The DOI matches its Crossref record; 264 of the 264 references it cites were found in a registry or an index.
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
Open accessAbstract
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication forks from attrition. BRCA1 partners with BRCA1-associated RING domain protein 1 (BARD1) and other tumour suppressor proteins to mediate the initial nucleolytic resection of DNA lesions and the recruitment and regulation of the recombinase RAD51. The discovery of the opposing functions of BRCA1 and the p53-binding protein 1 (53BP1)-associated complex in DNA resection sheds light on how BRCA1 influences the choice of homologous recombination over non-homologous end joining and potentially other mutagenic pathways of DSB repair. Understanding the functional crosstalk between BRCA1–BARD1 and its cofactors and antagonists will illuminate the molecular basis of cancers that arise from a deficiency or misregulation of chromosome damage repair and replication fork maintenance. Such knowledge will also be valuable for understanding acquired tumour resistance to poly(ADP-ribose) polymerase (PARP) inhibitors and other therapeutics and for the development of new treatments. In this Review, we discuss recent advances in elucidating the mechanisms by which BRCA1–BARD1 functions in DNA repair, replication fork maintenance and tumour suppression, and its therapeutic relevance. BRCA1 and its partner BARD1 support repair of double-strand breaks by homologous recombination and protect replication forks from damage. Recent studies have improved our understanding of the molecular mechanisms of these tumour-suppressive functions of BRCA1–BARD1 and how they are subverted in therapy-resistant cancers.
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1 retracted
RETRACTED ARTICLE: A mechanism for the suppression of homologous recombination in G1 cells
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Cited by
Huang, R., & Zhou, P.-K. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00648-7 · Cited by 907
Targeting DNA damage response pathways in cancer
Groelly, F. J., Fawkes, M., Dagg, R. A., Blackford, A. N., & Tarsounas, M. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00535-5 · Cited by 836
Self-citationRegulating tumor suppressor genes: post-translational modifications
Chen, L., Liu, S., & Tao, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0196-9 · Cited by 449
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing
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SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
Minten, E. V., Kapoor-Vazirani, P., Li, C., Zhang, H., Balakrishnan, K., & Yu, D. S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108921 · Cited by 34
Metadata
- Authors
- Tarsounas, M., & Sung, P.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2020-02-24
- Volume
- 21
- Issue
- 5
- Pages
- 284-299
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W3007516256
- Cited by
- 359
- References
- 264
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- green
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