Kinase inhibition in autoimmunity and inflammation

Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C

Flores-Contreras, L., Sandoval-Rodriguez, A. S., Múgica, M. M. M., Lucano‐Landeros, S., Arellano-Olivera, I., Álvarez-Álvarez, A., Parada, M. G. S., & Armendáriz‐Borunda, J. (2014) · BMC Gastroenterology · doi:10.1186/1471-230x-14-131 · Cited by 79

TPL2 kinase action and control of inflammation

Xu, D., Matsumoto, M. L., McKenzie, B. S., & Zarrin, A. A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.031 · Cited by 78

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

Hrdinka, M., Schlicher, L., Dai, B., Pinkas, D. M., Bufton, J. C., Picaud, S., Ward, J. A., Rogers, C., Suebsuwong, C., Nikhar, S., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201899372 · Cited by 78

Inhibitors of BTK and ITK : State of the New Drugs for Cancer, Autoimmunity and Inflammatory Diseases

Vargas, L., Hamasy, A., Nore, B. F., & Smith, C. I. E. (2013) · Scandinavian Journal of Immunology · doi:10.1111/sji.12069 · Cited by 77

Fostamatinib for Persistent/Chronic Adult Immune Thrombocytopenia

Newland, A. C., Lee, E., McDonald, V., & Bussel, J. B. (2017) · Immunotherapy · doi:10.2217/imt-2017-0097 · Cited by 77

Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease

Cameron, B., Tse, W., Lamb, R., Li, X., Lamb, B. T., & Landreth, G. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1729-12.2012 · Cited by 76

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice

Hasan, M., Dobbs, N., Khan, S., White, M. A., Wakeland, E. K., Li, Q., & Yan, N. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500162 · Cited by 76

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

Cushing, L., Winkler, A. R., Jelinsky, S. A., Lee, K. L., Korver, W., Hawtin, R. E., Rao, V. R., Fleming, M. M., & Lin, L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.796912 · Cited by 76

A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4

Alsina, L., Israelsson, E., Altman, M. C., Dang, K. K., Ghandil, P., Israël, L., von Bernuth, H., Baldwin, N. E., Qin, H., Jin, Z., et al. (2014) · Nature Immunology · doi:10.1038/ni.3028 · Cited by 75

Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

Dudhgaonkar, S. P., Ranade, S., Nagar, J., Subramani, S., Prasad, D. S., Karunanithi, P., Srivastava, R., Venkatesh, K., Selvam, S., Krishnamurthy, P., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600583 · Cited by 74

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells

Johannessen, L. H., Sundberg, T. B., O'Connell, D. J., Kolde, R., Berstler, J., Billings, K., Khor, B., Seashore-Ludlow, B. A., Fassl, A., Russell, C. N., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2458 · Cited by 73

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell–associated damage in IFNα-driven lupus nephritis

Katewa, A., Wang, Y., Hackney, J. A., Huang, T., Suto, E., Ramamoorthi, N., Austin, C. D., Bremer, M. C. D., Chen, J. Z., Crawford, J. J., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.90111 · Cited by 72

Safety of combination therapy with two bDMARDs in patients with rheumatoid arthritis: A systematic review and meta-analysis

Boleto, G., Kanagaratnam, L., Dramé, M., & Salmon, J. (2018) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2018.12.003 · Cited by 72

Inhibition of Signaling Through the B Cell Antigen Receptor by the Protooncogene Product, c-Cbl, Requires Syk Tyrosine 317 and the c-Cbl Phosphotyrosine-Binding Domain

Yankee, T. M., Keshvara, L. M., Sawasdikosol, S., Harrison, M. L., & Geahlen, R. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.5827 · Cited by 70

Essential Role of p38γ in K-Ras Transformation Independent of Phosphorylation

Tang, J., Qi, X.-M., Mercola, D., Han, J., & Chen, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500699200 · Cited by 68

A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of 2 Dosing Regimens of Fostamatinib in Patients with Rheumatoid Arthritis with an Inadequate Response to a Tumor Necrosis Factor-α Antagonist

Genovese, M. C., van der Heijde, D. M. F. M., Keystone, E. C., et al. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.140238 · Cited by 67

Conditional Deletion of NF-κB–Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation

Brightbill, H. D., Jackman, J. K., Suto, E., Kennedy, H., Jones, C., Chalasani, S., Lin, Z., Tam, L., Roose-Girma, M., Balázs, M., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401514 · Cited by 65

ERK5 Is a Critical Mediator of Inflammation-Driven Cancer

Finegan, K. G., Madrigal, D. P., Hitchin, J. R., Davies, C. C., Jordan, A. M., & Tournier, C. (2015) · Cancer Research · doi:10.1158/0008-5472.can-13-3043 · Cited by 63

Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses

Li, Y., Wang, H., Zhou, X., Xie, X., Chen, X. '., Jie, Z., Zou, Q., Hu, H., Zhu, L., Cheng, X., et al. (2016) · Scientific Reports · doi:10.1038/srep22115 · Cited by 63

Ubiquitin-Specific Protease 2b Negatively Regulates IFN-β Production and Antiviral Activity by Targeting TANK-Binding Kinase 1

Zhang, L., Zhao, X., Zhang, M., Zhao, W., & Gao, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302634 · Cited by 62

A Controlled Clinical Trial With Pirfenidone in the Treatment of Pathological Skin Scarring Caused by Burns in Pediatric Patients

Armendáriz‐Borunda, J., Lyra-González, I., Medina-Preciado, D., Gonzalez-García, I., Martínez‐Fong, D., Miranda-Altamirano, R. A., Magaña-Castro, R., Peña-Santoyo, P., García-Rocha, S., Bautista, C. A., et al. (2011) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e31821b6d08 · Cited by 61

Cofactors Required for TLR7- and TLR9-Dependent Innate Immune Responses

Chiang, C.-Y., Engel, A., Opaluch, A. M., Ramos, I., Maestre, A. M., Secundino, I., Jesus, P. D. D., Nguyen, Q., Welch, G. L., Bonamy, G. M. C., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.02.002 · Cited by 60

Distinct Roles for the Linker Region Tyrosines of Syk in FcϵRI Signaling in Primary Mast Cells

Simon, M., Vanes, L., Geahlen, R. L., & Tybulewicz, V. L. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410326200 · Cited by 59

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

Senger, K., Pham, V. C., Varfolomeev, E. E., Hackney, J. A., Corzo, C. A., Collier, J. L., Lau, V. W. C., Huang, Z., Hamidzadeh, K., Caplazi, P., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aah4273 · Cited by 59

Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care

Gillooly, K. M., Pulicicchio, C. M., Pattoli, M. A., Cheng, L., Skala, S., Heimrich, E., McIntyre, K. W., Taylor, T. L., Kukral, D. W., Dudhgaonkar, S. P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181782 · Cited by 59

BTK inhibition is a potent approach to block IgE‐mediated histamine release in human basophils

Smiljkovic, D., Blatt, K., Stefanzl, G., Dorofeeva, Y., Skrabs, C., Focke‐Tejkl, M., Sperr, W. R., Jaeger, U., Valenta, R., & Valent, P. (2017) · Allergy · doi:10.1111/all.13166 · Cited by 58

Turning the Tide Against Regulatory T Cells

Han, S., Toker, A., Liu, Z. Q., & Ohashi, P. S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00279 · Cited by 58

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Jones, P., Storer, R. I., Sabnis, Y. A., Wakenhut, F., Whitlock, G. A., England, K. S., MUKAIYAMA, T., Dehnhardt, C. M., Coe, J. W., Kortum, S. W., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01634 · Cited by 57

Tyrosine Phosphorylation and Activation of Bruton Tyrosine Kinase upon FceRI Cross-Linking

Kawakami, Y., Yao, L., Miura, T., Tsukada, S., Witte, O. N., & Kawakami, T. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5108-5113.1994 · Cited by 57

Baricitinib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Janus Kinases

Mayence, A., & Eynde, J. J. V. (2019) · Pharmaceuticals · doi:10.3390/ph12010037 · Cited by 56

Dual B Cell Immunotherapy Is Superior to Individual Anti‐CD20 Depletion or BAFF Blockade in Murine Models of Spontaneous or Accelerated Lupus

Lin, W., Seshasayee, D., Lee, W. P., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38907 · Cited by 54

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1

Nanda, S. K., López‐Peláez, M., Arthur, J. S. C., Marchesi, F., & Cohen, P. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600788 · Cited by 54

Inhibition of Cdk8/Cdk19 Activity Promotes Treg Cell Differentiation and Suppresses Autoimmune Diseases

Guo, Z., Wang, G., Lv, Y., Wan, Y. Y., & Zheng, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01988 · Cited by 54

RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation

Charron, C. E., Russell, P., Ito, K., Lea, S., Kizawa, Y., Brindley, C., & Singh, D. (2017) · European Respiratory Journal · doi:10.1183/13993003.00188-2017 · Cited by 53

Btk inhibition treats TLR7/IFN driven murine lupus

Bender, A. T., Pereira, A., Fu, K., Samy, E. T., Wu, Y., Liu‐Bujalski, L., Caldwell, R. D., Chen, Y.-Y., Tian, H., Morandi, F., et al. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.01.012 · Cited by 52

Dendritic cells require NIK for CD40-dependent cross-priming of CD8 + T cells

Katakam, A. K., Brightbill, H. D., Franci, C., Kung, C., Núñez, V., Jones, C., Peng, I., Jeet, S., Wu, L. C., Mellman, I., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520627112 · Cited by 51

Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis

Ozaki, N., Suzuki, S., Ishida, M., Harada, Y., Tanaka, K., Sato, Y., Kono, T., Kubo, M., Kitamura, D., Encinas, J., et al. (2012) · International Immunology · doi:10.1093/intimm/dxs078 · Cited by 49

Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts

Mina, E. D., Borghesi, A., Zhou, H., Bougarn, S., Boughorbel, S., Israël, L., Meloni, I., Chrabieh, M., Ling, Y., Itan, Y., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620139114 · Cited by 47

Alternative p38 MAPKs Are Essential for Collagen‐Induced Arthritis

Criado, G., Risco, A., Alsina‐Beauchamp, D., Pérez-Lorenzo, M. J., Escós, A., & Cuenda, A. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38327 · Cited by 46

Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling

De, S., Karim, F., Kiessu, E., Cushing, L., Lin, L.-L., Ghandil, P., Hoarau, C., Casanova, J., Puel, A., & Rao, V. R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003831 · Cited by 46

Beyond Ruxolitinib: Fedratinib and Other Emergent Treatment Options for Myelofibrosis

Bewersdorf, J. P., Jaszczur, S. M., Afifi, S., Zhao, J. C., & Zeidan, A. M. (2019) · Cancer Management and Research · doi:10.2147/cmar.s212559 · Cited by 46

Pirfenidone gel in patients with localized scleroderma: a phase II study

RODRÍGUEZ-CASTELLANOS, M. A., Tlacuilo‐Parra, A., Sánchez‐Enríquez, S., et al. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0510-4 · Cited by 43

Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation

Rekhter, M. D., Staschke, K. A., Estridge, T. B., Rutherford, P., Jackson, N. K., Gifford‐Moore, D. S., FOXWORTHY, P. S., Reidy, C. A., Huang, X.-D., Kalbfleisch, M. J., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.186 · Cited by 42

Genetic interferonopathies: An overview

Eleftheriou, D., & Brogan, P. A. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.12.002 · Cited by 41

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

Corzo, C. A., Varfolomeev, E. E., Setiadi, A., Francis, R., Klabunde, S., Senger, K., Sujatha-Bhaskar, S., Drobnick, J., Do, S., Suto, E., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aaz1053 · Cited by 41

Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation

Wilhelmsen, K., Xu, F., Farrar, K., Tran, A., Khakpour, S., Sundar, S. V., Prakash, A., Wang, J., Gray, N. S., & Hellman, J. (2015) · Science Signaling · doi:10.1126/scisignal.aaa3206 · Cited by 40

Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase

Chalmers, S. A., Doerner, J., Bosanac, T., Khalil, S. D. S., Smith, D. M., Harcken, C., Dimock, J., Der, E. B., Herlitz, L., Webb, D., et al. (2016) · Scientific Reports · doi:10.1038/srep26164 · Cited by 40

Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells

Wang, J., Lau, K., Jung, J., Ravindran, P., & Barrat, F. J. (2013) · European Journal of Immunology · doi:10.1002/eji.201344030 · Cited by 39

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

Sun, Y., Peng, I., Webster, J. D., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aab0949 · Cited by 39

Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trials

Kunwar, S., Devkota, A. R., & Ghimire, D. K. C. (2016) · Rheumatology International · doi:10.1007/s00296-016-3482-7 · Cited by 39

Filgotinib, a JAK1 Inhibitor, Modulates Disease-Related Biomarkers in Rheumatoid Arthritis: Results from Two Randomized, Controlled Phase 2b Trials

Tarrant, J. M., Galien, R., Li, W., Goyal, L., Pan, Y., Hawtin, R. E., Zhang, W., der Aa, A. V., & Taylor, P. C. (2020) · Rheumatology and Therapy · doi:10.1007/s40744-019-00192-5 · Cited by 38

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

Webster, J. D., Kwon, Y. C., Park, S., Zhang, H., Corr, N., Ljumanovic, N., Adedeji, A. O., Varfolomeev, E. E., Goncharov, T., Preston, J., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma1219-398r · Cited by 38

Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase

Sriskantharajah, S., Gückel, E., Tsakiri, N., Kierdorf, K., Brender, C., Ben-Addi, A., Veldhoen, M., Tsichlis, P. N., Stockinger, B., O’Garra, A., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300172 · Cited by 37

IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

Zhou, H., Bulek, K., Li, X., Herjan, T., Yu, M., Qian, W., Wang, H., Zhou, G., Chen, X., Yang, H., et al. (2017) · eLife · doi:10.7554/elife.29630 · Cited by 37

The Interleukin-1 Receptor-Associated Kinase M Selectively Inhibits the Alternative, Instead of the Classical NFκB Pathway

Su, J., Zhang, T., Tyson, J. J., et al. (2008) · Journal of Innate Immunity · doi:10.1159/000158541 · Cited by 33

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α

Flannery, S. M., Keating, S. E., Szymak, J., & Bowie, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248351 · Cited by 33

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

Dengler, H. S., Wu, X., Peng, I., Rinderknecht, C. H., Kwon, Y. C., Suto, E., Kohli, P. B., Liimatta, M. B., Barrett, K., Lloyd, J., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao2151 · Cited by 33

p38 Mitogen-Activated Protein Kinase Inhibitors: A Review on Pharmacophore Mapping and QSAR Studies

Gangwal, R. P., Bhadauriya, A., Damre, M. V., et al. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611313090005 · Cited by 23

FDA approves first-in-class SYK inhibitor

Mullard, A. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.96 · Cited by 22

Deficiency in IRAK4 activity attenuates manifestations of murine Lupus

Murphy, M., Pattabiraman, G., Manavalan, T. T., & Medvedev, A. E. (2017) · European Journal of Immunology · doi:10.1002/eji.201646641 · Cited by 21

On the origin of transformative drugs

Mullard, A. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.95 · Cited by 19

Species-specific TLR signalling — insight into human disease

Perkins, D. J., & Vogel, S. N. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.36 · Cited by 17

TPL2 meets p38MAPK: emergence of a novel positive feedback loop in inflammation

Menon, M., & Gaestel, M. (2016) · Biochemical Journal · doi:10.1042/bcj20160672c · Cited by 16

Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus

Luk, A. D. W., Ni, K., Wu, Y., Lam, K.-T., Chan, K. W., Lee, P. P. W., Tu, W., Mao, H., & Lau, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01826 · Cited by 13

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700614 · Cited by 11

Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ

Kondoh, Y., Honda, K., Hiranuma, S., et al. (2016) · Scientific Reports · doi:10.1038/srep29881 · Cited by 10

Intestinal Myofibroblast-Specific Tpl2-Cox-2-Pge2 Pathway Links Innate Sensing To Epithelial Homeostasis

Roulis, M., Nikolaou, C., Kotsaki, E., et al. (2017) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.291416 · Cited by 10

Specific delivery of kinase inhibitors in nonmalignant and malignant diseases

van Beuge, M. M., Poelstra, K., & Prakash, J. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.638625 · Cited by 5

THU0055 TPL2 INHIBITION SUPPRESSES MEK-ERK INFLAMMATORY SIGNALING AND PROINFLAMMATORY CYTOKINE PRODUCTION IN PRIMARY HUMAN MONOCYTES

Warr, M. R., Hammond, A., Park, G. S. H., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-eular.2512 · Cited by 1

PROTAC targeted protein degraders: the past is prologue

Békés, M., Langley, D. R., & Crews, C. M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00371-6 · Cited by 3,395

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Ahern, D. J., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., Angus, B., Ansari, M. A., Arancibia-Cárcamo, C. V., Aschenbrenner, D., Attar, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.012 · Cited by 328

BLNK mediates Syk-dependent Btk activation

Baba, Y., Hashimoto, S., Matsushita, M., Watanabe, D., Kishimoto, T., Kurosaki, T., & Tsukada, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051626198 · Cited by 148

Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets

Zhang, P., Solari, F. A., Heemskerk, J. W. M., Kuijpers, M. J. E., Sickmann, A., Walter, U., & Jurk, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097776 · Cited by 10

Development of a Pharmacodynamic Assay Based on PLCγ2 Phosphorylation for Quantifying Spleen Tyrosine Kinase (SYK)–Bruton’s Tyrosine Kinase (BTK) Signaling

Hsu, J., Zhang, J., Kitson, C., et al. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113489881 · Cited by 2

Tyrosine Kinase Inhibitors (TKIs) Targeting Syk and BTK Signaling Differentially Affect PI3K Signalosome Organization and Platelet Function

Zheng, T. J., Lofurno, E. R., Elgamal, S., et al. (2019) · Blood · doi:10.1182/blood-2019-129066 · Cited by 1

Potential applications of Bruton’s tyrosine kinase inhibitors for the prevention of allergic reactions

Dispenza, M. C., Regan, J. A., & Bochner, B. S. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1370374 · Cited by 22