Cited by 92Pancreatic function and diabetesDiabetes and associated disordersDiabetes Management and Research

The DOI matches its Crossref record; 227 of the 227 references it cites were found in a registry or an index.

Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

Open access

Grattoni, Alessandro, Korbutt, Gregory, Tomei, Alice A., García, Andrés J., Pepper, Andrew R., Stabler, Cherie, Brehm, Michael, Papas, Klearchos, Citro, Antonio, Shirwan, Haval, Millman, Jeffrey R., Melero-Martin, Juan, Graham, Melanie, Sefton, Michael, Ma, Minglin, Kenyon, Norma, Veiseh, Omid, Desai, Tejal A., Nostro, M. Cristina, Marinac, Marjana, Sykes, Megan, Russ, Holger A., Odorico, Jon, Tang, Qizhi, Ricordi, Camillo, Latres, Esther, Mamrak, Nicholas E., Giraldo, Jaime, Poznansky, Mark C., de Vos, Paul·2025·Nature Reviews Endocrinology

DOI 10.1038/s41574-024-01029-0PMC PMC11938328

Open this paper in CoChat — free account Open PDF

Abstract

Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune destruction of pancreatic β cells, leading to a disruption in glucose homeostasis. Therapeutic intervention for T1DM requires a complex regimen of glycaemic monitoring and the administration of exogenous insulin to regulate blood glucose levels. Advances in continuous glucose monitoring and algorithm-driven insulin delivery devices have improved the quality of life of patients. Despite this, mimicking islet function and complex physiological feedback remains challenging. Pancreatic islet transplantation represents a potential functional cure for T1DM but is hindered by donor scarcity, variability in harvested cells, aggressive immunosuppressive regimens and suboptimal clinical outcomes. Current research is directed towards generating alternative cell sources, improving transplantation methods, and enhancing cell survival without chronic immunosuppression. This Review maps the progress in cell replacement therapies for T1DM and outlines the remaining challenges and future directions. We explore the state-of-the-art strategies for generating replenishable β cells, cell delivery technologies and local targeted immune modulation. Finally, we highlight relevant animal models and the regulatory aspects for advancing these technologies towards clinical deployment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41574-024-01029-0

Cites

227 of 227 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

International Diabetes Federation 2017
Carracher, A. M., Marathe, P. H., & Close, K. L. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12644 · Cited by 13,379
Alginate: Properties and biomedical applications
Lee, K. Y., & Mooney, D. J. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.06.003 · Cited by 8,477
Generation of Functional Human Pancreatic β Cells In Vitro
Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025
Self-citation
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913
Efficient differentiation of human embryonic stem cells to definitive endoderm
D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730
p53 mutations in cancer
Muller, P. A. J., & Vousden, K. H. (2013) · Nature Cell Biology · doi:10.1038/ncb2641 · Cited by 1,647
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575
Humanized mice in translational biomedical research
Shultz, L. D., Ishikawa, F., & Greiner, D. L. (2007) · Nature reviews. Immunology · doi:10.1038/nri2017 · Cited by 1,393
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
Laurent, L. C., Ulitsky, I., Slavin, I., Tran, H., Schork, A., Morey, R., Lynch, C., Harness, J. V., Lee, S., Barrero, M. J., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.003 · Cited by 890
Streptozotocin‐Induced Diabetic Models in Mice and Rats
Furman, B. L. (2021) · Current Protocols · doi:10.1002/cpz1.78 · Cited by 887
Successful Islet Transplantation
Ryan, E. A., Lakey, J. R. T., Paty, B. W., Imes, S., Korbutt, G. S., Kneteman, N. M., Bigam, D., Rajotte, R. V., & Shapiro, A. M. J. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2148 · Cited by 719
Self-citation
Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice
Vegas, A. J., Veiseh, O., Gürtler, M., Millman, J. R., Pagliuca, F. W., Bader, A. R., Doloff, J. C., Li, J., Chen, M., Olejnik, K., et al. (2016) · Nature Medicine · doi:10.1038/nm.4030 · Cited by 710
Self-citation
Humanized Mouse Models of Clinical Disease
Walsh, N. C., Kenney, L. L., Jangalwe, S., Aryee, K., Greiner, D. L., Brehm, M. A., & Shultz, L. D. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100332 · Cited by 585
Self-citation
Charting cellular identity during human in vitro β-cell differentiation
Veres, A., Faust, A. L., Bushnell, H. L., Engquist, E. N., Kenty, J. H.-R., Harb, G., Poh, Y.-C., Sintov, E., Gürtler, M., Pagliuca, F. W., et al. (2019) · Nature · doi:10.1038/s41586-019-1168-5 · Cited by 552
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Merkle, F. T., Ghosh, S., Kamitaki, N., Mitchell, J., Avior, Y., Mello, C., Kashin, S., Mekhoubad, S., Ilic, D., Charlton, M., et al. (2017) · Nature · doi:10.1038/nature22312 · Cited by 506
Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells
Nair, G. G., Liu, J. S., Russ, H. A., Tran, S., Saxton, M. S., Chen, R., Juang, C., Li, M.-L., Nguyen, V. Q., Giacometti, S., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0271-4 · Cited by 472
Self-citation
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells
Balboa, D., Barsby, T., Lithovius, V., Saarimäki-Vire, J., Omar-Hmeadi, M., Dyachok, O., Montaser, H., Lund, P.-E., Yang, M., Ibrahim, H., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01219-z · Cited by 433
Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation
Elliott, R. B., Escobar, L., Tan, P., Muzina, M., Zwain, S., & Buchanan, C. M. (2007) · Xenotransplantation · doi:10.1111/j.1399-3089.2007.00384.x · Cited by 409
Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells
Velazco-Cruz, L., Song, J., Maxwell, K. G., Goedegebuure, M. M., Augsornworawat, P., Hogrebe, N. J., & Millman, J. R. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.012 · Cited by 399
Self-citation
A prevascularized subcutaneous device-less site for islet and cellular transplantation
Pepper, A. R., Gala-Lopez, B., Pawlick, R., Merani, S., Kin, T., & Shapiro, A. M. J. (2015) · Nature Biotechnology · doi:10.1038/nbt.3211 · Cited by 381
Self-citation
Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
Hogrebe, N. J., Augsornworawat, P., Maxwell, K. G., Velazco-Cruz, L., & Millman, J. R. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0430-6 · Cited by 373
Self-citation
Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine
Rongvaux, A., Takizawa, H., Strowig, T., Willinger, T., Eynon, E. E., Flavell, R. A., & Manz, M. G. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095921 · Cited by 359
T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes
Burrack, A. L., Martinov, T., & Fife, B. T. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00343 · Cited by 356
Isolated Human Islets Trigger an Instant Blood Mediated Inflammatory Reaction: Implications for Intraportal Islet Transplantation as a Treatment for Patients with Type 1 Diabetes
Bennet, W., Groth, C., Larsson, R. L., Nilsson, B., & Korsgren, O. (2000) · Upsala Journal of Medical Sciences · doi:10.1517/03009734000000059 · Cited by 352
Immune-evasive human islet-like organoids ameliorate diabetes
Yoshihara, E., O’Connor, C., Gasser, E., Wei, Z., Oh, T. G., Tseng, T. W., Wang, D., Cayabyab, F., Dai, Y., Yu, R. T., et al. (2020) · Nature · doi:10.1038/s41586-020-2631-z · Cited by 333
Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions
Rickels, M. R., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00154 · Cited by 329
Karyotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells
Taapken, S. M., Nisler, B. S., Newton, M. A., Sampsell-Barron, T. L., Leonhard, K. A., McIntire, E. M., & Montgomery, K. D. (2011) · Nature Biotechnology · doi:10.1038/nbt.1835 · Cited by 327
Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution
Scharp, D. W., & Marchetti, P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.018 · Cited by 314
Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device
Shapiro, A. M. J., Thompson, D., Donner, T. W., Bellin, M. D., Hsueh, W., Pettus, J., Wilensky, J., Daniels, M., Wang, R. M., Brandon, E. P., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100466 · Cited by 313
Experimental animal models for diabetes and its related complications—a review
Kottaisamy, C. P. D., Raj, D. S., Kumar, V., & Umamaheswari, S. (2021) · Laboratory Animal Research · doi:10.1186/s42826-021-00101-4 · Cited by 301
The pig as a model for immunology research
Pabst, R. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03206-9 · Cited by 293
Type 1 Diabetes Mellitus
Syed, F. Z. (2022) · Annals of Internal Medicine · doi:10.7326/aitc202203150 · Cited by 289
Transplantation of human islets without immunosuppression
Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A. V., Block, N. L., Colton, C. K., Ludwig, S., Kersting, S., Bonifacio, E. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317561110 · Cited by 286
Immunosuppressive Agents and Infectious Risk in Transplantation: Managing the “Net State of Immunosuppression”
Roberts, M. B., & Fishman, J. A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1189 · Cited by 283
Perfusion decellularization of whole organs
Guyette, J. P., Gilpin, S. E., Charest, J. M., Tapias, L. F., Ren, X., & Ott, H. C. (2014) · Nature Protocols · doi:10.1038/nprot.2014.097 · Cited by 275
Experimental diabetes induced by alloxan and streptozotocin: The current state of the art
Radenković, M., Stojanović, M., & Prostran, M. S. (2015) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2015.11.004 · Cited by 271
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
Paull, D., Sevilla, A., Zhou, H., Hahn, A. K., Kim, H., Napolitano, C., Tsankov, A., Shang, L., Krumholz, K., Jagadeesan, P., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3507 · Cited by 263
Alginate Macroencapsulation of Pig Islets Allows Correction of Streptozotocin-Induced Diabetes in Primates up to 6 Months Without Immunosuppression
Dufrane, D., Goebbels, R., & Gianello, P. (2010) · Transplantation · doi:10.1097/tp.0b013e3181f6e267 · Cited by 248
Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study
Valdés-González, R., Dorantes, L. M., Garibay-Nieto, N., Bracho‐Blanchet, E., Mendez, A. J., Dávila-Pérez, R., Elliott, R. B., Terán, L., & White, D. J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01982 · Cited by 241
Teratomas from pluripotent stem cells: A clinical hurdle
Fong, C., Gauthaman, K., & Bongso, A. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22775 · Cited by 222
Generation of human embryonic stem cell‐derived mesoderm and cardiac cells using size‐specified aggregates in an oxygen‐controlled bioreactor
Niebruegge, S., Bauwens, C. L., Peerani, R., Thavandiran, N., Masse, S., Sevaptisidis, E., Nanthakumar, K., Woodhouse, K., Husain, M., Kumacheva, E., et al. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22065 · Cited by 222
Rat Models of Type 1 Diabetes: Genetics, Environment, and Autoimmunity
Mordes, J. P., Bortell, R., Blankenhorn, E. P., Rossini, A. A., & Greiner, D. L. (2004) · ILAR Journal · doi:10.1093/ilar.45.3.278 · Cited by 217
RIKEN suspends first clinical trial involving induced pluripotent stem cells
Garber, K. (2015) · Nature Biotechnology · doi:10.1038/nbt0915-890 · Cited by 215
Longitudinal Trends in Glycemic Outcomes and Technology Use for Over 48,000 People with Type 1 Diabetes (2016–2022) from the T1D Exchange Quality Improvement Collaborative
Ebekozien, O. A., Mungmode, A., Sanchez, J. E., Rompicherla, S., Demeterco‐Berggren, C., Weinstock, R. S., Jacobsen, L. M., Davis, G. M., McKee, A. M., Aktürk, H. K., et al. (2023) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2023.0320 · Cited by 214
Advances in β-cell replacement therapy for the treatment of type 1 diabetes
Vantyghem, M., de Koning, E. J. P., Pattou, F. N., & Rickels, M. R. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31334-0 · Cited by 212
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210 · cited 1×
“In addition, the rapid evolution of additive manufacturing technologies offers new opportunities for the generation of hybrid biomaterial structures with tissue-mimetic properties and geometrical features that are ripe for new developments in β cell transplantation 19 .”
Self-citation
Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
Carlsson, P.-O., Espes, D., Sedigh, A., Rotem, A., Zimerman, B., Grinberg, H., Goldman, T., Barkai, U., Avni, Y., Westermark, G. T., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14642 · Cited by 205 · cited 1×
“Furthermore, immune rejection requires lifelong systemic immunosuppressive enabling on-target cell types to be purified 22,25,26 , which might improve the functional potency and safety of the stem cell-derived islet drug product, but this approach might be difficult to scale up for manufacturing.”
Pancreatic islet transplantation in type 1 diabetes: 20-year experience from a single-centre cohort in Canada
Marfil-Garza, B. A., Imes, S., Verhoeff, K., Hefler, J., Lam, A., Dajani, K., Anderson, B., O'Gorman, D., Kin, T., Bigam, D., et al. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00114-0 · Cited by 205
Advanced strategies to thwart foreign body response to implantable devices
Capuani, S., Malgir, G., Chua, C. Y. X., & Grattoni, A. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10300 · Cited by 204
Self-citation
Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes
An, D., Chiu, A., Flanders, J. A., Song, W., Shou, D., Lu, Y.-C., Grunnet, L. G., Winkel, L., Ingvorsen, C., Christophersen, N. S., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708806115 · Cited by 200 · cited 1×
“Technological innovations such as continuous glucose sensing and smart infusion pumps alleviate this burden for patients 5 .”
Self-citation
The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow
Almaça, J., Weitz, J., Rodriguez‐Diaz, R., Pereira, E., & Caicedo, A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.016 · Cited by 200
A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice.
Davalli, A., Ogawa, Y., Ricordi, C., Scharp, D., Bonner-Weir, S., & Weir, G. (1995) · Transplantation · doi:10.1097/00007890-199503000-00003 · Cited by 198
Self-citation
Device design and materials optimization of conformal coating for islets of Langerhans
Tomei, A. A., Manzoli, V., Fraker, C. A., Giraldo, J. A., Velluto, D., Najjar, M., Pileggi, A., Molano, R. D., Ricordi, C., Stabler, C. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402216111 · Cited by 198
Self-citation
Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes
Yu, A., Snowhite, I. V., Vendrame, F., Rosenzwajg, M., Klatzmann, D., Pugliese, A., & Malek, T. R. (2015) · Diabetes · doi:10.2337/db14-1322 · Cited by 197
Protection of Encapsulated Human Islets Implanted Without Immunosuppression in Patients With Type I or Type II Diabetes and in Nondiabetic Control Subjects
Scharp, D. W., Swanson, C., Olack, B. J., Latta, P. P., Hegre, O. D., Doherty, E. J., Gentile, F. T., Flavin, K. S., Ansara, M. F., & Lacy, P. E. (1994) · Diabetes · doi:10.2337/diab.43.9.1167 · Cited by 186
Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques
Hu, X., White, K. A., Olroyd, A. G., DeJesus, R., Dominguez, A. A., Dowdle, W. E., Friera, A. M., Young, C., Wells, F., CHU, E. Y. L., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01784-x · Cited by 184
Self-citation
BCOR Involvement in Cancer
Astolfi, A., Fiore, M., Melchionda, F., Indio, V., Bertuccio, S. N., & Pession, A. (2019) · Epigenomics · doi:10.2217/epi-2018-0195 · Cited by 183
Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies
van der Windt, D. J., Bottino, R., Casu, A., Campanile, N., & Cooper, D. K. C. (2007) · Xenotransplantation · doi:10.1111/j.1399-3089.2007.00419.x · Cited by 179
Insulin Independence Following Isolated Islet Transplantation and Single Islet Infusions
Markmann, J. F., Deng, S., Huang, X., Desai, N. M., Velidedeoglu, E. H., Lui, C., Frank, A., Markmann, E., Palanjian, M., Brayman, K., et al. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000072110.93780.52 · Cited by 175
Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites
Weaver, J. D., Headen, D. M., Aquart, J., Johnson, C. T., Shea, L. D., Shirwan, H., & García, A. J. (2017) · Science Advances · doi:10.1126/sciadv.1700184 · Cited by 170
Self-citation
Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged <20 Years Through 2060: The SEARCH for Diabetes in Youth Study
Tönnies, T., Brinks, R., Isom, S. P., Dabelea, D., Divers, J., Mayer‐Davis, E. J., Lawrence, J. M., Pihoker, C., Dolan, L. M., Liese, A. D., et al. (2022) · Diabetes Care · doi:10.2337/dc22-0945 · Cited by 166
Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution
Ricordi, C., Fraker, C. A., Szust, J., Al-Abdullah, I. H., Poggioli, R., Kirlew, T. J., Khan, A., & Alejandro, R. (2003) · Transplantation · doi:10.1097/01.tp.0000058813.95063.7a · Cited by 162
Self-citation
International Society for Stem Cell Research
Bouhassira, E. E. (2015) · The SAGE Encyclopedia of Stem Cell Research · doi:10.4135/9781483347660.n214 · Cited by 160
Oxygen supply to encapsulated therapeutic cells.
Colton, C. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.007 · Cited by 153
Crossing the bridge: large animal models in translational transplantation research
Kirk, A. D. (2003) · Immunological Reviews · doi:10.1046/j.1600-065x.2003.00081.x · Cited by 146
Clinical Porcine Islet Xenotransplantation Under Comprehensive Regulation
Matsumoto, S., Tan, P. L. J., Baker, J., Durbin, K., Tomiya, M., Azuma, K., Doi, M., & Elliott, R. B. (2014) · Transplantation Proceedings · doi:10.1016/j.transproceed.2014.06.008 · Cited by 143
The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future
Chen, Y., Mathews, C. E., & Driver, J. P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00051 · Cited by 142
Progress in xenotransplantation: overcoming immune barriers
Sykes, M., & Sachs, D. H. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00624-6 · Cited by 132
Self-citation
Alginate-microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression
Alagpulinsa, D. A., Cao, J. J. L., Driscoll, R. K., Sîrbulescu, R. F., Penson, M. F. E., Sremac, M., Engquist, E. N., Brauns, T. A., Markmann, J. F., Melton, D. A., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15308 · Cited by 130 · cited 8×
“Immunocompetent models, using rats, pigs and NHPs, can mimic different aspects of the immune response seen in humans, which are fundamental for evaluating inflammatory responses, FBR and immune protection strategies 194 .”
InfluentialSelf-citation
Hyaluronic acid methacrylate/pancreatic extracellular matrix as a potential 3D printing bioink for constructing islet organoids
Wang, D., Guo, Y., Zhu, J., Liu, F., Xue, Y., Huang, Y. H., Zhu, B., Wu, D., Pan, H., Gong, T., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.06.036 · Cited by 130
Attenuation of Donor-Reactive T Cells Allows Effective Control of Allograft Rejection Using Regulatory T Cell Therapy
Lee, K., Nguyen, V. Q., Lee, K.-M., Kang, S., & Tang, Q. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12509 · Cited by 125
Self-citation
Alginate Encapsulant Incorporating CXCL12 Supports Long-Term Allo- and Xenoislet Transplantation Without Systemic Immune Suppression
Chen, T., Yuan, J., Duncanson, S., Hibert, M. L., Kodish, B., Mylavaganam, G., Maker, M. S., Li, H.-X., Sremac, M., Santosuosso, M., et al. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13049 · Cited by 125
Self-citation
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models
Aghazadeh, Y., Poon, F., Sarangi, F., Wong, F., Khan, S. T., Sun, X., Hatkar, R., Cox, B., Nunes, S. S., & Nostro, M. C. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.08.001 · Cited by 124
Self-citation
HLA-A*0201-Restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes
Takaki, T., Marron, M. P., Mathews, C. E., Guttmann, S. T., Bottino, R., Trucco, M., DiLorenzo, T. P., & SERREZE, D. V. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3257 · Cited by 122
Permanent Neonatal Diabetes inINSC94Y Transgenic Pigs
Renner, S., Braun-Reichhart, C., Blutke, A., Herbach, N., Emrich, D., Streckel, E., Wünsch, A., Keßler, B., Kurome, M., Bähr, A., et al. (2012) · Diabetes · doi:10.2337/db12-1065 · Cited by 120
Engineering the vasculature for islet transplantation
Bowers, D. T., Song, W., Wang, L., & Ma, M. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.051 · Cited by 116
Self-citation
Generation of pancreatic β cells from CD177+ anterior definitive endoderm
Mahaddalkar, P. U., Scheibner, K., Pfluger, S., Ansarullah, Sterr, M., Beckenbauer, J., Irmler, M., Beckers, J., Knöbel, S., & Lickert, H. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0492-5 · Cited by 115
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
Yu, M., Agarwal, D., Korutla, L., May, C. L., Wang, W., Griffith, N. N., Hering, B. J., Kaestner, K. H., Velazquez, O. C., Markmann, J. F., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0269-7 · Cited by 113
Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients
Sicard, A., Lamarche, C., Speck, M., Wong, M. Q., Rosado‐Sánchez, I., Blois, M., Glaichenhaus, N., Mojibian, M., & Levings, M. K. (2020) · American Journal of Transplantation · doi:10.1111/ajt.15787 · Cited by 112
T cells expressing chimeric antigen receptor promote immune tolerance
Pierini, A., Iliopoulou, B. P., Peiris, H. S., Pérez-Cruz, M., Baker, J. B., Hsu, K., Gu, X., Zheng, P., Erkers, T., Tang, S.-W., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92865 · Cited by 107
Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells
Rouhani, F. J., Zou, X., Danecek, P., Badja, C., Amarante, T. D., Koh, G., Wu, Q., Memari, Y., Durbin, R., Martincorena, I., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01147-3 · Cited by 105
Engineering transferrable microvascular meshes for subcutaneous islet transplantation
Song, W., Chiu, A., Wang, L., Schwartz, R. E., Li, B., Bouklas, N., Bowers, D. T., An, D., Cheong, S. H., Flanders, J. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12373-5 · Cited by 105
Self-citation
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice
Hu, X., Gattis, C., Olroyd, A. G., Friera, A. M., White, K. A., Young, C., Basco, R., Lamba, M., Wells, F., Ankala, R., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adg5794 · Cited by 104
Self-citation
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection
Parent, A. V., Faleo, G., Chavez, J., Saxton, M., Berrios, D. I., Kerper, N. R., Tang, Q., & Hebrok, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109538 · Cited by 96
Self-citation
Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site
Pepper, A. R., Pawlick, R., Bruni, A., Wink, J., Rafiei, Y., O’Gorman, D., Yan-Do, R., Gala-Lopez, B., Kin, T., MacDonald, P. E., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.004 · Cited by 96
Self-citation
Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy
Chang, R., Faleo, G., Russ, H. A., Parent, A. V., Elledge, S. K., Bernards, D. A., Allen, J. L., Villanueva, K. E., Hebrok, M., Tang, Q., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b01239 · Cited by 96
Self-citation
Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice
Casu, A., Bottino, R., Balamurugan, A. N., Hara, H., van der Windt, D. J., Campanile, N., Smetanka, C., Cooper, D. K. C., & Trucco, M. (2007) · Diabetologia · doi:10.1007/s00125-007-0844-4 · Cited by 95
Type 1 diabetes induction in humanized mice
Tan, S., Li, Y., Xia, J., Jin, C., Hu, Z., Duinkerken, G., Li, Y., Maharlooei, M. K., Chavez, É., Nauman, G., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710415114 · Cited by 93
Self-citation
Flow Characterization of a Spinner Flask for Induced Pluripotent Stem Cell Culture Application
Ismadi, M.-Z., Gupta, P., Fouras, A., Verma, P., Jadhav, S., Bellare, J., & Hourigan, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106493 · Cited by 93
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
Augsornworawat, P., Hogrebe, N. J., Ishahak, M., Schmidt, M. D., Marquez, E., Maestas, M. M., Veronese-Paniagua, D., Gale, S. E., Miller, J. R., Velazco-Cruz, L., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01150-8 · Cited by 91
Self-citation
Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes
Stock, A. A., Manzoli, V., Toni, T. D., Abreu, M. M., Poh, Y., Ye, L., Roose, A. N., Pagliuca, F., Thanos, C., Ricordi, C., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.11.004 · Cited by 90
Self-citation
Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival
Coronel, M. M., Martin, K. E., Hunckler, M. D., Barber, G., O’Neill, E. B., Medina, J. D., Opri, E., McClain, C. A., Batra, L., Weaver, J. D., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba5573 · Cited by 89
Self-citation
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Gerace, D., Zhou, Q., Kenty, J. H.-R., Veres, A., Sintov, E., Wang, X., Boulanger, K. R., Li, H., & Melton, D. A. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100879 · Cited by 88
Oxygenation strategies for encapsulated islet and beta cell transplants
Papas, K. K., León, H. D., Suszynski, T. M., & Johnson, R. C. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.05.002 · Cited by 88
Self-citation
Pancreatic islet-specific engineered T regs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models
Yang, S. J., Singh, A. K., Drow, T., Tappen, T., Honaker, Y., Barahmand-pour-Whitman, F., Linsley, P. S., Cerosaletti, K. M., Mauk, K. E., Xiang, Y., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn1716 · Cited by 88
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes
Zhu, H., Wang, G., Nguyen-Ngoc, K.-V., Kim, D., Miller, M., Goss, G., Kovsky, J., Harrington, A. R., Saunders, D. C., Hopkirk, A. L., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.03.011 · Cited by 88
Co-encapsulation and co-transplantation of mesenchymal stem cells reduces pericapsular fibrosis and improves encapsulated islet survival and function when allografted
Vaithilingam, V., Evans, M. D. M., Lewy, D., Bean, P. A., Bal, S., & Tuch, B. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-10359-1 · Cited by 85
Modulating the foreign body response of implants for diabetes treatment
Kharbikar, B. N., Chendke, G. S., & Desai, T. A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.011 · Cited by 85
Self-citation
Biofabrication of a vascularized islet organ for type 1 diabetes
Citro, A., Moser, P. T., Dugnani, E., Rajab, T. K., Ren, X., Evangelista-Leite, D., Charest, J. M., Peloso, A., Podesser, B. K., Manenti, F., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.035 · Cited by 82
Self-citation
Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models
Gibly, R. F., Zhang, X., Graham, M. L., Hering, B. J., Kaufman, D. B., Lowe, W. L., & Shea, L. D. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.084 · Cited by 81
Self-citation
Navigating the Regulatory Pathway for Medical Devices—a Conversation with the FDA, Clinicians, Researchers, and Industry Experts
Lottes, A. E., Cavanaugh, K. J., Chan, Y. Y.-F., Devlin, V. J., Goergen, C. J., Jean, R., Linnes, J. C., Malone, M. L., Peat, R., Reuter, D. G., et al. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10232-1 · Cited by 79
The importance of large animal models in transplantation
Dehoux, J. (2007) · Frontiers in bioscience · doi:10.2741/2434 · Cited by 74
Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2rγnull Ins2Akita Mice
Brehm, M., Bortell, R., Diiorio, P., Leif, J., Laning, J., Cuthbert, A., Yang, C.-X., Herlihy, M., Burzenski, L., Gott, B., et al. (2010) · Diabetes · doi:10.2337/db10-0323 · Cited by 74
Self-citation
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate
Hu, X., White, K., Young, C., Olroyd, A. G., Kievit, P., Connolly, A. J., Deuse, T., & Schrepfer, S. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.02.001 · Cited by 73
An inverse-breathing encapsulation system for cell delivery
Wang, L.-H., Ernst, A. U., Flanders, J. A., Liu, W., Wang, X., Datta, A. K., Epel, B., Kotecha, M., Papas, K. K., & Ma, M. (2021) · Science Advances · doi:10.1126/sciadv.abd5835 · Cited by 73
Self-citation
Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes
Goswami, D., Domingo‐Lopez, D. A., Ward, N. A., Millman, J. R., Duffy, G. P., Dolan, E. B., & Roche, E. T. (2021) · Advanced Science · doi:10.1002/advs.202100820 · Cited by 72
Self-citation
Safety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment
Brennan, F. R., Cavagnaro, J., McKeever, K., Ryan, P. C., Schutten, M. M., Vahle, J., Weinbauer, G. F., Marrer-Berger, E., & Black, L. E. (2018) · mAbs · doi:10.1080/19420862.2017.1389364 · Cited by 70 · cited 1×
“To this end, Breakthrough T1D (formerly JDRF), the world’s largest non-profit funder of T1DM research and a key advocacy group for the T1DM community, has worked closely with key opinion leaders to outline a developmental roadmap (Table 1).”
The Role of Vascular Cells in Pancreatic Beta-Cell Function
Burganova, G., Bridges, C. A., Thorn, P., & Landsman, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.667170 · Cited by 70
Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research
Graham, M. L., & Schuurman, H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.054 · Cited by 66
Self-citation
Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes
Zhang, Q., Gonelle‐Gispert, C., Li, Y., Geng, Z., Gerber‐Lemaire, S., Wang, Y., & Bühler, L. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869984 · Cited by 66
Hyaluronic Acid/Collagen Hydrogel as an Alternative to Alginate for Long-Term Immunoprotected Islet Transplantation
Harrington, S., Williams, J., Rawal, S., Ramachandran, K., & Stehno‐Bittel, L. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0477 · Cited by 66
Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes
Wassmer, C., Lebreton, F., Bellofatto, K., Perez, L., Cottet‐Dumoulin, D., Andrès, A., Bosco, D., Berney, T., Othenin‐Girard, V., de Tejada, B. M., et al. (2022) · Transplant International · doi:10.3389/ti.2021.10214 · Cited by 65
Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.
Kin, T., Korbutt, G., Kobayashi, T., Dufour, J., & Rajotte, R. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1032 · Cited by 65
Self-citation
Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival
Hu, S., Kuwabara, R., Chica, C. E. N., Smink, A. M., Koster, T., Medina, J. D., de Haan, B. J., Beukema, M., Lakey, J. R. T., Garcı́a, A. J., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120460 · Cited by 64
Self-citation
Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats
Paez‐Mayorga, J., Campa‐Carranza, J. N., Capuani, S., Hernandez, N., Liu, H., Chua, C. Y. X., Pons-Faudoa, F. P., Malgir, G., Alvarez, B., Niles, J. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35629-z · Cited by 64
Self-citation
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation
Aghazadeh, Y., Sarangi, F., Poon, F., Nkennor, B., McGaugh, E. C., Nunes, S. S., & Nostro, M. C. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.03.004 · Cited by 62
Self-citation
The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates
Anwar, I. J., Berman, D. M., DeLaura, I. F., Gao, Q., Willman, M. A., Miller, A., Gill, A., Gill, C., Perrin, S., Ricordi, C., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf6376 · Cited by 62
Self-citation
Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression
Wang, X., Wang, K., Yu, M., Velluto, D., Hong, X., Wang, B., Chiu, A., Melero-Martin, J. M., Tomei, A. A., & Ma, M. (2022) · Science Advances · doi:10.1126/sciadv.abn0071 · Cited by 62
Self-citation
Immunoisolation of murine islet allografts in vascularized sites through conformal coating with polyethylene glycol
Manzoli, V., Villa, C., Bayer, A. L., Morales, L. C., Molano, R. D., Torrente, Y., Ricordi, C., Hubbell, J. A., & Tomei, A. A. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14547 · Cited by 60
Self-citation
Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition
Castro-Gutiérrez, R., Alkanani, A. K., Mathews, C. E., Michels, A. W., & Russ, H. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.707881 · Cited by 60
Self-citation
Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells
Farina, M., Chua, C. Y. X., Ballerini, A., Thekkedath, U. R., Alexander, J. F., Rhudy, J. R., Torchio, G., Fraga, D. W., Pathak, R. R., Villanueva, M., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.047 · Cited by 59
Self-citation
A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion
Yang, K., O’Cearbhaill, E. D., Liu, S. S., Zhou, A., Chitnis, G. D., Hamilos, A. E., Xu, J., Verma, M. K. S., Giraldo, J. A., Kudo, Y., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2101258118 · Cited by 58 · cited 1×
“To address these design challenges, a broad range of macrocapsule devices have been developed, including hollow-fibre (intravascular or extravascular) 72,73 , planar 15,74,75 and cylindrical structures 76 , with advances in 3D printing and microfabrication leading to more complex designs 77,78 .”
Self-citation
Differential Function and Maturation of Human Stem Cell-Derived Islets After Transplantation
Maxwell, K. G., Kim, M. H., Gale, S. E., & Millman, J. R. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szab013 · Cited by 54 · cited 1×
“Although a few million stem cell-derived islet cells can restore glycaemic control in a mouse model of diabetes 27 , ~10 9 cells per dose will probably be necessary to treat adult human patients 28,29 .”
Self-citation
Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization
Forbes, S., Bond, A. R., Thirlwell, K. L., Burgoyne, P., Samuel, K., Noble, J., Borthwick, G., Colligan, D., McGowan, N. W. A., Lewis, P. S., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5907 · Cited by 54
A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment
Tremmel, D. M., Sackett, S. D., Feeney, A. K., Mitchell, S. A., Schaid, M. D., Polyák, E., Chlebeck, P. J., Gupta, S., Kimple, M. E., Fernandez, L. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11085-z · Cited by 53
Self-citation
Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
Mohammadi, M. R., Rodriguez, S. M., Luong, J. C., Li, S., Cao, R., Alshetaiwi, H., Lau, H., Davtyan, H., Jones, M. B., Jafari, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02229-4 · Cited by 53
Humanized Mice for the Study of Type 1 Diabetes and Beta Cell Function
King, M., Pearson, T., Rossini, A. A., Shultz, L. D., & Greiner, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1447.009 · Cited by 52
Engineering a Macroporous Oxygen-generating Scaffold for Enhancing Islet Cell Transplantation within an Extrahepatic Site.
Liang, J.-P., Accolla, R. P., Soundirarajan, M., Emerson, A. E., Coronel, M. M., & Stabler, C. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.028 · Cited by 52
Self-citation
Factors associated with favourable 5 year outcomes in islet transplant alone recipients with type 1 diabetes complicated by severe hypoglycaemia in the Collaborative Islet Transplant Registry
Hering, B. J., Ballou, C. M., Bellin, M. D., Payne, E. H., Kandeel, F., Witkowski, P., Alejandro, R., Rickels, M. R., & Barton, F. B. (2023) · Diabetologia · doi:10.1007/s00125-022-05804-4 · Cited by 51
A hydrogel platform for in vitro three dimensional assembly of human stem cell-derived islet cells and endothelial cells
Augsornworawat, P., Velazco-Cruz, L., Song, J., & Millman, J. R. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.08.031 · Cited by 51
Self-citation
Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats
Cheng, Y., Liu, Y., Zhang, J., Li, T.-M., & Zhao, N. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i20.2862 · Cited by 51
Localized immune tolerance from FasL-functionalized PLG scaffolds
Skoumal, M., Woodward, K. B., Zhao, H., Wang, F., Yolcu, E. S., Pearson, R. M., Hughes, K. R., Garcı́a, A. J., Shea, L. D., & Shirwan, H. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.015 · Cited by 50
Self-citation
Degradable methacrylic acid-based synthetic hydrogel for subcutaneous islet transplantation
Kinney, S. M., Ortaleza, K., Vlahos, A. E., & Sefton, M. V. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121342 · Cited by 50
Self-citation
Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells
Roschke, A. V., & Kirsch, I. R. (2010) · Current Drug Targets · doi:10.2174/1389450111007011341 · Cited by 49
Human Pluripotent Stem Cells to Model Islet Defects in Diabetes
Balboa, D., Iworima, D. G., & Kieffer, T. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.642152 · Cited by 49
Emerging immunomodulatory strategies for cell therapeutics
Chua, C. Y. X., Jiang, A. Y., Eufrásio-da-Silva, T., Dolatshahi‐Pirouz, A., Langer, R., Orive, G., & Grattoni, A. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.11.008 · Cited by 48
Self-citation
Pathogenesis of Type 1 Diabetes Mellitus and Rodent Experimental Models
Gvazava, I. G., Rogovaya, O. S., Borisov, M. A., Vorotelyak, E. A., & Vasiliev, A. V. (2018) · Acta Naturae · doi:10.32607/20758251-2018-10-1-24-33 · Cited by 47
Considerations and challenges of islet transplantation and future therapies on the horizon
Walker, S. L. M., Appari, M., & Forbes, S. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2021 · Cited by 47
Quality control for clinical islet transplantation: organ procurement and preservation, the islet processing facility, isolation, and potency tests
Yamamoto, T., Horiguchi, A., Ito, M., Nagata, H., Ichii, H., Ricordi, C., & Miyakawa, S. (2009) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-009-0064-z · Cited by 46
Self-citation
IL‐10 producing type 2 innate lymphoid cells prolong islet allograft survival
Huang, Q., Ma, X., Wang, Y., Niu, Z., Wang, R., Yang, F., Wu, M., Liang, G., Rong, P., Wang, H., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012305 · Cited by 46
Immunomodulation Followed by Antigen-Specific Treg Infusion Controls Islet Autoimmunity
Cabello-Kindelan, C., Mackey, S., Sands, A., Rodriguez, J., Vazquez, C., Pugliese, A., & Bayer, A. L. (2019) · Diabetes · doi:10.2337/db19-0061 · Cited by 44
A 3D bioprinted hybrid encapsulation system for delivery of human pluripotent stem cell-derived pancreatic islet-like aggregates
Hwang, D. G., Jo, Y., Kim, M., Yong, U., Cho, S., Choi, Y., Kim, J., & Jang, J. (2021) · Biofabrication · doi:10.1088/1758-5090/ac23ac · Cited by 43
Emerging strategies for beta cell transplantation to treat diabetes
Paez‐Mayorga, J., Lukin, I., Emerich, D. F., de Vos, P., Orive, G., & Grattoni, A. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.11.007 · Cited by 43
Self-citation
Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice
Hu, M., Hawthorne, W. J., Nicholson, L., Burns, H., Yi, Q., Liuwantara, D., Vera, E. J., Chew, Y. V., Williams, L. J., Yi, S., et al. (2020) · Diabetes · doi:10.2337/db19-0525 · Cited by 42
Modeling human T1D-associated autoimmune processes
Maharlooei, M. K., Madley, R., Borsotti, C., Ferreira, L. M. R., Sharp, R. C., Brehm, M. A., Greiner, D. L., Parent, A. V., Anderson, M. S., Sykes, M., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101417 · Cited by 42
Self-citation
Molecular and genetic regulation of pig pancreatic islet cell development
Kim, S., Whitener, R. L., Peiris, H. S., Gu, X., Chang, C., Lam, J. Y., Camuñas-Soler, J., Park, I., Bevacqua, R. J., Tellez, K., et al. (2020) · Development · doi:10.1242/dev.186213 · Cited by 41
Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes
Citro, A., Neroni, A., Pignatelli, C., Campo, F., Policardi, M., Monieri, M., Pellegrini, S., Dugnani, E., Manenti, F., Maffia, M. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36582-1 · Cited by 41
Self-citation
Country-specific regulation and international standardization of cell-based therapeutic products derived from pluripotent stem cells
Hirai, T., Yasuda, S., Umezawa, A., & Sato, Y. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.05.003 · Cited by 41
Engineered Cytokine‐Primed Extracellular Vesicles with High PD‐L1 Expression Ameliorate Type 1 Diabetes
Wang, L., Qi, C., Cao, H., Zhang, Y., Liu, X., Qiu, L., Wang, H., Xu, L., Wu, Z., Liu, J., et al. (2023) · Small · doi:10.1002/smll.202301019 · Cited by 39
Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation
Gammon, J. M., Carey, S. T., Saxena, V., Eppler, H. B., Tsai, S. J., Paluskievicz, C., Xiong, Y., Li, L., Ackun‐Farmmer, M. A., Tostanoski, L. H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36225-5 · Cited by 38
Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient MicePreprint
Brehm, M. A., Powers, A. C., Shultz, L. D., & Greiner, D. L. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007757 · Cited by 37
Self-citation
Engineering “cell-particle hybrids” of pancreatic islets and bioadhesive FK506-loaded polymeric microspheres for local immunomodulation in xenogeneic islet transplantation
Nguyen, T. T., Pham, T. T., Nguyen, H. T., Nepal, M. R., Phung, C. D., You, Z., Katila, N., Pun, N. T., Jeong, T. C., Choi, D., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119415 · Cited by 36
Pancreatic islets engineered with a FasL protein induce systemic tolerance at the induction phase that evolves into long-term graft-localized immune privilege
Woodward, K. B., Zhao, H., Shrestha, P., Batra, L., Tan, M., Grimany-Nuno, O., Bandura-Morgan, L., Askenasy, N., Shirwan, H., & Yolcu, E. S. (2020) · American Journal of Transplantation · doi:10.1111/ajt.15747 · Cited by 35 · cited 1×
“…II while expressing HLA-E 180 in combination with overexpression of immunomodulatory signals, such as PDL1 and FasL (to induce T cell deletion and anergy) 181–183 , CD47 (‘don’t eat me’ signal) 184–186 , HLA-G (tolerogenic placenta-mimicking signal for T cells) 187 and indoleamine dioxygenase 188 .”
Self-citation
Co-localized immune protection using dexamethasone-eluting micelles in a murine islet allograft model
Kuppan, P., Kelly, S. E., Polishevska, K., Hojanepesov, O., Seeberger, K. L., Korbutt, G. S., & Pepper, A. R. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15662 · Cited by 35
Self-citation
Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment
Qin, T., Smink, A. M., & de Vos, P. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.06.038 · Cited by 35
Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts
Pepper, A. R., Bruni, A. D. C., Pawlick, R. L., O’Gorman, D., Kin, T., Thiesen, A., & Shapiro, A. M. J. (2018) · Diabetes · doi:10.2337/db18-0788 · Cited by 34
Self-citation
Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye
Fan, Y., Zheng, X., Ali, Y., Berggren, P., & Loo, S. C. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-40404-0 · Cited by 34
A spectacular year for islet and stem cell transplantation
Shapiro, A. M. J., & Verhoeff, K. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00790-4 · Cited by 34
Toward 3D-bioprinting of an endocrine pancreas: A building-block concept for bioartificial insulin-secreting tissue
Salg, G., Poisel, E., Neulinger-Muñoz, M., Gerhardus, J., Cebulla, D., Bludszuweit-Philipp, C., Vieira, V., Nickel, F., Herr, I., Blaeser, A., et al. (2021) · bioRxiv · doi:10.1177/20417314221091033 · Cited by 33
Risks of Multiple Skin Cancers in Organ Transplant Recipients
Wehner, M. R., Niu, J., Wheless, L., Baker, L. X., Cohen, O. G., Margolis, D. J., Giordano, S. H., & Shin, T. M. (2021) · JAMA Dermatology · doi:10.1001/jamadermatol.2021.4148 · Cited by 33
Translational impact of NIH-funded nonhuman primate research in transplantation
Knechtle, S. J., Shaw, J. M., Hering, B. J., Kraemer, K., & Madsen, J. C. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau0143 · Cited by 32
How Safe Are Universal Pluripotent Stem Cells?
González, B. J., Creusot, R. J., Sykes, M., & Egli, D. M. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.02.006 · Cited by 32
Self-citation
Genetic Engineering of Immune Evasive Stem Cell-Derived Islets
Sackett, S. D., Kaplan, S. J., Mitchell, S. A., Brown, M. E., Burrack, A. L., Grey, S., Huangfu, D., & Odorico, J. (2022) · Transplant International · doi:10.3389/ti.2022.10817 · Cited by 32
Self-citation
Anti-Inflammatory Strategies in Intrahepatic Islet Transplantation
Citro, A., Cantarelli, E., Pellegrini, S., Dugnani, E., & Piemonti, L. (2017) · Transplantation · doi:10.1097/tp.0000000000001925 · Cited by 31
Self-citation
Preliminary Studies of the Impact of CXCL12 on the Foreign Body Reaction to Pancreatic Islets Microencapsulated in Alginate in Nonhuman Primates
Sremac, M., Lei, J., Parr, M. F. E., Schuetz, C., Lakey, J. R. T., Papas, K. K., Varde, P. S., Hering, B. J., de Vos, P., Brauns, T. A., et al. (2019) · Transplantation Direct · doi:10.1097/txd.0000000000000890 · Cited by 31
Self-citation
Functionalization of Alginate with Extracellular Matrix Peptides Enhances Viability and Function of Encapsulated Porcine Islets
Medina, J. D., Alexander, M., Hunckler, M. D., Fernández, M., Coronel, M. M., Smink, A. M., Lakey, J. R. T., de Vos, P., & Garcı́a, A. J. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000102 · Cited by 31
Self-citation
Enhanced In Vivo Vascularization of 3D‐Printed Cell Encapsulation Device Using Platelet‐Rich Plasma and Mesenchymal Stem Cells
Paez-Mayorga, J., Capuani, S., Farina, M., Lotito, M., Niles, J. A., Salazar, H. F., Rhudy, J., Esnaola, L., Chua, C. Y., Taraballi, F., et al. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000670 · Cited by 31
Self-citation
Current status of porcine islet xenotransplantation
Coe, T. M., Markmann, J., & Rickert, C. (2020) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000794 · Cited by 30
Immunosuppressive PLGA TGF-β1 Microparticles Induce Polyclonal and Antigen-Specific Regulatory T Cells for Local Immunomodulation of Allogeneic Islet Transplants
Li, Y., Frei, A. W., Labrada, I. M., Rong, Y., Liang, J., Samojlik, M. M., Sun, C., BARASH, S. D., Keselowsky, B. G., Bayer, A. L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653088 · Cited by 30
Self-citation
Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice
Wrublewsky, S., Weinzierl, A., Hornung, I., Roma, L. P., Menger, M. D., Laschke, M. W., & Ampofo, E. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00262-3 · Cited by 29
Engineering of hybrid spheroids of mesenchymal stem cells and drug depots for immunomodulating effect in islet xenotransplantation
Nguyen, T. T., Pham, D., Park, J., Phung, C. D., Nepal, M. R., Pandit, M., Shrestha, M., Son, Y., Joshi, M., Jeong, T. C., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn8614 · Cited by 28
Opportunities and challenges in closed-loop systems in type 1 diabetes
Wilson, L. M., Jacobs, P. G., Riddell, M. C., Zaharieva, D. P., & Castle, J. R. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00289-8 · Cited by 27
Skepticism surrounds diabetes xenograft experiment
Birmingham, K. (2002) · Nature Medicine · doi:10.1038/nm1002-1047 · Cited by 26
Co‐transplantation of human adipose‐derived mesenchymal stem cells with neonatal porcine islets within a prevascularized subcutaneous space augments the xenograft function
Kuppan, P., Seeberger, K. L., Kelly, S. E., Rosko, M., Adesida, A. B., Pepper, A. R., & Korbutt, G. S. (2020) · Xenotransplantation · doi:10.1111/xen.12581 · Cited by 26
Self-citation
Reversing type 1 diabetes with stem cell–derived islets: a step closer to the dream?
Butler, P. C., & Gale, E. A. M. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158305 · Cited by 26
Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I
Santini-González, J., Castro-Gutiérrez, R., Becker, M. W., Rancourt, C., Russ, H. A., & Phelps, E. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.989815 · Cited by 26
Self-citation
Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response
Doloff, J. C., Ma, M., Sadraei, A., Tam, H. H., Farah, S., Hollister‐Lock, J., Vegas, A. J., Omid Veiseh, A., Quiroz, V. M., Rakoski, A. I., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade9488 · Cited by 26
Self-citation
Islet encapsulation therapy — racing towards the finish line?
Desai, T. A., & Tang, Q. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0100-7 · Cited by 25
Self-citation
HLA-G1+ Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses
Rao, J. S., Hosny, N., Kumbha, R., Naqvi, R. A., Singh, A. R., Swanson, Z. A., Levy, H., Matson, A. W., Steinhoff, M., Forneris, N., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.730545 · Cited by 25
BioBreeding/Worcester (BB/Wor) rats are deficient in the generation of functional cytotoxic T cells.
Woda, B. A., & Padden, C. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.5.1514 · Cited by 25
Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T Cells
Li, Y., Teteloshvili, N., Tan, S., Rao, S., Han, A. S., Yang, Y., & Creusot, R. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00063 · Cited by 23
Glycaemic control in diabetic rats treated with islet transplantation using plasma combined with hydroxypropylmethyl cellulose hydrogel
Schaschkow, A., Sigrist, S., Mura, C., Barthès, J., Vrana, N. E., Czuba, E., Lemaire, F., Neidl, R., Dissaux, C., Lejay, A., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.11.047 · Cited by 23
Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells
Lebreton, F., Hanna, R., Wassmer, C., Bellofatto, K., Perez, L., Othenin‐Girard, V., de Tejada, B. M., Cohen, M., & Berishvili, E. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10269-w · Cited by 23
Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques
Graham, M. L., Ramachandran, S., Singh, A. R., Moore, M. E. G., Flanagan, E. B., Azimzadeh, A. M., Burlak, C., Mueller, K. R., Martins, K. V., Anazawa, T., et al. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16876 · Cited by 23
Self-citation
The impact of locally-delivered tacrolimus-releasing microspheres and polyethylene glycol-based islet surface modification on xenogeneic islet survival.
Nguyen, T., Phung, C. D., Kim, J. O., Yong, C., Kim, J.-R., Yook, S., & Jeong, J.-H. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.020 · Cited by 22
Extracellular matrix inclusion in immunoisolating alginate-based microcapsules promotes longevity, reduces fibrosis, and supports function of islet allografts in vivo
Kuwabara, R., Qin, T., Llacua, L. A., Hu, S., Boekschoten, M. V., de Haan, B. J., Smink, A. M., & de Vos, P. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.12.068 · Cited by 22
Generating low immunogenic pig pancreatic islet cell clusters for xenotransplantation
Oliveira, M. C., Valdivia, E., Verboom, M., Yuzefovych, Y., Sake, H. J., Pogozhykh, O., Niemann, H., Schwinzer, R., Petersen, B., Seißler, J., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15136 · Cited by 22
Immune checkpoint CD47 molecule engineered islets mitigate instant blood‐mediated inflammatory reaction and show improved engraftment following intraportal transplantation
Shrestha, P., Batra, L., Malik, M. T., Tan, M., Yolcu, E., & Shirwan, H. (2020) · American Journal of Transplantation · doi:10.1111/ajt.15958 · Cited by 20
Self-citation
Regulation of Blood Glucose Using Islets Encapsulated in a Melanin-Modified Immune-Shielding Hydrogel
Huang, L., Xiang, J., Cheng, Y.-K., Xiao, L., Wang, Q., Zhang, Y., Xu, T., Chen, Q., Xin, H., & Wang, X. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c23010 · Cited by 20
A hydrogel platform for co‐delivery of immunomodulatory proteins for pancreatic islet allografts
Medina, J. D., Barber, G. F., Coronel, M. M., Hunckler, M. D., Linderman, S. W., Quizon, M. J., Ulker, V., Yolcu, E. S., Shirwan, H., & García, A. J. (2022) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37429 · Cited by 20
Self-citation
Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the NOD Mouse
Jamison, B. L., DiLisio, J. E., Beard, K. S., Neef, T., Bradley, B., Goodman, J., Gill, R. G., Miller, S. D., Baker, R. L., & HASKINS, K. M. (2022) · Diabetes · doi:10.2337/db20-1170 · Cited by 20
Supporting Survival of Transplanted Stem‐Cell‐Derived Insulin‐Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids
Chendke, G. S., Faleo, G., Juang, C., Parent, A. V., Bernards, D. A., Hebrok, M., Tang, Q., & Desai, T. A. (2019) · Advanced Biosystems · doi:10.1002/adbi.201900086 · Cited by 19
Self-citation
Particulate‐Based Single‐Dose Local Immunosuppressive Regimen for Inducing Tolerogenic Dendritic Cells in Xenogeneic Islet Transplantation
Pathak, S., Acharya, S., Regmi, S., Shrestha, P., You, Z., Bae, Y., Park, M., Yook, S., Kim, J.-R., Park, S., et al. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001157 · Cited by 19
Extended survival versus accelerated rejection of nonhuman primate islet allografts: Effect of mesenchymal stem cell source and timing
Kenyon, N. S., Willman, M. A., Han, D., Kronenfeld, R. S., Rabassa, A., Díaz, W., Geary, J. C., Poumian-Ruiz, E., Griswold, A. J., Booven, D. J. V., et al. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16693 · Cited by 19
Self-citation
Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression
Paul, P. K., Das, R., Drow, T., Nylen, E. A., de Souza, A. H., Wang, Z., Wood, M. W., Davis, D. B., Bjorling, D. E., & Galipeau, J. (2022) · American Journal of Transplantation · doi:10.1111/ajt.17162 · Cited by 19
Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans
SERREZE, D. V., Niens, M., Kulik, J., & DiLorenzo, T. P. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3661-8_9 · Cited by 18
Drug-Integrating Amphiphilic Nanomaterial Assemblies: 1. Spatiotemporal control of cyclosporine delivery and activity using nanomicelles and nanofibrils
Velluto, D., Bojadzic, D., Toni, T. D., Buchwald, P., & Tomei, A. A. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.026 · Cited by 18
Self-citation
Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents
Marshall, G. P., Cserny, J., Wang, C., Looney, B. M., Posgai, A. L., Bacher, R. L., Keselowsky, B. G., & Brusko, T. M. (2022) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37442 · Cited by 17
Diabetes cell therapies take evasive action
Dolgin, E. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01246-w · Cited by 15
Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation
Fitch, Z. W., Schmitz, R., Kwun, J., Hering, B. J., Madsen, J. C., & Knechtle, S. J. (2019) · Transplantation Reviews · doi:10.1016/j.trre.2019.03.002 · Cited by 14

Research works printed but not linked: 2

Sernova Corp. Sernova provides recap of 2023 accomplishments and anticipated 2024 milestones. Sernova Corp www.sernova.com/press/release/?id=388 (2024).
Sohni, A. & Verfaillie, C. M. Mesenchymal stem cells migration homing and tracking. Stem Cell Int. 2013, 130763 (2013).

Sorted by citations

Smart closed-loop drug delivery systems
Paci, M. M., Saha, T., Djassemi, O., Wu, S. T., Chua, C. Y. X., Wang, J., & Grattoni, A. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00328-z · Cited by 96
Self-citation
The future of type 1 diabetes therapy
Ziegler, A.-G., Cengiz, E., & Kay, T. W. H. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01438-2 · Cited by 42
Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets
Kim, M., Cho, S., Hwang, D. G., Shim, I. K., Kim, S. C., Jang, J., & Jang, J. (2025) · Nature Communications · doi:10.1038/s41467-025-56665-5 · Cited by 32
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease
Hu, X., Beauchesne, P. R., Wang, C., Wong, A. W., Deuse, T., & Schrepfer, S. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.07.009 · Cited by 20
Role of the Pancreatic Islet Microvasculature in Health and Disease
Aplin, A. C., Aghazadeh, Y., Mohn, O. G., & Hull, R. L. (2024) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554241299862 · Cited by 21

See all 92

Authors: Grattoni, A., Korbutt, G., Tomei, A. A., García, A. J., Pepper, A. R., Stabler, C., Brehm, M., Papas, K., Citro, A., Shirwan, H., Millman, J. R., Melero-Martin, J., Graham, M., Sefton, M., Ma, M., Kenyon, N., Veiseh, O., Desai, T. A., Nostro, M. C., Marinac, M., Sykes, M., Russ, H. A., Odorico, J., Tang, Q., Ricordi, C., Latres, E., Mamrak, N. E., Giraldo, J., Poznansky, M. C., & de Vos, P.
Affiliations: Houston Methodist (US)
University of Alberta (CA)
University of Miami (US)
University of Florida (US)
University of Massachusetts Chan Medical School (US)
University of Arizona (US)
IRCCS Ospedale San Raffaele (IT)
University of Missouri (US)
Washington University in St. Louis (US)
University of Minnesota (US)
University of Toronto (CA)
Cornell University (US)
University of California, San Francisco (US)
University Health Network (CA)
Breakthrough T1D (US)
Columbia University (US)
University of Wisconsin–Madison (US)
Harvard University (US)
University Medical Center Groningen (NL)
Corresponding author: Grattoni, Alessandro
Giraldo, Jaime
Poznansky, Mark C.
de Vos, Paul
ORCID: Grattoni, Alessandro
Korbutt, Gregory
Tomei, Alice A.
García, Andrés J.
Pepper, Andrew R.
Stabler, Cherie
Brehm, Michael
Papas, Klearchos
Citro, Antonio
Shirwan, Haval
Millman, Jeffrey R.
Melero-Martin, Juan
Graham, Melanie
Sefton, Michael
Ma, Minglin
Kenyon, Norma
Veiseh, Omid
Desai, Tejal A.
Nostro, M. Cristina
Marinac, Marjana
Sykes, Megan
Russ, Holger A.
Odorico, Jon
Tang, Qizhi
Ricordi, Camillo
Latres, Esther
Mamrak, Nicholas E.
Giraldo, Jaime
Poznansky, Mark C.
de Vos, Paul
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2024-09-03
Volume: 21
Issue: 1
Pages: 14-30
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-024-01029-0
PMC: PMC11938328
OpenAlex: W4402197225
Cited by: 92
References: 227
Citations by year: 2026: 42 · 2025: 47 · 2024: 3
FWCI: 10.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders: Edward Mallinckrodt, Jr. Foundation
Diabetes Research Connection
Canada Research Chairs
Ministero della Salute (2018-)
National Institutes of Health (SCR_014393, 1uc4dk104218-01)
National Institute of Diabetes and Digestive and Kidney Diseases (UC4-DK-104218, R01DK120444, UC24 DK104162, SCR_014393, U01DK104218, DK104162, R01 DK12044, R01DK132104, U24DK104162, R01DK114233, R01DK133610, R01DK133702, R01DK128840, R01DK132387)
National Institute of Neurological Disorders and Stroke (R01NS122911)
Breakthrough T1D Canada (5-CDA-2020-945-A-N, 2-SRA-2021-1079-S-B, 1-SRA-2022-1229-S-B, 5-SRA-2020-1058-S-B)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 1 diabetes, islet transplantation, cell therapy, beta cell regeneration, immunosuppression, continuous glucose monitoring, insulin delivery devices, animal models of diabetes, regulatory approval
MeSH terms: Animals, Diabetes Mellitus, Type 1, Humans, Islets of Langerhans Transplantation, Insulin-Secreting Cells, Cell- and Tissue-Based Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks