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Cited by 1,065Biosensors and Analytical DetectionClinical Laboratory Practices and Quality ControlSARS-CoV-2 detection and testing

REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes

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Land, Kevin J., Boeras, Debrah I., Chen, Xiang-Sheng, Ramsay, Andrew R., Peeling, Rosanna W.·2018·Nature Microbiology
DOI 10.1038/s41564-018-0295-3PMC PMC7097043
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Abstract

Lack of access to quality diagnostics remains a major contributor to health burden in resource-limited settings. It has been more than 10 years since ASSURED (affordable, sensitive, specific, user-friendly, rapid, equipment-free, delivered) was coined to describe the ideal test to meet the needs of the developing world. Since its initial publication, technological innovations have led to the development of diagnostics that address the ASSURED criteria, but challenges remain. From this perspective, we assess factors contributing to the success and failure of ASSURED diagnostics, lessons learnt in the implementation of ASSURED tests over the past decade, and highlight additional conditions that should be considered in addressing point-of-care needs. With rapid advances in digital technology and mobile health (m-health), future diagnostics should incorporate these elements to give us REASSURED diagnostic systems that can inform disease control strategies in real-time, strengthen the efficiency of health care systems and improve patient outcomes.

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  • The implementation of POCT outside the laboratory has facilitated access to diagnostics for remote and regional populations, disadvantaged communities and individuals at high risk of infection.

    “The implementation of POCT outside the laboratory has facilitated access to diagnostics for remote and regional populations, disadvantaged communities and individuals at high risk of infection [66].”

    From Point-of-care testing: state-of-the art and perspectives (2025) · cites this paper as [66]

    The ASSURED criteria section (page unavailable) explains that point-of-care tests can serve community and primary-care settings with limited laboratory access, and the implementation section describes rapid testing in the Amazon forest and rural China. The paper also discusses increased access in low- and middle-income countries, but the passages found do not establish improved access specifically for individuals at high risk of infection. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • An independent FDA-university-commercial evaluation of RAgTs provided repeat home testing performance data used in theoretical calculations.

    “An independent FDA-university-commercial evaluation of RAgTs provided repeat home testing performance data [66] used in theoretical calculations.”

    From Point-of-care testing: state-of-the art and perspectives (2025) · cites this paper as [66]

    The ASSURED diagnostic tests section discusses rapid tests for HIV, malaria, syphilis and TB, not an independent evaluation of repeat at-home RAgT testing. Searches for FDA–university–commercial evaluation and serial home-testing performance found no passage addressing the attributed data; the copy provides no page numbers for these passages. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Land, K. J., Boeras, D. I., Chen, X.-S., Ramsay, A. R., & Peeling, R. W.
Affiliations
  • Council for Scientific and Industrial Research (ZA)
  • Chinese Center For Disease Control and Prevention (CN)
  • University of St Andrews (GB)
  • London School of Hygiene & Tropical Medicine (GB)
Corresponding author
  • Chen, Xiang-Sheng
  • Peeling, Rosanna W.
ORCID
Venue
Nature Microbiology
Publisher
Springer Science and Business Media LLC
Published
2018-12-13
Volume
4
Issue
1
Pages
46-54
ISSN
2058-5276 (ISSN-L)
DOI
10.1038/s41564-018-0295-3
PMC
PMC7097043
OpenAlex
W2901655212
Cited by
1,065
References
2
Citations by year
2026: 194 · 2025: 220 · 2024: 224 · 2023: 177 · 2022: 129 · 2021: 70 · 2020: 37 · 2019: 13
FWCI
2.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Engineering and Physical Sciences Research Council (EP/K031953/1)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Keywords
point-of-care testing, resource-limited settings, infectious disease diagnostics, mobile health, digital diagnostics, disease control strategies, health system strengthening
MeSH terms
Communicable Disease Control, Communicable Diseases, Diagnostic Services, Humans, Malaria, Syphilis, Tuberculosis, Pulmonary, HIV Infections, Point-of-Care Systems

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