The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
Open accessAbstract
SUMMARY: The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous in these bacteria greatly contribute to antibiotic resistance and present a major challenge for antibiotic development. Multidrug pumps, particularly those represented by the clinically relevant AcrAB-TolC and Mex pumps of the resistance-nodulation-division (RND) superfamily, not only mediate intrinsic and acquired multidrug resistance (MDR) but also are involved in other functions, including the bacterial stress response and pathogenicity. Additionally, efflux pumps interact synergistically with other resistance mechanisms (e.g., with the outer membrane permeability barrier) to increase resistance levels. Since the discovery of RND pumps in the early 1990s, remarkable scientific and technological advances have allowed for an in-depth understanding of the structural and biochemical basis, substrate profiles, molecular regulation, and inhibition of MDR pumps. However, the development of clinically useful efflux pump inhibitors and/or new antibiotics that can bypass pump effects continues to be a challenge. Plasmid-borne efflux pump genes (including those for RND pumps) have increasingly been identified. This article highlights the recent progress obtained for organisms of clinical significance, together with methodological considerations for the characterization of MDR pumps.
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Cited by
Extensive impact of non-antibiotic drugs on human gut bacteria
Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., et al. (2018) · Nature · doi:10.1038/nature25979 · Cited by 1,905
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Drug combinations: a strategy to extend the life of antibiotics in the 21st century
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Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It
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Metadata
- Authors
- Li, X.-Z., Plésiat, P., & Nikaido, H.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2015-04
- Volume
- 28
- Issue
- 2
- Pages
- 337-418
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W1999979510
- Cited by
- 1,614
- References
- 16
- FWCI
- 42.19
- Type
- journal article
- Language
- en
- Open access
- green
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