The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Engineering Entropy-Driven Reactions and Networks Catalyzed by DNA
Abstract
Artificial biochemical circuits are likely to play as large a role in biological engineering as electrical circuits have played in the engineering of electromechanical devices. Toward that end, nucleic acids provide a designable substrate for the regulation of biochemical reactions. However, it has been difficult to incorporate signal amplification components. We introduce a design strategy that allows a specified input oligonucleotide to catalyze the release of a specified output oligonucleotide, which in turn can serve as a catalyst for other reactions. This reaction, which is driven forward by the configurational entropy of the released molecule, provides an amplifying circuit element that is simple, fast, modular, composable, and robust. We have constructed and characterized several circuits that amplify nucleic acid signals, including a feedforward cascade with quadratic kinetics and a positive feedback circuit with exponential growth kinetics.
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Citations
Cites
Mfold web server for nucleic acid folding and hybridization prediction
Zuker, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg595 · Cited by 13,404
Cited by
Dynamic DNA nanotechnology using strand-displacement reactions
Zhang, D. Y., & Seelig, G. (2011) · Nature Chemistry · doi:10.1038/nchem.957 · Cited by 1,785
Self-citationProgrammable materials and the nature of the DNA bond
Jones, M. R., Seeman, N. C., & Mirkin, C. A. (2015) · Science · doi:10.1126/science.1260901 · Cited by 1,347
Seeman, N. C. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-102244 · Cited by 992
Principles and Applications of Nucleic Acid Strand Displacement Reactions
Simmel, F. C., Yurke, B., & Singh, H. R. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00580 · Cited by 792
Self-citationDNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
Metadata
- Authors
- Zhang, D. Y., Turberfield, A. J., Yurke, B., & Winfree, E.
- Venue
- Science
- Published
- 2007-11-16
- Volume
- 318
- Issue
- 5853
- Pages
- 1121-1125
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050630660
- Cited by
- 1,242
- References
- 1
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, D. Y., Turberfield, A. J., Yurke, B., & Winfree, E. (2007). Engineering Entropy-Driven Reactions and Networks Catalyzed by DNA. Science. https://doi.org/10.1126/science.1148532
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
