The DOI matches its Crossref record; 227 of the 227 references it cites were found in a registry or an index.
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead
Open accessAbstract
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune destruction of pancreatic β cells, leading to a disruption in glucose homeostasis. Therapeutic intervention for T1DM requires a complex regimen of glycaemic monitoring and the administration of exogenous insulin to regulate blood glucose levels. Advances in continuous glucose monitoring and algorithm-driven insulin delivery devices have improved the quality of life of patients. Despite this, mimicking islet function and complex physiological feedback remains challenging. Pancreatic islet transplantation represents a potential functional cure for T1DM but is hindered by donor scarcity, variability in harvested cells, aggressive immunosuppressive regimens and suboptimal clinical outcomes. Current research is directed towards generating alternative cell sources, improving transplantation methods, and enhancing cell survival without chronic immunosuppression. This Review maps the progress in cell replacement therapies for T1DM and outlines the remaining challenges and future directions. We explore the state-of-the-art strategies for generating replenishable β cells, cell delivery technologies and local targeted immune modulation. Finally, we highlight relevant animal models and the regulatory aspects for advancing these technologies towards clinical deployment.
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“One approach is to use encapsulation within devices that exclude immune cells from direct interaction with transplanted cells, 73 which is a bioengineering challenge for which high oxygen tension is required.”
From The future of type 1 diabetes therapy (2025) · cites this paper as [73]
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Cites
International Diabetes Federation 2017
Carracher, A. M., Marathe, P. H., & Close, K. L. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12644 · Cited by 13,379
Alginate: Properties and biomedical applications
Lee, K. Y., & Mooney, D. J. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.06.003 · Cited by 8,477
Generation of Functional Human Pancreatic β Cells In Vitro
Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025
Self-citationProduction of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913
Efficient differentiation of human embryonic stem cells to definitive endoderm
D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730
Muller, P. A. J., & Vousden, K. H. (2013) · Nature Cell Biology · doi:10.1038/ncb2641 · Cited by 1,647
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575
Humanized mice in translational biomedical research
Shultz, L. D., Ishikawa, F., & Greiner, D. L. (2007) · Nature reviews. Immunology · doi:10.1038/nri2017 · Cited by 1,393
Laurent, L. C., Ulitsky, I., Slavin, I., Tran, H., Schork, A., Morey, R., Lynch, C., Harness, J. V., Lee, S., Barrero, M. J., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.003 · Cited by 890
Streptozotocin‐Induced Diabetic Models in Mice and Rats
Furman, B. L. (2021) · Current Protocols · doi:10.1002/cpz1.78 · Cited by 887
Research works printed but not linked: 2
- Sernova Corp. Sernova provides recap of 2023 accomplishments and anticipated 2024 milestones. Sernova Corp www.sernova.com/press/release/?id=388 (2024).
- Sohni, A. & Verfaillie, C. M. Mesenchymal stem cells migration homing and tracking. Stem Cell Int. 2013, 130763 (2013).
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Self-citationThe future of type 1 diabetes therapy
Ziegler, A.-G., Cengiz, E., & Kay, T. W. H. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01438-2 · Cited by 42
Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets
Kim, M., Cho, S., Hwang, D. G., Shim, I. K., Kim, S. C., Jang, J., & Jang, J. (2025) · Nature Communications · doi:10.1038/s41467-025-56665-5 · Cited by 32
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease
Hu, X., Beauchesne, P. R., Wang, C., Wong, A. W., Deuse, T., & Schrepfer, S. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.07.009 · Cited by 20
Role of the Pancreatic Islet Microvasculature in Health and Disease
Aplin, A. C., Aghazadeh, Y., Mohn, O. G., & Hull, R. L. (2024) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554241299862 · Cited by 21
Metadata
- Authors
- Grattoni, A., Korbutt, G., Tomei, A. A., García, A. J., Pepper, A. R., Stabler, C., Brehm, M., Papas, K., Citro, A., Shirwan, H., Millman, J. R., Melero-Martin, J., Graham, M., Sefton, M., Ma, M., Kenyon, N., Veiseh, O., Desai, T. A., Nostro, M. C., Marinac, M., Sykes, M., Russ, H. A., Odorico, J., Tang, Q., Ricordi, C., Latres, E., Mamrak, N. E., Giraldo, J., Poznansky, M. C., & de Vos, P.
- Affiliations
- Houston Methodist (US)
- University of Alberta (CA)
- University of Miami (US)
- University of Florida (US)
- University of Massachusetts Chan Medical School (US)
- University of Arizona (US)
- IRCCS Ospedale San Raffaele (IT)
- University of Missouri (US)
- Washington University in St. Louis (US)
- University of Minnesota (US)
- University of Toronto (CA)
- Cornell University (US)
- University of California, San Francisco (US)
- University Health Network (CA)
- Breakthrough T1D (US)
- Columbia University (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University Medical Center Groningen (NL)
- Corresponding author
- Grattoni, Alessandro
- Giraldo, Jaime
- Poznansky, Mark C.
- de Vos, Paul
- ORCID
- Grattoni, Alessandro
- Korbutt, Gregory
- Tomei, Alice A.
- García, Andrés J.
- Pepper, Andrew R.
- Stabler, Cherie
- Brehm, Michael
- Papas, Klearchos
- Citro, Antonio
- Shirwan, Haval
- Millman, Jeffrey R.
- Melero-Martin, Juan
- Graham, Melanie
- Sefton, Michael
- Ma, Minglin
- Kenyon, Norma
- Veiseh, Omid
- Desai, Tejal A.
- Nostro, M. Cristina
- Marinac, Marjana
- Sykes, Megan
- Russ, Holger A.
- Odorico, Jon
- Tang, Qizhi
- Ricordi, Camillo
- Latres, Esther
- Mamrak, Nicholas E.
- Giraldo, Jaime
- Poznansky, Mark C.
- de Vos, Paul
- Venue
- Nature Reviews Endocrinology
- Published
- 2024-09-03
- Volume
- 21
- Issue
- 1
- Pages
- 14-30
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC11938328
- OpenAlex
- W4402197225
- Cited by
- 92
- References
- 227
- Citations by year
- 2026: 42 · 2025: 47 · 2024: 3
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Edward Mallinckrodt, Jr. Foundation
- Diabetes Research Connection
- Canada Research Chairs
- Ministero della Salute (2018-)
- National Institutes of Health (SCR_014393, 1uc4dk104218-01)
- National Institute of Diabetes and Digestive and Kidney Diseases (UC4-DK-104218, R01DK120444, UC24 DK104162, SCR_014393, U01DK104218, DK104162, R01 DK12044, R01DK132104, U24DK104162, R01DK114233, R01DK133610, R01DK133702, R01DK128840, R01DK132387)
- National Institute of Neurological Disorders and Stroke (R01NS122911)
- Breakthrough T1D Canada (5-CDA-2020-945-A-N, 2-SRA-2021-1079-S-B, 1-SRA-2022-1229-S-B, 5-SRA-2020-1058-S-B)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 1 diabetes, islet transplantation, cell therapy, beta cell regeneration, immunosuppression, continuous glucose monitoring, insulin delivery devices, animal models of diabetes, regulatory approval
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Humans, Islets of Langerhans Transplantation, Insulin-Secreting Cells, Cell- and Tissue-Based Therapy
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