The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.
Imaging the evolution and pathophysiology of Alzheimer disease
Open accessAbstract
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit studies of the relationships between the two major proteins deposited in this disease - amyloid-β (Aβ) and tau - and their effects on measures of neurodegeneration and cognition in humans. Deposition of Aβ in the medial parietal cortex appears to be the first stage in the development of AD, although tau aggregates in the medial temporal lobe (MTL) precede Aβ deposition in cognitively healthy older people. Whether aggregation of tau in the MTL is the first stage in AD or a fairly benign phenomenon that may be transformed and spread in the presence of Aβ is a major unresolved question. Despite a strong link between Aβ and tau, the relationship between Aβ and neurodegeneration is weak; rather, it is tau that is associated with brain atrophy and hypometabolism, which, in turn, are related to cognition. Although there is support for an interaction between Aβ and tau resulting in neurodegeneration that leads to dementia, the unknown nature of this interaction, the strikingly different patterns of brain Aβ and tau deposition and the appearance of neurodegeneration in the absence of Aβ and tau are challenges to this model that ultimately must be explained.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These and other studies 13,24,133,134 strongly support the concept of AD as being an amyloid-provoked, or facilitated, tauopathy, although there is also evidence that both pathologies act in synergy 135 .”
From The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396
Self-citationWhat is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Cited by
Sorted by citations
Items 201–300 of 610
Liang, Z., Li, X., Luo, X., Luo, H.-J., Chen, Y., Cai, M., Zhong, X.-X., Fang, Y., Guo, T., Shi, Y., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.02.018 · Cited by 22
Wang, P., Yu, L., Gong, J., Xiong, J., Zi, S., Xie, H., Zhang, F., Mao, Z., Liu, Z., & Kim, J. S. (2022) · Angewandte Chemie · doi:10.1002/ange.202206894 · Cited by 20
Angelucci, F., Veverová, K., Katonová, A., Piendel, L. A., Vyhnálek, M., & Hort, J. (2022) · Pharmaceuticals · doi:10.3390/ph15091074 · Cited by 20
Samir, S. M., Hassan, H. M., Elmowafy, R., Nashar, E. M. E., Alghamdi, M. A., AlSheikh, M. H., Al-Zahrani, N. S., Alasiri, F. M., & Elhadidy, M. G. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1267675 · Cited by 22
Relationship between β-amyloid and structural network topology in decedents without dementia
Jonkman, L. E., Steenwijk, M. D., Boesen, N., Rozemüller, A. J. M., Barkhof, F., Geurts, J. J. G., Douw, L., & van de Berg, W. D. J. (2020) · Neurology · doi:10.1212/wnl.0000000000009910 · Cited by 19
Altered functional connectivity of the insula in a rat model of recurrent headache
Jia, Z., Yu, S., Tang, W., & Zhao, D. (2020) · Molecular Pain · doi:10.1177/1744806920922115 · Cited by 19
Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels
Webster, J. M., Darling, A. L., Sanders, T. A., Blazier, D. M., Vidal-Aguiar, Y., Beaulieu‐Abdelahad, D., Plemmons, D. G., Hill, S. E., Uversky, V. N., Bickford, P. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155442 · Cited by 18
Diagnosis of Alzheimer's Disease Based on Deeply-Fused Nets
Chen, C. Z., Wu, Q., Li, Z., Xiao, L., & Hu, Z. Y. (2020) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207323666200825092649 · Cited by 19
A New Highly Deuterated [18F]AV-45, [18F]D15FSP, for Imaging β-Amyloid Plaques in the Brain
Xiao, H., Choi, S., Zhao, R., Plöessl, K., Alexoff, D., Zhu, L., Zha, Z., & Kung, H. F. (2021) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.1c00062 · Cited by 19
Yang, J., Zhou, Y. M., Ban, Y., Mi, J., He, Y., Li, X., Liu, Z., Wang, K., Zhu, G., Liu, W., et al. (2022) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2022.2041627 · Cited by 19
Araki, W. (2023) · Cells · doi:10.3390/cells12101386 · Cited by 20
Gallagher, R. L., Koscik, R. L., Moody, J. F., Vogt, N. M., Adluru, N., Kecskemeti, S., Hulle, C. A. V., Chin, N. A., Asthana, S., Kollmorgen, G., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01281-y · Cited by 22
Qi, X., Yuan, S., Ding, J., Sun, W., Shi, Y., Xing, Y., Liu, Z., Yao, Y., Fu, S., Sun, B., et al. (2024) · Aging Cell · doi:10.1111/acel.14352 · Cited by 18
Zou, Y., Zhang, J., Chen, L., Xu, Q., Yao, S., & Chen, H. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030388 · Cited by 19
Richardson, T. E., Walker, J. M., Farrell, K. W., Oliveira, T. G., White, C. L., & Crary, J. F. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02943-x · Cited by 25
Badrikoohi, M., Esmaeili‐bandboni, A., & Babaei, P. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.12.004 · Cited by 18
Classification of Alzheimer’s Disease Subjects from MRI Using Deep Convolutional Neural Networks
Papadimitriou, O., Kanavos, A., Phivos Mylonas, B., & Μaragoudakis, M. (2023) · Lecture notes in networks and systems · doi:10.1007/978-3-031-44146-2_28 · Cited by 19
IG-GCN: Empowering e-Health Services for Alzheimer’s Disease Prediction
Chen, X., Yao, W., Li, Y., Liang, D., Zheng, H., Shakil, S., Wang, S., & Sun, T. (2024) · IEEE Transactions on Consumer Electronics · doi:10.1109/tce.2024.3439594 · Cited by 19
Behl, T., Makkar, R., Sehgal, A., Sharma, N., Singh, S., Albratty, M., Najmi, A., Meraya, A. M., & BUNGAU, S. G. (2022) · Molecules · doi:10.3390/molecules27154970 · Cited by 18
Merde, İ. B., Önel, G. T., Türkmenoğlu, B., Gürsoy, Ş., & Dilek, E. (2022) · Medicinal Chemistry Research · doi:10.1007/s00044-022-02968-x · Cited by 17
Zhang, Y., Xie, X., Chen, B., Pan, L., Li, J., Wang, W., Wang, J., Tang, R., Huang, Q., Chen, X., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.02.051 · Cited by 19
Advanced brain imaging for the diagnosis of Alzheimer disease
Wang, Y.-T. T., Rosa‐Neto, P., & Gauthier, S. G. (2023) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001198 · Cited by 16
Atypical intrinsic neural timescale in the left angular gyrus in Alzheimer’s disease
Murai, S. A., Mano, T., Sanes, J. N., & Watanabe, T. (2024) · Brain Communications · doi:10.1093/braincomms/fcae199 · Cited by 17
Xu, T., Weng, L., Zhang, C., Xiao, X., Yang, Q., Zhu, Y., Zhou, Y., Liao, X., Luo, S., Wang, J., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14215 · Cited by 18
A review on gut microbiota and miRNA crosstalk: implications for Alzheimer’s disease
Ayyanar, M. P., & Vijayan, M. (2024) · GeroScience · doi:10.1007/s11357-024-01432-5 · Cited by 22
von Maydell, D. K., & Jorfi, M. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00395.2019 · Cited by 19
Meyer, P., McSweeney, M., Gonneaud, J., & Villeneuve, S. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.05.001 · Cited by 20
Tu, T., Jiang, J., Zhang, Q., Wan, L., Li, Y., Pan, A., Manavis, J., & Yan, X. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00093 · Cited by 16
Harrison, T. M., Ward, T. J., Taggett, J. Z., Maillard, P., Lockhart, S. N., Jung, Y., Lovato, L., Koeppe, R. A., Jagust, W. J., Harvey, D. J., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14399 · Cited by 16
Self-citationDistinct Factors Drive the Spatiotemporal Progression of Tau Pathology in Older Adults.
Adams, J. N., Harrison, T. M., Maaß, A., Baker, S. L., & Jagust, W. J. (2022) · DZNE Pub · Cited by 16
Self-citationRoe, J. M., Dídac Vidal-piñeiro, A., Sørensen, Ø., Grydeland, H., Leonardsen, E. H., Iakunchykova, O. P., Pan, M., Mowinckel, A. M., Strømstad, M., Nawijn, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53548-z · Cited by 20
Cofilin 2 in Serum as a Novel Biomarker for Alzheimer’s Disease in Han Chinese
Sun, Y., Liang, L., Dong, M., Li, C., Liu, Z., & Gao, H. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00214 · Cited by 17
Dynamic Interplay between Copper Toxicity and Mitochondrial Dysfunction in Alzheimer’s Disease
Tassone, G., Kola, A., Valensin, D., & Pozzi, C. (2021) · Life · doi:10.3390/life11050386 · Cited by 16
Aging impacts memory for perceptual, but not narrative, event detailsPreprint
Delarazan, A. I., Charan Ranganath, A., & Reagh, Z. M. (2023) · Learning & Memory · doi:10.1101/lm.053740.122 · Cited by 16
Slow wave synchrony during NREM sleep tracks cognitive impairment in prodromal Alzheimer's disease
Sharon, O., Zhelezniakov, V., Gat, Y., Falach, R., Narbayev, D., Shiner, T., Walker, M. P., Tauman, R., Bregman, N., & Nir, Y. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70247 · Cited by 23
Sadleir, K. R., Gómez, K., Edwards, A. E., Patel, A. J., Ley, M. L., Khatri, A. W., Guo, J., Mahesh, S., Watkins, E. A., Popović, J., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02888-1 · Cited by 18
Ranasinghe, K. G., Kudo, K., Syed, F., Yballa, C., Kramer, J. H., Miller, B. L., Rankin, K. P., Garcia, P. A., Kirsch, H. E., Vossel, K. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62798-4 · Cited by 18
Self-citationA CHCHD6–APP axis connects amyloid and mitochondrial pathology in Alzheimer’s disease
Shang, Y., Sun, X., Chen, X., Wang, Q., Wang, E. J., Miller, E., Xu, R., Pieper, A. A., & Qi, X. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02499-0 · Cited by 15
Luo, K., Chen, J., Li, H., Wu, D., Du, Y., Zhao, S., Liu, T., Li, L., Dai, Z., Li, Y., et al. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106596 · Cited by 15
Wolf, T. N., Pölsterl, S., & Wachinger, C. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-34048-2_7 · Cited by 15
Dato, S., Rango, F. D., Crocco, P., Pallotti, S., Belloy, M. E., Guen, Y. L., Greicius, M. D., Passarino, G., Rose, G., & Napolioni, V. (2023) · Aging Cell · doi:10.1111/acel.13938 · Cited by 12
Clinical application of MAO‐B PET using 18F‐THK5351 in neurological disorders
Ishibashi, K. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14729 · Cited by 14
Hojjati, S. H., Abbas Babajani-feremi, A., & Initiative, T. A. D. N. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1356656 · Cited by 15
Aliaga, A., Therriault, J., Quispialaya, K. M., Aliaga, A., Hopewell, R., Rahmouni, N., Macedo, A. C., Kunach, P., Soucy, J., Massarweh, G., et al. (2024) · Journal of Nuclear Medicine · doi:10.2967/jnumed.124.267539 · Cited by 18
Pharmacogenomics for neurodegenerative disorders - a focused review
Ahmad, S. R., Zeyaullah, M., Khan, M. S. A. A., AlShahrani, A. M., Altijani, A. A. G., Ali, H., Dawria, A., Mohieldin, A., Alam, M. S., & Mohamed, A. O. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1478964 · Cited by 17
Sang, Z., Shi, J., Zhou, Y. M., Wang, K., Zhao, Y., Li, Q., Qiao, Z., Wu, A., Tan, Z., & Liu, W. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104602 · Cited by 15
Detection and quantification of Aβ−3–40 (APP669‐711) in cerebrospinal fluid
Klafki, H., Wirths, O., Mollenhauer, B., Liepold, T., Rieper, P., Esselmann, H., Vogelgsang, J. S., Wiltfang, J., & Jahn, O. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15571 · Cited by 15
Hallmarks of healthy cognitive aging: Inter-individual differences in aging trajectories
Abrous, D. N., Blin, N., Boraxbekk, C., Catheline, G., Fitzsimons, C. P., Hilscher, M. M., Lemoine, M., Lopes, L. V., Maass, A., Nilsson, M., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103102 · Cited by 18
Peptidotriazolamers Inhibit Aβ(1–42) Oligomerization and Cross a Blood‐Brain‐Barrier Model
Tonali, N., Hericks, L., Schröder, D. C., Kracker, O., Krzemieniecki, R., Kaffy, J., Joncour, V. L., Laakkonen, P., Marion, A., Ongeri, S., et al. (2021) · ChemPlusChem · doi:10.1002/cplu.202000814 · Cited by 14
Nikolaeva, N. S., Yandulova, E. Y., Aleksandrova, Y. R., Starikov, A. S., & Неганова, М. Е. (2022) · Acta Naturae · doi:10.32607/actanaturae.11723 · Cited by 15
Sciuto, M., & Catanzaro, R. (2023) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/030.2023.02134 · Cited by 15
Li, Q., Hu, H., Zhang, G.-W., Hu, H., Ou, Y., Huang, L., Wang, A.-Y., Gao, P., Ma, L., Tan, L., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01396-w · Cited by 15
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease
Raulin, A., Doss, S. V., Heckman, M. G., Craver, E. C., Li, Z., Ikezu, T. C., Sekiya, H., Liu, C., Martens, Y. A., Rosenberg, C. L., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01731-0 · Cited by 14
Doering, S., McCullough, A. A., Gordon, B. A., Chen, C. D., McKay, N. S., Hobbs, D. A., Keefe, S., Flores, S. E., Scott, J., Smith, H. D., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105080 · Cited by 19
Advances of therapy for Alzheimer's disease: An updated review
Mei, C., Zhan, J., Zhu, S., Zhang, Y., Xiong, C., Wang, J., Xu, Y. J., Zhong, H., & Cheng, J. (2024) · Brain‐X · doi:10.1002/brx2.68 · Cited by 15
Hojjati, S. H., Butler, T., de Leon, M. J., Gupta, A. K., Nayak, S., Luchsinger, J. A., Razlighi, Q. R., & Chiang, G. C.-Y. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.01.005 · Cited by 18
Li, Y., Zhou, G., Peng, J., Liu, L., Zhang, F., Iturria‐Medina, Y., Yao, D., Biswal, B. B., & Wang, P. (2025) · Communications Biology · doi:10.1038/s42003-025-08177-7 · Cited by 18
Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study
Padilla, C., Montal, V., Walpert, M., Hong, Y. T., Fryer, T. D., Coles, J., Aigbirhio, F. I., Hartley, S. L., Cohen, A. D., Tudorascu, D., et al. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12288 · Cited by 14
Jin, X., Wang, M., Shentu, J., Huang, C., Bai, Y., Pan, H., Zhang, D., Yuan, Z., Zhang, H., Xiao, X., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.11226 · Cited by 14
Peptidyl arginine deiminase 4 and its potential role in Alzheimer's disease
Wang, L., Song, Y., Mi, J.-H., & Ding, M. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110466 · Cited by 13
Li, R., Miao, X., Han, B., & Li, J. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14971 · Cited by 13
Deep Learning Implementation using Convolutional Neural Network for Alzheimer’s Classification
Priyatama, A., Sari, Z., & Azhar, Y. (2023) · Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) · doi:10.29207/resti.v7i2.4707 · Cited by 13
Dynamic functional connectivity MEG features of Alzheimer’s disease
Jin, H., Ranasinghe, K. G., Prabhu, P., Dale, C. L., Gao, Y., Kudo, K., Vossel, K. A., Raj, A., Nagarajan, S. S., & Jiang, F. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120358 · Cited by 15
Griffiths-King, D., WOOD, A. G., & Novák, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-42414-5 · Cited by 13
Early Alzheimer’s disease diagnosis using an XG-Boost model applied to MRI images
Nguyen, K., Nguyen, M., Dang, T. T. K., Pham, B. H., Huynh, V., Toi, V. V., Ngo, L. T., & Ha, H. (2023) · Biomedical Research and Therapy · doi:10.15419/bmrat.v10i9.832 · Cited by 14
Energy landscape analysis of brain network dynamics in Alzheimer’s disease
Xing, L., Guo, Z., & Long, Z. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1375091 · Cited by 12
Initiative, T. A. D. N., Wang, M., Yan, Z., Zhang, H., Lu, J., Li, L., Yu, J., Wang, J., Matsuda, H., Zuo, C., et al. (2020) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-20-110 · Cited by 13
Jing, J., Zhang, F., Zhao, L., Xie, J., Chen, J., Zhong, R., Zhang, Y., & Dong, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201335 · Cited by 13
Monoamine oxidase binding not expected to significantly affect [18F]flortaucipir PET interpretation
Wright, J. P., Goodman, J. R., Lin, Y., Lieberman, B. P., Clemens, J., Gomez, L. F., Liang, Q., Hoye, A. T., Pontecorvo, M. J., & Conway, K. A. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-022-05822-9 · Cited by 13
Deep joint learning of pathological region localization and Alzheimer’s disease diagnosis
Park, C., Jung, W., & Suk, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-38240-4 · Cited by 13
Amyloid‐dependent and amyloid‐independent effects of Tau in individuals without dementia
Therriault, J., Pascoal, T. A., Sefranek, M., Mathotaarachchi, S. S., Benedet, A. L., Chamoun, M., Lussier, F. Z., Tissot, C., Bellaver, B., Ferreira, P. L., et al. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51457 · Cited by 13
Insights for Alzheimer's disease pharmacotherapy and current clinical trials
do Nascimento, A. L. C. S., Fernandes, R. P., Carvalho, A. C. S., Frigieri, I., Alves, R. C., & Chorilli, M. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105401 · Cited by 13
Roe, J. M., Dídac Vidal-piñeiro, A., Sørensen, Ø., Brandmaier, A. M., Düzel, S., Gonzalez, H. A., Kievit, R., Knights, E., Kühn, S., Lindenberger, U., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.18.158980 · Cited by 13
Mohiuddin, M., Asghar, T., Hameed, H., Din, A. M., Siddique, A., Younas, S., Din, M. M. U., & Ara, R. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04632-z · Cited by 13
Adeowo, F. Y., Oyetunji, T. P., Ejalonibu, M. A., Ndagi, U., Kumalo, H. M., & Lawal, M. M. (2021) · Chemistry & Biodiversity · doi:10.1002/cbdv.202100361 · Cited by 12
Mapping the association between tau-PET and Aβ-amyloid-PET using deep learning
Ruwanpathirana, G. P., Williams, R. C., Masters, C. L., Rowe, C. C., Johnston, L. A., & Davey, C. E. (2022) · Scientific Reports · doi:10.1038/s41598-022-18963-6 · Cited by 13
Muntsant-Soria, A., Castillo-Ruiz, M. D. M., & Giménez‐Llort, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813796 · Cited by 14
Cohen, B. M., & Sonntag, K. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105238 · Cited by 13
Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study
Xu, G., Zheng, S., Zhu, Z., Yu, X., Jiang, J. C., Jiang, J., Chu, Z., & Initiative, A. D. N. (2020) · Annals of Nuclear Medicine · doi:10.1007/s12149-020-01506-2 · Cited by 13
Baena, A. Y., Bocanegra, Y., Torres, V. L., Vila‐Castelar, C., Guzmán‐Vélez, E., Fox‐Fuller, J. T., Gatchel, J. R., Sanchez, J. S., Pluim, C. F., Ramirez-Gomez, L. A., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210185 · Cited by 12
Focus on Alzheimer’s Disease: The Role of Fibroblast Growth Factor 21 and Autophagy
Yang, L., & Nao, J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.11.003 · Cited by 11
Astrocyte Circadian Timekeeping in Brain Health and Neurodegeneration
Brancaccio, M., Wolfes, A. C., & Ness, N. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-81147-1_6 · Cited by 12
Gülcan, H. O., & Koşar, M. (2021) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026621666211111153626 · Cited by 12
Merde, İ. B., Önel, G. T., Türkmenoğlu, B., Gürsoy, Ş., & Dilek, E. (2022) · ChemistrySelect · doi:10.1002/slct.202202446 · Cited by 11
Grid codes underlie multiple cognitive maps in the human brain
Chen, D., Axmacher, N., & Wang, L. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102569 · Cited by 13
Wang, M., Huang, K., Jin, Y., & Zheng, Z.-J. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.47 · Cited by 12
Xu, C., Mei, Y., Yang, R., Luo, Q., Zhang, J., Kou, X., Hu, J., Wang, Y., Li, Y., Chen, R., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01230-8 · Cited by 13
Unraveling the Role of LRP1 in Alzheimer’s Disease: A Focus on Aβ Clearance and the Liver-Brain Axis
Yang, W., Wei, Z., & Wang, T. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02339-2 · Cited by 14
Holmes, B. B., Weigel, T. K., Chung, J. M., Kaufman, S. K., Apresa, B. I., Byrnes, J. R., Kumru, K. S., Vaquer‐Alicea, J., Gupta, A., Rose, I. V. L., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00883-4 · Cited by 14
Allosteric Modulators of Potential Targets Related to Alzheimer's Disease: a Review
Silva, G. M., Barcelos, M. P., Poiani, J. G. C., Hage-Melim, L. I. D. S., & da Silva, C. H. T. D. P. (2019) · ChemMedChem · doi:10.1002/cmdc.201900299 · Cited by 12
A Novel Metabolic Connectome Method to Predict Progression to Mild Cognitive Impairment
Wang, M., Yan, Z., Xiao, S., Zuo, C., & Jiang, J. (2020) · Behavioural Neurology · doi:10.1155/2020/2825037 · Cited by 11
Jiang, J., Zhang, J., Li, Z., Li, L., Huang, B., & Initiative, A. D. N. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.894726 · Cited by 12
Kurowska, E., Ruciński, J., Myślińska, D., Grembecka, B., Wrona, D., & Majkutewicz, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415449 · Cited by 12
Perani, D., Iaccarino, L., Jacobs, A. H., IMBI Brain Imaging Working Group, Lammertsma, A. A., Nordberg, A. K., Windhorst, A. D., Gerhard, A., Winkeler, A., Jacobs, A. H., et al. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.02.004 · Cited by 11
Aging and Alzheimer’s Disease Have Dissociable Effects on Medial Temporal Lobe ConnectivityPreprint
Hrybouski, S., Das, S. R., Xie, L., Wisse, L. E. M., Kelley, M., Lane, J., Sherin, M., DiCalogero, M., Nasrallah, I. M., Detre, J. A., et al. (2023) · medRxiv · doi:10.1101/2023.01.18.23284749 · Cited by 11
Fischer, L., Parker, D. M., Maboudian, S. A., Fonseca, C. S., Tato-Fernández, C., Annen, L., Arunachalam, P., Bacci, J. R., Barboure, M. C., Capelli, S., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01920-6 · Cited by 13
Self-citationMedial temporal lobe atrophy in Down syndrome along the Alzheimer’s disease continuum
Buehner, B. J., Morcillo-Nieto, A. O., Zsadanyi, S. E., Aranha, M. R., Arriola‐Infante, J. E., Vaqué‐Alcázar, L., Arranz, J., Rodríguez‐Baz, Í., Maure‐Blesa, L., Videla, L., et al. (2025) · Brain · doi:10.1093/brain/awaf133 · Cited by 12
Hojjati, S. H., Chiang, G. C.-Y., Butler, T., Chen, K., Khalafi, M., Yazdi, B. G., Foldi, N. S., Nayak, S., de Leon, M. J., Li, Y., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70153 · Cited by 12
Plasma p-tau217 predicting brain-wide tau accumulation in preclinical AD
Moon, H., & Chen, X. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100252 · Cited by 12
Linking Stage-Specific Plasma Biomarkers to Gray Matter Atrophy in Parkinson Disease
Lin, W., Lee, P., Lu, C., Lin, C., & Chou, K. (2021) · American Journal of Neuroradiology · doi:10.3174/ajnr.a7171 · Cited by 11
Metadata
- Authors
- Jagust, W.
- Affiliations
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Jagust, William
- ORCID
- Jagust, William
- Venue
- Nature Reviews Neuroscience
- Published
- 2018-09-28
- Volume
- 19
- Issue
- 11
- Pages
- 687-700
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC7032048
- OpenAlex
- W2894357926
- Cited by
- 604
- References
- 213
- Citations by year
- 2026: 73 · 2025: 85 · 2024: 89 · 2023: 94 · 2022: 76 · 2021: 85 · 2020: 58 · 2019: 40 · 2018: 2
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG045611, R01AG062542, P01AG019724, R01AG034570)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid-beta, tau protein, neurodegeneration, brain atrophy, hypometabolism, medial parietal cortex, medial temporal lobe, cognitive decline, dementia, disease progression
- MeSH terms
- Aging, Alzheimer Disease, Brain, Humans, Amyloid beta-Peptides, tau Proteins, Disease Progression, Multimodal Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review