The DOI matches its Crossref record; 238 of the 242 references it cites were found in a registry or an index.
Melatonin in type 2 diabetes mellitus and obesity
Abstract
Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus (T2DM) remain two major challenges for public health systems globally. In the past 9 years, genome-wide association studies (GWAS) have established a major role for genetic variation within the MTNR1B locus in regulating fasting plasma levels of glucose and in affecting the risk of T2DM. This discovery generated a major interest in the melatonergic system, in particular the melatonin MT 2 receptor (which is encoded by MTNR1B). In this Review, we discuss the effect of melatonin and its receptors on glucose homeostasis, obesity and T2DM. Preclinical and clinical post-GWAS evidence of frequent and rare variants of the MTNR1B locus confirmed its importance in regulating glucose homeostasis and T2DM risk with minor effects on obesity. However, these studies did not solve the question of whether melatonin is beneficial or detrimental, an issue that will be discussed in the context of the peculiarities of the melatonergic system. Melatonin receptors might have therapeutic potential as they belong to the highly druggable G protein-coupled receptor superfamily. Clarifying the precise role of melatonin and its receptors on glucose homeostasis is urgent, as melatonin is widely used for other indications, either as a prescribed medication or as a supplement without medical prescription, in many countries in Europe and in the USA.
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“This difference might be partly due to the 3.5-fold higher melatonin concentrations, as supported by our earlier trial in which acute melatonin administration impaired glucose tolerance and in vitro b-cell experiments showing decreased insulin secretion due to melatonin (10,11,18,28).”
From Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [28]
In the citing paper
“Notably, the common intronic gain-of-function variant rs10830963 G in MTNR1B shows the strongest association among known single nucleotide polymorphisms with elevated fasting glucose and impaired insulin secretion (6,7)”
From Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant (2026) · cites this paper as [6]
In the citing paper
“The common melatonin receptor 1B gene (MTNR1B) variant increases risk of type 2 diabetes”
From Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant (2026) · cites this paper as [6]
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Metadata
- Authors
- Karamitri, A., & Jockers, R.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Jockers, Ralf
- Venue
- Nature Reviews Endocrinology
- Published
- 2018-12-07
- Volume
- 15
- Issue
- 2
- Pages
- 105-125
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2904409392
- Cited by
- 268
- References
- 242
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 35 · 2023: 44 · 2022: 41 · 2021: 42 · 2020: 45 · 2019: 18 · 2018: 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-META-0003, ANR-11-BSV1-0012)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- melatonin, type 2 diabetes, obesity, MTNR1B, MT2 receptor, glucose homeostasis, genetic variants, G protein-coupled receptors, melatonin supplementation, diabetes risk
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Female, Gene Expression Regulation, Glucose, Homeostasis, Humans, Male, Melatonin, Mutation, Obesity, RNA, Messenger, Genetic Variation, Signal Transduction, Receptor, Melatonin, MT2, Mice, Genome-Wide Association Study
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