The G protein-coupled oestrogen receptor GPER in health and disease: an update

Mechanisms of Estradiol-induced EGF-like Factor Expression and Oocyte Maturation via G Protein-coupled Estrogen Receptor

Zhang, H., Lu, S., Xu, R., Tang, Y., Liu, J., Li, C., Wei, J., Yao, R., Zhao, X., Wei, Q., et al. (2020) · Endocrinology · doi:10.1210/endocr/bqaa190 · Cited by 43

Activation of Estrogen Receptor G Protein–Coupled Receptor 30 Enhances Cholesterol Cholelithogenesis in Female Mice

Wang, H. H., de Bari, O., Arnatt, C. K., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2020) · Hepatology · doi:10.1002/hep.31212 · Cited by 43

GPER agonist dilates mesenteric arteries via PI3K-Akt-eNOS and potassium channels in both sexes

Peixoto, P., Aires, R. D., Lemos, V. S., Bissoli, N. S., & dos Santos, R. L. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.06.020 · Cited by 42

Proteolytic Targeting Chimeras with Specificity for Plasma Membrane and Intracellular Estrogen Receptors

Lu, A. S., Rouhimoghadam, M., Arnatt, C. K., Filardo, E. J., & Salem, A. K. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00018 · Cited by 40

Next-Generation Endocrine Therapies for Breast Cancer

McDonnell, D. P., Wardell, S. E., Chang, C., & Norris, J. D. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.03565 · Cited by 40

Improving clinical outcomes through attention to sex and hormones in research

Mielke, M. M., & Miller, V. M. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00531-z · Cited by 40

G protein-coupled estrogen receptor activation improves contractile and diastolic functions in rat renal interlobular artery to protect against renal ischemia reperfusion injury

Chang, Y.-C., Han, Z., Zhang, Y., Zhou, Y., Feng, Z., Chen, L., Li, X., Li, L., & Si, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108666 · Cited by 40

Additive effects of low concentrations of estradiol-17β and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways

Pang, Y., & Thomas, P. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.06.014 · Cited by 40

G-Protein-Coupled Estrogen Receptor Agonist Suppresses Airway Inflammation in a Mouse Model of Asthma through IL-10

Itoga, M., Konno, Y., Moritoki, Y., Saito, Y., Ito, W., Tamaki, M., Kobayashi, Y., Kayaba, H., Kikuchi, Y., Chihara, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123210 · Cited by 39

G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity

Meyer, M. R., Fredette, N. C., Barton, M., & Prossnitz, E. R. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0257 · Cited by 39

Expression of G protein-coupled estrogen receptor in irritable bowel syndrome and its clinical significance.

Qin, B. Y., Dong, L., Guo, X., Jiang, J., He, Y.-X., Wang, X., Li, L., & Zhao, J. (2014) · PubMed Central · Cited by 38

Activation of GPER ameliorates experimental pulmonary hypertension in male rats

Alencar, A. K. N., Montes, G. C., Montagnoli, T. L., Silva, A. M., Martinez, S. T., Fraga, A. G. M., Wang, H., Groban, L., Sudo, R. T., & Zapata‐Sudo, G. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.11.009 · Cited by 38

GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior

Zheng, Y., Wu, M., Gao, T., Li, M., Ding, X., Meng, Y., Jiao, Y., Luo, P., He, Z., Sun, T., et al. (2020) · Neural Plasticity · doi:10.1155/2020/8866187 · Cited by 37

Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance

Jiao, Y., Gao, P., Li, D., Ding, X., Meng, Y., Qian, J., Gao, T., Wang, R., Jiang, T., Zhang, Y., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154588 · Cited by 37

4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells

Li, Y., Chen, Y., Zhu-xia, Z., Liu, X., Yang, L., Wan, L., Lei, T., & Wang, X. (2013) · Toxicology · doi:10.1016/j.tox.2013.04.012 · Cited by 36

Icariin attenuates high glucose‐induced type IV collagen and fibronectin accumulation in glomerular mesangial cells by inhibiting transforming growth factor‐β production and signalling through G protein‐coupled oestrogen receptor 1

Li, Y., Ding, X., Li, H., & Zhang, C. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12143 · Cited by 36

Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen

Seifert, H. A., Benedek, G., Nguyen, H., Kent, G., Vandenbark, A. A., & Offner, H. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0063-8 · Cited by 36

GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after cerebral ischemia/reperfusion injury

Han, Z., Chang, Y.-C., Zhou, Y., Zhang, H., Chen, L., Zhang, H., Si, J., & Li, L. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.251571 · Cited by 36

G protein-coupled estrogen receptor-1 agonist induces chemotherapeutic effect via ER stress signaling in gastric cancer

Lee, S., Kim, T. W., Park, G. L., Hwang, Y. S., Cho, H. J., Kim, J.-T., & Lee, H. G. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.11.007 · Cited by 35

A Series of Indole-Thiazole Derivatives Act as GPER Agonists and Inhibit Breast Cancer Cell Growth

O’Dea, A. T., Sondergard, C., Sweeney, P. R., & Arnatt, C. K. (2018) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.8b00212 · Cited by 35

PERIPHERAL VASCULAR ACTION OF ESTROGEN IN THE HUMAN MALE 1

Reynolds, S. R. M., & Foster, F. I. (1939) · Journal of Clinical Investigation · doi:10.1172/jci101080 · Cited by 34

The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism

Tian, L., Shao, W., Ip, W., Song, Z., Badakhshi, Y., & Jin, T. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000444 · Cited by 34

Genistein improves viability, proliferation and mitochondrial function of cardiomyoblasts cultured in physiologic and peroxidative conditions

Farruggio, S., Raina, G., Cocomazzi, G., Librasi, C., Mary, D., Gentilli, S., & Grossini, E. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4365 · Cited by 33

Activation of G protein–coupled estrogen receptor protects intestine from ischemia/reperfusion injury in mice by protecting the crypt cell proliferation

Chai, S., Liu, K., Feng, W., Liu, T., Wang, Q., Zhou, R., Chen, S., Wang, L., Chen, G., Ming, T., et al. (2019) · Clinical Science · doi:10.1042/cs20180919 · Cited by 32

The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells

Ribeiro, M. P. C., Santos, A. E., & Custódio, J. B. A. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.09.017 · Cited by 31

Role of estrogens in fish immunity with special emphasis on GPER1

Cabas, I., Chaves-Pozo, E., Mulero, V., & Ayala, A. G. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.08.001 · Cited by 31

GPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin

Triplett, K. D., Pokhrel, S., Castleman, M. J., Daly, S. M., Elmore, B. O., Joyner, J. A., Sharma, G., Herbert, G., Campen, M. J., Hathaway, H. J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37951-3 · Cited by 31

Aldosterone-induced hypertension is sex-dependent, mediated by T cells and sensitive to GPER activation

Dinh, Q. N., Vinh, A., Kim, H. A., Saini, N., Broughton, B. R. S., Chrissobolis, S., Diep, H., Judkins, C. P., Drummond, G. R., & Sobey, C. G. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa075 · Cited by 31

G Protein-Coupled Receptor 30 (GPR30) Expression Pattern in Inflammatory Bowel Disease Patients Suggests its Key Role in the Inflammatory Process. A Preliminary Study

Włodarczyk, M., Sobolewska-Włodarczyk, A., Cygankiewicz, A. I., Jacenik, D., Piechota-Polańczyk, A., & Stec‐Michalska, K. (2017) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld.2014.1121.261.gpr · Cited by 31

NLRP3 inhibition improves heart function in GPER knockout mice

Wang, H., Sun, X., Hodge, H. S., Ferrario, C. M., & Groban, L. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.045 · Cited by 31

Neonatal cardiomyocyte hypertrophy induced by endothelin-1 is blocked by estradiol acting on GPER

Gonçalves, G. K. N., Scalzo, S., Alves, A. P., Agero, U., Guatimosim, S., & dos Reis, A. M. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00060.2017 · Cited by 30

GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer

Cirillo, F., PELLEGRINO, M. A., Malivindi, R., Rago, V., Avino, S., Muto, L., Dolce, V., Vivacqua, A., Rigiracciolo, D. C., Marco, P. D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22541 · Cited by 30

The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries

Yu, X., Stallone, J. N., Heaps, C. L., & Han, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191418 · Cited by 30

Differential vasoactive effects of oestrogen, oestrogen receptor agonists and selective oestrogen receptor modulators in rat middle cerebral artery

Patkar, S., Farr, T. D., Cooper, E., Dowell, F. J., & Carswell, H. V. O. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.05.006 · Cited by 29

A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice

DeLeon, C., Wang, H. H., Gunn, J., Wilhelm, M., Cole, A., Arnett, S. D., Wang, D. Q. ‐., & Arnatt, C. K. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000592 · Cited by 29

The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines

Niro, S., Pereira, E., Pélissier, M. A., Morfin, R. F., & Hennebert, O. (2012) · Steroids · doi:10.1016/j.steroids.2012.01.019 · Cited by 28

Nox1 downregulators: A new class of therapeutics

Barton, M., Meyer, M. R., & Prossnitz, E. R. (2019) · Steroids · doi:10.1016/j.steroids.2019.108494 · Cited by 28

Exploiting off-target effects of estrogen deprivation to sensitize estrogen receptor negative breast cancer to immune killing

Wolfson, B., Padget, M. R., Schlom, J., & Hodge, J. W. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002258 · Cited by 28

Tamoxifen and ICI 182,780 negatively influenced cardiac cell growth via an estrogen receptor-independent mechanism

Mercier, I. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00517-0 · Cited by 28

The protective role of G protein-coupled estrogen receptor 1 (GPER-1) on methotrexate-induced nephrotoxicity in human renal epithelium cells

Kurt, A. H., Bozkuş, F., Üremiş, N., & Üremi̇ş, M. M. (2016) · Renal Failure · doi:10.3109/0886022x.2016.1155398 · Cited by 27

GPER blockers as Nox downregulators: A new drug class to target chronic non-communicable diseases

Meyer, M. R., & Barton, M. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.03.019 · Cited by 27

Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension

Alencar, A. K. N., Montes, G. C., Costa, D. G., Mendes, L. V. P., Silva, A. M. S., Martinez, S. T., Trachez, M. M., Cunha, V. D. M. N., Montagnoli, T. L., Fraga, A. G. M., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly068 · Cited by 27

Why do women with melanoma do better than men?

Smalley, K. S. (2018) · eLife · doi:10.7554/elife.33511 · Cited by 27

17β-Estradiol inhibits cardiac fibroblast growth through both subtypes of estrogen receptor

Watanabe, T., Akishita, M., He, H., Miyahara, Y., Nagano, K., Nakaoka, T., Yamashita, N., Kozaki, K., & Ouchi, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.232 · Cited by 27

Rapid actions of aldosterone revisited: Receptors in the limelight

Wehling, M. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.01.016 · Cited by 26

Ligand-Independent G Protein–Coupled Estrogen Receptor/G Protein–Coupled Receptor 30 Activity: Lack of Receptor-Dependent Effects of G-1 and 17β-Estradiol

Tutzauer, J., de Valdivia, E. G., Swärd, K., Eilard, I. A., Broselid, S., Kahn, R., Olde, B., & Leeb-Lundberg, L. M. F. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000259 · Cited by 26

Activation of the G Protein–Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell

Wang, Q., Zhao, L., Liu, K., Liu, J., Chai, S., Chen, G., Wen, S., Ming, T., Wang, J., Ma, Y., et al. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000216 · Cited by 26

G15 sensitizes epithelial breast cancer cells to doxorubicin by preventing epithelial-mesenchymal transition through inhibition of GPR30.

Liu, Y., Du, F.-Y., Chen, W., Fu, P.-F., Yao, M., & Zheng, S.-S. (2015) · Europe PMC (PubMed Central) · Cited by 25

Aldosterone Stimulates Its Biosynthesis Via a Novel GPER-Mediated Mechanism

Caroccia, B., Seccia, T. M., Piazza, M., Prisco, S., Zanin, S., Iacobone, M., Lenzini, L., Pallafacchina, G., Domening, O., Poglitsch, M., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00043 · Cited by 24

Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate

Yue, J., Wang, X., Feng, B., Hu, L., Yang, L.-K., Lu, L., Zhang, K., Wang, Y., & Liu, S. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00287 · Cited by 24

27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer

Avena, P., Casaburi, I., Zavaglia, L., Nocito, M. C., Padula, D. L., Rago, V., Dong, J., Thomas, P., Mineo, C., Sirianni, R., et al. (2022) · Cancers · doi:10.3390/cancers14061521 · Cited by 24

Nicolaus Copernicus and the rapid vascular responses to aldosterone

Barton, M., & Meyer, M. R. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.05.005 · Cited by 24

GPER-1 expression is associated with a decreased response rate to primary tamoxifen therapy of breast cancer patients

Ignatov, T., Treeck, O., Kalinski, T., Ortmann, O., & Ignatov, A. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-019-05384-6 · Cited by 24

E2-BSA and G1 exert neuroprotective effects and improve behavioral abnormalities following traumatic brain injury: The role of classic and non-classic estrogen receptors

Amirkhosravi, L., Khaksari, M., Soltani, Z., Esmaeili‐Mahani, S., Karam, G. A., & Hoseini, M. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147168 · Cited by 23

Chronic Estrogen Supplementation Prevents the Increase in Blood Pressure in Female Intrauterine Growth-Restricted Offspring at 12 Months of Age

Davis, G. K., Newsome, A. D., Cole, A. B., Ojeda, N. B., & Alexander, B. T. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12379 · Cited by 22

G protein-coupled estrogen receptor is involved in the neuroprotective effect of IGF-1 against MPTP/MPP+-induced dopaminergic neuronal injury

Yuan, L.-J., Wang, X., Wang, H.-T., Zhang, M., Sun, J., & Chen, W. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105384 · Cited by 22

S -Equol, a Major Isoflavone from Soybean, Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated Rat Astrocytes Partially via the GPR30-Mediated Pathway

Moriyama, M., Hashimoto, A., Satoh, H., Kawabe, K., Mizue, O., Takano, K., & Nakamura, Y. (2018) · International Journal of Inflammation · doi:10.1155/2018/8496973 · Cited by 21

Selective activation of estrogen receptors, ERα and GPER-1, rapidly decreases food intake in female rats

Butler, M. J., Hildebrandt, R. P., & Eckel, L. A. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.018 · Cited by 21

Activation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats

Gohar, E. Y., Almutlaq, R. N., Daugherty, E. M., Butt, M. K., Jin, C., Pollock, J. S., Pollock, D. M., & Miguel, C. D. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00267.2020 · Cited by 21

A Conversation with Elwood Jensen

Moore, D. D. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153327 · Cited by 21

The G protein–coupled estrogen receptor agonist, G‐1, attenuates BK channel activation in cerebral arterial smooth muscle cells

Evanson, K. W., Goldsmith, J. A., Ghosh, P., & Delp, M. D. (2018) · Pharmacology Research & Perspectives · doi:10.1002/prp2.409 · Cited by 21

Screening and Survival Analysis of Hub Genes in Gastric Cancer Based on Bioinformatics

Zheng, S., Yang, L., Dai, Y., Jiang, L., Wei, Y., Wen, H., & Xu, Y. (2019) · Journal of Computational Biology · doi:10.1089/cmb.2019.0119 · Cited by 21

Regulation of beta adrenoceptor-mediated myocardial contraction and calcium dynamics by the G protein-coupled estrogen receptor 1

Whitcomb, V., Wauson, E., Christian, D., Clayton, S., Giles, J. R., & Tran, Q. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113727 · Cited by 21

Mechanism of GPER promoting proliferation, migration and invasion of triple-negative breast cancer cells through CAF.

Yang, K., & Yao, Y. (2019) · PubMed Central · Cited by 20

A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling

Revankar, C. M., Bologa, C., Pepermans, R. A., Sharma, G., Petrie, W. K., Alcon, S. N., Field, A. S., Ramesh, C., Parker, M. A., Savchuk, N., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.10.009 · Cited by 20

GPER Mediates Functional Endothelial Aging in Renal Arteries

Meyer, M. R., Rosemann, T. J., Barton, M., & Prossnitz, E. R. (2017) · Pharmacology · doi:10.1159/000478732 · Cited by 19

The antidepressant and anxiolytic effect of GPER on translocator protein (TSPO) via protein kinase a (PKA) signaling in menopausal female rats

Wang, J., Li, H., Shen, S.-Y., Zhang, J., Liang, L., Huang, H., Li, B., Wu, G.-C., Zhang, Y., & Yu, J. M. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105807 · Cited by 19

Heart Failure With Preserved Ejection Fraction in Women

Barton, M., & Meyer, M. R. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.02.001 · Cited by 19

Contribution of GPR30 for 1,25 dihydroxyvitamin D3 protection in EAE

Subramanian, S., Miller, L., Grafe, M. R., Vandenbark, A. A., & Offner, H. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9266-6 · Cited by 18

Phase 1b study of the novel first-in-class G protein-coupled estrogen receptor (GPER) agonist, LNS8801, in combination with pembrolizumab in patients with immune checkpoint inhibitor (ICI)-relapsed and refractory solid malignancies and dose escalation update.

Muller, C. Y., Chaney, M. F., Cohen, J. V., Garyantes, T. K., Lin, J. J., LoRusso, P. M., Mita, A. C., Mita, M. M., Natale, C. A., Orloff, M. M., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.2022.40.16_suppl.2574 · Cited by 17

Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein–Coupled Estrogen Receptor 1

Gohar, E. Y., & Pollock, D. M. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000322 · Cited by 16

Estradiol mediates relaxation of porcine lower esophageal sphincter

Tsai, C., Tey, S., Chang, L.-C., Su, Y., Lin, K.-J., & Huang, S. (2018) · Steroids · doi:10.1016/j.steroids.2018.05.001 · Cited by 16

Phase 1 trial of a novel, first-in-class G protein-coupled estrogen receptor (GPER) agonist, LNS8801, in patients with advanced or recurrent treatment-refractory solid malignancies.

Muller, C. Y., Brown-Glaberman, U. A., Chaney, M. F., Garyantes, T. K., LoRusso, P. M., McQuade, J. L., Mita, A. C., Mita, M. M., Natale, C. A., Orloff, M. M., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.3084 · Cited by 16

GPER is required for the age-dependent upregulation of the myocardial endothelin system

Meyer, M. R., Fredette, N. C., Sharma, G., Barton, M., & Prossnitz, E. R. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.041 · Cited by 15

THE CHEMICAL NATURE OF EMMENIN

Collip, J. B., Browne, J. S. L., & Thomson, D. L. (1934) · Endocrinology · doi:10.1210/endo-18-1-71 · Cited by 15

Estradiol stimulates cell proliferation via classic estrogen receptor-alpha and G protein-coupled estrogen receptor-1 in human renal tubular epithelial cell primary cultures

Sánchez, D. S., Sigel, L. K. F., Azurmendi, P. J., Vlachovsky, S. G., Oddo, E. M., Armando, I., Ibarra, F. R., & Silberstein, C. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.056 · Cited by 14

Overexpression of estrogen receptor GPER1 and G1 treatment reduces SARS-CoV-2 infection in BEAS-2B bronchial cells

Costa, A. J., Lemes, R. M. R., Bartolomeo, C. S., Nunes, T. A., Pereira, G. C., Oliveira, R. B., Gomes, A. L., Smaili, S. S., Maciel, R. M. B., Newson, L. R., et al. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111775 · Cited by 14

The G protein-coupled estrogen receptor (GPER) regulates recognition and aversively–motivated memory in male rats

de Souza, L. O., Machado, G. D. B., de Freitas, B. S., Rodrigues, S. L. C., Severo, M. P. A., Molz, P., da Silva, J. A. C., Bromberg, E., Roesler, R., & Schröder, N. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107499 · Cited by 13

Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia

Morelli, E., Hunter, Z. R., Fulciniti, M., Gullà, A., Perrotta, I. D., Zuccalà, V., Federico, C., Juli, G., Manzoni, M., Ronchetti, D., et al. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00305-x · Cited by 13

MicroRNA‐2861 and microRNA‐5115 regulates myocardial ischemia–reperfusion injury through the GPR30/mTOR signaling pathway by binding to GPR30

Zhu, L., Li, Q., Li, Q., Qi, D., Gao, C., & Yang, H. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29427 · Cited by 13

The G-Protein-Coupled Estrogen Receptor Agonist Prevents Cardiac Lipid Accumulation by Stimulating Cardiac Peroxisome Proliferator-Activated Receptor α: A Preclinical Study in Ovariectomized-Diabetic Rat Model

Jafarynezhad, F., Shahbazian, M., Farhadi, Z., Yadeghari, M., Rezvani, M. E., Safari, F., & Azizian, H. (2022) · Intern J Endocrinol Metab · doi:10.5812/ijem-123560 · Cited by 11

Effects of certain 19-nor steroids on reproductive processes and fertility.

Pincus, G., Rock, J. A., Chang, M. C., & García, C.-R. (1959) · PubMed · Cited by 11

MiR-155-Mediated Deregulation of GPER1 Plays an Important Role in the Gender Differences Related to Inflammatory Bowel Disease

Shao, X., Li, J., Xu, F., Chen, D., & Liu, K. (2020) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2020/8811477 · Cited by 11

Multiplex G Protein–Coupled Receptor Screen Reveals Reliably Acting Agonists and a Gq-Phospholipase C Coupling Mode of GPR30/GPER1

Urban, N. D., Leonhardt, M., & Schaefer, M. (2022) · Molecular Pharmacology · doi:10.1124/molpharm.122.000580 · Cited by 11

A hypertension patient-derived iPSC model demonstrates a role for G protein-coupled estrogen receptor in hypertension risk and development

Fredette, N. C., Malik, E., Mukhtar, M., Prossnitz, E. R., & Terada, N. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00350.2019 · Cited by 10

The pharmacological actions of diethyl‐stilboestrol and other oestrogenic and non‐oestrogenic substances

Dawson, R. F., & Robson, J. M. (1939) · The Journal of Physiology · doi:10.1113/jphysiol.1939.sp003739 · Cited by 9

Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway

Zhou, C., Li, P., Han, M., & Gao, X. (2020) · Animal Biotechnology · doi:10.1080/10495398.2020.1842749 · Cited by 9

Stress-related arterial hypertension in Gper-deficient rats.

Luo, P., Wu, M., Gao, P., Gao, T., Li, D., Ding, X., Meng, Y., Qian, J., Zhang, G., & Rong, W. (2017) · PubMed · Cited by 8

Eplerenone inhibits oxidized low-density lipoprotein-induced proliferation and migration of vascular smooth muscle cells by downregulating GPER expression

Wang, D., Wang, M., Sun, P., & Gao, Q. (2021) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/133484 · Cited by 6

G protein-coupled estrogen receptor GPR30 exerts vasoprotective effects in apolipoprotein E-deficient mice

Jehle, J., Becher, U. M., Nöthel, M., Adler, S., Groll, K., Nickenig, G., & Tiyerili, V. (2021) · Archives of Medical Science · doi:10.5114/aoms/127200 · Cited by 3

Abstract P607: Deletion of GPER Protects from Age-related Renovascular Dysfunction and Tubulo-interstitial Injury

Meyer, M. R., Daniel, C., Fredette, N. C., Amann, K., Barton, M., & Prossnitz, E. R. (2015) · Hypertension · doi:10.1161/hyp.66.suppl_1.p607 · Cited by 1

Abstract P261: GPER is Required for Age-dependent Albuminuria and Glomerulosclerosis: Evidence for its Role in Podocyte Injury and Mesangial Nox1 Regulation

Meyer, M. R., Daniel, C., Woods, C. D., Sharma, G., Fredette, N. C., Amann, K., Barton, M., & Prossnitz, E. R. (2018) · Hypertension · doi:10.1161/hyp.72.suppl_1.p261 · Cited by 1

Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments

Hsu, S.-H., Chen, L.-R., & Chen, K.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212139 · Cited by 105

Identification, structure, and agonist design of an androgen membrane receptor

Yang, Z., Ping, Y.-Q., Wang, M., Zhang, C., Zhou, S., Xi, Y.-T., Zhu, K., Ding, W., Zhang, Q., Song, Z.-C., et al. (2025) · Cell · doi:10.1016/j.cell.2025.01.006 · Cited by 74

Treating ER-positive breast cancer: a review of the current FDA-approved SERMs and SERDs and their mechanisms of action

Kim, N., & Lukong, K. E. (2025) · Oncology Reviews · doi:10.3389/or.2025.1564642 · Cited by 73

Estrogen-immuno-neuromodulation disorders in menopausal depression

Zhang, Y., Tan, X., & Tang, C. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03152-1 · Cited by 76

From physiology to pathology: Emerging roles of GPER in cardiovascular disease

Wang, Z., Liu, J., Chen, Y., Tang, Y., Chen, T., Zhou, C. S., Wang, S., Chang, R., Chen, Z., Yang, W., et al. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108801 · Cited by 57

The G-protein-coupled estrogen receptor GPER in health and disease

Prossnitz, E. R., & Barton, M. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.122 · Cited by 925

Estrogen biology: New insights into GPER function and clinical opportunities

Prossnitz, E. R., & Barton, M. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.02.002 · Cited by 404

G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications

Arterburn, J. B., & Prossnitz, E. R. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-031122-121944 · Cited by 114

Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER

Barton, M. (2016) · Steroids · doi:10.1016/j.steroids.2016.02.016 · Cited by 57

GPER–novel membrane oestrogen receptor

Zimmerman, M. A., Budish, R. A., Kashyap, S. N., & Lindsey, S. H. (2016) · Clinical Science · doi:10.1042/cs20160114 · Cited by 114