Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore

Dynamic RNA Modifications in Gene Expression Regulation

Roundtree, I. A., Evans, M., Pan, T., & He, C. (2017) · Cell · doi:10.1016/j.cell.2017.05.045 · Cited by 3,512

Structure of Staphylococcal α-Hemolysin, a Heptameric Transmembrane Pore

Song, L., Hobaugh, M. R., Shustak, C., Cheley, S., Bayley, H., & Gouaux, J. E. (1996) · Science · doi:10.1126/science.274.5294.1859 · Cited by 2,426

Continuous base identification for single-molecule nanopore DNA sequencing

Clarke, J., Wu, H., Jayasinghe, L., Patel, A., Reid, S., & Bayley, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.12 · Cited by 1,813

MODOMICS: a database of RNA modification pathways. 2017 update

Boccaletto, P., Machnicka, M. A., Purta, E., Piątkowski, P., Bagiński, B., Wirecki, T. K., de Crécy‐Lagard, V., Ross, R. L., Limbach, P. A., Kötter, A., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1030 · Cited by 1,767

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

Linder, B., Grozhik, A. V., Olarerin-George, A. O., Meydan, C., Mason, C. E., & Jaffrey, S. R. (2015) · Nature Methods · doi:10.1038/nmeth.3453 · Cited by 1,569

A detailed examination of boronic acid–diol complexation

Springsteen, G., & Wang, B. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)00489-1 · Cited by 1,483

Role of RNA modifications in cancer

Barbieri, I., & Kouzarides, T. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0253-2 · Cited by 1,350

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

Yang, X., Yang, Y., Sun, B., Chen, Y., Xu, J., Lai, W., Li, A., Wang, X., Bhattarai, D. P., Xiao, W., et al. (2017) · Cell Research · doi:10.1038/cr.2017.55 · Cited by 1,141

The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

Dominissini, D., Nachtergaele, S., Moshitch-Moshkovitz, S., Peer, E., Kol, N., Ben-Haim, M. S., Dai, Q., Segni, A. D., Salmon‐Divon, M., Clark, W. C., et al. (2016) · Nature · doi:10.1038/nature16998 · Cited by 1,047

Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

Carlile, T. M., Rojas-Durán, M. F., Zinshteyn, B., Shin, H., Bartoli, K. M., & Gilbert, W. V. (2014) · Nature · doi:10.1038/nature13802 · Cited by 1,042

Emerging Approaches to DNA Data Storage: Challenges and Prospects

Doricchi, A., Platnich, C. M., Gimpel, A., Horn, F., Earle, M., Lanzavecchia, G., Cortajarena, A. L., Liz-Marzán, L. M., Liu, N., Heckel, R., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c06748 · Cited by 235

Designing nanotheranostics with machine learning

Rao, L., Yuan, Y., Shen, X., Yu, G., & Chen, X. S. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01753-8 · Cited by 231

Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore

Wang, K., Zhang, S., Zhou, X., Yang, X., Li, X., Wang, Y., Fan, P., Xiao, Y., Sun, W. J., Zhang, P., et al. (2023) · Nature Methods · doi:10.1038/s41592-023-02021-8 · Cited by 201

Parallel molecular data storage by printing epigenetic bits on DNA

Zhang, C., Wu, R., Sun, F., Lin, Y., Liang, Y., Liang, Y., Chen, Y., Teng, J., Song, Z., Liu, N., et al. (2024) · Nature · doi:10.1038/s41586-024-08040-5 · Cited by 97

Engineering Biological Nanopore Approaches toward Protein Sequencing

Wei, X., Penkauskas, T., Reiner, J. E., Kennard, C., Uline, M. J., Wang, Q., Li, S., Aksimentiev, A., Robertson, J. W. F., & Liu, C. (2023) · ACS Nano · doi:10.1021/acsnano.3c05628 · Cited by 81

Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases

Zhang, Y., Lei, Y., Dong, Y., Chen, S., Sun, S., Zhou, F., Zhao, Z., Chen, B., Lv, W., Chen, J., et al. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108576 · Cited by 79

Identification of tagged glycans with a protein nanopore

Li, M., Xiong, Y., Cao, Y., Zhang, C., Li, Y., Ning, H., Liu, F., Zhou, H., Li, X., Ye, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37348-5 · Cited by 68

tRNA modifications: insights into their role in human cancers

Wang, Y., Tao, E., Tan, J., Gao, Q., Chen, Y., & Fang, J. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.04.002 · Cited by 53

Nanopore approaches for single-molecule temporal omics: promises and challenges

Li, M., Jiang, J., Li, J., Niu, H., Ying, Y., Tian, R., & Long, Y. (2024) · Nature Methods · doi:10.1038/s41592-024-02492-3 · Cited by 63

Discrimination of Disaccharide Isomers of Different Glycosidic Linkages Using a Modified MspA Nanopore

Zhang, S., Cao, Z., Fan, P., Sun, W., Xiao, Y., Zhang, P., Wang, Y., & Huang, S. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202316766 · Cited by 51

Nanopore discrimination of rare earth elements

Sun, W. J., Xiao, Y., Wang, K., Zhang, S., Yao, L., Li, T., Cheng, B., Zhang, P., & Huang, S. (2025) · Nature Nanotechnology · doi:10.1038/s41565-025-01864-w · Cited by 58

Nanopore single-molecule analysis of biomarkers: Providing possible clues to disease diagnosis

Chen, X., Zhou, S., Wang, Y., Zheng, L., Guan, S., Wang, D., Wang, L., & Guan, X. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117060 · Cited by 48

Nanopore analysis of cis-diols in fruits

Fan, P., Cao, Z., Zhang, S., Wang, Y., Xiao, Y., Jia, W., Zhang, P., & Huang, S. (2024) · Nature Communications · doi:10.1038/s41467-024-46303-x · Cited by 45

An Integrated Dual‐Functional Nanotool Capable of Studying Single‐Cell Epigenetics and Programmable Gene Regulation

Shi, X., Xu, Y., Wang, B., Li, Z., Yu, S., Dong, H., Zhao, W., Jiang, D., Chen, H., & Xu, J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202302930 · Cited by 39

Nanopore analysis of salvianolic acids in herbal medicines

Fan, P., Zhang, S., Wang, Y., Li, T., Zhang, H., Zhang, P., & Huang, S. (2024) · Nature Communications · doi:10.1038/s41467-024-45543-1 · Cited by 39

Nanopore signal deviations from pseudouridine modifications in RNA are sequence-specific: quantification requires dedicated synthetic controls

Makhamreh, A. K., Tavakoli, S., Fallahi, A., Kang, X., Gamper, H., Nabizadehmashhadtoroghi, M., Jain, M., Hou, Y., Rouhanifard, S. H., & Wanunu, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-72994-9 · Cited by 32

Discrimination of Ribonucleoside Mono-, Di-, and Triphosphates Using an Engineered Nanopore

Wang, Y., Fan, P., Zhang, S., Wang, L., Li, X., Jia, W., Liu, Y., Wang, K., Du, X., Zhang, P., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c09662 · Cited by 31

Harnessing DNA computing and nanopore decoding for practical applications: from informatics to microRNA-targeting diagnostics

Takiguchi, S., Takeuchi, N., Shenshin, V., Gines, G., Genot, A. J., Nivala, J., Rondelez, Y., & Kawano, R. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00396e · Cited by 34

Ex Vivo Surface Decoration of Phenylboronic Acid onto Natural Killer Cells for Sialic Acid-Mediated Versatile Cancer Cell Targeting

Jangid, A. K., Kim, S., Park, H. W., Kim, H. J., & Kim, K. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.3c00916 · Cited by 28

Single-Molecule Interconversion between Chiral Configurations of Boronate Esters Observed in a Nanoreactor

Du, X., Zhang, S., Wang, L., Wang, Y., Fan, P., Jia, W., Zhang, P., & Huang, S. (2023) · ACS Nano · doi:10.1021/acsnano.2c11286 · Cited by 26

Neuron-Inspired Nanofluidic Biosensors for Highly Sensitive and Selective Imidacloprid Detection

Li, X., Yang, L., Zhou, S., Qian, Y., Wu, Y., He, X., Chen, W., Zhang, Z., Li, T., Wang, Q., et al. (2023) · ACS Sensors · doi:10.1021/acssensors.3c00875 · Cited by 26

Single-Molecule Bioelectronic Sensors with AI-Aided Data Analysis: Convergence and Challenges

Yang, Y., Li, Y., Tang, L., & Li, J. (2024) · Precision Chemistry · doi:10.1021/prechem.4c00048 · Cited by 26

Nanopore discrimination and sensitive plasma detection of multiple natriuretic peptides: The representative biomarker of human heart failure

Zhang, S., Wang, Y., Song, D., Guan, S., Zhou, D., Gong, L., Liang, L., Guan, X., & Wang, L. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115299 · Cited by 28

Functional Nanopores Enabled with DNA

Xing, Y., Rottensteiner, A., Ciccone, J., & Howorka, S. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202303103 · Cited by 26

An aptamer-triggered hybridization chain reaction strategy for ultra-sensitive biological nanopore detection of aflatoxin B1

Su, Z., Kong, Y., Li, T., Zhao, Y., Zhang, X., Wu, Y., Wu, Y., & Li, G. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.135457 · Cited by 26

Quantification and mapping of RNA modifications

Xiong, J., Wu, J., Liu, Y., Feng, Y.-J., & Yuan, B. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117606 · Cited by 25

Nanopore sensing and beyond: Electrochemical systems for optically-coupled single-entity studies, stimulus-responsive gating applications, and point-of-care sensors

Reitemeier, J., Metro, J., & Fu, K. X. (2024) · Sensors and Actuators Reports · doi:10.1016/j.snr.2024.100225 · Cited by 25

Dynamic Features Driven by Stochastic Collisions in a Nanopore for Precise Single-Molecule Identification

Wang, J., Liu, S.-C., Hu, Z., Ying, Y., & Long, Y. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.4c13664 · Cited by 21

mRNA vaccines: immunogenicity and quality characteristics

Quan, Y., Yang, H., Li, W., & Li, L. X. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03800-5 · Cited by 27

Recent advances in nanopore-based analysis for carbohydrates and glycoconjugates

Zhao, Y., Su, Z., Zhang, X., Wu, D., Wu, Y., & Li, G. (2024) · Analytical Methods · doi:10.1039/d3ay02040a · Cited by 20

Nanopore Environmental Analysis

Lu, X., Du, X., Zhong, D., Li, R., Cao, J., Huang, S., & Wang, Y. (2025) · JACS Au · doi:10.1021/jacsau.5c00114 · Cited by 20

Simultaneous Identification of Major Thyroid Hormones by a Nickel Immobilized Biological Nanopore

Wang, K., Yang, X., Xiao, Y., Cao, Z., Zhang, S., Zhang, P., & Huang, S. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c04024 · Cited by 20

Engineered Nanofluidics for Molecular Recognition and Physical Perception

Zhu, C., Wu, Y., Li, X., Li, X., Liang, X., Jiang, L., & Wen, L. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202506689 · Cited by 19

Observing Confined Local Oxygen‐induced Reversible Thiol/Disulfide Cycle with a Protein Nanopore

Liu, W., Yang, C., Yang, Z., Yu, R., Long, Y., & Ying, Y. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202304023 · Cited by 19

Nanopore Signatures of Nucleoside Drugs

Jia, W., Ouyang, Y., Zhang, S., Du, X., Zhang, P., & Huang, S. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c02872 · Cited by 19

Gram-scale enzymatic synthesis of 2′-deoxyribonucleoside analogues using nucleoside transglycosylase-2

Salihovic, A., Ascham, A., Taladriz‐Sender, A., Bryson, S., Withers, J. M., McKean, I. J. W., Hoskisson, P. A., Grogan, G., & Burley, G. A. (2024) · Chemical Science · doi:10.1039/d4sc04938a · Cited by 19

In Situ Glycan Analysis and Editing in Living Systems

Li, Y., Wang, H., Chen, Y., Ding, L., & Ju, H. (2024) · JACS Au · doi:10.1021/jacsau.3c00717 · Cited by 18

Solid-State Nanopore Distinguishes Ferritin and Apo-Ferritin with Identical Exteriors through Amplified Flexibility at Single-Molecule Level

Yin, Y., Chen, F., Hu, J., Yang, L., Song, X., Guo-rong, W., Xu, M., & Gu, Z. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02041 · Cited by 16

Real-Space Spectral Determination of Short Single-Stranded DNA Sequence Structures

Han, Y. K., Li, D., Zhu, L., Hu, C., Li, H., Zhang, Y., Zhang, C., Zhang, Y., & Dong, Z. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c12393 · Cited by 17

Chiral Discrimination of all Proteinogenic Amino Acid Enantiomers by Nanopore Sensing

Zhang, H., Wang, K., Zhou, X., Wang, Y., Zhang, P., Li, W., & Huang, S. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202515531 · Cited by 16

Nanopore Discrimination of Nucleotide Sugars

Wang, K., Yang, X., Zhang, S., Zhang, P., & Huang, S. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c02455 · Cited by 15

Native globular ferritin nanopore sensor

Yin, Y., Zhang, Y.-W., Song, X., Hu, J., Chen, Y., Lai, W., Li, Y., & Gu, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-60322-2 · Cited by 16

Bio-nanopore technology for biomolecules detection

Li, P., Liang, D., Yang, E., Zeb, M., Huang, H., Sun, H., Zhang, W., Peng, C., Zhao, Y., & Ma, W. (2024) · Advanced Biotechnology · doi:10.1007/s44307-024-00051-7 · Cited by 14

Multiplex Nanopore Detection of Structurally Diverse Per- and Polyfluoroalkyl Substances in Surface Water

Lu, X., Zhong, D., An, Q., Kang, L., Fan, N., Cao, J., Li, R., Cao, Q., Zhou, Y., Du, X., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c12164 · Cited by 17

Recent advances of small molecule detection in nanopore sensing

Wang, R., Zhang, Y., Qianli, D. Y., & Wu, L. (2024) · Talanta · doi:10.1016/j.talanta.2024.126323 · Cited by 13

Ions in motion: From biological channels to engineered transport systems

Wu, B., Yan, Y., Zhu, Y., Ji, C., Lin, Y., & Lang, C. (2025) · Giant · doi:10.1016/j.giant.2025.100352 · Cited by 13

Iminodiacetic acid modification enables nanopore identification of major divalent metal ions in natural water samples

Sun, W. J., Li, T., Wang, Z., Xiao, Y., Zhang, P., Wang, K., & Huang, S. (2026) · Nature Water · doi:10.1038/s44221-025-00544-2 · Cited by 12

The Modification and Applications of Nanopipettes in Electrochemical Analysis

Wang, X., Lv, J. C., Wu, X. F., Hong, Q., & Qian, R. (2023) · ChemPlusChem · doi:10.1002/cplu.202300100 · Cited by 12

Molecular sandwich-based DNAzyme catalytic reaction towards transducing efficient nanopore electrical detection of antigen proteins

Wang, L., Zhou, S., Wang, Y., Wang, Y., Li, J., Chen, X., Zhou, D., Liang, L., Yin, B., Zhang, Y., et al. (2024) · Faraday Discussions · doi:10.1039/d4fd00146j · Cited by 12

Nanopore-based direct sequencing of RNA transcripts with 10 different modified nucleotides reveals gaps in existing technology

Burdick, J. T., Comai, A., Bruzel, A., Sun, G., Dedon, P. C., & Cheung, V. G. (2023) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkad200 · Cited by 11

Bisulfite-free whole-genome mapping of 5-methylcytosine at single-base resolution by NTD-seq

Wang, M., Xie, N., Gang, F., Zhang, S., Zeng, L., Ji, T., Xiong, J., Guo, X., Hao, Y., Liu, Y., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2702-8 · Cited by 11

Nanopore Identification of Nicotinamide Adenine Nucleotide and Its Derivatives

Jia, W., Chen, J., Yao, L., Zhang, P., & Huang, S. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202508787 · Cited by 13

Nanopore profiling and structure determination of oligosaccharides by fragmentation

Xiao, Y., Zhang, S., Gao, X., Li, T., Zhang, H., Zhang, P., & Huang, S. (2026) · Science Advances · doi:10.1126/sciadv.aea8462 · Cited by 10

Capped or uncapped? Techniques to assess the quality of mRNA molecules

Tu, Y., Das, A., Redwood-Sawyerr, C., & Polizzi, K. M. (2024) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2023.100503 · Cited by 11

In-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules

Yang, J., Pan, T., Xie, Z., Yuan, W., & Ho, H. (2024) · Nature Communications · doi:10.1038/s41467-024-48630-5 · Cited by 10

Probing nanopores: molecular dynamics insights into the mechanisms of DNA and protein translocation through solid-state and biological nanopores

Zhang, Y., & Ding, M. (2025) · Soft Matter · doi:10.1039/d4sm01534g · Cited by 10

Identification of Isomerically Diverse Ginsenosides Using Engineered Aerolysin Nanopore via Non‐Translocation Blockade Sensing

Wang, J., Li, M., Zhang, C., Zhao, X., Xiong, Y., Cao, Y., Wang, D., Li, X., Liang, X., & Qing, G. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202506741 · Cited by 10

Nanopore‐Based Metal Ion Detection and Metal Ion‐Mediated Nanopore Sensing†

Song, X., Yin, Y., Wu, G., Xu, M., & Gu, Z. (2023) · Chinese Journal of Chemistry · doi:10.1002/cjoc.202300211 · Cited by 9

Holistic Prediction of AuNP Aggregation in Diverse Aqueous Suspensions Based on Machine Vision and Dark-Field Scattering Imaging

Wang, X., Hong, Q., Zhou, Z., Jin, Z.-Y., Li, D., & Qian, R. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03968 · Cited by 9

Single-Molecule Analysis of SARS-CoV-2 Double-Stranded Polynucleotides Using Solid-State Nanopore with AI-Assisted Detection and Classification: Implications for Understanding Disease Severity

Alam, I., Boonkoom, T., Pitakjakpipop, H., Boonbanjong, P., Loha, K., Saeyang, T., Vanichtanankul, J., & Japrung, D. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00998 · Cited by 9

Beta-Barrel Nanopores as Diagnostic Sensors: An Engineering Perspective

Wiswedel, R., Bui, A. T. N., Kim, J.-H., & Lee, M. (2024) · Biosensors · doi:10.3390/bios14070345 · Cited by 9

Encodable DNA Hairpin Probes for Nanopore Multiplexed Target Detection

Sun, F., Liu, J., Su, Z., Wu, D., Qu, S., Wu, Y., Li, L., & Li, G. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c03469 · Cited by 8

Nanopore signatures of major alcoholic beverages

Fan, P., Li, K., Li, T., Zhang, P., & Huang, S. (2024) · Matter · doi:10.1016/j.matt.2024.11.025 · Cited by 8

Programmable Hairpin Argonaute–Nanopore Detection System for Multiplex Mycotoxin Analysis

Su, Z., Pei, Z., Chen, J., Song, W., Wu, D., Wang, Y., & Li, G. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c03586 · Cited by 8

De Novo Design of α-helical Peptide Nanopores for Single-Molecule Detection Using Helix Packing Motifs

Peng, Z., Usami, M., Nakada, A., Sekiya, Y., Fujita, S., Mijiddorj, B., Kawamura, I., & Kawano, R. (2025) · ACS Nano · doi:10.1021/acsnano.5c15080 · Cited by 8

Nanopore Identification of Biogenic Amines and Its Applications in Food Freshness Evaluation

Xiao, Y., Du, X., Zhao, L., Dai, X., Qian, L., Zhang, S., Zhang, P., Huang, S., & Wang, K. (2026) · ACS Nano · doi:10.1021/acsnano.5c16056 · Cited by 8

Single-molecule recognition of Nucleolin and the interactions with DNA/RNA G-quadruplexes via nanopore decoding

Wang, Z., Qin, F., Wu, J., Ma, W.-H., Li, R.-S., Weng, T., Yin, B.-H., Wang, L., Wang, D.-Q., & Liang, L.-Y. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145311 · Cited by 8

Recent Advances and Emerging Trends in Nanopore‐Based Single‐Molecule Sensing of Proteins

Zhang, Z., Sha, J., Qin, G., Chen, D., Si, W., Wang, Q., & Liu, L. (2025) · Small Methods · doi:10.1002/smtd.202501603 · Cited by 7

Nanopore sensing: current progress and future challenges tackled by nanofluidic devices

Chanakul, W., Chantipmanee, N., Sandell, M., An, R., Mayer, M., & Xu, Y. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118541 · Cited by 7

Machine learning-driven molecular engineering of nucleic acids

Shi, Q., Lv, H., Wang, F., Fan, C., & Li, M. (2026) · Chemical Society Reviews · doi:10.1039/d5cs01091h · Cited by 10

An Integrated Dual‐Functional Nanotool Capable of Studying Single‐Cell Epigenetics and Programmable Gene Regulation

Shi, X., Xu, Y., Wang, B., Li, Z., Yu, S., Dong, H., Zhao, W., Jiang, D., Chen, H., & Xu, J. (2023) · Angewandte Chemie · doi:10.1002/ange.202302930 · Cited by 7

Pioneering Role of Nanopore Single-Molecule Sensing in Environmental and Food Surveillance

Tian, W., Wang, X., Zhang, Y., Weng, T., Tlili, C., Chen, X., Kong, Q., & Wang, D. (2025) · Biosensors · doi:10.3390/bios15010041 · Cited by 6

Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing

Liu, Y., Li, Y., & Sun, Q. (2025) · Advanced Genetics · doi:10.1002/ggn2.202500041 · Cited by 6

Nanopore Single-Molecule Chemistry

Liu, Y., Gao, X., & Huang, S. (2026) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-021424-125106 · Cited by 7

Single‐Nanoparticle‐Based Nanomachining for Fabrication of a Uniform Nanochannel Sensor

Miao, L., Huang, B., Fang, H., Chai, J., Liu, Z., & Zhai, Y. (2023) · Advanced Materials · doi:10.1002/adma.202305159 · Cited by 6

Discrimination of Disaccharide Isomers of Different Glycosidic Linkages Using a Modified MspA Nanopore

Zhang, S., Cao, Z., Fan, P., Sun, W., Xiao, Y., Zhang, P., Wang, Y., & Huang, S. (2023) · Angewandte Chemie · doi:10.1002/ange.202316766 · Cited by 6

Advances in mapping analysis of ribonucleic acid modifications through sequencing

Xiong, J., Feng, T., & Yuan, B. (2024) · Chinese Journal of Chromatography · doi:10.3724/sp.j.1123.2023.12025 · Cited by 6

Advancements in the Application of the Intersection of Medicine and Engineering in Cancer Research

Chen, H., Zhang, G.-M., Qian, Y., Yang, P., Li, X., Wang, J., Wang, J., Hu, Y.-X., Xiao, H., Zhong, Q., et al. (2025) · Cancer Nexus · doi:10.1002/cnx2.70003 · Cited by 6

Tracking single-molecule ferritin reassembly and disassembly using polymer-coated nanopores

Assadipapari, M., Soleimanian, A., Adam, M., Li, J., Yousefi, A., Zargarbashi, S., Xu, L., Wills, M. F. K., Kara, H., Vega, M. S., et al. (2025) · Nanoscale · doi:10.1039/d5nr02885j · Cited by 5

Single-Molecule Analysis of Glycopeptide Antibiotic–Target Interactions Using Nanopore-Based Biomimetic Probes

Su, Z., Zhao, Y., Jiao, L., Wu, D., Wu, Y., & Li, G. B. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c07349 · Cited by 5

Following the central dogma: Nanopore sequencing from DNA and RNA to proteins

Wang, Y., Han, Q., He, Y., Deng, S., Huang, Z., Zhang, Z., Dai, S., & Dong, Z. (2026) · iScience · doi:10.1016/j.isci.2026.114835 · Cited by 5

Bioinformatic and computational biophysics tools for nanopore engineering: a review from standard approaches to machine learning advancements

Reccia, M., Quilli, F., Willems, K., della Rocca, B. M., Raimondo, D., & Chinappi, M. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04225-4 · Cited by 5

SmartImage: A Machine Learning Method for Nanopore Identifying Chemical Modifications on RNA

Li, S., Li, X., Wan, Y., Ying, Y., Yu, R., & Long, Y. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202201144 · Cited by 5

A possible mechanism of neural read-out from a molecular engram

Mollon, J. D., Danilova, M. V., & Zhuravlev, A. V. (2023) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2023.107748 · Cited by 5

Observing Confined Local Oxygen‐induced Reversible Thiol/Disulfide Cycle with a Protein Nanopore

Liu, W., Yang, C., Yang, Z., Yu, R., Long, Y., & Ying, Y. (2023) · Angewandte Chemie · doi:10.1002/ange.202304023 · Cited by 5

Identification of Isomerically Diverse Ginsenosides Using Engineered Aerolysin Nanopore via Non‐Translocation Blockade Sensing

Wang, J., Li, M., Zhang, C., Zhao, X., Xiong, Y., Cao, Y., Wang, D., Li, X., Liang, X., & Qing, G. (2025) · Angewandte Chemie · doi:10.1002/ange.202506741 · Cited by 4

Pulse counting of nanobubbles inside DNA-functionalized nanopores and the application for highly sensitive electroanalysis

Guo, J., Wang, X., Huang, Q., & Miao, P. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117928 · Cited by 4

Unveiling Acidophilic Secretin Nanopores for Ion Exclusion and Single‐Molecule Sensing

Liu, R., Zhang, K., Feng, Q., He, S., Fan, Q., Zhang, X., Li, W., Bao, Z., Lin, W., Fu, Y., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202517259 · Cited by 4

Chiral Discrimination of all Proteinogenic Amino Acid Enantiomers by Nanopore Sensing

Zhang, H., Wang, K., Zhou, X., Wang, Y., Zhang, P., Li, W., & Huang, S. (2025) · Angewandte Chemie · doi:10.1002/ange.202515531 · Cited by 4

NanoSSL: attention mechanism-based self-supervised learning method for protein identification using nanopores

Xie, Y., Li, J., Zhang, Z., Meng, B., Dai, S., Zhou, Y., Kennedy, E., Jiao, N., Chen, H. I., & Dong, Z. (2025) · Bioinformatics · doi:10.1093/bioinformatics/btaf657 · Cited by 4

Resolving the Amino Acid Sequence of Aβ1‐42 at the Single‐Residue Level Using Subnanopores in Ultrathin Films

Chen, L., Meng, B., Xie, Y. F., Yao, Z., Chen, H., & Dong, Z. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202404799 · Cited by 3

Detection of modified RNA with an engineered nanopore

Punthambaker, S. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01210-4 · Cited by 4

Functional Nanopores Enabled with DNA

Xing, Y., Rottensteiner, A., Ciccone, J., & Howorka, S. (2023) · Angewandte Chemie · doi:10.1002/ange.202303103 · Cited by 4

A dual-excitation-driven full-component-responsive lanthanide-based metal-organic framework for switchable profiling of multi-disease markers

Chen, G., Dai, B., Hao, J., & Li, Y. (2025) · Science China Materials · doi:10.1007/s40843-024-3214-y · Cited by 4

A Smart Photoswitchable Sensor for Differential Detection of Multiple Nucleotides In Two Photoswitchable States using Machine Learning Techniques

Sahanawaz, M., Maity, M. L., Koppayithodi, S., & Bandyopadhyay, S. (2025) · Analysis & Sensing · doi:10.1002/anse.202500082 · Cited by 3

Functionalized protein nanopores: Strategies and applications

Sun, K., Wu, M., Yu, X., Li, Y., Li, M., Wang, J., Ju, Y., Zhang, S., & Geng, J. (2025) · Nano Research · doi:10.26599/nr.2026.94908343 · Cited by 3

Sequential reading of a stepwise-shortened peptide immobilized on nanopore

Chen, J., Zhang, H., Wang, K., Li, T., Wen, S. U. N., Wang, Z., Gao, X., Cao, Z., Ouyang, Y., Yao, L., et al. (2026) · Nature · doi:10.1038/s41586-026-10881-1 · Cited by 3

Characterization and modulation of the unimolecular conformation of integrins with nanopore sensors

Li, R., Liu, D., Ren, M., Qin, F., Qi, G., Tian, D., Zhang, M., Xie, W., Wang, L., Lü, S., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152374 · Cited by 3

Tuning the Sensitivity of MoS 2 Nanopores: From Labeling to Labeling‐Free Detection of DNA Methylation

Zhao, C., Yang, Y., Zhao, P., Shi, C., Tan, T., Bai, H., & Feng, J. (2024) · Small Methods · doi:10.1002/smtd.202401532 · Cited by 3

Nanopore detection of guanine derivatives based on vacancy G-quadruplex DNA

Ren, T., Feng, Z., Jiang, F., Liu, X., Chen, T., Guo, Y., Tian, L., Kang, X., & Yao, F. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.112366 · Cited by 3

Modification Detection using Nanopore Sequencing

Bailey, A. D. (2021) · eScholarship (California Digital Library)

Systematic assessment of diverse RNA modifications using nanopore direct RNA sequencing

Kang, X., Zhang, K., Goyon, A., & Stephenson, W. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag411 · Cited by 9

Computational methods for RNA modification detection from nanopore direct RNA sequencing data

Furlan, M., Delgado-Tejedor, A., Mulroney, L., Pelizzola, M., Novoa, E. M., & Leonardi, T. (2021) · RNA Biology · doi:10.1080/15476286.2021.1978215 · Cited by 111

Direct detection of RNA modifications and structure using single-molecule nanopore sequencing

Stephenson, W., Razaghi, R., Busan, S., Weeks, K. M., Timp, W., & Smibert, P. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100097 · Cited by 162

SmartImage: A Machine Learning Method for Nanopore Identifying Chemical Modifications on RNA

Li, S., Li, X., Wan, Y., Ying, Y., Yu, R., & Long, Y. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202201144 · Cited by 5