Transient Regenerative Potential of the Neonatal Mouse Heart
Open accessAbstract
The heart in a newborn mouse can rebuild itself after injury, but this regenerative capacity is lost within a few days.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The damaged area could have been overlooked in other studies, including Porrello et al., 2011, where 140 sections per heart were examined.
“hence, the damaged area could have been overlooked in other studies, including that of Porrello et al., 2011, where 140 sections per heart were examined”
From Response to Sadek et al. and Kotlikoff et al. (2014) · cites this paper as Porrello et al., 2011
Porrello et al., 2011 examined 140 sections per heart.
“where 140 sections per heart were examined”
From Response to Sadek et al. and Kotlikoff et al. (2014) · cites this paper as Porrello et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130 · see citing works
Heart Regeneration in Zebrafish
Poss, K. D., Wilson, L. G., & Keating, M. T. (2002) · Science · doi:10.1126/science.1077857 · Cited by 1,938 · see citing works
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., & Belmonte, J. C. I. (2010) · Nature · doi:10.1038/nature08899 · Cited by 1,333 · see citing works
Chimerism of the Transplanted Heart
Quaini, F., Urbanek, K., Beltrami, A. P., Finato, N., Beltrami, C. A., Nadal‐Ginard, B., Kajstura, J., Leri, A., & Anversa, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012081 · Cited by 1,264 · see citing works
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
Kikuchi, K., Holdway, J. E., Werdich, A. A., Anderson, R. M., Fang, Y., Egnaczyk, G. F., Evans, T., MacRae, C. A., Stainier, D. Y. R., & Poss, K. D. (2010) · Nature · doi:10.1038/nature08804 · Cited by 1,056 · see citing works
Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury
Bersell, K. R., Arab, S., Haring, B., & Kühn, B. (2009) · Cell · doi:10.1016/j.cell.2009.04.060 · Cited by 1,023 · see citing works
Rapid Transition of Cardiac Myocytes from Hyperplasia to Hypertrophy During Postnatal Development
Li, F. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0163 · Cited by 837 · see citing works
Lepilina, A., Coon, A. N., Kikuchi, K., Holdway, J. E., Roberts, R. W., Burns, C. G., & Poss, K. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.052 · Cited by 833 · see citing works
Hsieh, P. C. H., Segers, V. F. M., Davis, M. E., MacGillivray, C., Gannon, J., Molkentin, J. D., Robbins, J. M., & Lee, R. T. (2007) · Nature Medicine · doi:10.1038/nm1618 · Cited by 768 · see citing works
Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration
Ahuja, P., Sdek, P., & MacLellan, W. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00032.2006 · Cited by 568 · see citing works
Response of the adult newt ventricle to injury
Oberpriller, J. O., & Oberpriller, J. C. (1974) · Journal of Experimental Zoology · doi:10.1002/jez.1401870208 · Cited by 405 · see citing works
Pasumarthi, K. B. S., Nakajima, H., Nakajima, H. O., Soonpaa, M. H., & Field, L. J. (2004) · Circulation Research · doi:10.1161/01.res.0000152326.91223.4f · Cited by 345 · see citing works
Walsh, S., Pontén, A., Fleischmann, B. K., & Jovinge, S. V. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq005 · Cited by 290 · see citing works
Drenckhahn, J., Schwarz, Q., Gray, S. P., Laskowski, A., Kiriazis, H., Ming, Z., Harvey, R. P., Du, X., Thorburn, D. R., & Cox, T. C. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.09.005 · Cited by 176 · see citing works
Sequential myofibrillar breakdown accompanies mitotic division of mammalian cardiomyocytes
Ahuja, P., Perriard, E. R., Perriard, J., & Ehler, E. (2004) · Journal of Cell Science · doi:10.1242/jcs.01159 · Cited by 170 · see citing works
Getting to the heart of regeneration in zebrafish
Poss, K. D. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.11.009 · Cited by 149 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mammalian heart renewal by pre-existing cardiomyocytes
Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T.-D., Guerquin-Kern, J.-L., Lechene, C. P., & Lee, R. T. (2013) · Nature · doi:10.1038/nature11682 · Cited by 1,343 · see citing works
Functional screening identifies miRNAs inducing cardiac regeneration
Eulalio, A., Mano, M., Ferro, M. D., Zentilin, L., Sinagra, G., Zacchigna, S., & Giacca, M. (2012) · Nature · doi:10.1038/nature11739 · Cited by 1,029 · see citing works
Hippo pathway effector Yap promotes cardiac regeneration
Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313192110 · Cited by 895 · see citing works
Self-citationSelf-Renewing Resident Cardiac Macrophages Limit Adverse Remodeling Following Myocardial Infarction
Dick, S. A., Macklin, J. A., Nejat, S., Momen, A., Clemente-Casares, X., Althagafi, M. G., Chen, J., Kantores, C., Hosseinzadeh, S., Aronoff, L., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0272-2 · Cited by 883 · see citing works
Lavine, K. J., Epelman, S., Uchida, K., Weber, K. J., Nichols, C. G., Schilling, J. D., Ornitz, D. M., Randolph, G. J., & Mann, D. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406508111 · Cited by 818 · see citing works
Burridge, P. W., Keller, G., Gold, J. D., & Wu, J. C. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.12.013 · Cited by 670 · see citing works
Cardioids reveal self-organizing principles of human cardiogenesis
Hofbauer, P., Jahnel, S. M., Papai, N., Giesshammer, M., Deyett, A., Schmidt, C., Penc, M., Tavernini, K., Grdseloff, N., Meledeth, C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.034 · Cited by 588 · see citing works
Guidelines for experimental models of myocardial ischemia and infarction
Lindsey, M. L., Bolli, R., Canty, J. M., Du, X.-J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2017 · Cited by 526 · see citing works
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair
Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514 · see citing works
Self-citationMills, R. J., Titmarsh, D. M., Koenig, X., Parker, B. L., Ryall, J. G., Quaife-Ryan, G. A., Voges, H. K., Hodson, M. P., Ferguson, C., Drowley, L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707316114 · Cited by 478 · see citing works
Self-citationMicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs
Gabisonia, K., Prosdocimo, G., Aquaro, G. D., Carlucci, L., Zentilin, L., Secco, I., Ali, H., Braga, L., Gorgodze, N., Bernini, F., et al. (2019) · Nature · doi:10.1038/s41586-019-1191-6 · Cited by 478 · see citing works
Hippo signaling impedes adult heart regeneration
Heallen, T., Morikawa, Y., Leach, J., Tao, G., Willerson, J. T., Johnson, R. L., & Martin, J. F. (2013) · Development · doi:10.1242/dev.102798 · Cited by 458 · see citing works
A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice
Tian, Y., Liu, Y., Wang, T., Zhou, N., Kong, J., Chen, L., Snitow, M., Morley, M., Li, D., Petrenko, N., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010841 · Cited by 381 · see citing works
Macrophages modulate adult zebrafish tail fin regeneration
Petrie, T. A., Strand, N. S., Tsung-Yang, C., Rabinowitz, J. S., & Moon, R. T. (2014) · Development · doi:10.1242/dev.098459 · Cited by 365 · see citing works
Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair
Tang, T. W. H., Chen, H.-C., Chen, C.-Y., Yen, C. Y. T., Lin, C.-J., Prajnamitra, R. P., Chen, L.-L., Ruan, S.-C., Lin, J.-H., Lin, P.-J., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035235 · Cited by 348 · see citing works
Mills, R. J., Parker, B. L., Quaife-Ryan, G. A., Voges, H. K., Needham, E. J., Bornot, A., Ding, M., Andersson, H., Polla, M., Elliott, D. A., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.009 · Cited by 312 · see citing works
Self-citationA Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number
Naqvi, N., Li, M., Calvert, J. W., Tejada, T., Lambert, J. P., Wu, J., Kesteven, S. H., Holman, S. R., Matsuda, T., Lovelock, J. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.035 · Cited by 295 · see citing works
Heart Fields and Cardiac Morphogenesis
Kelly, R. G., Buckingham, M. E., & Moorman, A. F. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015750 · Cited by 283 · see citing works
Complete cardiac regeneration in a mouse model of myocardial infarction
Haubner, B. J., Adamowicz-Brice, M., Khadayate, S., Tiefenthaler, V., Metzler, B., Aitman, T., & Penninger, J. M. (2012) · Aging · doi:10.18632/aging.100526 · Cited by 261 · see citing works
Embryonic Heart Progenitors and Cardiogenesis
Brade, T., Pane, L. S., Moretti, A., Chien, K. R., & Laugwitz, K.-L. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013847 · Cited by 254 · see citing works
Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues
Feric, N. T., & Radisic, M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.019 · Cited by 247 · see citing works
Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates
Wang, W., Hu, C.-K., Zeng, A., Alegre, D., Hu, D., Gotting, K., Ortega Granillo, A., Wang, Y., Robb, S., Schnittker, R., et al. (2020) · Science · doi:10.1126/science.aaz3090 · Cited by 210 · see citing works
Jesty, S. A., Steffey, M. A., Lee, F. K., Breitbach, M., Hesse, M., Reining, S., Lee, J. C., Doran, R. M., Nikitin, A. Y., Fleischmann, B. K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208114109 · Cited by 223 · see citing works
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works
The Role of the Epicardium During Heart Development and Repair
Quijada, P., Trembley, M. A., & Small, E. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.315857 · Cited by 201 · see citing works
Bargehr, J., Ong, L. P., Colzani, M., Davaapil, H., Hofsteen, P., Bhandari, S., Gambardella, L., Le Novère, N., Iyer, D., Sampaziotis, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0197-9 · Cited by 195 · see citing works
Kensah, G., Roa Lara, A., Dahlmann, J., Zweigerdt, R., Schwanke, K., Hegermann, J., Skvorc, D., Gawol, A., Azizian, A., Wagner, S., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs349 · Cited by 193 · see citing works
mRNA-Based Protein Replacement Therapy for the Heart
Magadum, A., Kaur, K., & Zangi, L. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.11.018 · Cited by 176 · see citing works
Bär, C., de Jesus, B. B., Serrano, R., Tejera, A., Ayuso, E., Jimenez, V., Formentini, I., Bobadilla, M., Mizrahi, J., de Martino, A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6863 · Cited by 162 · see citing works
Machado, L., Geara, P., Camps, J., Dos Santos, M., Teixeira-Clerc, F., Van Herck, J., Varet, H., Legendre, R., Pawlotsky, J.-M., Sampaolesi, M., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.017 · Cited by 170 · see citing works
View from the heart: cardiac fibroblasts in development, scarring and regeneration
Furtado, M. B., Nim, H. T., Boyd, S. E., & Rosenthal, N. A. (2016) · Development · doi:10.1242/dev.120576 · Cited by 144 · see citing works
Später, D., Hansson, E. M., Zangi, L., & Chien, K. R. (2014) · Development · doi:10.1242/dev.091538 · Cited by 143 · see citing works
Origins of cardiac fibroblasts
Moore-Morris, T., Cattaneo, P., Puceat, M., & Evans, S. M. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.031 · Cited by 139 · see citing works
Do Neonatal Mouse Hearts Regenerate following Heart Apex Resection?
Andersen, D. C., Ganesalingam, S., Jensen, C. H., & Sheikh, S. P. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.02.008 · Cited by 115 · see citing works
Ritschka, B., Knauer-Meyer, T., Gonçalves, D. S., Mas, A., Plassat, J.-L., Durik, M., Jacobs, H., Pedone, E., Di Vicino, U., Cosma, M. P., et al. (2020) · Genes & Development · doi:10.1101/gad.332643.119 · Cited by 105 · see citing works
Guo, Y., Jardin, B. D., Zhou, P., Sethi, I., Akerberg, B. N., Toepfer, C. N., Ai, Y., Li, Y., Ma, Q., Guatimosim, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06347-2 · Cited by 96 · see citing works
The Hippo signal transduction network in skeletal and cardiac muscle
Wackerhage, H., Del Re, D. P., Judson, R. N., Sudol, M., & Sadoshima, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005096 · Cited by 92 · see citing works
Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease
Cui, M., Wang, Z., Bassel-Duby, R., & Olson, E. N. (2018) · Development · doi:10.1242/dev.171983 · Cited by 92 · see citing works
Self-citationIron regulator hepcidin impairs macrophage-dependent cardiac repair after injury
Zlatanova, I., Pinto, C., Bonnin, P., Mathieu, J. R. R., Bakker, W., Vilar, J., Lemitre, M., Voehringer, D., Vaulont, S., Peyssonnaux, C., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.034545 · Cited by 81 · see citing works
BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C–deficient mice
Auguste, G., Rouhi, L., Matkovich, S. J., Coarfa, C., Robertson, M. J., Czernuszewicz, G., Gurha, P., & Marian, A. J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135922 · Cited by 77 · see citing works
Titmarsh, D. M., Glass, N. R., Mills, R. J., Hidalgo, A., Wolvetang, E. J., Porrello, E. R., Hudson, J. E., & Cooper-White, J. J. (2016) · Scientific Reports · doi:10.1038/srep24637 · Cited by 59 · see citing works
Self-citationLin, Z., & Pu, W. T. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.04.010 · Cited by 52 · see citing works
Chanthra, N., Abe, T., Miyamoto, M., Sekiguchi, K., Kwon, C., Hanazono, Y., & Uosaki, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-61163-3 · Cited by 36 · see citing works
The Regenerative Activity of Interleukin-6
Galun, E., & Rose-John, S. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-308-4_4 · Cited by 34 · see citing works
More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium
Dueñas, A., Aranega, A. E., & Franco, D. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00044 · Cited by 25 · see citing works
Response to Sadek et al. and Kotlikoff et al.
Andersen, D. C., Jensen, C. H., & Sheikh, S. P. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.06.011 · Cited by 14 · see citing works
- Authors
- Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Olson, Eric N.
- Sadek, Hesham A.
- ORCID
- Venue
- Science
- Published
- 2011-02-25
- Volume
- 331
- Issue
- 6020
- Pages
- 1078-1080
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3099478
- OpenAlex
- W1969038150
- Cited by
- 2,545
- References
- 16
- Citations by year
- 2026: 116 · 2025: 171 · 2024: 193 · 2023: 165 · 2022: 193 · 2021: 227 · 2020: 215 · 2019: 167 · 2018: 194 · 2017: 176 · 2016: 145 · 2015: 138 · 2014: 160 · 2013: 121 · 2012: 109
- FWCI
- 57.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (HL100401-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- cardiac regeneration, neonatal heart, cardiomyocyte proliferation, myocardial fibrosis, cardiac hypertrophy, ventricular function, mouse heart
- MeSH terms
- Aging, Animals, Animals, Newborn, Echocardiography, Fibrosis, Heart, Cardiomegaly, Heart Ventricles, Myocardial Contraction, Myocardium, Regeneration, Sarcomeres, Stroke Volume, Cell Lineage, Myocytes, Cardiac, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
