Microbiota and colorectal cancer: colibactin makes its mark

Arthur, Janelle C.

doi:10.1038/s41575-020-0303-y

Cited by 31Gut microbiota and healthGenetic factors in colorectal cancerEscherichia coli research studies

Microbiota and colorectal cancer: colibactin makes its mark

Arthur, Janelle C.·2020·Nature Reviews Gastroenterology & Hepatology

DOI 10.1038/s41575-020-0303-y

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From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [34]
E. coli Nissle 1917 synthesizes and releases colibactin, a mutagenic substance that promotes colorectal polyposis and cancer and reduces cancer response to irinotecan.
“having the capability of synthetizing and releasing colibactin, a mutagenic substance described to promote colorectal polyposis and cancer, and reducing cancer response to irinotecan [26, 34–39].”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [34]

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Authors: Arthur, J. C.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Arthur, Janelle C.
ORCID: Arthur, Janelle C.
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2020-04-21
Volume: 17
Issue: 6
Pages: 317-318
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/s41575-020-0303-y
OpenAlex: W3017291956
Cited by: 30
References: 11
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 7 · 2020: 2
Type: other
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P30CA016086)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK124617)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords: colibactin, colorectal cancer, gut microbiota, carcinogenesis, intestinal epithelial cells, mutational signatures, bacterial metabolites
MeSH terms: DNA Damage, Escherichia coli, Humans, Peptides, Colorectal Neoplasms, Polyketides, Microbiota

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Microbiota and colorectal cancer: colibactin makes its mark

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