The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.
Notch and interacting signalling pathways in cardiac development, disease, and regeneration
Open accessAbstract
Cardiogenesis is a complex developmental process involving multiple overlapping stages of cell fate specification, proliferation, differentiation, and morphogenesis. Precise spatiotemporal coordination between the different cardiogenic processes is ensured by intercellular signalling crosstalk and tissue–tissue interactions. Notch is an intercellular signalling pathway crucial for cell fate decisions during multicellular organismal development and is aptly positioned to coordinate the complex signalling crosstalk required for progressive cell lineage restriction during cardiogenesis. In this Review, we describe the role of Notch signalling and the crosstalk with other signalling pathways during the differentiation and patterning of the different cardiac tissues and in cardiac valve and ventricular chamber development. We examine how perturbation of Notch signalling activity is linked to congenital heart diseases affecting the neonate and adult, and discuss studies that shed light on the role of Notch signalling in heart regeneration and repair after injury.In this Review, de la Pompa and colleagues describe the role of the Notch pathway during the differentiation and patterning of cardiac tissues and in valve and ventricular chamber development, discussing the crosstalk with other signalling pathways, how defective Notch signalling is linked to congenital heart diseases, and the relevance of the Notch pathway in heart regeneration and repair.Key pointsVertebrate heart development is a complex multistep process that relies on the contribution of several cellular lineages in a spatiotemporally regulated manner.Notch is a highly conserved, local cell–cell signalling pathway required for proliferation, differentiation, and tissue patterning in a variety of tissues, including the heart.Notch signalling in the endocardium regulates cardiac specification, progenitor cell differentiation, valve primordium formation and morphogenesis, ventricular trabeculation and compaction, and coronary vessel development.Notch coordinates cellular interactions during heart development by cross talking with other fundamental signalling pathways, including WNT, bone morphogenetic protein, and neuregulin 1–ERBB.Defective Notch signalling during heart development causes congenital heart disease affecting neonates and adults.Notch regulates cardiac regenerative processes in zebrafish, providing an incentive for evaluating Notch-based cell therapies in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Maron, B. J., Towbin, J. A., Thiene, G., Antzelevitch, C., Corrado, D., Arnett, D., Moss, A. J., Seidman, C. E., & Young, J. B. (2006) · Circulation · doi:10.1161/circulationaha.106.174287 · Cited by 3,436
Transient Regenerative Potential of the Neonatal Mouse Heart
Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A. (2011) · Science · doi:10.1126/science.1200708 · Cited by 2,545
Heart Regeneration in Zebrafish
Poss, K. D., Wilson, L. G., & Keating, M. T. (2002) · Science · doi:10.1126/science.1077857 · Cited by 1,932
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Hellström, M., Phng, L.-K., Hofmann, J. J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.-K., Karlsson, L., Gaiano, N., et al. (2007) · Nature · doi:10.1038/nature05571 · Cited by 1,775
Jenni, R., Oechslin, E., Schneider, J., Jost, C. A., & Kaufmann, P. A. (2001) · Heart · doi:10.1136/heart.86.6.666 · Cited by 1,549
Mutations in NOTCH1 cause aortic valve disease
Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509
Isolated noncompaction of left ventricular myocardium. A study of eight cases.
Chin, T. K., Perloff, J. K., Williams, R. G., Jue, K., & Mohrmann, R. (1990) · Circulation · doi:10.1161/01.cir.82.2.507 · Cited by 1,418
Signalling downstream of activated mammalian Notch
Jarriault, S., Brou, C., Logeat, F., Schroeter, E. H., Kopan, R., & Israel, A. (1995) · Nature · doi:10.1038/377355a0 · Cited by 1,390
Mammalian heart renewal by pre-existing cardiomyocytes
Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T.-D., Guerquin-Kern, J.-L., Lechene, C. P., & Lee, R. T. (2013) · Nature · doi:10.1038/nature11682 · Cited by 1,343
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., & Belmonte, J. C. I. (2010) · Nature · doi:10.1038/nature08899 · Cited by 1,333
Cited by
Zhao, F., He, Y., Zhao, Z., He, J., Huang, H., Ai, K., Liu, L., & Cai, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1272133 · Cited by 42
Svoboda, L. K., Ishikawa, T., & Dolinoy, D. C. (2022) · Environmental Epigenetics · doi:10.1093/eep/dvac017 · Cited by 27
Engineering the cardiac tissue microenvironment
Ronan, G., Bahcecioglu, G., Aliyev, N., & Zorlutuna, P. (2024) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad0ea7 · Cited by 4
Metadata
- Authors
- MacGrogan, D., Münch, J., & de la Pompa, J. L.
- Venue
- Nature Reviews Cardiology
- Published
- 2018-10-04
- Volume
- 15
- Issue
- 11
- Pages
- 685-704
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2894764101
- Cited by
- 287
- References
- 202
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Notch and interacting signalling pathways in cardiac development, disease, and regeneration. https://app.cochat.ai/papers/10.1038/s41569-018-0100-2
- The paper
- MacGrogan, D., Münch, J., & de la Pompa, J. L. (2018). Notch and interacting signalling pathways in cardiac development, disease, and regeneration. Nature Reviews Cardiology. https://doi.org/10.1038/s41569-018-0100-2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
