Cited by 880Sarcoma Diagnosis and TreatmentChromatin Remodeling and CancerAcute Lymphoblastic Leukemia research

The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.

Ewing sarcoma

Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Surdez, Didier, Tomazou, Eleni M., de Álava, Enrique, Kovar, Heinrich, Sorensen, Poul H., Delattre, Olivier, Dirksen, Uta·2018·Nature Reviews Disease Primers

DOI 10.1038/s41572-018-0003-x

Open this paper in CoChat — free account

Abstract

Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of 70-80% for patients with standard-risk and localized disease and ~30% for those with metastatic disease. Treatment comprises local surgery, radiotherapy and polychemotherapy, which are associated with acute and chronic adverse effects that may compromise quality of life in survivors. Histologically, Ewing sarcomas are composed of small round cells expressing high levels of CD99. Genetically, they are characterized by balanced chromosomal translocations in which a member of the FET gene family is fused with an ETS transcription factor, with the most common fusion being EWSR1-FLI1 (85% of cases). Ewing sarcoma breakpoint region 1 protein (EWSR1)-Friend leukaemia integration 1 transcription factor (FLI1) is a tumour-specific chimeric transcription factor (EWSR1-FLI1) with neomorphic effects that massively rewires the transcriptome. Additionally, EWSR1-FLI1 reprogrammes the epigenome by inducing de novo enhancers at GGAA microsatellites and by altering the state of gene regulatory elements, creating a unique epigenetic signature. Additional mutations at diagnosis are rare and mainly involve STAG2, TP53 and CDKN2A deletions. Emerging studies on the molecular mechanisms of Ewing sarcoma hold promise for improvements in early detection, disease monitoring, lower treatment-related toxicity, overall survival and quality of life.

Integrity signals

Registry

Crossref · 10.1038/s41572-018-0003-x

Cites

251 of 251 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED ARTICLE: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
Javaheri, T., Kazemi, Z., Pěnčík, J., Pham, H. T., Kauer, M. O., Noorizadeh, R., Sax, B., Nivarthi, H., Schlederer, M., Maurer, B., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.268 · Cited by 18
Self-citation
Retracted
Bone marrow transplant
Szer, J. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb127745.x · Cited by 3,373
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G., et al. (1992) · Nature · doi:10.1038/359162a0 · Cited by 1,907
Self-citation
Targeting EZH2 in cancer
Kim, K. H., & Roberts, C. W. M. (2016) · Nature Medicine · doi:10.1038/nm.4036 · Cited by 1,471
Germline Mutations in Predisposition Genes in Pediatric Cancer
Zhang, J., Walsh, M. F., Wu, G., Edmonson, M. N., Gruber, T. A., Easton, J., Hedges, D., Ma, X., Zhou, X., Yergeau, D. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1508054 · Cited by 1,345
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
Xu, N., Papagiannakopoulos, T. Y., Pan, G., Thomson, J. A., & Kosik, K. S. (2009) · Cell · doi:10.1016/j.cell.2009.02.038 · Cited by 1,160
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
Shi, J., & Vakoc, C. R. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.016 · Cited by 888
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
Kadoch, C., & Crabtree, G. R. (2015) · Science Advances · doi:10.1126/sciadv.1500447 · Cited by 877
JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor
Yamane, K., Toumazou, C., Tsukada, Y.-I., Erdjument‐Bromage, H., Tempst, P., Wong, J., & Zhang, Y. (2006) · Cell · doi:10.1016/j.cell.2006.03.027 · Cited by 860
Randomized Controlled Trial of Interval-Compressed Chemotherapy for the Treatment of Localized Ewing Sarcoma: A Report From the Children's Oncology Group
Womer, R. B., West, D. C., Krailo, M., Dickman, P. S., Pawel, B., Grier, H. E., Marcus, K. J., Sailer, S. L., Healey, J. H., Dormans, J. P., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.41.5703 · Cited by 761
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration
Gaspar, N., Hawkins, D. S., Dirksen, U., Lewis, I. J., Ferrari, S., Deley, M. L., Kovar, H., Grimer, R. J., Whelan, J., Claude, L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.5256 · Cited by 757
Self-citation
A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG
Sorensen, P. H. B., Lessnick, S. L., Lopez-Terrada, D. H., Liu, X. F., Triche, T. J., & Denny, C. T. (1994) · Nature Genetics · doi:10.1038/ng0294-146 · Cited by 747
Self-citation
Realizing the promise of cancer predisposition genes
Rahman, N. (2014) · Nature · doi:10.1038/nature12981 · Cited by 632
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
Eirew, P. D., Steif, A., Khattra, J. S., Ha, G., Yap, D., Farahani, H., Gelmon, K. A., Chia, S., Mar, C., Wan, A., et al. (2014) · Nature · doi:10.1038/nature13952 · Cited by 599
Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations
Tirode, F., Surdez, D., Ma, X., Parker, M. D., Deley, M. L., Bahrami, A., Zhang, Z., Lapouble, E., Grossetête, S., Rusch, M., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0622 · Cited by 594
Self-citation
The Genomic Landscape of Pediatric Ewing Sarcoma
Crompton, B. D., Stewart, C., Taylor-Weiner, A. N., Alexe, G., Kurek, K. C., Calicchio, M. L., Kieżun, A., Carter, S. L., Shukla, S. A., Mehta, S. S., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-1037 · Cited by 592
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.
May, W. A., Gishizky, M. L., Lessnick, S. L., Lunsford, L. B., Lewis, B. C., Delattre, O., Zucman‐Rossi, J., Thomas, G. D., & Denny, C. T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5752 · Cited by 576
Self-citation
Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
Edmunds, J. W., Mahadevan, L. C., & Clayton, A. L. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601967 · Cited by 547
Combinatorial generation of variable fusion proteins in the Ewing family of tumours.
Zucman‐Rossi, J., Melot, T., Desmaze, C., Ghysdael, J., Plougastel-Douglas, B., Peter, M., Zucker, J. M., Triche, T. J., Sheer, D., & Turc‐Carel, C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06137.x · Cited by 545
Cancer biology and NuRD: a multifaceted chromatin remodelling complex
Lai, A. Y., & Wade, P. A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3091 · Cited by 541
Non-coding RNAs as direct and indirect modulators of epigenetic regulation
Peschansky, V. J., & Wahlestedt, C. (2013) · Epigenetics · doi:10.4161/epi.27473 · Cited by 539
Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial
Ladenstein, R. L., Pötschger, U., Deley, M. L., Whelan, J. S., Paulussen, M., Oberlin, O., van den Berg, H., Dirksen, U., Hjorth, L., Michon, J. M., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.9864 · Cited by 538
Self-citation
Mesenchymal Stem Cell Features of Ewing Tumors
Tirode, F., Laud-Duval, K., Prieur, A., Delorme, B., Charbord, P., & Delattre, O. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.027 · Cited by 525
Self-citation
EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.
de Álava, E., Kawai, A., Healey, J. H., Fligman, I., Meyers, P. A., Huvos, A. G., Gerald, W. L., Jhanwar, S. C., Argani, P., Antonescu, C. R., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.4.1248 · Cited by 522
Self-citation
Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain
Boulay, G., Sandoval, G. J., Riggi, N., Iyer, S., Buisson, R., Naigles, B., Awad, M. E., Rengarajan, S., Volorio, A., McBride, M. J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.036 · Cited by 487
A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion
Pierron, G., Tirode, F., Lucchesi, C., Reynaud, S., Ballet, S., Cohen‐Gogo, S., Perrin, V., Coindre, J., & Delattre, O. (2012) · Nature Genetics · doi:10.1038/ng.1107 · Cited by 481
Self-citation
BCoR, a novel corepressor involved in BCL-6 repressionPreprint
Huynh, K. D., Fischle, W., Verdin, E. M., & Bardwell, V. J. (2000) · Genes & Development · doi:10.1101/gad.14.14.1810 · Cited by 475
A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.
Jeon, I. S., Davis, J. N., Braun, B. S., Sublett, J. E., Roussel, M. F., Denny, C. T., & Shapiro, D. N. (1995) · PubMed · Cited by 471
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
Erkizan, H. V., Kong, Y., Merchant, M. S., Schlottmann, S., Barber-Rotenberg, J. S., Yuan, L., Abaan, O. D., Chou, T.-F., Dakshanamurthy, S., Brown, M. L., et al. (2009) · Nature Medicine · doi:10.1038/nm.1983 · Cited by 467
EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma
Riggi, N., Knoechel, B., Gillespie, S. M., Rheinbay, E., Boulay, G., Suvà, M. L., Rossetti, N. E., Boonseng, W. E., Oksuz, O., Cook, E., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.004 · Cited by 466
The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation
Brohl, A. S., Solomon, D. A., Chang, W., Wang, J., Song, Y., Sindiri, S., Patidar, R., Hurd, L., Chen, L., Shern, J. F., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004475 · Cited by 440
Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer
Solomon, D. A., Kim, T., Díaz-Martínez, L. A., Fair, J., ELKAHLOUN, A. G., Harris, B. T., Toretsky, J. A., Rosenberg, S. A., Shukla, N. N., Ladanyi, M., et al. (2011) · Science · doi:10.1126/science.1203619 · Cited by 430
Sarcoma classification: An update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone
Doyle, L. A. (2014) · Cancer · doi:10.1002/cncr.28657 · Cited by 423
Sarcomas With CIC-rearrangements Are a Distinct Pathologic Entity With Aggressive Outcome
Antonescu, C. R., Owosho, A. A., Zhang, L., Chen, S. D., Denız, K., Huryn, J. M., Kao, Y., Huang, S., Singer, S., Tap, W. D., et al. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000846 · Cited by 408
Chromatin crosstalk in development and disease: lessons from REST
Ooi, L., & Wood, I. C. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2100 · Cited by 405
A new member of the ETS family fused to EWS in Ewing tumors
Peter, M., Couturier, J., Pacquement, H., Michon, J. M., Thomas, G. D., Magdelénat, H., & Delattre, O. (1997) · Oncogene · doi:10.1038/sj.onc.1200933 · Cited by 397
Self-citation
Positron Emission Tomography for Staging of Pediatric Sarcoma Patients: Results of a Prospective Multicenter Trial
Völker, T., Denecke, T., Steffen, I. G., Misch, D., Schönberger, S., Plotkin, M., Ruf, J., Furth, C., Stöver, B., Hautzel, H., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.2473 · Cited by 395
Initial Symptoms and Clinical Features in Osteosarcoma and Ewing Sarcoma*
Widhe, B., & Widhe, T. L. (2000) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200005000-00007 · Cited by 378
Development of Ewing's Sarcoma from Primary Bone Marrow–Derived Mesenchymal Progenitor Cells
Riggi, N., Cironi, L., Provero, P., Suvà, M.-L., Kaloulis, K., Garcı́a-Echeverrı́a, C., Hoffmann, F., Trumpp, A., & Stamenkovic, I. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1696 · Cited by 369
Regulation of gene transcription by Polycomb proteins
Aranda, S., Martín, G. M., & Croce, L. D. (2015) · Science Advances · doi:10.1126/sciadv.1500737 · Cited by 358
Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials
Schuck, A., Ahrens, S., Paulussen, M., Kuhlen, M., Könemann, S., Rübe, C., Winkelmann, W., Kotz, R. I., Dunst, J., Willich, N. A., et al. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)03797-5 · Cited by 348
Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
Hahm, K., Cho, K., Lee, C., Im, Y., Chang, J., Choi, S.-G., Sorensen, P. H. B., Thiele, C. J., & Kim, S. (1999) · Nature Genetics · doi:10.1038/13854 · Cited by 347
Self-citation
EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells
Riggi, N., Suvà, M.-L., Suvà, D., Cironi, L., Provero, P., Tercier, S., Joseph, J., Stehle, J., Baumer, K., Kindler, V., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-1761 · Cited by 342
Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study
Worst, B. C., van Tilburg, C. M., Balasubramanian, G. P., Fiesel, P., Witt, R., Freitag, A., Boudalil, M., Previti, C., Wolf, S., Schmidt, S., et al. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.06.009 · Cited by 338
Self-citation
Transcriptomic definition of molecular subgroups of small round cell sarcomas
Watson, S., Perrin, V., Guillemot, D., Reynaud, S., Coindre, J., Karanian, M., Guinebretière, J., Fréneaux, P., Loarer, F. L., Bouvet, M., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5053 · Cited by 335
Self-citation
EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
Gorthi, A., Romero, J. C., Loranc, E., Cao, L., Lawrence, L. A., Goodale, E., Iniguez, A. B., Bernard, X., Masamsetti, V. P., Roston, S. R., et al. (2018) · Nature · doi:10.1038/nature25748 · Cited by 334
Risk of recurrence and survival after relapse in patients with Ewing sarcoma
Stahl, M., Ranft, A., Paulussen, M., Bölling, T., Vieth, V., Bielack, S., Görtitz, I., Braun‐Munzinger, G., Hardes, J., Jürgens, H., et al. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.23040 · Cited by 316
Self-citation
SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions
Zhang, T., & Kraus, W. L. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.10.022 · Cited by 314
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation
Richter, G. H. S., Plehm, S., Fasan, A., Rössler, S., Unland, R., Bennani-Baı̈ti, I. M., Hotfilder, M., Löwel, D., von Luettichau, I., Moßbrugger, I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810759106 · Cited by 312
Self-citation
Microsatellites as EWS/FLI response elements in Ewing's sarcoma
Gangwal, K., Sankar, S., Hollenhorst, P. C., Kinsey, M., Haroldsen, S. C., Shah, A. A., Boucher, K. M., Watkins, W. S., Jorde, L. B., Graves, B. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801073105 · Cited by 297
MicroRNA-34a: a potential therapeutic target in human cancer
Li, X. J., Ren, Z. J., & Tang, J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.270 · Cited by 289
Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis
El-Naggar, A. M., Veinotte, C. J., Cheng, H., Grünewald, T. G. P., Negri, G. L., Somasekharan, S. P., Corkery, D., Tirode, F., Mathers, J. A., Khan, D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.003 · Cited by 287
Self-citation
YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1
Somasekharan, S. P., El-Naggar, A. M., Leprivier, G., Cheng, H., Hajee, S., Grünewald, T. G. P., Zhang, F., Ng, T., Delattre, O., Evdokimova, V. E., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201411047 · Cited by 287
Self-citation
Orthotopic patient-derived xenografts of paediatric solid tumours
Stewart, E., Federico, S. M., Chen, X., Shelat, A. A., Bradley, C., Gordon, B., Karlstrom, A., Twarog, N. R., Clay, M. R., Bahrami, A., et al. (2017) · Nature · doi:10.1038/nature23647 · Cited by 286
Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO‐E.W.I.N.G. 99 clinical trial
Juergens, C., Weston, C. L., Lewis, I. J., Whelan, J. S., Paulussen, M., Oberlin, O., Michon, J. M., Zoubek, A., Juergens, H., & Craft, A. W. (2006) · Pediatric Blood & Cancer · doi:10.1002/pbc.20820 · Cited by 282
Ewing sarcoma demonstrates racial disparities in incidence‐related and sex‐related differences in outcome
Jawad, M. U., Cheung, M. C., Min, E. S., Schneiderbauer, M. M., Koniaris, L. G., & Scully, S. P. (2009) · Cancer · doi:10.1002/cncr.24388 · Cited by 281
EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cellsPreprint
Riggi, N., Suvà, M.-L., Vito, C. D., Provero, P., Stehle, J., Baumer, K., Cironi, L., Janiszewska, M., Petricevic, T., Suvà, D., et al. (2010) · Genes & Development · doi:10.1101/gad.1899710 · Cited by 281
BCOR-CCNB3 Fusion Positive Sarcomas
Kao, Y., Owosho, A. A., Sung, Y., Zhang, L., Fujisawa, Y., Lee, J., Wexler, L. H., Argani, P., Swanson, D. M., Dickson, B. C., et al. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000965 · Cited by 275
Promiscuous partnerships in Ewing's sarcoma
Sankar, S., & Lessnick, S. L. (2011) · Cancer Genetics · doi:10.1016/j.cancergen.2011.07.008 · Cited by 273
Condensin and cohesin complexity: the expanding repertoire of functions
Wood, A. J., Severson, A. F., & Meyer, B. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2794 · Cited by 268
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma
Sheffield, N. C., Pierron, G., Klughammer, J., Datlinger, P., Schönegger, A., Schuster, M. K., Hadler, J., Surdez, D., Guillemot, D., Lapouble, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4273 · Cited by 258
Self-citation
Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1
Tomazou, E. M., Sheffield, N. C., Schmidl, C., Schuster, M. K., Schönegger, A., Datlinger, P., Kubicek, S., Bock, C., & Kovar, H. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.042 · Cited by 256
Self-citation
Ewing Sarcomas With p53 Mutation or p16/p14ARF Homozygous Deletion: A Highly Lethal Subset Associated With Poor Chemoresponse
Huang, H.-Y., Illei, P. B., Zhao, Z., Mazumdar, M., Huvos, A. G., Healey, J. H., Wexler, L. H., Gorlick, R. G., Meyers, P. A., & Ladanyi, M. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.081 · Cited by 252
Ewing's tumors with primary lung metastases: survival analysis of 114 (European Intergroup) Cooperative Ewing's Sarcoma Studies patients.
Paulussen, M., Ahrens, S., Craft, A. W., Dunst, J., Fröhlich, B., Jabar, S., Rübe, C., Winkelmann, W., Wissing, S., Zoubek, A., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.9.3044 · Cited by 250
The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of Fibroblasts
Toretsky, J. A., Kalebic, T., Blakesley, V., LeRoith, D., & Helman, L. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.30822 · Cited by 247
Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells
Franzetti, G.-A., Laud-Duval, K., van der Ent, W., Brisac, A., Irondelle, M., Aubert, S., Dirksen, U., Bouvier, C., Pinieux, G. D. B. D., Snaar-Jagalska, E. B., et al. (2017) · Oncogene · doi:10.1038/onc.2016.498 · Cited by 233
Self-citation
Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target.
Scotlandi, K., Benini, S., Sarti, M., Serra, M., Lollini, P., Maurici, D., Picci, P., Manara, M. C., & Baldini, N. (1996) · PubMed · Cited by 227
The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function
Guillon, N., Tirode, F., Boeva, V., Zynovyev, A., Barillot, E., & Delattre, O. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004932 · Cited by 218
Self-citation
Histological heterogeneity of Ewing’s sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support
Llombart‐Bosch, A., Machado, I., Navarro, S., Bertoni, F., Bacchini, P., Alberghini, M., Karzeladze, A., Савелов, Н. А., Petrov, S., Alvarado‐Cabrero, I., et al. (2009) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-009-0842-7 · Cited by 217
DNA Microarrays Reveal Relationship of Ewing Family Tumors to Both Endothelial and Fetal Neural Crest-Derived Cells and Define Novel Targets
Staege, M. S., Hutter, C., Neumann, I., Foja, S., Hattenhorst, U. E., Hansen, G., Afar, D., & Burdach, S. E. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-4059 · Cited by 217
Translocation involving chromosome 22 in Ewing's Sarcoma. A cytogenetic study of four fresh tumors
Aurias, A., Rimbaut, C., Buffe, D., Zucker, J., & Mazabraud, A. (1984) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(84)90003-7 · Cited by 214
FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: Comparison with spiral CT
Franzius, C., Daldrup-Link, H. E., Sciuk, J., Rummeny, E., Bielack, S., Jürgens, H., & Schober, O. (2001) · Annals of Oncology · doi:10.1023/a:1011111322376 · Cited by 211
Increased Risk of Systemic Relapses Associated With Bone Marrow Micrometastasis and Circulating Tumor Cells in Localized Ewing Tumor
Schleiermacher, G., Peter, M., Oberlin, O., Philip, T. O., Rubie, H., Mechinaud, F. M., Sommelet-Olive, D., Landman‐Parker, J., Bours, D., Michon, J. M., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2003.03.006 · Cited by 211
Self-citation
Preliminary Efficacy of the Anti-Insulin–Like Growth Factor Type 1 Receptor Antibody Figitumumab in Patients With Refractory Ewing Sarcoma
Juergens, H., Daw, N. C., Geoerger, B., Ferrari, S., Milena Villarroel, C., Aerts, I., Whelan, J., Dirksen, U., Hixon, M. L., Yin, D., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.0670 · Cited by 208
Self-citation
The NFATc2 Gene Is Involved in a Novel Cloned Translocation in a Ewing Sarcoma Variant That Couples Its Function in Immunology to Oncology
Szuhai, K., IJszenga, M. J., de Jong, D., Karseladze, A. I., Tanke, H. J., & Hogendoorn, P. C. W. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2184 · Cited by 206
High-Dose Melphalan, Etoposide, Total-Body Irradiation, and Autologous Stem-Cell Reconstitution as Consolidation Therapy for High-Risk Ewing’s Sarcoma Does Not Improve Prognosis
Meyers, P. A., Krailo, M., Ladanyi, M., Chan, K., Sailer, S. L., Dickman, P. S., Baker, D. L., Davis, J. H., Gerbing, R. B., Grovas, A. C., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.11.2812 · Cited by 205
Recent advances in the molecular pathogenesis of Ewing's sarcoma
Toomey, E. C., Schiffman, J. D., & Lessnick, S. L. (2010) · Oncogene · doi:10.1038/onc.2010.205 · Cited by 203
Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer
Senzer, N. N., Barve, M. A., Kuhn, J. A., Melnyk, A., Beitsch, P. D., Lazar, M. L., Lifshitz, S. G., Magee, M. J., Oh, J., Mill, S. W., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.269 · Cited by 201
Impact of EWS-ETS Fusion Type on Disease Progression in Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: Prospective Results From the Cooperative Euro-E.W.I.N.G. 99 Trial
Deley, M. L., Delattre, O., Schaefer, K., Burchill, S. A., Koehler, G., Hogendoorn, P. C. W., Lion, T., Poremba, C., Marandet, J., Ballet, S., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.3585 · Cited by 200
Self-citation
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite
Grünewald, T. G. P., Bernard, V., Gilardi‐Hebenstreit, P., Raynal, V., Surdez, D., Aynaud, M.-M., Mirabeau, O., Cidre‐Aranaz, F., Tirode, F., Zaïdi, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3363 · Cited by 200
Self-citation
A phase 2 trial of R1507, a monoclonal antibody to the insulin‐like growth factor‐1 receptor (IGF‐1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: Results of a Sarcoma Alliance for Research Through Collaboration study
Pappo, A. S., Vassal, G., Crowley, J. J., Bolejack, V., Hogendoorn, P. C. W., Chugh, R. K., Ladanyi, M., Grippo, J. F., Dall, G., Staddon, A. P., et al. (2014) · Cancer · doi:10.1002/cncr.28728 · Cited by 198
Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: A report from the Children's Oncology Group
DuBois, S. G., Krailo, M., Gebhardt, M. C., Donaldson, S. S., Marcus, K. J., Dormans, J. P., Shamberger, R. C., Sailer, S. L., Nicholas, R. W., Healey, J. H., et al. (2014) · Cancer · doi:10.1002/cncr.29065 · Cited by 189
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma
Postel-Vinay, S. C., Véron, A. S., Tirode, F., Pierron, G., Reynaud, S., Kovar, H., Oberlin, O., Lapouble, E., Ballet, S., Lucchesi, C., et al. (2012) · Nature Genetics · doi:10.1038/ng.1085 · Cited by 184
Self-citation
EWS-FLI1 and EWS-ERG Gene Fusions Are Associated With Similar Clinical Phenotypes in Ewing's Sarcoma
Ginsberg, J. P., de Álava, E., Ladanyi, M., Wexler, L. H., Kovar, H., Paulussen, M., Zoubek, A., Dockhorn‐Dworniczak, B., Juergens, H., Wunder, J. S., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.6.1809 · Cited by 183
Self-citation
Targeting the DNA Repair Pathway in Ewing Sarcoma
Stewart, E. A., Goshorn, D. R., Bradley, C. L., Griffiths, L. M., Benavente, C. A., Twarog, N. R., Miller, G. M., Caufield, W. V., Freeman, B. B., Bahrami, A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.028 · Cited by 183
Cyclophosphamide Compared With Ifosfamide in Consolidation Treatment of Standard-Risk Ewing Sarcoma: Results of the Randomized Noninferiority Euro-EWING99-R1 Trial
Deley, M. L., Paulussen, M., Lewis, I. J., Brennan, B. M. D., Ranft, A., Whelan, J. S., Teuff, G. L., Michon, J. M., Ladenstein, R. L., Marec‐Bérard, P., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.4833 · Cited by 182
Self-citation
Specific Sites in the C Terminus of CTCF Interact with the SA2 Subunit of the Cohesin Complex and Are Required for Cohesin-Dependent Insulation Activity
Xiao, T., Wallace, J., & Felsenfeld, G. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05093-11 · Cited by 182
Second cancers following non-Hodgkin's lymphoma
Travis, L. B., Curtis, R. E., Boice, J. D., Hankey, B. F., & Fraumeni, J. F. (1991) · Cancer · doi:10.1002/1097-0142(19910401)67:7 · Cited by 179
Self-citation
Modeling Initiation of Ewing Sarcoma in Human Neural Crest Cells
von Levetzow, C., Jiang, X., Gwye, Y., von Levetzow, G., Hung, L. T., Cooper, A. R., Hsu, J. H.-R., & Lawlor, E. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019305 · Cited by 179
CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis
Rocchi, A., Manara, M. C., Sciandra, M., Zambelli, D., Nardi, F., Nicoletti, G., Garofalo, C., Meschini, S., Astolfi, A., Colombo, M. P., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci36667 · Cited by 179
Long-term Survivors of Childhood Ewing Sarcoma: Report From the Childhood Cancer Survivor Study
Ginsberg, J. P., Goodman, P. J., Leisenring, W. M., Ness, K. K., Meyers, P. A., Wolden, S. L., Smith, S. M., Stovall, M. A., Hammond, S., Robison, L. L., et al. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq278 · Cited by 176
Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
Sankar, S., Bell, R. N., Stephens, B. J., Zhuo, R., Sharma, S., Bearss, D. J., & Lessnick, S. L. (2012) · Oncogene · doi:10.1038/onc.2012.525 · Cited by 176
Ganglioside GD2 as a therapeutic target for antibody‐mediated therapy in patients with osteosarcoma
Roth, M. E., Linkowski, M., Tarim, J., Piperdi, S., Sowers, R. S., Geller, D., Gill, J. B., & Gorlick, R. G. (2013) · Cancer · doi:10.1002/cncr.28461 · Cited by 174
Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth
Sankar, S., Theisen, E. R., Bearss, J. J., Mulvihill, T. S., Hoffman, L. M., Sorna, V., Beckerle, M. C., Sharma, S., & Lessnick, S. L. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0072 · Cited by 172
The value of local treatment in patients with primary, disseminated, multifocal Ewing sarcoma (PDMES)
Haeusler, J., Ranft, A., Boelling, T., Gosheger, G., Braun‐Munzinger, G., Vieth, V., Burdach, S. E. G., van den Berg, H., Juergens, H., & Dirksen, U. (2009) · Cancer · doi:10.1002/cncr.24740 · Cited by 166
Self-citation
PRDM9 and Its Role in Genetic Recombination
Paigen, K., & Petkov, P. M. (2018) · Trends in Genetics · doi:10.1016/j.tig.2017.12.017 · Cited by 166
Macrophage Infiltration Predicts a Poor Prognosis for Human Ewing Sarcoma
Fujiwara, T., Fukushi, J., Yamamoto, S., Matsumoto, Y., Setsu, N., Oda, Y., Yamada, H., Okada, S., Watari, K., Ono, M., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.05.034 · Cited by 165
Phase I Trial of a Novel Anti-GD2 Monoclonal Antibody, Hu14.18K322A, Designed to Decrease Toxicity in Children With Refractory or Recurrent Neuroblastoma
Navid, F., Sondel, P. M., Barfield, R. C., Shulkin, B. L., Kaufman, R. A., Allay, J., Gan, J., Hutson, P. R., Seo, S., Kim, K., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.50.4423 · Cited by 165
CD99 at the crossroads of physiology and pathology
Pasello, M., Manara, M. C., & Scotlandi, K. (2018) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-017-0445-z · Cited by 161
Pro‐inflammatory chemokine–chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8+ T‐lymphocyte infiltration and affect tumour progression
Berghuis, D., Santos, S. J., Baelde, H. J., Taminiau, A. H. M., Egeler, R. M., Schilham, M. W., Hogendoorn, P. C. W., & Lankester, A. C. (2010) · The Journal of Pathology · doi:10.1002/path.2819 · Cited by 159
Ewing Sarcoma with Novel Translocation t(2;16) Producing an In-Frame Fusion of FUS and FEV
Ng, T., O’Sullivan, M. J., Pallen, C. J., Hayes, M. M., Clarkson, P. W., Winstanley, M., Sorensen, P. H. B., Nielsen, T. O., & Horsman, D. E. (2007) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2007.070009 · Cited by 159
Self-citation
Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial
Harttrampf, A. C., Lacroix, L., Deloger, M., Deschamps, F., Puget, S., Auger, N., Vielh, P. R., Varlet, P., Balogh, Z., Abbou, S. D., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0381 · Cited by 155
A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature
Hancock, J. D., & Lessnick, S. L. (2008) · Cell Cycle · doi:10.4161/cc.7.2.5229 · Cited by 154
Current Treatment Protocols Have Eliminated the Prognostic Advantage of Type 1 Fusions in Ewing Sarcoma: A Report From the Children's Oncology Group
van Doorninck, J., Ji, L., Schaub, B., Shimada, H., Wing, M. R., Krailo, M., Lessnick, S. L., Marina, N. M., Triche, T. J., Sposto, R., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.5845 · Cited by 152
miR‐34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo‐sensitivity and malignancy
Nakatani, F., Ferracin, M., Manara, M. C., Ventura, S., Monaco, V. D., Ferrari, S., Alberghini, M., Grilli, A., Knuutila, S., Schaefer, K., et al. (2011) · The Journal of Pathology · doi:10.1002/path.3007 · Cited by 151
The ganglioside antigen GD2 is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting
Kailayangiri, S., Altvater, B., Meltzer, J., Pscherer, S., Luecke, A., Dierkes, C., Titze, U., Leuchte, K., Landmeier, S., Hotfilder, M., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.57 · Cited by 145
Self-citation
Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas?
Sannino, G., Marchetto, A., Kirchner, T., & Grünewald, T. G. P. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0032 · Cited by 145
Self-citation
Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS‐ERG and common pitfalls in detecting EWSR1‐ERG fusions by FISH
Chen, S. D., Denız, K., Sung, Y., Zhang, L., Dry, S., & Antonescu, C. R. (2015) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22336 · Cited by 141
Reverse Transcriptase PCR Amplification of EWS/FLI-1 Fusion Transcripts as a Diagnostic Test for Peripheral Primitive Neuroectodermal Tumors of Childhood
Sorensen, P. H. B., Liu, X. F., Delattre, O., Rowland, J. M., Biggs, C. A., Thomas, G. D., & Triche, T. J. (1993) · Diagnostic Molecular Pathology · doi:10.1097/00019606-199309000-00002 · Cited by 141
Self-citation
Significant Benefit of Multimodal Imaging: PET/CT Compared with PET Alone in Staging and Follow-up of Patients with Ewing Tumors
Gerth, H. U., Juergens, K. U., Dirksen, U., Gerss, J., Schober, O., & Franzius, C. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.045286 · Cited by 139
Self-citation
Rhabdomyosarcoma, Ewing Sarcoma, and Other Round Cell Sarcomas
Pappo, A. S., & Dirksen, U. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.74.7402 · Cited by 138
Self-citation
STEAP1 Is Associated with the Invasive and Oxidative Stress Phenotype of Ewing Tumors
Grünewald, T. G. P., Diebold, I., Esposito, I., Plehm, S., Hauer, K., Thiel, U., da Silva‐Buttkus, P., Neff, F., Unland, R., Müller‐Tidow, C., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0524 · Cited by 135
Self-citation
Impact of megatherapy in children with high-risk Ewing's tumours in complete remission: a report from the EBMT Solid Tumour Registry.
Ladenstein, R. L., Lasset, C., Pinkerton, R., Jm, Z., Peters, C., Burdach, S. E. G., Pardo, N., Dallorso, S., Coze, C., & Dollorso, G. (1995) · PubMed · Cited by 133
Stress-mediated translational control in cancer cells
Leprivier, G., Rotblat, B., Khan, D., Jan, E., & Sorensen, P. H. B. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.11.002 · Cited by 132
Self-citation
Impact of High-Dose Busulfan Plus Melphalan As Consolidation in Metastatic Ewing Tumors: A Study by the Société Française des Cancers de l'Enfant
Oberlin, O., Rey, A., Defachelles, A. S., Philip, T. O., Plantaz, D., Schmitt, C., Plouvier, E., Lejars, O., Rubie, H., Terrier, P., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.05.7059 · Cited by 131
Chromosomes in Ewing's sarcoma. II. Nonrandom additional changes, trisomy 8 and der(16)t(1;16)
Mugneret, F., Lizard, S., Aurias, A., & Turc‐Carel, C. (1988) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(88)90286-5 · Cited by 129
Expression of the EWS/FLI-1 Oncogene in Murine Primary Bone-Derived Cells Results in EWS/FLI-1–Dependent, Ewing Sarcoma–Like Tumors
Castillero-Trejo, Y., Eliazer, S., Xiang, L., Richardson, J. A., & Ilaria, R. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1704 · Cited by 129
BMI-1 Promotes Ewing Sarcoma Tumorigenicity Independent of CDKN2A Repression
Douglas, D. N., Hsu, J. H.-R., Hung, L. T., Cooper, A. R., Abdueva, D. A., van Doorninck, J., Peng, G. L., Shimada, H., Triche, T. J., & Lawlor, E. R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6152 · Cited by 129
Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol
Ferrari, S., Hall, K. S., Luksch, R., Tienghi, A., Wiebe, T., Fagioli, F., Alvegård, T. A., del Prever, A. B., Tamburini, A., Alberghini, M., et al. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq573 · Cited by 126
Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts
van der Lelij, P., Lieb, S., Jude, J., Wutz, G., Santos, C. P., Falkenberg, K. J., Schlattl, A., Ban, J., Schwentner, R., Hoffmann, T., et al. (2017) · eLife · doi:10.7554/elife.26980 · Cited by 124
Self-citation
A clinicopathologic study of 20 cases of large-cell (atypical) Ewingʼs sarcoma of bone
Nascimento, A. G., Unni, K. K., Pritchard, D. J., Cooper, K. L., & Dahlin, D. C. (1980) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198002000-00003 · Cited by 123
Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcriptionPreprint
Patel, M., Simon, J. M., Iglesia, M. D., Wu, S. B., McFadden, A. W., Lieb, J. D., & Davis, I. J. (2011) · Genome Research · doi:10.1101/gr.125666.111 · Cited by 120
Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Chest Wall
Shamberger, R. C., LaQuaglia, M. P., Gebhardt, M. C., Neff, J. R., Tarbell, N. J., Marcus, K. C., Sailer, S. L., Womer, R. B., Miser, J. S., Dickman, P. S., et al. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000089857.45191.52 · Cited by 118
Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancerPreprint
Bilke, S., Schwentner, R., Yang, F., Kauer, M. O., Jug, G., Walker, R. L., Davis, S. R., Zhu, Y. J., Pineda, M. A., Meltzer, P. S., et al. (2013) · Genome Research · doi:10.1101/gr.151340.112 · Cited by 118
Self-citation
MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research
Chang, W., Brohl, A. S., Patidar, R., Sindiri, S., Shern, J. F., Wei, J. S., Song, Y., Yohe, M. E., Gryder, B. E., Zhang, S., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2717 · Cited by 117
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma
Mackintosh, C., Ordóñez, J. L., García-Domínguez, D. J., Sevillano, V., Llombart‐Bosch, A., Szuhai, K., Scotlandi, K., Alberghini, M., Sciot, R., Sinnaeve, F., et al. (2011) · Oncogene · doi:10.1038/onc.2011.317 · Cited by 115
Self-citation
Adjuvant Immunotherapy to Improve Outcome in High-Risk Pediatric Sarcomas
Merchant, M. S., Bernstein, D. B., Amoako, M. O., Baird, K., Fleisher, T. A., Morre, M., Steinberg, S. M., Sabatino, M., Stroncek, D. F., Venkatasan, A. M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2550 · Cited by 115
Prognostic impact of chromosomal aberrations in Ewing tumours
Hattinger, C. M., Pötschger, U., Tarkkanen, M., Squire, J. A., Zieleńska, M., Kiuru‐Kuhlefelt, S., Kager, L., Thorner, P. S., Knuutila, S., Niggli, F. K., et al. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600332 · Cited by 113
EWS-FLI1 Suppresses NOTCH-Activated p53 in Ewing's Sarcoma
Ban, J., Bennani-Baı̈ti, I. M., Kauer, M., Schaefer, K., Poremba, C., Jug, G., Schwentner, R., Smrzka, O. W., Muehlbacher, K., Aryee, D. N. T., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6145 · Cited by 112
Self-citation
Late effects of chemotherapy and radiotherapy in osteosarcoma and Ewing sarcoma patients
Longhi, A., Ferrari, S., Tamburini, A., Luksch, R., Fagioli, F., Bacci, G., & Ferrari, C. (2012) · Cancer · doi:10.1002/cncr.27493 · Cited by 111
Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model
Minas, T. Z., Surdez, D., Javaheri, T., Tanaka, M., Howarth, M., Kang, H., Han, J. J., Han, Z., Sax, B., Kream, B. E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9388 · Cited by 111
Self-citation
Reaction to a diagnosis of breast cancer relationship between denial, delay and rates of psychological morbidity
Watson, M., Greer, S., Blake, S., & Shrapnell, K. (1984) · Cancer · doi:10.1002/1097-0142(19840501)53:9 · Cited by 110
High-Dose Therapy for Patients With Primary Multifocal and Early Relapsed Ewing’s Tumors: Results of Two Consecutive Regimens Assessing the Role of Total-Body Irradiation
Burdach, S. E. G., Meyer‐Bahlburg, A., Laws, H. ‐., Haase, R., van Kaick, B., Metzner, B., Wawer, A., Finke, R., Göbel, U., Haerting, J., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.12.039 · Cited by 107
Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: A children's oncology group study
Bagatell, R., Norris, R. E., Ingle, A. M., Ahern, C. H., Voss, S. D., Fox, E., Little, A., Weigel, B. J., Adamson, P. C., & Blaney, S. M. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24874 · Cited by 103
CD99: A Cell Surface Protein with an Oncojanus Role in Tumors
Manara, M. C., Pasello, M., & Scotlandi, K. (2018) · Genes · doi:10.3390/genes9030159 · Cited by 103
Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis
Marques, M. R., Simpson, D. R., Ngok, S. P., Nieves, B., Ron, C., Siprashvili, Z., Vaka, D., Breese, M. R., Crompton, B. D., Alexe, G., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72124 · Cited by 102
Genomic EWSR1 Fusion Sequence as Highly Sensitive and Dynamic Plasma Tumor Marker in Ewing Sarcoma
Krumbholz, M., Hellberg, J., Steif, B., Bäuerle, T., Gillmann, C., Fritscher, T., Agaimy, A., Frey, B., Juengert, J., Wardelmann, E., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3028 · Cited by 100
Self-citation
Vincristine, irinotecan, and temozolomide in patients with relapsed and refractory Ewing sarcoma
Raciborska, A., Bilska, K., Drabko, K. A., Chaber, R., Pogorzała, M., Wyrobek, E., Połczyńska, K., Rogowska, E., Galindo, C. R., & Wozniak, W. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24621 · Cited by 98
EWS-FLI1 Induces Developmental Abnormalities and Accelerates Sarcoma Formation in a Transgenic Mouse Model
Lin, P. P., Pandey, M. K., Jin, F., Xiong, S., Deavers, M. T., Parant, J. M., & Lozano, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0573 · Cited by 98
Primary metastatic Ewing's family tumors: results of the Italian Sarcoma Group and Scandinavian Sarcoma Group ISG/SSG IV Study including myeloablative chemotherapy and total-lung irradiation
Luksch, R., Tienghi, A., Hall, K. S., Fagioli, F., Picci, P., Barbieri, E., Gandola, L., Eriksson, M., Ruggieri, P., Daolio, P. A., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds117 · Cited by 98
A TARBP2-Dependent miRNA Expression Profile Underlies Cancer Stem Cell Properties and Provides Candidate Therapeutic Reagents in Ewing Sarcoma
Vito, C. D., Riggi, N., Buros, S. C., Suvà, M.-L., Baumer, K., Provero, P., & Stamenkovic, I. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.023 · Cited by 96
The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin
Ordóñez, J. L., Amaral, A. T., Carcaboso, A. M., Herrero‐Martín, D., García-Macías, M. D. C., Sevillano, V., Alonso, D., Pascual‐Pasto, G., San‐Segundo, L., Vilà-Ubach, M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4303 · Cited by 95
Ewingʼs sarcoma and peripheral primitive neuroectodermal tumors after their genetic union
Kovar, H. (1998) · Current Opinion in Oncology · doi:10.1097/00001622-199807000-00010 · Cited by 95
Self-citation
Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E.W.I.N.G group
Foulon, S., Brennan, B. M. D., Gaspar, N., Dirksen, U., Jeys, L. M., Cassoni, A. M., Claude, L., Seddon, B. M., Marec‐Bérard, P., Whelan, J. S., et al. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.03.075 · Cited by 95
Self-citation
A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma
Anderson, P. M., Bielack, S., Gorlick, R. G., Skubitz, K. M., Daw, N. C., Herzog, C. E., Monge, O. R., Lassaletta, Á., Boldrini, É., Pápai, Z., et al. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26087 · Cited by 95
Gene expression profiling of E wing sarcoma tumours reveals the prognostic importance of tumour–stromal interactions: a report from the C hildren's O ncology G roup
Volchenboum, S. L., Andrade, J., Huang, L., Barkauskas, D. A., Krailo, M., Womer, R. B., Ranft, A., Potratz, J. C., Dirksen, U., Triche, T. J., et al. (2015) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.9 · Cited by 94
Self-citation
Reduced human leukocyte antigen expression in advanced‐stage Ewing sarcoma: implications for immune recognition
Berghuis, D., de Hooge, A. S. K., Santos, S. J., Horst, D., Wiertz, E. J. H. J., van Eggermond, M. C. J. A., van den Elsen, P. J., Taminiau, A. H. M., Ottaviano, L., Schaefer, K., et al. (2009) · The Journal of Pathology · doi:10.1002/path.2537 · Cited by 94
Self-citation
Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma
Bán, J., Jug, G., Mestdagh, P., Schwentner, R., Kauer, M. O., Aryee, D. N. T., Schaefer, K.-L., Nakatani, F., Scotlandi, K., Reiter, M., et al. (2011) · Oncogene · doi:10.1038/onc.2010.581 · Cited by 93
Self-citation
Second malignancies after Ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study
Paulussen, M., Ahrens, S., Lehnert, M., Taeger, D., Hense, H., Wagner, A., Dunst, J., Harms, D., Reiter, A., Henze, G., et al. (2001) · Annals of Oncology · doi:10.1023/a:1013148730966 · Cited by 93
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model
Villasante, A., Marturano-Kruik, A., Ambati, S. R., Liu, Z., Godier-Furnémont, A., Parsa, H., Lee, B. W., Moore, M. A. S., & Vunjak‐Novakovic, G. (2016) · Theranostics · doi:10.7150/thno.13944 · Cited by 93
Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets
Baldauf, M. C., Orth, M. F., Dallmayer, M., Marchetto, A., Gerke, J. S., Rubío, R. A., Kıran, M. M., Musa, J., Knott, M. M. L., Ohmura, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20098 · Cited by 93
Self-citation
CIC – DUX 4 fusion‐positive round‐cell sarcomas of soft tissue and bone: a single‐institution morphological and molecular analysis of seven cases
Gambarotti, M., Benini, S., Gamberi, G., Cocchi, S., Palmerini, E., Sbaraglia, M., Donati, D. M., Picci, P., Vanel, D., Ferrari, S. M., et al. (2016) · Histopathology · doi:10.1111/his.12985 · Cited by 92
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repairPreprint
Leung, J. W. C., Makharashvili, N., Agarwal, P., Chiu, L.-Y., Pourpre, R., Cammarata, M. B., Cannon, J. R., Sherker, A., Durocher, D., Brodbelt, J. S., et al. (2017) · Genes & Development · doi:10.1101/gad.292516.116 · Cited by 92
Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States
Pedersen, E. A., Menon, R., Bailey, K. M., Thomas, D. G., Noord, R. A. V., Tran, J. N., Wang, H., Qü, P., Hoering, A., Fearon, E. R., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3422 · Cited by 90
A clinicopathologic study of 20 cases of large-cell (atypical) Ewingʼs sarcoma of bone
Nascimento, A. G., Unni, K. K., Pritchard, D. J., et al. (1980) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198004010-00003 · Cited by 90
ERBB4 confers metastatic capacity in Ewing sarcoma
Mendoza‐Naranjo, A., El-Naggar, A. M., Wai, D., Mistry, P., Lazic, N., Ayala, F. R. R., da Cunha, I. W., Rodriguez‐Viciana, P., Cheng, H., Fregnani, J. H. T. G., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202343 · Cited by 89
Self-citation
Ewing’s sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors
Tanaka, M., Yamazaki, Y., Kanno, Y., Igarashi, K., Aisaki, K., Kanno, J., & Nakamura, T. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72399 · Cited by 86
An evaluation of [F‐18]‐fluorodeoxy‐ D ‐glucose positron emission tomography, bone scan, and bone marrow aspiration/biopsy as staging investigations in Ewing Sarcoma
Newman, E. N., Jones, R. L., & Hawkins, D. S. (2012) · Pediatric Blood & Cancer · doi:10.1002/pbc.24406 · Cited by 86
Zoledronic Acid as a New Adjuvant Therapeutic Strategy for Ewing's Sarcoma Patients
Odri, G. A., Dumoucel, S., Picarda, G. G. A., Battaglia, S., Lamoureux, F., Corradini, N., Rousseau, J., Tirode, F., Laud, K., Delattre, O., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4272 · Cited by 84
Self-citation
Novel uses of immunohistochemistry in the diagnosis and classification of soft tissue tumors
Hornick, J. L. (2014) · Modern Pathology · doi:10.1038/modpathol.2013.177 · Cited by 83
Frequent inactivating germline mutations in DNA repair genes in patients with Ewing sarcoma
Brohl, A. S., Patidar, R., Turner, C., Wen, X., Song, Y., Wei, J. S., Calzone, K. A., & Khan, J. I. (2017) · Genetics in Medicine · doi:10.1038/gim.2016.206 · Cited by 83
Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth
Johnson, K. M., Mahler, N., Saund, R. S., Theisen, E. R., Taslim, C., Callender, N. W., Crow, J. C., Miller, K. R., & Lessnick, S. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701872114 · Cited by 83
Molecular Analysis of Ewing's Sarcoma: Another Fusion Gene, EWS‐E1AF, Available for Diagnosis
Urano, F., Umezawa, A., Yabe, H., Hong, W., Yoshida, K., Fujinaga, K., & Hata, J. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb03274.x · Cited by 82
A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP
Pagan, J. K., Arnold, J. M., Hanchard, K. J., Kumar, R., Bruno, T., Jones, M. V., Richard, D. J., Forrest, A. R. R., Spurdle, A. B., Verdin, E. M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700246200 · Cited by 81
Histone deacetylase inhibitors induce cell death and enhance the apoptosis-inducing activity of TRAIL in Ewing’s sarcoma cells
Sonnemann, J., Dreyer, L., Hartwig, M., Palani, C. D., Hong, L. T. T., Klier, U., Bröker, B. M., Völker, U., & Beck, J. F. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-007-0227-8 · Cited by 81
Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells
Üren, A., Merchant, M. S., Sun, C. J., Vitolo, M. I., Sun, Y., Tsokos, M., Illei, P. B., Ladanyi, M., Passaniti, A., Mackall, C. L., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206330 · Cited by 80
Molecular Diagnosis of Ewing Sarcoma Family of Tumors
Machado, I., Noguera, R., Pellı́n, A., López‐Guerrero, J. A., Piqueras, M., Navarro, S., & Llombart‐Bosch, A. (2009) · Diagnostic Molecular Pathology · doi:10.1097/pdm.0b013e3181a06f66 · Cited by 79
A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis
Leacock, S. W., Basse, A. N., Chandler, G. L., Kirk, A., Rakheja, D., & Amatruda, J. F. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007401 · Cited by 77
Longitudinal follow‐up of adult survivors of Ewing sarcoma: A report from the Childhood Cancer Survivor Study
Marina, N. M., Liu, Q., Donaldson, S. S., Sklar, C. A., Armstrong, G. T., Oeffinger, K. C., Leisenring, W. M., Ginsberg, J. P., Henderson, T. O., Neglia, J. P., et al. (2017) · Cancer · doi:10.1002/cncr.30627 · Cited by 77
Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: A study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group
Roberts, P., Burchill, S. A., Brownhill, S. C., Cullinane, C. J., Johnston, C., Griffiths, M., McMullan, D., Bown, N. P., Morris, S. P., & Lewis, I. J. (2007) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20523 · Cited by 76
Hypoxia Modulates EWS-FLI1 Transcriptional Signature and Enhances the Malignant Properties of Ewing's Sarcoma Cells In vitro
Aryee, D. N. T., Niedan, S., Kauer, M. O., Schwentner, R., Bennani-Baı̈ti, I. M., Ban, J., Muehlbacher, K., Kreppel, M., Walker, R. L., Meltzer, P. S., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4333 · Cited by 76
Self-citation
EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma
Cidre‐Aranaz, F., & Alonso, J. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00162 · Cited by 75
Self-citation
RARITY OF EWING'S SARCOMA AMONG U.S. NEGRO CHILDREN
Fraumeni, J., & Glass, A. (1970) · The Lancet · doi:10.1016/s0140-6736(70)90754-3 · Cited by 74
Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma
Chaturvedi, A. P., Hoffman, L. M., Jensen, C. C., Lin, Y.-C., Grossmann, A. H., Randall, R. L., Lessnick, S. L., Welm, A. L., & Beckerle, M. C. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-01-0007 · Cited by 73
EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma
Katschnig, A. M., Kauer, M. O., Schwentner, R., Tomazou, E. M., Mutz, C., Linder, M., Sibilia, M. C., Alonso, J., Aryee, D. N. T., & Kovar, H. (2017) · Oncogene · doi:10.1038/onc.2017.202 · Cited by 72
Self-citation
Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
Theisen, E. R., Pishas, K. I., Saund, R. S., & Lessnick, S. L. (2016) · Oncotarget · doi:10.18632/oncotarget.7124 · Cited by 70
The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis
Sechler, M., Parrish, J. K., Birks, D. K., & Jedlicka, P. (2017) · Oncogene · doi:10.1038/onc.2017.44 · Cited by 70
First identification of Ewing's sarcoma‐derived extracellular vesicles and exploration of their biological and potential diagnostic implications
Miller, I. V., Raposo, G., Welsch, U., da Costa, O. P., Thiel, U., Lebar, M., Maurer, M., Bender, H., von Luettichau, I., Richter, G., et al. (2013) · Biology of the Cell · doi:10.1111/boc.201200086 · Cited by 69
Self-citation
Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma
Ban, J., Aryee, D. N. T., Fourtouna, A., van der Ent, W., Kauer, M., Niedan, S., Machado, I., Galindo, C. R., Tirado, Ò. M., Schwentner, R., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1736 · Cited by 68
Self-citation
Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma
Gangwal, K., Close, D., Enriquez, C. A., Hill, C. P., & Lessnick, S. L. (2010) · Genes & Cancer · doi:10.1177/1947601910361495 · Cited by 67
PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway
Engert, F., Schneider, C., Weiβ, L. M., Probst, M., & Fulda, S. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0587 · Cited by 67
Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma
Hensel, T., Giorgi, C., Schmidt, O., Calzada‐Wack, J., Neff, F., Buch, T., Niggli, F. K., Schäfer, B. W., Burdach, S. E. G., & Richter, G. H. S. (2015) · Oncotarget · doi:10.18632/oncotarget.6385 · Cited by 67
Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1–PI3K–Rac1 pathway
Kamura, S., Matsumoto, Y., Fukushi, J.-I., Fujiwara, T., Iida, K.-I., Okada, Y., & Iwamoto, Y. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605775 · Cited by 66
Fractures in Pediatric Ewing Sarcoma
Wagner, L. M., Neel, M. D., Pappo, A. S., Merchant, T. E., Poquette, C. A., Rao, B. N., & Galindo, C. R. (2001) · The American journal of pediatric hematology/oncology · doi:10.1097/00043426-200112000-00003 · Cited by 66
Inhibition of the oncogenic fusion protein EWS-FLI1 causes G 2 -M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma
Zöllner, S. K., Selvanathan, S. P., Graham, G. T., Commins, R., Hong, S. H., Moseley, E., Parks, S. E., Haladyna, J. N., Erkizan, H. V., Dirksen, U., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aam8429 · Cited by 66
Self-citation
Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, “undifferentiated small round cell tumors”. A clinicopathologic, immunophenotypic and molecular analysis
Machado, I., Yoshida, A., Nieto, G., Abrahão‐Machado, L. F., Navarro, S., Cruz, J., Lavernia, J., Parafioriti, A., Picci, P., & Llombart‐Bosch, A. (2017) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2017.11.011 · Cited by 66
ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma
Wiles, E. T., Bell, R. N., Thomas, D. B., Beckerle, M. C., & Lessnick, S. L. (2013) · Genes & Cancer · doi:10.1177/1947601913506115 · Cited by 64
Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrow
DuBois, S. G., Epling, C. L., Teague, J., Matthay, K. K., & Sinclair, E. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22245 · Cited by 63
DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma
Hauer, K., Calzada‐Wack, J., Steiger, K., Grünewald, T. G. P., Baumhoer, D., Plehm, S., Buch, T., da Costa, O. P., Esposito, I., Burdach, S. E. G., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1492 · Cited by 63
Self-citation
Definitive Radiotherapy for Ewing Tumors of Extremities and Pelvis: Long-Term Disease Control, Limb Function, and Treatment Toxicity
Indelicato, D. J., Keole, S. R., Shahlaee, A. H., Shi, W., Morris, C. G., & Marcus, R. B. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.02.023 · Cited by 62
Carboplatin in the treatment of Ewing sarcoma: Results of the first Brazilian Collaborative Study Group for Ewing Sarcoma Family Tumors-EWING1
Brunetto, A. L., Castillo, L. A., Petrilli, A. S., Macedo, C. D., Boldrini, É., da Costa, C. M. L., de Almeida, M. T. A., Kirst, D., Galindo, C. R., Pereira, W. V., et al. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25562 · Cited by 61
The value of high‐dose chemotherapy in patients with first relapsed Ewing sarcoma
Rasper, M., Jabar, S., Ranft, A., Jürgens, H., Amler, S., & Dirksen, U. (2014) · Pediatric Blood & Cancer · doi:10.1002/pbc.25042 · Cited by 61
Self-citation
A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells
Girnita, L., Girnita, A., Wang, M., Meis‐Kindblom, J. M., Kindblom, L., & Larsson, O. (2000) · Oncogene · doi:10.1038/sj.onc.1203755 · Cited by 61
Local Control in Ewing Sarcoma of the Chest Wall: Results of the EURO-EWING 99 Trial
Bedetti, B., Wiebe, K., Ranft, A., Aebert, H., Schmidt, J., Jürgens, H., & Dirksen, U. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4630-0 · Cited by 59
Self-citation
G‐Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1
Richter, G. H. S., Fasan, A., Hauer, K., Grünewald, T. G. P., Berns, C., Rössler, S., Naumann, I., Staege, M. S., Fulda, S., Esposito, I., et al. (2013) · The Journal of Pathology · doi:10.1002/path.4170 · Cited by 57
Self-citation
Stress-Induced CXCR4 Promotes Migration and Invasion of Ewing Sarcoma
Krook, M. A., Nicholls, L. A., Scannell, C. A., Chugh, R. K., Thomas, D. G., & Lawlor, E. R. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0668 · Cited by 57
Impact of IGF-I/IGF-IR Circuit on the Angiogenetic Properties of Ewing’s Sarcoma Cells
Strammiello, R., Benini, S., Manara, M. C., Perdichizzi, S., Serra, M., Spisni, E., Picci, P., & Scotlandi, K. (2003) · Hormone and Metabolic Research · doi:10.1055/s-2004-814149 · Cited by 57
Racial Differences in the Incidence of Mesenchymal Tumors Associated with EWSR1 Translocation
Worch, J., Cyrus, J., Goldsby, R. E., Matthay, K. K., Neuhaus, J. M., & DuBois, S. G. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-1170 · Cited by 56
Pilot Trial of FANG Immunotherapy in Ewing's Sarcoma
Ghisoli, M. L., Barve, M. A., Schneider, R., Mennel, R. G., Lenarsky, C., Wallraven, G., Pappen, B. O., LaNoue, J., Kumar, P., Nemunaitis, D., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.43 · Cited by 54

Research works printed but not linked: 8

Ewing, J. Diffuse endothelioma of bone. Proc. N. Y. Pathol. Soc. 21, 17 (1921).
Lessnick, S. L., Braun, B. S., Denny, C. T. & May, W. A. Multiple domains mediate transformation by the Ewing’s sarcoma EWS/FLI-1 fusion gene. Oncogene 10, 423–431 (1995).
Ohno, T., Rao, V. N. & Reddy, E. S. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res. 53, 5859–5863 (1993).
Pizzo, P. A. & Poplack, D. G. (eds) Principles and Practice of Pediatric Oncology 7th edn (Lippincott Wililiams & Wilkins, Philadelphia, 2015).
ESMO/European Sarcoma Network Working Group. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 25 (Suppl 3), iii113–iii123 (2014).
Machado, I., López-Guerrero, J. A., Scotlandi, K., Picci, P. & Llombart-Bosch, A. Immunohistochemical analysis and prognostic significance of PD-L1, PD-1, and CD8+ tumor-infiltrating lymphocytes in Ewing’s sarcoma family of tumors (ESFT). Virchows Arch. Int. J. Pathol. 472, 815–824 (2018).
Wang, Y. X. et al. Inhibiting platelet-derived growth factor beta reduces Ewing’s sarcoma growth and metastasis in a novel orthotopic human xenograft model. In Vivo 23, 903–909 (2009).
Bhan, A. & Mandal, S. S. LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer. Biochim. Biophys. Acta 1856, 151–164 (2015).

Sorted by citations

A framework for understanding the functions of biomolecular condensates across scales
Lyon, A. S., Peeples, W. B., & Rosen, M. K. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00303-z · Cited by 895
Bone sarcomas: ESMO-PaedCan-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up.
Casali, P. G., Bielack, S., Abecassis, N., Aro, H. T., Bauer, S., Biagini, R., Bonvalot, S., Boukovinas, I., Bovee, J. V. M. G., Brennan, B., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy310 · Cited by 617
Current advance of nanotechnology in diagnosis and treatment for malignant tumors
Wang, B., Hu, S., Teng, Y., Chen, J., Wang, H., Xu, Y., Wang, K., Xu, J., Cheng, Y., & Gao, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01889-y · Cited by 641
Ewing’s Sarcoma
Riggi, N., Suvà, M. L., & Stamenkovic, I. (2021) · New England Journal of Medicine · doi:10.1056/nejmra2028910 · Cited by 374
Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
Zöllner, S. K., Amatruda, J. F., Bauer, S., Collaud, S., de Álava, E., DuBois, S. G., Hardes, J., Hartmann, W., Kovar, H., Metzler, M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081685 · Cited by 292
Self-citation

See all 880

Authors: Grünewald, T. G. P., Cidre-Aranaz, F., Surdez, D., Tomazou, E. M., de Álava, E., Kovar, H., Sorensen, P. H., Delattre, O., & Dirksen, U.
Affiliations: German Cancer Research Center (DE)
Inserm (FR)
St. Anna Children's Cancer Research Institute (AT)
University of British Columbia (CA)
Corresponding author: Grünewald, Thomas G. P.
ORCID: Grünewald, Thomas G. P.
Surdez, Didier
Tomazou, Eleni M.
Kovar, Heinrich
Sorensen, Poul H.
Delattre, Olivier
Dirksen, Uta
Venue: Nature Reviews Disease Primers
Publisher: Springer Science and Business Media LLC
Published: 2018-07-05
Volume: 4
Issue: 1
Pages: 5-5
ISSN: 2056-676X (ISSN-L)
DOI: 10.1038/s41572-018-0003-x
OpenAlex: W4211227438
Cited by: 873
References: 250
Citations by year: 2026: 114 · 2025: 155 · 2024: 104 · 2023: 103 · 2022: 158 · 2021: 115 · 2020: 66 · 2019: 49 · 2018: 8
FWCI: 10.61
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Disease Primers (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Keywords: Ewing sarcoma, EWSR1-FLI1 fusion, CD99, epigenetic reprogramming, STAG2 mutation, TP53 mutation, CDKN2A deletion, treatment toxicity, cancer survivorship, soft tissue sarcoma
MeSH terms: 12E7 Antigen, Humans, Neoplasm Metastasis, Quality of Life, Radiography, Risk Factors, Sarcoma, Ewing, RNA-Binding Protein EWS, Proto-Oncogene Protein c-fli-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ewing sarcoma

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks