Autophagy in the renewal, differentiation and homeostasis of immune cells
Abstract
Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specialization. However, although the requirement for autophagy in normal immune cell function is clear, the mechanisms involved are much less so and encompass control of metabolism, selective degradation of substrates and organelles and participation in cell survival decisions. We review here the crucial functions of autophagy in controlling the differentiation and homeostasis of multiple immune cell types and discuss the potential mechanisms involved.
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Autophagy takes direct part in cellular differentiation and plasticity.
“cellular differentiation and plasticity (Boya et al, 2018; Clarke & Simon, 2019)”
From Autophagy in major human diseases (2021) · cites this paper as Clarke & Simon, 2019
Autophagy mediates quintessential functions in virtually all immune cell subtypes, both at sites of hematopoiesis and in peripheral tissues.
“First, autophagy mediates quintessential (and cell type defining) functions in virtually all the immune cell subtypes, both at sites of hematopoiesis and in peripheral tissues (Ma et al, 2013c; Clarke & Simon, 2019).”
From Autophagy in major human diseases (2021) · cites this paper as Clarke & Simon, 2019
Autophagy deficiency affects generation, survival, maturation, and effector properties of central cellular components of innate and adaptive immunity.
“Accordingly, autophagy deficiency affects generation, survival, maturation, and effector properties of central cellular components of innate and adaptive immunity (Ma et al, 2013c; Clarke & Simon, 2019; Deretic, 2021).”
From Autophagy in major human diseases (2021) · cites this paper as Clarke & Simon, 2019
Autophagy supports the development and function of several immune effector cells, including DCs, macrophages, CD4+ T cells, CD8+ T cells, and NK cells.
“autophagy supports the development and function of various immune effector cells, including DCs, macrophages, as well as CD4 + , CD8 + , and NK cells (Clarke and Simon, 2019)”
From Immunomodulation by targeted anticancer agents (2021) · cites this paper as Clarke and Simon, 2019
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References 136 · Cited by 361
- Authors
- Clarke, A. J., & Simon, A. K.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Simon, Anna Katharina
- Venue
- Nature Reviews Immunology
- Published
- 2018-12-07
- Volume
- 19
- Issue
- 3
- Pages
- 170-183
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2903895128
- Cited by
- 361
- References
- 136
- Citations by year
- 2026: 34 · 2025: 50 · 2024: 44 · 2023: 40 · 2022: 57 · 2021: 54 · 2020: 47 · 2019: 35
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- Wellcome Trust (104549/Z/14/Z, 103830/Z/14/Z)
- Kennedy Trust for Rheumatology Research (KENN161708)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- autophagy, immune cell differentiation, immune cell homeostasis, cellular metabolism, selective degradation, organelle degradation, cell survival
- MeSH terms
- Autophagy, B-Lymphocytes, Cell Differentiation, Homeostasis, Humans, Lymphocytes, T-Lymphocytes, Myeloid Cells
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