Cited by 115Blood disorders and treatmentsImmunodeficiency and Autoimmune DisordersNeutropenia and Cancer Infections

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Mouse models of neutropenia reveal progenitor-stage-specific defects

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Muench, David E., Olsson, Andre, Ferchen, Kyle, Pham, Giang, Serafin, Rachel A., Chutipongtanate, Somchai, Dwivedi, Pankaj, Song, Baobao, Hay, Stuart, Chetal, Kashish, Trump-Durbin, Lisa R., Mookerjee-Basu, Jayati, Zhang, Kejian, Yu, Jennifer C., Lutzko, Carolyn, Myers, Kasiani C., Nazor, Kristopher L., Greis, Kenneth D., Kappes, Dietmar J., Way, Sing Sing, Salomonis, Nathan, Grimes, H. Leighton·2020·Nature

DOI 10.1038/s41586-020-2227-7PMC PMC8041154

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Abstract

Advances in genetics and sequencing have identified a plethora of disease-associated and disease-causing genetic alterations. To determine causality between genetics and disease, accurate models for molecular dissection are required; however, the rapid expansion of transcriptional populations identified through single-cell analyses presents a major challenge for accurate comparisons between mutant and wild-type cells. Here we generate mouse models of human severe congenital neutropenia (SCN) using patient-derived mutations in the GFI1 transcription factor. To determine the effects of SCN mutations, we generated single-cell references for granulopoietic genomic states with linked epitopes 1, aligned mutant cells to their wild-type equivalents and identified differentially expressed genes and epigenetic loci. We find that GFI1-target genes are altered sequentially, as cells go through successive states of differentiation. These insights facilitated the genetic rescue of granulocytic specification but not post-commitment defects in innate immune effector function, and underscore the importance of evaluating the effects of mutations and therapy within each relevant cell state.

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Show all 35 references

Research works printed but not linked: 1

Gilbert, S. F. Developmental Biology, 6th edition (Sinauer Associates, 2000).

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Braun, T. P., Estabrook, J., Schonrock, Z., Curtiss, B. M., Darmusey, L., Macaraeg, J., Enright, T., Coblentz, C., Callahan, R. L., Yashar, W. M., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01792-x · Cited by 7
Development of red blood cell-derived extracellular particles as a biocompatible nanocarrier of microRNA-204 (REP-204) to harness anti-neuroblastoma effect
Chiangjong, W., Panachan, J., Keadsanti, S., Newburg, D. S., Morrow, A. L., Hongeng, S., & Chutipongtanate, S. (2024) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2024.102760 · Cited by 7
Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer
Caronni, N., Montaldo, E., Mezzanzanica, L., Cilenti, F., Genua, M., & Ostuni, R. (2021) · Immunological Reviews · doi:10.1111/imr.12944 · Cited by 6
Activation of a branched-chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness
Bartram, J., Treichel, S., Song, B. A., Xu, J., Sharma, D., Nasr, W., Frangiosa, M., Harley, A., Nemkov, T. G., D'Alessandro, A., et al. (2026) · Cell stem cell · doi:10.1016/j.stem.2025.12.018 · Cited by 7
The metabolic basis of inherited neutropenias
Oyarbide, U., Crane, G. M., & Corey, S. J. (2023) · British Journal of Haematology · doi:10.1111/bjh.19192 · Cited by 6
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Fu, T., Zhang, L., Zuo, M., Feng, L., Shi, C., & Chen, H. (2023) · Medicine · doi:10.1097/md.0000000000033324 · Cited by 3
MLG: multilayer graph clustering for multi-condition scRNA-seq data
Lu, S., Conn, D. J., Chen, S., Johnson, K. D., Bresnick, E. H., & Keleş, S. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab823 · Cited by 3
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Steier, Z., Maslan, A., & Streets, A. (2022) · Neuromethods · doi:10.1007/978-1-0716-2525-5_4 · Cited by 2
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Yiqin, W., Ruimeng, Y., Peihong, W., Liu, X., Yuan, H., Hongli, H., Yongjian, Z., & Baoshu, X. (2025) · Advanced Science · doi:10.1002/advs.202505441 · Cited by 1
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Zhu, X., Xu, T., Lai, X., Lian, X., Cheng, H., & Wang, J. (2025) · IEEE Transactions on Software Engineering · doi:10.1109/tse.2025.3641225 · Cited by 2
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Arreba-Tutusaus, P., Borbaran-Bravo, N., Doll, L., Ritter, M. U., Kretschmer, D., Haaf, J., Hellmuth, A.-S., Zeidler, C., Klimiankou, M., Welte, K., et al. (2026) · Experimental Hematology · doi:10.1016/j.exphem.2026.105418 · Cited by 1
Neutrophils as chameleons of tissue inflammation and host-pathogen interactions
Zhu, Y. P., Catz, S. D., & Croker, B. A. (2026) · Blood · doi:10.1182/blood.2025029580 · Cited by 1
Construction of TSC2 knockout cell line using CRISPR/Cas9 system and demonstration of its effects on NIH-3T3 cells
Wang, X., Zhao, Y., Wang, Z., Liao, Z., & Zhang, Y. (2022) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-022-01094-0 · Cited by 1
Gfi1 in the inner ear: A retrospective review
Li, Z., Chen, H., & Feng, H. (2025) · Developmental Dynamics · doi:10.1002/dvdy.70019 · Cited by 1
Editorial: The Function of Phagocytes in Non-Mammals
Lu, X., Deng, Q., & Thompson, K. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.628847 · Cited by 1
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Mixing “good and bad” annoys neutrophils
Trompouki, E. (2021) · Blood · doi:10.1182/blood.2020009854

Authors: Muench, D. E., Olsson, A., Ferchen, K., Pham, G., Serafin, R. A., Chutipongtanate, S., Dwivedi, P., Song, B., Hay, S., Chetal, K., Trump-Durbin, L. R., Mookerjee-Basu, J., Zhang, K., Yu, J. C., Lutzko, C., Myers, K. C., Nazor, K. L., Greis, K. D., Kappes, D. J., Way, S. S., Salomonis, N., & Grimes, H. L.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
Mahidol University (TH)
University of Cincinnati (US)
University of California San Diego (US)
BioLegend (United States) (US)
Fox Chase Cancer Center (US)
Corresponding author: Salomonis, Nathan
Grimes, H. Leighton
ORCID: Muench, David E.
Ferchen, Kyle
Pham, Giang
Chutipongtanate, Somchai
Dwivedi, Pankaj
Song, Baobao
Chetal, Kashish
Zhang, Kejian
Yu, Jennifer C.
Lutzko, Carolyn
Myers, Kasiani C.
Nazor, Kristopher L.
Greis, Kenneth D.
Kappes, Dietmar J.
Way, Sing Sing
Salomonis, Nathan
Grimes, H. Leighton
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2020-04-22
Volume: 582
Issue: 7810
Pages: 109-114
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/s41586-020-2227-7
PMC: PMC8041154
OpenAlex: W3018353191
Cited by: 115
References: 35
Citations by year: 2026: 11 · 2025: 17 · 2024: 12 · 2023: 17 · 2022: 20 · 2021: 29 · 2020: 8
FWCI: 10.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (DK78392, AR‐47363)
National Heart, Lung, and Blood Institute (R01HL122661)
National Cancer Institute (T32CA117846)
National Institute of Allergy and Infectious Diseases (DP1AI131080)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK090971, P30DK078392)
National Institute of Environmental Health Sciences (T32ES007250)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR047363)
National Center for Research Resources (S10RR027015)
Topics: Health Sciences › Medicine › Hematology › Blood disorders and treatments
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Keywords: severe congenital neutropenia, GFI1, mouse model, granulopoiesis, genetic rescue
MeSH terms: Animals, Candida albicans, Disease Models, Animal, DNA-Binding Proteins, Female, Humans, Immunity, Innate, Male, Mice, Transgenic, Mutation, Neutropenia, Neutrophils, Transcription Factors, Cell Lineage, Granulocyte Precursor Cells, Mice

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Mouse models of neutropenia reveal progenitor-stage-specific defects

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