Cited by 279Genomics and Chromatin DynamicsChromatin Remodeling and CancerNuclear Structure and Function

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Chromatin structure dynamics during the mitosis-to-G1 phase transition

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Zhang, Haoyue, Emerson, Daniel J., Gilgenast, Thomas G., Titus, Katelyn R., Lan, Yemin, Huang, Peng, Zhang, Di, Wang, Hongxin, Keller, Cheryl A., Giardine, Belinda, Hardison, Ross C., Phillips-Cremins, Jennifer E., Blobel, Gerd A.·2019·Nature

DOI 10.1038/s41586-019-1778-yPMC PMC6895436

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Abstract

Features of higher-order chromatin organization-such as A/B compartments, topologically associating domains and chromatin loops-are temporarily disrupted during mitosis 1,2. Because these structures are thought to influence gene regulation, it is important to understand how they are re-established after mitosis. Here we examine the dynamics of chromosome reorganization by Hi-C after mitosis in highly purified, synchronous mouse erythroid cell populations. We observed rapid establishment of A/B compartments, followed by their gradual intensification and expansion. Contact domains form from the 'bottom up'-smaller subTADs are formed initially, followed by convergence into multi-domain TAD structures. CTCF is partially retained on mitotic chromosomes and immediately resumes full binding in ana/telophase. By contrast, cohesin is completely evicted from mitotic chromosomes and regains focal binding at a slower rate. The formation of CTCF/cohesin co-anchored structural loops follows the kinetics of cohesin positioning. Stripe-shaped contact patterns-anchored by CTCF-grow in length, which is consistent with a loop-extrusion process after mitosis. Interactions between cis-regulatory elements can form rapidly, with rates exceeding those of CTCF/cohesin-anchored contacts. Notably, we identified a group of rapidly emerging transient contacts between cis-regulatory elements in ana/telophase that are dissolved upon G1 entry, co-incident with the establishment of inner boundaries or nearby interfering chromatin loops. We also describe the relationship between transcription reactivation and architectural features. Our findings indicate that distinct but mutually influential forces drive post-mitotic chromatin reconfiguration.

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Additional file 6 of Acute depletion of CTCF rewires genome-wide chromatin accessibility
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Additional file 2 of Acute depletion of CTCF rewires genome-wide chromatin accessibility
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Additional file 5 of Acute depletion of CTCF rewires genome-wide chromatin accessibility
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Additional file 1 of Acute depletion of CTCF rewires genome-wide chromatin accessibility
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Self-citation

Authors: Zhang, H., Emerson, D. J., Gilgenast, T. G., Titus, K. R., Lan, Y., Huang, P., Zhang, D., Wang, H., Keller, C. A., Giardine, B., Hardison, R. C., Phillips-Cremins, J. E., & Blobel, G. A.
Affiliations: Children's Hospital of Philadelphia (US)
University of Pennsylvania (US)
Pennsylvania State University (US)
Corresponding author: Blobel, Gerd A.
ORCID: Zhang, Haoyue
Emerson, Daniel J.
Titus, Katelyn R.
Lan, Yemin
Huang, Peng
Zhang, Di
Keller, Cheryl A.
Giardine, Belinda
Hardison, Ross C.
Blobel, Gerd A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2019-11-27
Volume: 576
Issue: 7785
Pages: 158-162
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/s41586-019-1778-y
PMC: PMC6895436
OpenAlex: W2990380375
Cited by: 271
References: 27
Citations by year: 2026: 31 · 2025: 57 · 2024: 28 · 2023: 45 · 2022: 31 · 2021: 48 · 2020: 29 · 2019: 2
FWCI: 9.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (U01HL129998)
National Institute of Mental Health (DP2MH110247)
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK058044, R01DK058044, R24DK106766)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: chromatin reorganization, A/B compartments, topologically associating domains, CTCF, cohesin, chromatin looping, loop extrusion, erythroid cells
MeSH terms: Cohesins, Animals, Chromatin, Chromosomal Proteins, Non-Histone, Mitosis, G1 Phase, Cell Cycle Proteins, Mice

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Chromatin structure dynamics during the mitosis-to-G1 phase transition

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