The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Targeted neurotechnology restores walking in humans with spinal cord injury
Open accessAbstract
Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control of walking in individuals who had sustained a spinal cord injury more than four years ago and presented with permanent motor deficits or complete paralysis despite extensive rehabilitation. Using an implanted pulse generator with real-time triggering capabilities, we delivered trains of spatially selective stimulation to the lumbosacral spinal cord with timing that coincided with the intended movement. Within one week, this spatiotemporal stimulation had re-established adaptive control of paralysed muscles during overground walking. Locomotor performance improved during rehabilitation. After a few months, participants regained voluntary control over previously paralysed muscles without stimulation and could walk or cycle in ecological settings during spatiotemporal stimulation. These results establish a technological framework for improving neurological recovery and supporting the activities of daily living after spinal cord injury.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“He had previously participated in the STIMO clinical trial (clinicaltrials.gov, NCT02936453), which involved a five-month neurorehabilitation programme supported by targeted epidural electrical stimulation of the spinal cord4,5.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [4]
In the citing paper
“In turn, recruiting these dorsal root entry zones with preprogrammed spatiotemporal sequences replicates the physiological activation of leg motor pools underlying standing and walking4,5,11,13,14.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [4]
In the citing paper
“This programme enabled him to regain the ability to step with the help of a front-wheel walker.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [4]
In the citing paper
“Walking involves well-defined sequences of muscle activation patterns that support weight acceptance, propulsion and swing of the left and right lower limbs. These sequences coincide with the activation of motor pools located within well-segregated regions of the lumbosacral spinal cord4,27.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [4]
In the citing paper
“First, the physiological principles underlying targeted epidural electrical stimulation of the spinal cord have now been validated in nine out nine treated individuals with incomplete4 and complete5 injuries6.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [4]
In the citing paper
“This chain of software and hardware enabled real-time control of stimulation protocols with a latency inferior to 150 ms (ref. 4).”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [4]
In the citing paper
“We implemented a grid search model to explore the different electrode configurations and frequencies to select the configurations of cathodes and anodes to achieve maximum selectivity in the recruitment of the targeted muscle groups4.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [4]
In the citing paper
“Application of EES during neurorehabilitation (EESREHAB) further improved recovery of walking, even when the stimulation was turned off1,21.”
From The neurons that restore walking after paralysis (2022) · cites this paper as [1]
Citations
Cites
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934
Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury
van den Brand, R., Heutschi, J., Barraud, Q., DiGiovanna, J., Bartholdi, K., Huerlimann, M., Friedli, L., Vollenweider, I., Moraud, E. M., Duis, S., et al. (2012) · Science · doi:10.1126/science.1217416 · Cited by 767
Self-citationAngeli, C. A., Edgerton, V. R., Gerasimenko, Y. P., & Harkema, S. J. (2014) · Brain · doi:10.1093/brain/awu038 · Cited by 750
Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury
Angeli, C. A., Boakye, M., Morton, R. A., Vogt, J., Benton, K., Chen, Y., Ferreira, C. K., & Harkema, S. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803588 · Cited by 670
A brain–spine interface alleviating gait deficits after spinal cord injury in primates
Capogrosso, M., Milekovic, T., Borton, D., Wagner, F., Moraud, E. M., Mignardot, J.-B., Buse, N., Gandar, J., Barraud, Q., Xing, D., et al. (2016) · Nature · doi:10.1038/nature20118 · Cited by 635
Self-citationSchieppati, M. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90007-4 · Cited by 624
Gill, M. L., Grahn, P. J., Calvert, J. S., Linde, M. B., Lavrov, I. A., Strommen, J. A., Beck, L. A., Sayenko, D. G., Van Straaten, M. G., Drubach, D. I., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0175-7 · Cited by 574
A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits
Capogrosso, M., Wenger, N., Raspopovic, S., Musienko, P., Beauparlant, J., Bassi Luciani, L., Courtine, G., & Micera, S. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1688-13.2013 · Cited by 435
Self-citationFormento, E., Minassian, K., Wagner, F., Mignardot, J. B., Le Goff-Mignardot, C. G., Rowald, A., Bloch, J., Micera, S., Capogrosso, M., & Courtine, G. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0262-6 · Cited by 370
Self-citationWenger, N., Moraud, E. M., Gandar, J., Musienko, P., Capogrosso, M., Baud, L., Le Goff, C. G., Barraud, Q., Pavlova, N., Dominici, N., et al. (2016) · Nature Medicine · doi:10.1038/nm.4025 · Cited by 369
Self-citation
Cited by
Sorted by citations
Items 101–200 of 1,000
Alginate Hydrogels as Scaffolds and Delivery Systems to Repair the Damaged Spinal Cord
Grijalvo, S., Nieto‐Díaz, M., Maza, R. M., Eritja, R., & Díaz, D. D. (2019) · Biotechnology Journal · doi:10.1002/biot.201900275 · Cited by 76
Soft Electronics Based on Stretchable and Conductive Nanocomposites for Biomedical Applications
Zambrano, B. L., Renz, A. F., Ruff, T., Lienemann, S., Tybrandt, K., Vörös, J., & Lee, J. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001397 · Cited by 74
Hybrid Human-Machine Interface for Gait Decoding Through Bayesian Fusion of EEG and EMG Classifiers
Tortora, S., Tonin, L., Chisari, C., Micera, S., Menegatti, E., & Artoni, F. (2020) · Frontiers in Neurorobotics · doi:10.3389/fnbot.2020.582728 · Cited by 78
Estes, S. P., Zarkou, A., Hope, J. M., Suri, C., & Field-Fote, E. C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061167 · Cited by 74
Gao, Z., Pang, Z., Chen, Y., Lei, G., Zhu, S., Li, G., Shen, Y., & Xu, W. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00959-x · Cited by 74
Valle, G., Katic, N., Eggemann, D., Gorskii, O., Pavlova, N., Petrini, F. M., Čvančara, P., Stieglitz, T., Евгеньевич, М. П., Bumbaširević, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45190-6 · Cited by 78
Han, Q., Ordaz, J. D., Liu, N., Richardson, Z., Wu, W., Xia, Y., Qu, W., Wang, Y., Dai, H., Zhang, Y. P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13854-3 · Cited by 73
Epidural electrical stimulation for spinal cord injury
Choi, E. H., Gattas, S., Brown, N. J., Hong, J. D., Limbo, J. N., Chan, A. Y., & Oh, M. Y. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.313017 · Cited by 74
Hofstoetter, U. S., Freundl, B., Binder, H., & Minassian, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0227057 · Cited by 73
Self-citationAbuhassan, K., Taylor, J. D., Morris, P. G., Donati, E., Bortolotto, Z. A., Indiveri, G., Paton, J. F. R., & Nogaret, A. (2019) · Nature Communications · doi:10.1038/s41467-019-13177-3 · Cited by 72
Shapkova, E. Y., Pismennaya, E. V., Емельянников, Д. В., & Ivanenko, Y. P. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00416 · Cited by 72
Taylor, C., McHugh, C., Mockler, D., Minogue, C. M., Reilly, R. B., & Fleming, N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260166 · Cited by 71
Masengo, G., Zhang, X., Dong, R., Alhassan, A. B., Hamza, K. K., & Mudaheranwa, E. (2023) · Frontiers in Neurorobotics · doi:10.3389/fnbot.2022.913748 · Cited by 71
Luo, B., Wang, S., Song, X., Chen, S., Qi, Q., Chen, W., Deng, X., Ni, Y., Chu, C., Zhou, G., et al. (2024) · Advanced Materials · doi:10.1002/adma.202401009 · Cited by 71
From cortex to cord: motor circuit plasticity after spinal cord injury
Martinez, M., & Brown, A. R. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.262572 · Cited by 75
Implantable hydrogels as pioneering materials for next-generation brain–computer interfaces
Khan, W. U., Shen, Z., Mugo, S. M., Wang, H., & Zhang, Q. M. (2025) · Chemical Society Reviews · doi:10.1039/d4cs01074d · Cited by 70
Fu, C., Pan, S., Ma, Y., Kong, W., Qi, Z., & Yang, X. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1613422 · Cited by 69
Sun, Z., Zhu, D., Zhao, H. Y., Liu, J., He, P., Luan, X., Hu, H., Zhang, X., Wei, G., & Xi, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01996-y · Cited by 68
Peripheral nerve bionic interface: a review of electrodes
Russell, C., Roche, A. D., & Chakrabarty, S. (2019) · International Journal of Intelligent Robotics and Applications · doi:10.1007/s41315-019-00086-3 · Cited by 67
Samejima, S., Caskey, C. D., İnanıcı, F., Shrivastav, S. R., Brighton, L. N., Pradarelli, J. J., Martínez, V., Steele, K. M., Saigal, R., & Moritz, C. T. (2021) · Physical Therapy · doi:10.1093/ptj/pzab228 · Cited by 67
Lai, B., Zeng, X., Han, W., Che, M., Ding, Y., Li, G., & Zeng, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121211 · Cited by 66
Qian, D., Xu, J., Zhang, X., Hu, F., Cao, S., Dong, Y., Liu, X., Yao, Y., Yu, H., Lu, Y., et al. (2024) · Advanced Materials · doi:10.1002/adma.202307624 · Cited by 66
McHugh, L. V., Miller, A. A., Leech, K. A., Salorio, C. F., & Martin, R. H. (2020) · Spinal Cord Series and Cases · doi:10.1038/s41394-020-00359-1 · Cited by 65
Bioelectronic medicine for the autonomic nervous system: clinical applications and perspectives
Cracchiolo, M., Ottaviani, M. M., Panarese, A., Strauss, I., Vallone, F., Mazzoni, A., & Micera, S. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abe6b9 · Cited by 66
Recent advances in upconversion nanoparticle-based nanocomposites for gas therapy
Yang, N., Gong, F., & Cheng, L. (2021) · Chemical Science · doi:10.1039/d1sc04413c · Cited by 65
Eisdorfer, J. T., Smit, R. D., Keefe, K. M., Lemay, M. A., Smith, G. M., & Spence, A. J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00163 · Cited by 65
Meyer, C., Hofstoetter, U. S., Hubli, M., Hassani, R. H., Rinaldo, C., Curt, A. E. P., & Bolliger, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113541 · Cited by 64
Brain-Computer-Spinal Interface Restores Upper Limb Function After Spinal Cord Injury
Samejima, S., Khorasani, A., Ranganathan, V. N., Nakahara, J., Tolley, N. M., Boissenin, A., Shalchyan, V., Daliri, M. R., Smith, J. R., & Moritz, C. T. (2021) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2021.3090269 · Cited by 69
Bonizzato, M., James, N. D., Pidpruzhnykova, G., Pavlova, N., Shkorbatova, P. Y., Baud, L., Martinez‐Gonzalez, C., Squair, J. W., DiGiovanna, J., Barraud, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22137-9 · Cited by 64
Self-citationVirgiliis, F. D., Hutson, T. H., Palmisano, I., Amachree, S., Miao, J., Zhou, L., Todorova, R., Thompson, R., Danzi, M. C., Lemmon, V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20179-z · Cited by 62
Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease
Thenaisie, Y., Lee, K., Moerman, C., Scafa, S., Gálvez, A., Pirondini, E., Burri, M., Ravier, J., Puiatti, A., Accolla, E. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo1800 · Cited by 62
Self-citationPrioritization of cell types responsive to biological perturbations in single-cell data with Augur
Squair, J. W., Skinnider, M. A., Gautier, M., Foster, L. J., & Courtine, G. (2021) · Nature Protocols · doi:10.1038/s41596-021-00561-x · Cited by 61
Self-citationPizzolato, C., Gunduz, M. A., Palipana, D. B., Wu, J., Grant, G. D., Hall, S., Dennison, R., ZAFONTE, R. D., Lloyd, D. G., & Teng, Y. D. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113612 · Cited by 64
Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents
Sun, G., Zeng, F., McCartin, M., Zhang, Q., Xu, H., Liu, Y., Chen, Z. S., & Wang, J. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm5868 · Cited by 63
Electrical stimulation for therapeutic approach
Kim, E., Kim, S., Kwon, Y. W., Seo, H., Kim, M., Chung, W. G., Park, W., Song, H., Lee, D. H., Lee, J., et al. (2023) · Interdisciplinary medicine · doi:10.1002/inmd.20230003 · Cited by 66
Flexible bioelectronics for physiological signals sensing and disease treatment
Yao, G., Yin, C., Wang, Q., Zhang, T., Chen, S., Lu, C., Zhao, K., Xu, W., Pan, T., Gao, M., et al. (2019) · Journal of Materiomics · doi:10.1016/j.jmat.2019.12.005 · Cited by 63
Liao, X., Wang, W., Wang, L., Jin, H., Shu, L., Xu, X., & Zheng, Y. (2020) · Nano Energy · doi:10.1016/j.nanoen.2020.105548 · Cited by 63
A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury
Hejrati, N., & Fehlings, M. G. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.08.009 · Cited by 61
Hofstoetter, U. S., Freundl, B., Lackner, P., & Binder, H. (2021) · Brain Sciences · doi:10.3390/brainsci11040472 · Cited by 59
Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury
Asan, A. S., McIntosh, J. R., & Carmel, J. B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.791824 · Cited by 71
Hypothalamic deep brain stimulation augments walking after spinal cord injury
Cho, N., Squair, J. W., Aureli, V., James, N. D., Bole-Feysot, L., Dewany, I., Hankov, N., Baud, L., Leonhartsberger, A., Sveistyte, K., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03306-x · Cited by 62
Self-citationFan, Y., Li, Y., Huang, S., Xu, H., Li, H., & Liu, B. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135262 · Cited by 59
A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles
Zheng, H., Zhang, Z., Jiang, S., Yan, B., Shi, X., Xie, Y., Huang, X., Yu, Z., Liu, H., Weng, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10418-3 · Cited by 58
Electrical Stimulation as a Tool to Promote Plasticity of the Injured Spinal Cord
Jack, A. S., Hurd, C., Martin, J. H., & Fouad, K. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7033 · Cited by 58
Seáñez, I., & Capogrosso, M. (2021) · Bioelectronic Medicine · doi:10.1186/s42234-021-00077-5 · Cited by 58
Self-citationThe future of brain circuit-targeted therapeutics
Siddiqi, S., Khosravani, S., Rolston, J. D., & Fox, M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01670-9 · Cited by 58
Zhou, K., Wei, W., Yang, D., Zhang, H., Yang, W., Zhang, Y., Nie, Y., Hao, M., Wang, P., Ruan, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44898-9 · Cited by 58
Kinany, N., Pirondini, E., Micera, S., & Ville, D. V. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.07.024 · Cited by 60
Self-citationBonizzato, M., & Martinez, M. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb4422 · Cited by 57
Mesenchymal Stem Cell Therapy in Traumatic Spinal Cord Injury: A Systematic Review
Montoto-Meijide, R., Meijide-Faílde, R., Díaz‐Prado, S., & Montoto-Marqués, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411719 · Cited by 57
Epidural Spinal Cord Stimulation for Spinal Cord Injury in Humans: A Systematic Review
Chalif, J. I., Chavarro, V. S., Mensah, E. O., Johnston, B. R., Fields, D. P., Chalif, E. J., Chiang, M., Sutton, O. M., Yong, R. J., Trumbower, R. D., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041090 · Cited by 60
Invasive Brain Computer Interface for Motor Restoration in Spinal Cord Injury: A Systematic Review
Levett, J. J., Elkaim, L. M., Niazi, F., Weber, M. H., Iorio‐Morin, C., Bonizzato, M., & Weil, A. G. (2023) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2023.10.006 · Cited by 56
Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Haro, S., Álvarez-Mon, M. Á., León-Oliva, D. D., Gomez-Lahoz, A. M., Monserrat, J., Atienza-Pérez, M., Díaz, D., et al. (2023) · Military Medical Research · doi:10.1186/s40779-023-00461-z · Cited by 54
Zheng, Z., Zhou, Y., Ye, L., Lu, Q., Zhang, K., Zhang, J., Xie, L., Wu, Y., Xu, K., Zhang, H., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113138 · Cited by 53
Wang, X., Zhou, T., Maynard, G. D., Terse, P., Cafferty, W. B. J., Kocsis, J. D., & Strittmatter, S. M. (2020) · Brain · doi:10.1093/brain/awaa116 · Cited by 54
Mechanisms of Stem Cell Therapy in Spinal Cord Injuries
Shinozaki, M., Nagoshi, N., Nakamura, M., & Okano, H. (2021) · Cells · doi:10.3390/cells10102676 · Cited by 58
Herrity, A. N., Aslan, S. C., Ugiliweneza, B., Mohamed, A., Hubscher, C. H., & Harkema, S. J. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.614691 · Cited by 53
Paired corticospinal-motoneuronal stimulation and exercise after spinal cord injury
Jo, H. J., Richardson, M. S. A., Oudega, M., & Pérez, M. A. (2021) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2021.1970908 · Cited by 52
A Review of Functional Restoration From Spinal Cord Stimulation in Patients With Spinal Cord Injury
Lin, A., Shaaya, E. A., Calvert, J. S., Parker, S. R., Borton, D. A., & Fridley, J. (2022) · Neurospine · doi:10.14245/ns.2244652.326 · Cited by 52
Patient-Specific Analysis of Neural Activation During Spinal Cord Stimulation for Pain
Lempka, S. F., Zander, H. J., Anaya, C. J., Wyant, A., Ozinga, J. G., & Machado, A. G. (2019) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13037 · Cited by 52
Marcantoni, M., Fuchs, A., Löw, P., Bartsch, D., Kiehn, O., & Bellardita, C. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay0167 · Cited by 52
Rigoard, P., Billot, M., Ingrand, P., Durand‐Zaleski, I., Manuel Roulaud, B., Peruzzi, P., Hieu, P. D., Voirin, J., Raoul, S., Page, P., et al. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13251 · Cited by 52
How is flexible electronics advancing neuroscience research?
Chen, Y., Rommelfanger, N. J., Mahdi, A. I., Wu, X., Keene, S. T., Obaid, A., Salleo, A., Wang, H., & Hong, G. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120559 · Cited by 58
A biomimetic electrical stimulation strategy to induce asynchronous stochastic neural activity
Formento, E., D’Anna, E., Gribi, S., Lacour, S. P., & Micera, S. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/aba4fc · Cited by 57
Shin, H. E., Kim, M., Lee, D., Jang, J. Y., Soh, Y., Yun, D. H., Kim, S. Y., Yang, J., Kim, M. K., Lee, H., et al. (2022) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.22.0006 · Cited by 51
Liu, H., Feng, Y., Che, S., Guan, L., Yang, X., Zhao, Y., Fang, L., Zvyagin, A. V., & Lin, Q. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c00920 · Cited by 51
Complications of epidural spinal stimulation: lessons from the past and alternatives for the future
Taccola, G., Barber, S. M., Horner, P. J., Bazo, H. A. C., & Sayenko, D. G. (2020) · Spinal Cord · doi:10.1038/s41393-020-0505-8 · Cited by 53
de Freitas, R. M., Sasaki, A., Sayenko, D. G., Masugi, Y., Nomura, T., Nakazawa, K., & Milosevic, M. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00132.2021 · Cited by 50
Li, G., Fan, Z., Gu, G., Jia, Z., Zhang, Q., Dai, J., & He, S. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00442-0 · Cited by 50
Plasticity and Adaptation in Neuromorphic Biohybrid Systems
George, R., Chiappalone, M., Giugliano, M., Levi, T., Vassanelli, S., Partzsch, J., & Mayr, C. (2020) · iScience · doi:10.1016/j.isci.2020.101589 · Cited by 56
New targets and therapeutics for neuroprotection, remyelination and repair in multiple sclerosis
Villoslada, P., & Steinman, L. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1757647 · Cited by 49
Developing Collaborative Platforms to Advance Neurotechnology and Its Translation
Borton, D. A., Dawes, H. E., Worrell, G. A., Starr, P. A., & Denison, T. (2020) · Neuron · doi:10.1016/j.neuron.2020.10.001 · Cited by 54
Self-citationMultisite Hebbian Plasticity Restores Function in Humans with Spinal Cord Injury
Jo, H. J., Kizziar, E., Sangari, S., Chen, D., Kessler, A., Kim, K., Anschel, A. S., Heinemann, A. W., Mensh, B. D., Awadalla, S., et al. (2023) · Annals of Neurology · doi:10.1002/ana.26622 · Cited by 48
Woodington, B. J., Jiang, L., Carnicer‐Lombarte, A., Güemes, A., Naegele, T. E., Hilton, S., Hadwe, S. E., Trivedi, R. A., Malliaras, G. G., & Barone, D. G. (2024) · Science Advances · doi:10.1126/sciadv.adl1230 · Cited by 49
Sui, Y., Tian, Y., Ko, W. K. D., Wang, Z., Jia, F., Horn, A., Ridder, D. D., Choi, K. S., Bari, A., Wang, S., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.597451 · Cited by 49
Angeli, C., Rejc, E., Boakye, M., Herrity, A. N., Mesbah, S., Hubscher, C. H., Forrest, G. F., & Harkema, S. J. (2023) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2023.03.014 · Cited by 47
Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside
Fonoff, E. T., de Lima‐Pardini, A. C., Coelho, D. B., de Mônaco, B. A., Machado, B. S., Souza, C. P., Ghilardi, M. G. D. S., & Hamani, C. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00905 · Cited by 47
Posteroanterior cervical transcutaneous spinal stimulation targets ventral and dorsal nerve roots
Wu, Y., Levine, J. M., Wecht, J. R., Maher, M. T., LiMonta, J. M., Saeed, S., Santiago, T. M., Bailey, E., Kastuar, S., Guber, K. S., et al. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.056 · Cited by 47
Spinal motor mapping by epidural stimulation of lumbosacral posterior roots in humans
Hofstoetter, U. S., Perret, I., Bayart, A., Lackner, P., Binder, H., Freundl, B., & Minassian, K. (2020) · iScience · doi:10.1016/j.isci.2020.101930 · Cited by 47
Self-citationCalvert, J. S., Manson, G. A., Grahn, P. J., & Sayenko, D. G. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00454.2019 · Cited by 46
Jacobson, P. B., Goody, R. J., Lawrence, M. S., Mueller, B. K., Zhang, X., Hooker, B. A., Pfleeger, K., Ziemann, A. E., Locke, C. S., Barraud, Q., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105385 · Cited by 46
Self-citationInvestigating the human spinal sensorimotor pathways through functional magnetic resonance imaging
Landelle, C., Lungu, O., Vahdat, S., Kavounoudias, A., Marchand‐Pauvert, V., Leener, B. D., & Doyon, J. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118684 · Cited by 45
Barss, T. S., Parhizi, B., Porter, J., & Mushahwar, V. K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030639 · Cited by 45
Ganguly, K., Khanna, P., Morecraft, R. J., & Lin, D. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.024 · Cited by 46
Romeni, S., Losanno, E., Emedoli, D., Albano, L., Agnesi, F., Mandelli, C., Barzaghi, L. R., Pompeo, E., Mura, C., Alemanno, F., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adp9607 · Cited by 45
Functional Electrical Stimulation and the Modulation of the Axon Regeneration Program
Jara, J. S., Agger, S., & Hollis, E. R., II (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00736 · Cited by 48
Mesbah, S., Ball, T., Angeli, C., Rejc, E., Dietz, N. E., Ugiliweneza, B., Harkema, S. J., & Boakye, M. (2020) · Brain · doi:10.1093/brain/awaa423 · Cited by 45
Mazzotta, A., Carlotti, M., & Mattoli, V. (2021) · Materials Advances · doi:10.1039/d0ma00817f · Cited by 46
Beck, L., Veith, D. D., Linde, M., Gill, M. L., Calvert, J. S., Grahn, P. J., Garlanger, K. L., Husmann, D. A., Lavrov, I. A., Sayenko, D. G., et al. (2020) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2020.1739894 · Cited by 44
The evolution of nerve transfers for spinal cord injury
Bazarek, S. F., & Brown, J. M. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113426 · Cited by 44
Xu, L., Mu, J., Ma, Z., Lin, P., Xia, F., Hu, X., Wu, J., Cao, J. X., Liu, S., Huang, T., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c06189 · Cited by 43
Feng, Y., Yu, Z., Liu, H., Guan, L., Yang, X., Zvyagin, A. V., Zhao, Y., Yang, X., Yang, B. J., & Lin, Q. (2023) · Materials Today · doi:10.1016/j.mattod.2023.10.011 · Cited by 43
Arpin, D. J., Ugiliweneza, B., Forrest, G. F., Harkema, S. J., & Rejc, E. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01310 · Cited by 43
Herrity, A. N., Aslan, S. C., Mesbah, S., Siu, R., Kalvakuri, K., Ugiliweneza, B., Mohamed, A., Hubscher, C. H., & Harkema, S. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-15315-2 · Cited by 42
Neurotechnologies to restore hand functions
Losanno, E., Mender, M. J., Chestek, C. A., Shokur, S., & Micera, S. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00054-4 · Cited by 45
Poststroke arm and hand paresis: should we target the cervical spinal cord?
Pirondini, E., Carranza, E., Balaguer, J.-M., Sorensen, E., Weber, D. J., Krakauer, J. W., & Capogrosso, M. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.05.002 · Cited by 42
Self-citationSamejima, S., Henderson, R. P., Pradarelli, J. J., Mondello, S. E., & Moritz, C. T. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114178 · Cited by 42
First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy
Prat-Ortega, G., Ensel, S., Donadio, S., Borda, L., Boos, A., Yadav, P., Verma, N., Ho, J. C., Carranza, E., Frazier-Kim, S., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03484-8 · Cited by 43
Self-citationRejc, E., Smith, A. C., Weber, K. A., II, Ugiliweneza, B., Bert, R. J., Negahdar, M., Boakye, M., Harkema, S. J., & Angeli, C. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.559313 · Cited by 41
Kumru, H., Flores, Á., Rodríguez-Cañón, M., Edgerton, V. R., García-Alén, L., Benito-Penalva, J., Navarro, X., Gerasimenko, Y., García‐Alías, G., & Vidal, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020195 · Cited by 40
Metadata
- Authors
- Wagner, F. B., Mignardot, J.-B., Le Goff-Mignardot, C. G., Demesmaeker, R., Komi, S., Capogrosso, M., Rowald, A., Seáñez, I., Caban, M., Pirondini, E., Vat, M., McCracken, L. A., Heimgartner, R., Fodor, I., Watrin, A., Seguin, P., Paoles, E., Van Den Keybus, K., Eberle, G., Schurch, B., Pralong, E., Becce, F., Prior, J., Buse, N., Buschman, R., Neufeld, E., Kuster, N., Carda, S., von Zitzewitz, J., Delattre, V., Denison, T., Lambert, H., Minassian, K., Bloch, J., & Courtine, G.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- University of Fribourg (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Geneva (CH)
- Medtronic (United States) (US)
- Foundation for Research on Information Technologies in Society (CH)
- ETH Zurich (CH)
- Corresponding author
- Courtine, Grégoire
- ORCID
- Wagner, Fabien B.
- Mignardot, Jean-Baptiste
- Demesmaeker, Robin
- Komi, Salif
- Capogrosso, Marco
- Rowald, Andreas
- Seáñez, Ismael
- Caban, Miroslav
- Pirondini, Elvira
- McCracken, Laura A.
- Heimgartner, Roman
- Fodor, Isabelle
- Eberle, Grégoire
- Schurch, Brigitte
- Becce, Fabio
- Prior, John
- Buse, Nicholas
- Buschman, Rik
- Neufeld, Esra
- Kuster, Niels
- Carda, Stefano
- Minassian, Karen
- Bloch, Jocelyne
- Courtine, Grégoire
- Venue
- Nature
- Published
- 2018-10-31
- Volume
- 563
- Issue
- 7729
- Pages
- 65-71
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2898429451
- Cited by
- 1,087
- References
- 46
- Citations by year
- 2026: 110 · 2025: 160 · 2024: 117 · 2023: 153 · 2022: 152 · 2021: 176 · 2020: 125 · 2019: 81 · 2018: 10
- FWCI
- 74.13
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- spinal cord injury, spinal cord stimulation, neurotechnology, lumbosacral spinal cord, implanted pulse generator, voluntary motor control, paralysis, locomotor rehabilitation, neurological recovery, activities of daily living
- MeSH terms
- Activities of Daily Living, Computer Simulation, Electromyography, Electric Stimulation Therapy, Epidural Space, Humans, Leg, Locomotion, Male, Motor Neurons, Paralysis, Spinal Cord, Spinal Cord Injuries, Walking, Muscle, Skeletal, Biomedical Technology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
