γδ T cells in tissue physiology and surveillance
Abstract
γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By rapidly producing large amounts of cytokines, γδ T cells make key contributions to immune responses in these tissues. In addition to their immune surveillance activities, recent reports have unravelled exciting new roles for γδ T cells in steady-state tissue physiology, with functions ranging from the regulation of thermogenesis in adipose tissue to the control of neuronal synaptic plasticity in the central nervous system. Here, we review the roles of γδ T cells in tissue homeostasis and in surveillance of infection, aiming to illustrate their major impact on tissue integrity, tissue repair and immune protection.
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Recent studies have revealed profound tissue-specific transcriptional signatures for human and mouse γδ T cells.
“Reflecting their tissue residency and the impact of the microenvironment on γδ T cell function, recent studies have revealed profound tissue-specific transcriptional signatures for human (9) and mouse γδ T cells (10).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [10]
Considerable numbers of Vγ4+ and Vγ6+ γδ T cells are present in mouse lungs, but their effect on lung tissue physiology is unclear.
“Considerable numbers of Vγ4+ and Vγ6+ γδ T cells are present in mouse lungs, but their effect on lung tissue physiology is unclear (28).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [28]
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The Immunology of Psoriasis-Current Concepts in Pathogenesis
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- Authors
- Ribot, J. C., Lopes, N., & Silva-Santos, B.
- Affiliations
- University of Lisbon (PT)
- Corresponding author
- Ribot, Julie C.
- Venue
- Nature Reviews Immunology
- Published
- 2020-10-14
- Volume
- 21
- Issue
- 4
- Pages
- 221-232
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W3093059312
- Cited by
- 532
- References
- 9
- Citations by year
- 2026: 92 · 2025: 112 · 2024: 115 · 2023: 103 · 2022: 73 · 2021: 36 · 2020: 1
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- γδ T cells, tissue homeostasis, immune surveillance, tissue physiology, thermogenesis, adipose tissue, tissue repair, cytokine production, infection surveillance, skin, intestine, lung
- MeSH terms
- Butyrophilins, Intraepithelial Lymphocytes, Adipose Tissue, Bone Regeneration, Central Nervous System, Female, Genitalia, Female, Gingiva, Homeostasis, Humans, Immunologic Surveillance, Infections, Intestinal Mucosa, Lung, Mucous Membrane, Neuronal Plasticity, Regeneration, T-Lymphocyte Subsets, Thermogenesis
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