Cited by 452Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerCancer-related gene regulation

Regulating tumor suppressor genes: post-translational modifications

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Chen, Ling, Liu, Shuang, Tao, Yongguang·2020·Signal Transduction and Targeted Therapy

Abstract

Tumor suppressor genes cooperate with each other in tumors. Three important tumor suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted on chromosome ten (PTEN) are functionally associated and they regulated by post-translational modification (PTMs) as well. PTMs include phosphorylation, SUMOylation, acetylation, and other novel modifications becoming growing appreciated. Because most of PTMs are reversible, normal cells use them as a switch to control the state of cells being the resting or proliferating, and PTMs also involve in cell survival and cell cycle, which may lead to abnormal proliferation and tumorigenesis. Although a lot of studies focus on the importance of each kind of PTM, further discoveries shows that tumor suppressor genes (TSGs) form a complex “network” by the interaction of modification. Recently, there are several promising strategies for TSGs for they change more frequently than carcinogenic genes in cancers. We here review the necessity, characteristics, and mechanisms of each kind of post-translational modification on Rb, p53, PTEN, and its influence on the precise and selective function. We also discuss the current antitumoral therapies of Rb, p53 and PTEN as predictive, prognostic, and therapeutic target in cancer.

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Authors
Chen, L., Liu, S., & Tao, Y.
Affiliations
Central South University (CN)
Corresponding author
Tao, Yongguang
Venue
Signal Transduction and Targeted Therapy
Published
2020-06-10
Volume
5
Issue
1
Pages
90-90
ISSN
2059-3635 (ISSN-L)
OpenAlex
W3035758066
Cited by
449
References
522
Citations by year
2026: 52 · 2025: 89 · 2024: 110 · 2023: 87 · 2022: 65 · 2021: 38 · 2020: 3 · 2019: 4 · 2018: 1
FWCI
5.23
Type
journal article
Language
en
Open access
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81672787, 111 Project, 81672991, 81874139)
  • Higher Education Discipline Innovation Project
  • Overseas Expertise Introduction Project for Discipline Innovation (“111” Project)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords
tumor suppressor, post-translational modification, retinoblastoma protein, p53, PTEN, phosphorylation, SUMOylation, acetylation, tumor suppressor network, cell cycle regulation, carcinogenesis, cancer therapy, therapeutic target
MeSH terms
Humans, Neoplasms, Protein Processing, Post-Translational, Genes, Tumor Suppressor, Tumor Suppressor Protein p53, Retinoblastoma Protein, PTEN Phosphohydrolase, Carcinogenesis

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