The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Envelope stress responses: balancing damage repair and toxicity
Open accessAbstract
The Gram-negative envelope is a complex structure that consists of the inner membrane, the periplasm, peptidoglycan and the outer membrane, and protects the bacterial cell from the environment. Changing environmental conditions can cause damage, which triggers the envelope stress responses to maintain cellular homeostasis. In this Review, we explore the causes, both environmental and intrinsic, of envelope stress, as well as the cellular stress response pathways that counter these stresses. Furthermore, we discuss the damage to the cell that occurs when these pathways are aberrantly activated either in the absence of stress or to an excessive degree. Finally, we review the mechanisms whereby the σE response constantly acts to prevent cell death caused by highly toxic unfolded outer membrane proteins. Together, the recent work that we discuss has provided insights that emphasize the necessity for proper levels of stress response activation and the detrimental consequences that can occur in the absence of proper regulation. In this Review, Mitchell and Silhavy explore the cellular envelope stress response pathways and discuss what occurs when these pathways are aberrantly activated. They also discuss how recent insights into stress response activation have highlighted the extreme toxicity of unfolded outer membrane proteins.
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Rai, A. K., Sawasato, K., Bennett, H. C., Kozlova, A., Sparagna, G. C., Bogdanov, M., & Mitchell, A. M. (2024) · PLOS Genetics · doi:10.1371/journal.pgen.1011335 · Cited by 19
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Metadata
- Authors
- Mitchell, A. M., & Silhavy, T. J.
- Venue
- Nature Reviews Microbiology
- Published
- 2019-05-31
- Volume
- 17
- Issue
- 7
- Pages
- 417-428
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2947447072
- Cited by
- 292
- References
- 149
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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