The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.
The role of platelets in immune-mediated inflammatory diseases
Open accessAbstract
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and uncontrolled inflammation and thrombosis, both of which are responsible for organ damage, morbidity and death. Platelets have long been known for their role in primary haemostasis, but they are now also considered to be components of the immune system and to have a central role in the pathogenesis of IMIDs. In patients with IMIDs, platelets are activated by disease-specific factors, and their activation often reflects disease activity. Here we summarize the evidence showing that activated platelets have an active role in the pathogenesis and the progression of IMIDs. Activated platelets produce soluble factors and directly interact with immune cells, thereby promoting an inflammatory phenotype. Furthermore, platelets participate in tissue injury and promote abnormal tissue healing, leading to fibrosis. Targeting platelet activation and targeting the interaction of platelets with the immune system are novel and promising therapeutic strategies in IMIDs. In addition to their well-established role in haemostasis, platelets also have an active role in the immune response. Here the authors summarize the evidence linking platelet activation to immune dysregulation and organ damage in immune-mediated inflammatory diseases, and discuss the therapeutic potential of targeting platelets.
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Cited by
Inflammation: Is It a Healer, Confounder, or a Promoter of Cardiometabolic Risks?
Tate, A. R., & Rao, G. H. R. (2024) · Biomolecules · doi:10.3390/biom14080948 · Cited by 42
Metadata
- Authors
- Scherlinger, M., Richez, C., Tsokos, G. C., Boilard, E., & Blanco, P.
- Venue
- Nature Reviews Immunology
- Published
- 2023-01-27
- Volume
- 23
- Issue
- 8
- Pages
- 495-510
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W4318262965
- Cited by
- 346
- References
- 162
- FWCI
- 25.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Scherlinger, M., Richez, C., Tsokos, G. C., Boilard, E., & Blanco, P. (2023). The role of platelets in immune-mediated inflammatory diseases. Nature Reviews Immunology. https://doi.org/10.1038/s41577-023-00834-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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