Cited by 271Circadian rhythm and melatoninRegulation of Appetite and ObesityPancreatic function and diabetes

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Melatonin in type 2 diabetes mellitus and obesity

Karamitri, Angeliki, Jockers, Ralf·2019·Nature Reviews Endocrinology

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Abstract

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus (T2DM) remain two major challenges for public health systems globally. In the past 9 years, genome-wide association studies (GWAS) have established a major role for genetic variation within the MTNR1B locus in regulating fasting plasma levels of glucose and in affecting the risk of T2DM. This discovery generated a major interest in the melatonergic system, in particular the melatonin MT 2 receptor (which is encoded by MTNR1B). In this Review, we discuss the effect of melatonin and its receptors on glucose homeostasis, obesity and T2DM. Preclinical and clinical post-GWAS evidence of frequent and rare variants of the MTNR1B locus confirmed its importance in regulating glucose homeostasis and T2DM risk with minor effects on obesity. However, these studies did not solve the question of whether melatonin is beneficial or detrimental, an issue that will be discussed in the context of the peculiarities of the melatonergic system. Melatonin receptors might have therapeutic potential as they belong to the highly druggable G protein-coupled receptor superfamily. Clarifying the precise role of melatonin and its receptors on glucose homeostasis is urgent, as melatonin is widely used for other indications, either as a prescribed medication or as a supplement without medical prescription, in many countries in Europe and in the USA.

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Authors: Karamitri, A., & Jockers, R.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Jockers, Ralf
ORCID: Karamitri, Angeliki
Jockers, Ralf
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2018-12-07
Volume: 15
Issue: 2
Pages: 105-125
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-018-0130-1
OpenAlex: W2904409392
Cited by: 268
References: 242
Citations by year: 2026: 19 · 2025: 23 · 2024: 35 · 2023: 44 · 2022: 41 · 2021: 42 · 2020: 45 · 2019: 18 · 2018: 1
FWCI: 3.71
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Agence Nationale de la Recherche (ANR-11-META-0003, ANR-11-BSV1-0012)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: melatonin, type 2 diabetes, obesity, MTNR1B, MT2 receptor, glucose homeostasis, genetic variants, G protein-coupled receptors, melatonin supplementation, diabetes risk
MeSH terms: Animals, Diabetes Mellitus, Type 2, Female, Gene Expression Regulation, Glucose, Homeostasis, Humans, Male, Melatonin, Mutation, Obesity, RNA, Messenger, Genetic Variation, Signal Transduction, Receptor, Melatonin, MT2, Mice, Genome-Wide Association Study

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Melatonin in type 2 diabetes mellitus and obesity

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