The DOI matches its Crossref record; 227 of the 227 references it cites were found in a registry or an index.
Towards a deeper understanding of the vaginal microbiota
Open accessAbstract
The human vaginal microbiota is a critical determinant of vaginal health. These communities live in close association with the vaginal epithelium and rely on host tissues for resources. Although often dominated by lactobacilli, the vaginal microbiota is also frequently composed of a collection of facultative and obligate anaerobes. The prevalence of these communities with a paucity of Lactobacillus species varies among women, and epidemiological studies have associated them with an increased risk of adverse health outcomes. The mechanisms that drive these associations have yet to be described in detail, with few studies establishing causative relationships. Here, we review our current understanding of the vaginal microbiota and its connection with host health. We centre our discussion around the biology of the vaginal microbiota when Lactobacillus species are dominant versus when they are not, including host factors that are implicated in shaping these microbial communities and the resulting adverse health outcomes. We discuss current approaches to modulate the vaginal microbiota, including probiotics and vaginal microbiome transplants, and argue that new model systems of the cervicovaginal environment that incorporate the vaginal microbiota are needed to progress from association to mechanism and this will prove invaluable for future research. This Review summarizes current knowledge on the vaginal microbiota and discusses how research can progress from association to mechanism to provide deeper insights into its role in health and disease.
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Cites
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Cited by
Zhang, D., Zhang, J., Kalimuthu, S., Liu, J., Song, Z.-M., He, B.-B., Cai, P., Zhong, Z., Feng, C., Neelakantan, P., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01540-y · Cited by 72
“…the acidification of the vagina can inhibit the growth of pathogenic and non-Lactobacillus microbes (such as Gardnerella , Prevotella , and Mobiluncus ), other factors, such as the production of bacteriocins and hydrogen per-oxide (H 2 O 2 ) also contribute to promoting vaginal health [46, 47].”
Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy
Boutouchent, N., Vu, T. N. A., Landraud, L., & Kennedy, S. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-76438-2 · Cited by 14
Metadata
- Authors
- France, M., Alizadeh, M., Brown, S., Ma, B., & Ravel, J.
- Venue
- Nature Microbiology
- Published
- 2022-03-04
- Volume
- 7
- Issue
- 3
- Pages
- 367-378
- ISSN
- 2058-5276 (ISSN-L)
- OpenAlex
- W4214858973
- Cited by
- 382
- References
- 227
- FWCI
- 36.70
- Type
- journal article
- Language
- en
- Open access
- green
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