The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.
Parkinson disease psychosis: from phenomenology to neurobiological mechanisms
Abstract
Parkinson disease (PD) psychosis (PDP) is a spectrum of illusions, hallucinations and delusions that are associated with PD throughout its disease course. Psychotic phenomena can manifest from the earliest stages of PD and might follow a continuum from minor hallucinations to structured hallucinations and delusions. Initially, PDP was considered to be a complication associated with dopaminergic drug use. However, subsequent research has provided evidence that PDP arises from the progression of brain alterations caused by PD itself, coupled with the use of dopaminergic drugs. The combined dysfunction of attentional control systems, sensory processing, limbic structures, the default mode network and thalamocortical connections provides a conceptual framework to explain how new incoming stimuli are incorrectly categorized, and how aberrant hierarchical predictive processing can produce false percepts that intrude into the stream of consciousness. The past decade has seen the publication of new data on the phenomenology and neurobiological basis of PDP from the initial stages of the disease, as well as the neurotransmitter systems involved in PDP initiation and progression. In this Review, we discuss the latest clinical, neuroimaging and neurochemical evidence that could aid early identification of psychotic phenomena in PD and inform the discovery of new therapeutic targets and strategies.
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“human and animal stimuli are often the content of VH in these patients32,50”
From Deviations in effective connectivity explain different hallucination subtypes in Parkinson's disease psychosis (2026) · cites this paper as [32]
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Items 201–213 of 213
Miloserdov, K., Schmidt‐Samoa, C., Williams, K. A., Weinrich, C. A., Kagan, I., Bürk, K., Trenkwalder, C., Bähr, M., & Wilke, M. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102076 · Cited by 13
Visual illusions in Parkinson's disease: an interview survey of symptomatology
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Othello syndrome in Parkinson’s disease: a systematic review and report of a case series
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The role of attentional control over interference in minor hallucinations in Parkinson’s disease
Bejr‐Kasem, H., Martínez‐Horta, S., Pagonabarraga, J., Marín‐Lahoz, J., Horta‐Barba, A., Sampedro, F., Aracil‐Bolaños, I., Pérez‐Pérez, J., Campolongo, A., Izquierdo, C., et al. (2022) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2022.07.009 · Cited by 7
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Catd: unified representation learning for eeg-to-fmri cross-modal generation
Yao, W., Lyu, Z., Mahmud, M., Zhong, N., Lei, B., & Wang, S. (2025) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2025.3550206 · Cited by 24
Stampacchia, S., Bernasconi, F., Van De Ville, D., Amico, E., Pagonabarraga, J., Kulisevsky, J., & Blanke, O. (2025) · doi:10.1101/2025.04.17.649310 · Cited by 5
Self-citationVignando, M., Ffytche, D., Mazibuko, N., Palma, G., Bhat, A., Montagnese, M., Dave, S., Tai, Y. F., Batzu, L., Leta, V., et al. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00669-7
“Inter-estingly, human and animal stimuli are often the content of VH in these patients 32,50 .”
Metadata
- Authors
- Pagonabarraga, J., Bejr-Kasem, H., Martinez-Horta, S., & Kulisevsky, J.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Pagonabarraga, Javier
- Venue
- Nature Reviews Neurology
- Published
- 2024-01-15
- Volume
- 20
- Issue
- 3
- Pages
- 135-150
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W4390879322
- Cited by
- 69
- References
- 213
- Citations by year
- 2026: 21 · 2025: 41 · 2024: 7
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- hallucinations, delusions, illusion, dopaminergic therapy, attentional control, sensory processing, limbic system, default mode network, thalamocortical connections, predictive processing, neurotransmitter systems, early detection, therapeutic target
- MeSH terms
- Brain, Hallucinations, Humans, Parkinson Disease, Psychotic Disorders
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