The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
DNA-based communication in populations of synthetic protocells
Open accessAbstract
Developing molecular communication platforms based on orthogonal communication channels is a crucial step towards engineering artificial multicellular systems. Here, we present a general and scalable platform entitled ‘biomolecular implementation of protocellular communication’ (BIO-PC) to engineer distributed multichannel molecular communication between populations of non-lipid semipermeable microcapsules. Our method leverages the modularity and scalability of enzyme-free DNA strand-displacement circuits to develop protocellular consortia that can sense, process and respond to DNA-based messages. We engineer a rich variety of biochemical communication devices capable of cascaded amplification, bidirectional communication and distributed computational operations. Encapsulating DNA strand-displacement circuits further allows their use in concentrated serum where non-compartmentalized DNA circuits cannot operate. BIO-PC enables reliable execution of distributed DNA-based molecular programs in biologically relevant environments and opens new directions in DNA computing and minimal cell technology.Semipermeable proteinosome membranes allow complex DNA message communication through compartmentalization and protect the DNA circuits from degradation in a biological environment.
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Cites
Monolithic Microfabricated Valves and Pumps by Multilayer Soft Lithography
Unger, M. A., Chou, H.-P., Thorsen, T., Scherer, A., & Quake, S. R. (2000) · Science · doi:10.1126/science.288.5463.113 · Cited by 4,010
QUORUM SENSING: Cell-to-Cell Communication in Bacteria
Waters, C. M., & Bassler, B. L. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131001 · Cited by 3,979
A DNA-fuelled molecular machine made of DNA
Yurke, B., Turberfield, A. J., Mills, A. P., Simmel, F. C., & Neumann, J. L. (2000) · Nature · doi:10.1038/35020524 · Cited by 2,448
Dynamic DNA nanotechnology using strand-displacement reactions
Zhang, D. Y., & Seelig, G. (2011) · Nature Chemistry · doi:10.1038/nchem.957 · Cited by 1,785
NUPACK: Analysis and design of nucleic acid systems
Zadeh, J. N., Steenberg, C. D., Bois, J. S., Wolfe, B. R., Pierce, M. B., Khan, A. R., Dirks, R. M., & Pierce, N. A. (2011) · Journal of Computational Chemistry · doi:10.1002/jcc.21596 · Cited by 1,670
Enzyme-Free Nucleic Acid Logic Circuits
Seelig, G., Soloveichik, D., Zhang, D. Y., & Winfree, E. (2006) · Science · doi:10.1126/science.1132493 · Cited by 1,540
Control of DNA Strand Displacement Kinetics Using Toehold Exchange
Zhang, D. Y., & Winfree, E. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906987s · Cited by 1,444
Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades
Qian, L., & Winfree, E. (2011) · Science · doi:10.1126/science.1200520 · Cited by 1,434
Engineering Entropy-Driven Reactions and Networks Catalyzed by DNA
Zhang, D. Y., Turberfield, A. J., Yurke, B., & Winfree, E. (2007) · Science · doi:10.1126/science.1148532 · Cited by 1,242
A synthetic multicellular system for programmed pattern formation
Basu, S., Gerchman, Y., Collins, C. H., Arnold, F. H., & Weiss, R. (2005) · Nature · doi:10.1038/nature03461 · Cited by 1,154
Research works printed but not linked: 3
- Dunn, K. E., Trefzer, M. A., Johnson, S. & Tyrrell, A. M. Investigating the dynamics of surface-immobilized DNA nanomachines. Sci. Rep. 6, 29581 (2016). · doi:10.1038/srep29581
- Fern, J. et al. DNA strand-displacement timer circuits. ACS Synth. Biol. 6, 190–193 (2017). · doi:10.1021/acssynbio.6b00170
- Padirac, A., Fujii, T. & Rondelez, Y. Quencher-free multiplexed monitoring of DNA reaction circuits. Nucleic Acids Res. 40, e118 (2012). · doi:10.1093/nar/gks621
Cited by
Cancer diagnosis with DNA molecular computation
Zhang, C., Zhao, Y., Xu, X., Xu, R., Li, H., Teng, X., Du, Y., Miao, Y., Lin, H.-C., & Han, D. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0699-0 · Cited by 258
Sustained enzymatic activity and flow in crowded protein droplets
Testa, A., Dindo, M., Rebane, A. A., Nasouri, B., Style, R. W., Golestanian, R., Dufresne, E. R., & Laurino, P. (2021) · Nature Communications · doi:10.1038/s41467-021-26532-0 · Cited by 144
A dissipative pathway for the structural evolution of DNA fibres
Rizzuto, F. J., Platnich, C. M., Luo, X., Shen, Y., Dore, M. D., Lachance-Brais, C., Guarné, A., Cosa, G., & Sleiman, H. F. (2021) · Nature Chemistry · doi:10.1038/s41557-021-00751-w · Cited by 120
Dynamic and scalable DNA-based information storage
Lin, K. N., Volkel, K., Tuck, J. M., & Keung, A. J. (2020) · Nature Communications · doi:10.1038/s41467-020-16797-2 · Cited by 117
Chemical-mediated translocation in protocell-based microactuators
Gao, N., Li, M., Tian, L., Patil, A. J., Pavan Kumar, B. V. V. S., & Mann, S. (2021) · Nature Chemistry · doi:10.1038/s41557-021-00728-9 · Cited by 60
Self-citation
Metadata
- Authors
- Joesaar, A., Yang, S., Bögels, B., van der Linden, A., Pieters, P., Kumar, B. V. V. S. P., Dalchau, N., Phillips, A., Mann, S., & de Greef, T. F. A.
- Venue
- Nature Nanotechnology
- Published
- 2019-03-04
- Volume
- 14
- Issue
- 4
- Pages
- 369-378
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2919102308
- Cited by
- 331
- References
- 54
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.springer.com/tdm (tdm)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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