Cited by 508Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsSpatial Cognition and Navigation

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Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

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Coughlan, Gillian, Laczó, Jan, Hort, Jakub, Minihane, Anne-Marie, Hornberger, Michael·2018·Nature Reviews Neurology

DOI 10.1038/s41582-018-0031-x

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Abstract

Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of developing this disease. By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals. This Review highlights a novel feature of cognitive evaluation for incipient AD by focusing on spatial navigation and orientation deficits, which are increasingly shown to be present in at-risk individuals. Importantly, the navigation system in the brain overlaps substantially with the regions affected by AD in both animal models and humans. Notably, spatial navigation has fewer verbal, cultural and educational biases than current cognitive tests and could enable a more uniform, global approach towards cognitive fingerprints of AD and better cognitive treatment outcome measures in future multicentre trials. The current Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed AD and identifies research gaps and future research priorities.

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Authors: Coughlan, G., Laczó, J., Hort, J., Minihane, A.-M., & Hornberger, M.
Affiliations: University of East Anglia (GB)
Charles University (CZ)
Corresponding author: Hornberger, Michael
ORCID: Coughlan, Gillian
Laczó, Jan
Hort, Jakub
Minihane, Anne-Marie
Hornberger, Michael
Venue: Nature Reviews Neurology
Publisher: Springer Science and Business Media LLC
Published: 2018-07-06
Volume: 14
Issue: 8
Pages: 496-506
ISSN: 1759-4758 (ISSN-L)
1759-4766
DOI: 10.1038/s41582-018-0031-x
OpenAlex: W2810517026
Cited by: 500
References: 159
Citations by year: 2026: 63 · 2025: 73 · 2024: 77 · 2023: 90 · 2022: 66 · 2021: 57 · 2020: 38 · 2019: 32 · 2018: 3
FWCI: 5.02
Type: journal article
Language: en
Open access: green
ueaeprints.uea.ac.uk
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Neurology (publishedVersion)
PubMed (publishedVersion)
UEA Digital Repository (University of East Anglia) (acceptedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
Keywords: preclinical Alzheimer's disease, spatial orientation, prodromal Alzheimer's disease, episodic memory, cognitive outcome measures, Alzheimer's disease biomarkers
MeSH terms: Alzheimer Disease, Animals, Humans, Biomarkers, Prodromal Symptoms, Spatial Navigation

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Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

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