03.005 · Cited by 10
Comparison of Four Different Preparation Methods for Making Injectable Microgels for Tissue Engineering and Cell Therapy
Hamami, R., Yameen, H. S., Gargioli, C., & Seliktar, D. (2022) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-022-00261-2 · Cited by 10
Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice
Wang, Y., Xu, Y. C., Tan, C. W., Qiao, L., Chia, W. N., Zhang, H., Huang, Q., Deng, Z., Wang, Z., Wang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35425-9 · Cited by 11
Microfluidics tubing as a synthesizer for ordered microgel networks
Ma, S. (2019) · Soft Matter · doi:10.1039/c9sm00626e · Cited by 10
Artificial Engineering of Immune Cells for Improved Immunotherapy
Li, C., Qi, Y., Zhang, Y. X., Chen, Y., Feng, J. X., & Zhang, X. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000081 · Cited by 9
Recent Advances in Localized Immunomodulation Technology: Application of NIR-PIT toward Clinical Control of the Local Immune System
Yamada, M., Matsuoka, K., Sato, M., & Sato, K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020561 · Cited by 9
Unlocking Transplant Tolerance with Biomaterials
Pham, J. A., & Coronel, M. M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400965 · Cited by 8
Self-citation
Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection
Tu, A. B., Krishna, G., Smith, K. R., & Lewis, J. S. (2024) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110122-014306 · Cited by 8
iPSC modification strategies to induce immune tolerance
Hong, Z., Zhao, Y. F., Pahlavan, S., Wang, X., Han, S., Wang, K., & Wang, K. (2025) · Life Medicine · doi:10.1093/lifemedi/lnaf016 · Cited by 9
Grafting Islets to a Dissected Peritoneal Pouch to Improve Transplant Survival and Function
Kumano, K., Vasu, S., Liu, Y., Lo, S., Mulgaonkar, A., Pennington, J., Darden, C., Sun, X.-K., Lawrence, M. C., & Naziruddin, B. (2020) · Transplantation · doi:10.1097/tp.0000000000003355 · Cited by 5
In Vitro Studies of Squalene‐Gusperimus Nanoparticles in Islet‐Containing Alginate Microcapsules to Regulate the Immune Response in the Immediate Posttransplant Period
Chica, C. E. N., Qin, T., de Haan, B. J., Faas, M. M., Smink, A. M., Sierra, L., López, B. L., & de Vos, P. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100055 · Cited by 8
From Edmonton to Lantidra and beyond: immunoengineering islet transplantation to cure type 1 diabetes
Mbaye, E. H. A., Scott, E. A., & Burke, J. A. (2025) · Frontiers in Transplantation · doi:10.3389/frtra.2025.1514956 · Cited by 9
Engineering hypoimmune stem cell-derived beta cells
Licht, B. J. M., Duffy, G. P., & Levey, R. E. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04745-0 · Cited by 8
Engineering pancreatic islets with a novel form of thrombomodulin protein to overcome early graft loss triggered by instant blood-mediated inflammatory reaction
Turan, A., Zhang, L., Tarique, M., Ulker, V., Arguc, F., Badal, D., Yolcu, E., & Shirwan, H. (2023) · American Journal of Transplantation · doi:10.1016/j.ajt.2023.02.021 · Cited by 7
Self-citation
Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease
Shrestha, P., Turan, A., Batra, L., Gulen, A. E., Sun, Z., Tan, H., Askenasy, N., Shirwan, H., & Yolcu, E. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022008495 · Cited by 3
Self-citation
Engineering Pancreatic Islets to Transiently Codisplay on Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction following Intraportal Transplantation
Turan, A., Tarique, M., Zhang, L., Kazmi, S., Ulker, V., Tedla, M. G., Badal, D., Yolcu, E. S., & Shirwan, H. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300743 · Cited by 6
Self-citation
Staphylococcal protein A-modified hydrogel facilitates in situ immunomodulation by capturing anti-HMGB1 for islet grafts
Bai, X., Wang, D., Wang, B., Zhang, X., Bai, Y., Zhang, X., Tian, R., Li, C., Yi, Q., Cheng, Y., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.05.008 · Cited by 6
Modulating Neutrophil Extracellular Trap Formation In Vivo with Locoregional Precision Using Differently Charged Self-Assembled Hydrogels
Lopez‐Silva, T. L., Anderson, C. F., & Schneider, J. P. (2025) · ACS Central Science · doi:10.1021/acscentsci.4c02198 · Cited by 5
Modulating immune response for the prevention and treatment of type 1 diabetes
Vohidova, D., Desai, P., Lozano, A. M., & Omid Veiseh, A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1715863 · Cited by 5
Immune modulation for β-cell replacement in type 1 diabetes
Yang, Q., Song, Y., Markmann, J. F., & Lei, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1785523 · Cited by 5
Immunological response of polysaccharide nanogel-incorporating PEG hydrogels in anin vivodiabetic model
Bal, T., Karaoğlu, İ. C., Murat, F. S., Yalcin, E., Sasaki, Y., Akiyoshi, K., & Kızılel, S. (2022) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2022.2077512 · Cited by 5
Bending the Rules: Amplifying PD-L1 Immunoregulatory Function Through Flexible Polyethylene Glycol Synthetic Linkers
Racca, N. M., Dontu, A., Riley, K., Yolcu, E. S., Shirwan, H., & Coronel, M. M. (2024) · Tissue Engineering Part A · doi:10.1089/ten.tea.2023.0274 · Cited by 5
Self-citation
A Case for Material Stiffness as a Design Parameter in Encapsulated Islet Transplantation
Johnson, C. D., Aranda‐Espinoza, H., & Fisher, J. P. (2022) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2022.0157 · Cited by 5
Self-citation
Engineering of Trophoblast Extracellular Vesicle-Delivering Hydrogels for Localized Tolerance Induction in Cell Transplantation
Hiremath, S. C., & Weaver, J. D. (2023) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-023-00778-8 · Cited by 6
Self-citation
Engineered 3D Hydrogel Matrices to Modulate Trophoblast Stem Cell-Derived Placental Organoid PhenotypePreprint
Slaby, E. M., Hansen, N. F., Sharma, R., Pirrotte, P., & Weaver, J. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.13.594007 · Cited by 5
Self-citation
Finishing the odyssey to a stem cell cure for type 1 diabetes
Hunault, L., & Hesselson, D. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00014-5 · Cited by 7
Engineering Functional Particles to Modulate T Cell Responses
Li, Y., Li, S., Scheerstra, J. F., Patiño, T., van Hest, J. C. M., & Abdelmohsen, L. K. E. A. (2024) · Accounts of Materials Research · doi:10.1021/accountsmr.4c00105 · Cited by 5
A new paradigm in transplant immunology: At the crossroad of synthetic biology and biomaterials
Zhang, Z., Ding, L.-Y., Zuo, X.-L., Feng, H., & Xia, Q. (2023) · Med · doi:10.1016/j.medj.2023.05.002 · Cited by 6
Combinatorial islet protective therapeutic approaches in β‐cell transplantation: Rationally designed solutions using a target product profile
Lu, K., Brauns, T. A., Sluder, A. E., Poznansky, M. C., & Doğan, F. (2023) · FASEB BioAdvances · doi:10.1096/fba.2023-00029 · Cited by 3
Controlled drug delivery system for wound healing: formulations and delivery required therapeutic agents
Man, E., & Hoskins, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90514-5.00019-5 · Cited by 3
Superimposed Electric Field Enhanced Electrospray for High‐Throughput and Consistent Cell Encapsulation
Fan, Z., Chen, Y., Yang, Z., Niu, Y., Liang, K., Zhang, Y., Zeng, J., Feng, Y., Zhang, Y., Liu, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400780 · Cited by 3
Introduction: Immune Response to the Implanted Biomaterial
Kim, B., & Mukherjee, S. (2024) · Synthesis lectures on biomedical engineering · doi:10.1007/978-3-031-50844-8_1 · Cited by 2
Scaffolds implanted
Mohammadi, M. R., Luong, J. C., Kim, G. G., Lau, H., & Lakey, J. R. T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102563-5.00007-1 · Cited by 2
Progress toward islet transplantation tolerance
Markmann, J. F., & Rickert, C. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814833-4.00058-7 · Cited by 2
Islet Immunoengineering
Teles, L. N., LI, C., Wilkes, Z. M., Stock, A. A., & Tomei, A. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_15 · Cited by 1
Antigen-delivering biomaterials for local enrichment and reprogramming of immune cells
Wheeler, S. N., & Morris, A. H. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115042 · Cited by 1
Localized immunomodulation with cytokine-producing cells to mitigate foreign body responses in rodents and a nonhuman primate
Kim, B., Vohidova, D., Nash, A., Chan, Y. S., Fleury, S., Deo, S., Murungi, D., Rios, P., Joshi, I., Nasir, H., et al. (2026) · Science Advances · doi:10.1126/sciadv.aec7053 · Cited by 2
Generating tolerance through in situ recruitment of regulatory T cells for allogeneic cell transplantation in a bioengineered lymphoid platform
Kota, N., Settis, D., Concato, M., Risso, N., Pol, R. V., Lewis, C., Liu, Y., Arefeayne, Y., Niclot, F. B., Segatori, L., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102469 · Cited by 1
Human embryonic stem cells (hESC) as a source of insulin-producing cells
Sackett, S. D., Tremmel, D. M., Feeney, A. K., Mitchell, S. A., & Odorico, J. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814831-0.00027-0 · Cited by 1
Whole Pancreas and Islet Cell Transplantation
Marfil‐Garza, B. A., Senior, P. A., & Shapiro, A. M. J. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch34 · Cited by 1
Localized immunomodulation with cytokine-producing cells to mitigate host immune rejection responses in rodents and a non-human primatePreprint
Kim, B., Vohidova, D., Nash, A., Chan, Y. S., Fleury, S., Deo, S., Murungi, D., Rios, P., Joshi, I., Nasir, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.13.682221 · Cited by 1
Regenerative medicine technologies applied to beta cell replacement: The industry perspective
Rust, W. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814831-0.00037-3
Transient display of chimeric proteins on biological surfaces as an effective strategy for modulations of innate and adaptive immune responses.
Shrestha, P. (2020) · doi:10.18297/etd/3413
Self-citation
Biomaterial strategies to treat autoimmunity and unwanted immune responses to drugs and transplanted tissues
Ishizuka, A. S., Lynn, G. M., & Jewell, C. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821440-4.00002-5
Design and experimental studies on squalene-gusperimus nanoparticles for managing immune responses against microencapsulated islets in the immediate posttransplant period
Chica, C. E. N. (2022) · doi:10.33612/diss.211898807
Cotransplantation of marginal mass allogeneic islets with 3D culture-derived adult human skin cells improves glycemia in diabetic mice
Andreone, L., dos Santos, A. F., Wailemann, R. A. M., Terra, L. F., Gomes, V. M., da Silva, J. M., Rosa-Fernandes, L., Sogayar, M. C., Palmisano, G., Labriola, L., et al. (2023) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2023e12611
Polymers for implantable bioartificial pancreas
Chen, J. T., Lee, J. M., Lim, E. X. H., Koh, Y., Yeong, W. Y., & Teo, A. K. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99690-7.00012-1
Selecting Biocompatible Biomaterials for Stem Cell-Derived β-Cell Transplantation
de Vries, R. H. W., & van Apeldoorn, A. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_6
Enhancing Pancreatic B-Cell Viability and Longevity Through Novel Microencapsulation Strategies and Stromal Cell Support
Qin, T. (2024) · doi:10.33612/diss.979224131
Nanotheranostics in Personalized Veterinary Medicine
Ghosh, M., Chowdhury, A., & Kumar, R. (2024) · Livestock diseases and management · doi:10.1007/978-981-16-1610-5_28
Sprayed Aqueous Microdroplets for Spontaneous Synthesis of Functional Microgels
Li, X., Zhang, W., Li, H., Shuai, Q., Zhang, X., & Pich, A. (2025) · Angewandte Chemie · doi:10.1002/ange.202420926
Co-Transplantation of Marginal Mass Allogeneic Islets with 3D-Culture-Derived Adult Human Skin Cells Improves Glycemia in Diabetic MicePreprint
Oliveira, T. C., Forni, M. F., Santos, A. F., Wailemann, R. A. M., Terra, L. F., Andreone, L., Gomes, V. M., da Silva, J. M., Rosa-Fernandes, L., Sogayar, M. C., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-951683/v1
In Vitro Evaluation of Necrostatin-1 Microparticles for Limiting Stress-induced Cell Death and Preserving Islet Function
Cuesta-Gomez, N., Kumar, P., Kuppan, P., Paramor, J., Saleh, A., Korbutt, G. S., & Pepper, A. R. (2026) · Transplantation Direct · doi:10.1097/txd.0000000000001945
Engineering organoids toward implantable living therapeutics
Shi, Z., Yang, Q., You, X., Wang, H., Wang, H., & Zhao, G. (2026) · hLife · doi:10.1016/j.hlife.2026.06.002
Condensate enabled delivery of Fas and IL-2 receptor agonists promotes T regulatory responses to alloantigens
Yee-Flores, K. M., Badal, D., Wright, N. S., Tarique, M., Yolcu, E. S., Wang, Y., & Shirwan, H. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.215100
Self-citation
Advances in nanomaterial-based delivery systems for inducing transplantation tolerance
Li, Q., Zhang, Y., Wu, J., Huang, D., & Qi, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1908621
Clinical Evolution, Outcomes, and Emerging Preservation Technologies in Pancreas and Islet Transplantation
Bellini, M. I., & Papalois, V. E. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15176774
Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction
Jiang, Y., Li, H., Wang, W., Guo, Q., Wang, C., Li, Y., Lu, H., Chen, J., Yang, H., Zhao, X., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.08.019
Engineering Immune‐Protective Stem Cell‐Derived β‐Cell Grafts for Type 1 Diabetes: Encapsulation Technologies and the Emerging Graft Ecosystem
Alanazi, M. A. (2026) · Artificial Organs · doi:10.1111/aor.70245

Authors: Headen, D. M., Woodward, K. B., Coronel, M. M., Shrestha, P., Weaver, J. D., Zhao, H., Tan, M., Hunckler, M. D., Bowen, W. S., Johnson, C. T., Shea, L., Yolcu, E. S., García, A. J., & Shirwan, H.
Affiliations: Georgia Institute of Technology (US)
University of Louisville (US)
Corresponding author: Shirwan, Haval
ORCID: Woodward, Kyle B.
Coronel, María M.
Shrestha, Pradeep
Weaver, Jessica D.
Zhao, Hong
Hunckler, Michael D.
Bowen, William S.
Johnson, Christopher T.
Shea, Lonnie
Yolcu, Esma S.
García, Andrés J.
Shirwan, Haval
Venue: Nature Materials
Publisher: Springer Science and Business Media LLC
Published: 2018-06-04
Volume: 17
Issue: 8
Pages: 732-739
ISSN: 1476-1122 (ISSN-L)
1476-4660
DOI: 10.1038/s41563-018-0099-0
PMC: PMC6060019
OpenAlex: W2807344337
Cited by: 175
References: 44
Citations by year: 2026: 12 · 2025: 12 · 2024: 29 · 2023: 27 · 2022: 24 · 2021: 25 · 2020: 16 · 2019: 23 · 2018: 7
FWCI: 18.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Materials (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (4t90dk097787-05, 1s10od016264-01a1)
National Institute of General Medical Sciences (T32GM008169)
National Institute of Allergy and Infectious Diseases (R21AI113348, U01AI132817, R56AI121281)
National Institute of Diabetes and Digestive and Kidney Diseases (T90-DK097787, P30DK020572)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (F30AR069472)
National Institute of Biomedical Imaging and Bioengineering (R21EB020107)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: islet transplantation, type 1 diabetes, allograft rejection, Fas ligand, microgels, streptavidin, rapamycin, regulatory T cells, effector T cells, immune privilege, biomaterials, graft acceptance
MeSH terms: Animals, Biocompatible Materials, Transplantation, Homologous, Islets of Langerhans Transplantation, Streptavidin, Mice, Fas Ligand Protein, Immunomodulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks