The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Circadian autophagy drives iTRF-mediated longevity
Open accessAbstract
Time-restricted feeding (TRF) has recently gained interest as a potential anti-ageing treatment for organisms from Drosophila to humans 1-5. TRF restricts food intake to specific hours of the day. Because TRF controls the timing of feeding, rather than nutrient or caloric content, TRF has been hypothesized to depend on circadian-regulated functions; the underlying molecular mechanisms of its effects remain unclear. Here, to exploit the genetic tools and well-characterized ageing markers of Drosophila, we developed an intermittent TRF (iTRF) dietary regimen that robustly extended fly lifespan and delayed the onset of ageing markers in the muscles and gut. We found that iTRF enhanced circadian-regulated transcription and that iTRF-mediated lifespan extension required both circadian regulation and autophagy, a conserved longevity pathway. Night-specific induction of autophagy was both necessary and sufficient to extend lifespan on an ad libitum diet and also prevented further iTRF-mediated lifespan extension. By contrast, day-specific induction of autophagy did not extend lifespan. Thus, these results identify circadian-regulated autophagy as a critical contributor to iTRF-mediated health benefits in Drosophila. Because both circadian regulation and autophagy are highly conserved processes in human ageing, this work highlights the possibility that behavioural or pharmaceutical interventions that stimulate circadian-regulated autophagy might provide people with similar health benefits, such as delayed ageing and lifespan extension.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Time-restricted feeding (TRF), a healthy diet, extends the Drosophila lifespan and delays the onset of ageing markers in the muscles and gut by stimulating circadian-regulated autophagy.487”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [487]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Life time extension of a similar intermittent fasting regimen in flies has been attributed to the nighttime-specific upregulation of autophagy-stimulatory genes 155 , but this has not yet been investigated in mammals.”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [155]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: LKB1 and AMPK maintain epithelial cell polarity under energetic stress
Mirouse, V., Swick, L. L., Kazgan, N., Johnston, D. S., & Brenman, J. E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702053 · Cited by 190
RetractedNIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Effects of intermittent fasting on health, aging, and disease
de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605
Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087
Claesson, M. J., Wang, Q., O’Sullivan, Ó., Greene-Diniz, R., Cole, J. R., Ross, R. P., & O’Toole, P. W. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq873 · Cited by 1,016
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013
Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body
Scott, R. C., Schuldiner, O., & Neufeld, T. P. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.009 · Cited by 979
Chaix, A., Zarrinpar, A., Miu, P., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.001 · Cited by 956
Research works printed but not linked: 1
- Delventhal, R. et al. Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption. eLife 8, e48308 (2019). · DOI
Cited by
Sorted by citations
Items 101–200 of 227
Li, T., Huang, N., Chen, H., Yu, Y., Zhang, J., Xu, W., Gong, H., Gong, C., Yang, M., Zhao, T., et al. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.70020 · Cited by 7
Zhang, Z., Liu, B., & Ding, S. (2025) · The FASEB Journal · doi:10.1096/fj.202501289r · Cited by 7
Running skeletal muscle clocks on time— the determining factors
Vaca-Dempere, M., Kumar, A., Sica, V., & Muñoz‐Cánoves, P. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112989 · Cited by 7
Alasmari, A. A., Alhussain, M. H., Alkhalifah, A., Alshiban, N. M., Alharthi, R., Alyami, N. M., Alodah, H. S., Alahmed, M. F., Aljahdali, B. A., & BaHammam, A. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-79557-y · Cited by 15
Circadian clock and its effect on aging and lifespan
Verma, A. K., Singh, S., & Rizvi, S. I. (2025) · Biogerontology · doi:10.1007/s10522-025-10281-4 · Cited by 8
Jiang, X., Lin, J., Dong, M., Liu, X., Huang, Y., Zhang, H., Ye, R., Zhou, H., Yan, C., Yuan, S., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.950619 · Cited by 7
Zhao, S., Han, T., Pei, X., Song, Y., Zhang, Y., Liu, L., Wang, X., Hou, W., & Sun, C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.991007 · Cited by 7
Chiang, C.-H., Li, S., Lin, Y.-H., Wang, P., Hsu, P., Lin, S., Chiang, T.-C., & Chen, C. (2023) · Biogerontology · doi:10.1007/s10522-023-10023-4 · Cited by 7
Does Exercise Regulate Autophagy in Humans? A Systematic Review and Meta-Analysis
Chen, X., Zheng, C., Siu, P. M., Sun, F., Wong, S. H., & Chun‐Hang, A. (2023) · Autophagy Reports · doi:10.1080/27694127.2023.2190202 · Cited by 7
Tataridas-Pallas, N., Aman, Y., Williams, R., Chapman, H., Cheng, K. J. H., Gomez-Paredes, C., Bates, G. P., & Labbadia, J. P. (2024) · iScience · doi:10.1016/j.isci.2024.109834 · Cited by 7
Rest, Repair, Repeat: The Complex Relationship of Autophagy and Sleep
Ullern, H., Schnur, P., Boccara, C. N., & Knævelsrud, H. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169227 · Cited by 8
Liang, Y., Krivograd, A., Hofer, S. J., Kollipara, L., Züllig, T., Sickmann, A., Eisenberg, T., & Sigrist, S. J. (2025) · Aging · doi:10.18632/aging.206267 · Cited by 6
Pfefferkorn, R., Mortzfeld, B. M., Fink, C., von Frieling, J., Bossen, J., Esser, D., Kaleta, C., Rosenstiel, P. C., Heine, H., & Roeder, T. (2023) · Aging and Disease · doi:10.14336/ad.2023.0517 · Cited by 6
Chi, S., Zhang, T., Yu, P., Niu, S., Zhao, L., Gu, Z., Liu, Q., Jin, A., Wang, W., & Tan, S. (2023) · Food & Function · doi:10.1039/d3fo02063k · Cited by 6
Hypothalamic circuits and aging: keeping the circadian clock updated
Vázquez-Lizárraga, R., Mendoza-Viveros, L., Cid‐Castro, C., Ruiz-Montoya, S., Carreño‐Vázquez, E., & Orozco-Solís, R. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389624 · Cited by 7
Li, Q., Tan, D., Xiong, S., Zheng, H., Li, L., Yu, K., Su, Y., & Zhu, W. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115186 · Cited by 6
Sultanova, Z., Shen, A., Hencel, K., Carlsson, H., Crighton, Z., Clifton, D., Akay, A., & Maklakov, A. A. (2025) · Aging Cell · doi:10.1111/acel.14481 · Cited by 6
Gao, Y., Cheng, X., Tian, Y., Yuan, Z., Fan, X., Yang, D., & Yang, M. (2023) · Nutrients · doi:10.3390/nu15081840 · Cited by 7
Li, R., Li, Y., Tian, M., Zhang, H., Lou, L., Liu, K., Zhang, J., Zhao, Y., Zhang, J., Le, S., et al. (2021) · FEBS Letters · doi:10.1002/1873-3468.14242 · Cited by 7
Aligning mealtimes to live longer
Deota, S., & Panda, S. (2022) · Science · doi:10.1126/science.adc8824 · Cited by 5
Dietary Restriction Impacts Peripheral Diurnal Rhythms Important for Longevity in DrosophilaPreprint
Hwangbo, D., Kwon, Y.-J., Iwanaszko, M., Sisobhan, S., Jiang, P., Abbasi, L., Wright, N., Alli, S., Hutchison, A. L., Dinner, A. R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.04.522718 · Cited by 6
Noncanonical clock regulators control stress responses in digestive diseases
Zhou, D., López-Valiente, R. E., Mattar, S. G., & Guan, D. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.07.002 · Cited by 5
Links Between Autophagy and Healthy Aging
Ebata, H., & Hansen, M. (2026) · Journal of Molecular Biology · doi:10.1016/j.jmb.2026.169656 · Cited by 10
Lin, S.-P., Bu, J., Shan, Y., Xie, Q., Wei, J.-X., Yin, X., Mei, F., Lin, P., & Chen, X.-H. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102039 · Cited by 5
Temperature-driven coordination of circadian transcriptional regulation
Xu, B., Hwangbo, D., Saurabh, S., Rosensweig, C., Allada, R., Kath, W. L., & Braun, R. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012029 · Cited by 5
Li, M., Huang, J., Du, S., Sun, K., Chen, J., & Guo, F. (2024) · British Journal Of Nutrition · doi:10.1017/s0007114524001739 · Cited by 5
Dietary Restriction against Parkinson’s Disease: What We Know So Far
Wang, Z., Cui, Y., Wen, L., Yu, H., Feng, J., Yuan, W., & He, X. (2022) · Nutrients · doi:10.3390/nu14194108 · Cited by 5
Soft-Shelled Turtle Peptides Extend Lifespan and Healthspan in Drosophila
Wang, Q., Zhang, J., Zhuang, J., Shen, F., Zhao, M., Du, J., Yu, P., Zhong, H., & Feng, F. (2022) · Nutrients · doi:10.3390/nu14245205 · Cited by 6
Ageing and the gut-brain axis: lessons from the Drosophila model.
Tan, F. H., Shamsuddin, S., & Zainuddin, A. (2023) · Beneficial Microbes · doi:10.1163/18762891-20230056 · Cited by 5
An Introductory Guide to Using Bloomington Drosophila Stock Center and FlyBase for Aging Research
Zheng, X. (2024) · Cells · doi:10.3390/cells13141192 · Cited by 5
Liu, A. C., Shen, Y., Serbinski, C. R., He, H., Roman, D., Endale, M., Aschbacher‐Smith, L., King, K. A., Granadillo, J. L., López, I., et al. (2024) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2024.100333 · Cited by 9
Dietary restriction in senolysis and prevention and treatment of disease
Aminzadeh-Gohari, S., Kofler, B., & Herzog, C. M. S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2153355 · Cited by 5
Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies
Mercola, J. M. (2025) · World Journal of Clinical Oncology · doi:10.5306/wjco.v16.i9.110686 · Cited by 4
Research progress on the mutual regulatory mechanism of circadian clock genes and autophagy
Ma, Y., Yu, R., Zheng, X., Rao, J., Shi, G., & Ding, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1696985 · Cited by 5
A deep learning and large language hybrid workflow for omics interpretation
Tang, D., Zhang, C., Zhang, W., Lu, F., Xiao, L., Huang, X., Shao, J., Liu, D., Fu, S., Zhao, M., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01576-5 · Cited by 5
Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice
Iiams, S. E., Skinner, N. J., Wight‐Carter, M., Acosta-Rodríguez, V. A., Green, C. B., & Takahashi, J. S. (2026) · Nature Aging · doi:10.1038/s43587-026-01129-8 · Cited by 6
Lenhart, B. A., Ahsan, A., McHaty, M., & Bergland, A. O. (2024) · Physiological Entomology · doi:10.1111/phen.12443 · Cited by 4
Tan, Y., Li, M., Li, H., Guo, Y., Zhang, B., Wu, G., Li, J., Zhang, Q., Sun, Y., Gao, F., et al. (2024) · Advanced Science · doi:10.1002/advs.202407677 · Cited by 4
Su, H., & Hao, N. (2025) · Quantitative Biology · doi:10.1002/qub2.70007 · Cited by 4
Time-restricted feeding rescues sociability deficits and reduces neuroinflammation in aged mice
Ince, L. M., Routh, B. N., Darling, J. S., Manem, K., Prabhakar, A., Martinez, S., Chan, E., Chen, R., Gaudet, A. D., & Fonken, L. K. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.11.007 · Cited by 8
Evidence that overnight fasting could extend healthy lifespan
Helfand, S. L., & de Cabo, R. (2021) · Nature · doi:10.1038/d41586-021-01578-8 · Cited by 4
Potential preventive effects of time-restricted eating on cancer
Fang, R., Yan, L., & Liao, Z. (2023) · journal of nutritional oncology · doi:10.1097/jn9.0000000000000004 · Cited by 4
Liu, J.-Y., Zhang, R., Ma, L., Yang, P., Wu, Z., Chen, Y., Peng, J., Yang, X., Huang, C., & Yan, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-90844-0 · Cited by 4
AmAtg2B-Mediated Lipophagy Regulates Lipolysis of Pupae in Apis mellifera
Chen, W., Wang, H., Wang, Y., Liu, Z., & Xu, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032096 · Cited by 4
Baheti, B., Liu, X., Wang, M., Zhang, C., Dong, X., Kang, N., Li, L., Li, X., Yu, S., Hou, J., et al. (2023) · Nutrients · doi:10.3390/nu15061348 · Cited by 5
Chen, X., Feng, X., Kong, X., Wang, H., Liu, T., Tang, L., & Zhuang, Z. (2023) · Medicinal Chemistry Research · doi:10.1007/s00044-023-03056-4 · Cited by 4
The central clock drives metabolic rhythms in muscle stem cells
Sica, V., Smith, J. G., Deryagin, O., Andrés, E., Lukesova, V., Egg, M., Cabezas‐Wallscheid, N., Benitah, S. A., Serrano, A. L., Perdiguero, E., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116354 · Cited by 3
Liu, S., Zhang, F., Wang, Y., Zhuo, K., & Zhao, Y. (2026) · Cells · doi:10.3390/cells15020193 · Cited by 3
Wang, X., Xing, K.-K., He, M., He, T., Xiang, X., Chen, T., Zhang, L., & Li, H. (2022) · National Science Review · doi:10.1093/nsr/nwac222 · Cited by 3
Wang, S., Xiao, F., Yuan, Y., Li, J., Liang, X., Fan, X., Zhang, M., Yan, T., Yang, M., He, Z., et al. (2023) · Genomics · doi:10.1016/j.ygeno.2023.110751 · Cited by 4
Dai, T., Qiu, J., Luo, C. Y., Cui, W., Liu, K., Li, J., Peng, R., Sima, Y., & Xu, S. (2024) · Insect Science · doi:10.1111/1744-7917.13381 · Cited by 4
Intercellular competitive growth dynamics with microenvironmental feedback
Liu, D., Wu, Z.-X., & Guan, J. (2023) · Physical review. E · doi:10.1103/physreve.108.054105 · Cited by 3
Boosting NAD+ levels through fasting to aid in COVID-19 recovery
Dongoran, R. A., Mardiana, M., Huang, C., & Situmorang, J. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1319106 · Cited by 3
Sciarretta, S., Forte, M., & Sadoshima, J. (2021) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2021.33 · Cited by 3
Liu, A. C., Shen, Y., Roman, D., He, H., Serbinski, C. R., Aschbacher‐Smith, L., King, K. A., Granadillo, J. L., López, I., Krueger, D. A., et al. (2022) · medRxiv · doi:10.1101/2022.02.15.22269076 · Cited by 3
Dietary Restriction Impacts Peripheral Diurnal Rhythms Important for Longevity in DrosophilaPreprint
Hwangbo, D., Kwon, Y.-J., Iwanaszko, M., Sisobhan, S., Jiang, P., Abbasi, L., Wright, N., Alli, S., Hutchison, A. L., Dinner, A. R., et al. (2023) · eLife · doi:10.7554/elife.86191 · Cited by 5
Gallage, S., Ali, A., Avila, J. E. B., Seymen, N., Ramadori, P., Joerke, V., Zizmare, L., Kosla, J., Li, X., Focaccia, E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.23.562885 · Cited by 3
Zampieri, S., Bersch, I., Smeriglio, P., Barbieri, E., Ganassi, M., Leeuwenburg, C., Rosati, R., Gargiulo, P., Pond, A. L., Sweeney, H. L., et al. (2023) · European Journal of Translational Myology · doi:10.4081/ejtm.2023.12161 · Cited by 5
Thakare, M. R., Choudhary, P., Pydah, B., Sunke, S., Yadav, R. S. P., Agrawal, P., & Das, G. (2024) · eLife · doi:10.7554/elife.97706.1 · Cited by 4
Murillo-Cancho, A. F., Lozano‐Paniagua, D., & Soriano, B. J. N. (2025) · Obesities · doi:10.3390/obesities5020030 · Cited by 2
The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer
Finger, A., Ector, C., & Weaver, V. M. (2026) · Cancers · doi:10.3390/cancers18060925 · Cited by 2
Common Ground between Biological Rhythms and Forensics
Janjić, K., Reisinger, C., & Kanz, F. (2022) · Biology · doi:10.3390/biology11071071 · Cited by 3
Huo, Q., Yue, T., Li, W., Wang, X., Dong, Y., Wu, X., He, X., Lu, L., Zhang, J., Zhao, Y., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111695 · Cited by 2
Circadian rhythms in muscle health and diseases
Kelu, J. J. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2024.10.002 · Cited by 2
Thakare, M. R., Choudhary, P., Pydah, B., Sunke, S., Yadav, R. S. P., Agrawal, P., & Das, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.07.543033 · Cited by 2
Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in DrosophilaPreprint
Hwangbo, D., Kwon, Y.-J., Iwanaszko, M., Jiang, P., Abbasi, L., Wright, N., Alli, S., Hutchison, A. L., Dinner, A. R., Braun, R., et al. (2023) · doi:10.7554/elife.86191.1 · Cited by 2
From Reactive to Proactive – The Future Life Design to Promote Health and Extend the Human Lifespan
Yao, L., Yang, C., Graff, J. C., Wang, G., Wang, G., & Gu, W. (2024) · Advanced Biology · doi:10.1002/adbi.202400148 · Cited by 1
Intestinal aging and dietary nutrition strategies: focusing on autophagy
Gu, Y., Xie, K., Qin, Y., & Han, J. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250636 · Cited by 1
Peng, J., Zheng, R., Zhao, J., Zhang, J., Li, Q., Huang, D., Zhou, X., Liu, L., Li, Z., Ning, X., et al. (2025) · Journal of Pest Science · doi:10.1007/s10340-025-01930-1 · Cited by 1
Autophagy and Intracellular Membrane Dynamics in Aging and Age-Related Diseases
Minami, S., Nakamura, S., & Yoshimori, T. (2025) · Learning materials in biosciences · doi:10.1007/978-3-031-88121-3_7 · Cited by 1
Leucokinin VIII acetate mitigates asthma severity by targeting ADCK5-induced cellular senescence
Feng, L., Zhong, Y., Li, L., Zhang, M., Zhu, M., Wang, J., Huang, M., Ji, N., & Ma, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115426 · Cited by 1
Rehman, Z., Altonji, O. M., Steger, F. L., Jamshed, H., Richman, J., Warriner, A. H., & Peterson, C. M. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101526 · Cited by 1
Zhou, Y., Yin, Z., Deng, X., Jiang, H., Zhou, Y., Wang, Y., Fu, L., & Tai, S. (2026) · MedComm · doi:10.1002/mco2.70910 · Cited by 1
Sleep Hungry for Cellular Cleanup!
Huh, J. Y. (2022) · Molecules and Cells · doi:10.14348/molcells.2021.5038 · Cited by 1
Deota, S., & Manoogian, E. N. C. (2024) · Springer eBooks · doi:10.1007/978-3-031-49622-6_3 · Cited by 1
Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila
Mosley, O. L., Villa, J. A., Kamalakkannan, A., James, E., Hoffman, J. M., & Lyu, Y. (2025) · GeroScience · doi:10.1007/s11357-025-01537-5 · Cited by 1
Yin, J., Gu, M., Zhou, Y., Wang, Y., Zhang, M., Yang, Y., Cai, Y., He, S., & Peng, D. (2025) · Depression and Anxiety · doi:10.1155/da/5544651 · Cited by 2
Metabolism and Multicellularity Revisited
Blackstone, N. W. (2022) · Springer eBooks · doi:10.1007/978-3-031-06059-5_10 · Cited by 1
Introduction: Trends, Puzzles, and Hopes for the Future of Healthcare
Ehsani, S., Glauner, P., Plugmann, P., & Thieringer, F. M. (2022) · Future of business and finance · doi:10.1007/978-3-030-99838-7_1 · Cited by 1
Xu, L., Wei, W., Qian, J., Zhang, S., Jin, Z., Wang, X., Li, L., Gu, Y., Lv, Y., Zhao, C. N., et al. (2022) · medRxiv · doi:10.1101/2022.08.18.22278875 · Cited by 1
Chen, H., Sun, L., Feng, L., Han, X., Zhang, Y., Zhai, W., Zhang, Z., Mulholland, M. T., Zhang, W., & Yin, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.29.555436 · Cited by 1
Chen, H., Sun, L., Feng, L., Han⊗, X., Zhang, Y., Zhai, W., Zhang, Z., Mulholland, M. T., Zhang, W., & Yin, Y. (2023) · eLife · doi:10.7554/elife.91060.1 · Cited by 1
Chen, H., Sun, L., Feng, L., Han⊗, X., Zhang, Y., Zhai, W., Zhang, Z., Mulholland, M. T., Zhang, W., & Yin, Y. (2024) · eLife · doi:10.7554/elife.91060.2 · Cited by 1
Kan periodisk faste øke sunn livslengde?
Benestad, H. B. (2021) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.21.0765
Huang, S., Piao, C., Beuschel, C. B., & Sigrist, S. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.29.498204
Editorial commentary: Targeting CLOCK: BMAL1 for treatment of ischemia/reperfusion injury
Sadoshima, J. (2022) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2022.10.004
The Gut Microbiota and Its Metabolites Contribute to Ageing and Ageing-Related Diseases
Chen, C., Cao, Z., Lei, H., & Zhang, L. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-14023-5_1
Ea, H., Gauffenic, A., & Pham, C. N. (2022) · Elsevier eBooks · doi:10.1016/b978-2-294-77859-9.00016-5
Bourg, É. L. (2023) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2023.03.003
Uncoupling of lifespan and reproductive tradeoffs by dietary methionine and one-carbon metabolismPreprint
Wei, F., Liu, S., Liu, J., Allen, A. E., Reid, M. A., & Locasale, J. W. (2023) · Research Square · doi:10.21203/rs.3.rs-3031504/v1
Temperature-driven coordination of circadian transcriptome regulationPreprint
Xu, B., Hwangbo, D., Saurabh, S., Rosensweig, C., Allada, R., Kath, W. L., & Braun, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.27.563979
Sultanova, Z., Shen, A., Hencel, K., Carlsson, H., Crighton, Z., Clifton, D., Akay, A., & Maklakov, A. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.22.573079
Thakare, M. R., Choudhary, P., Pydah, B., Sunke, S., Yadav, R. S. P., Agrawal, P., & Das, G. (2024) · eLife · doi:10.7554/elife.97706
Shao, Z., Wang, Y., Qu, P., Zheng, Z., Li, Y., Wang, W., Wu, Q. F., Xu, D., Wang, J. F., Ding, N., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4666704/v1
Mammalian autophagy—focusing on its relationship to disease and aging
Minami, S., & Yoshimori, T. (2024) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.35.666
The central clock drives metabolic rhythms in muscle stem cellsPreprint
Sica, V., Smith, J. G., Deryagin, O., Andres, E., Lukesova, V., Egg, M., Cabezas‐Wallscheid, N., Benitah, S. A., Serrano, A. L., Perdiguero, E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.15.633124
Gilgenkrantz, H. (2025) · médecine/sciences · doi:10.1051/medsci/2025051
Circadian control of cellular constituent turnover and growth
Kelu, J. J. (2025) · Current Opinion in Physiology · doi:10.1016/j.cophys.2025.100837
Time-series modeling with neural flow mapsPreprint
Xu, B., Ho, Z. E., & Huang, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.18.660388
Rajan, A., & Melkani, G. C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95424-2.00047-9
Metadata
- Authors
- Ulgherait, M., Midoun, A. M., Park, S. J., Gatto, J. A., Tener, S. J., Siewert, J., Klickstein, N., Canman, J. C., Ja, W. W., & Shirasu-Hiza, M.
- Affiliations
- Columbia University (US)
- Université Paris Sciences et Lettres (FR)
- Scripps Research Institute (US)
- ORCID
- Venue
- Nature
- Published
- 2021-09-29
- Volume
- 598
- Issue
- 7880
- Pages
- 353-358
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC9395244
- OpenAlex
- W3202239352
- Cited by
- 226
- References
- 46
- Citations by year
- 2026: 30 · 2025: 48 · 2024: 44 · 2023: 56 · 2022: 43 · 2021: 5
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (1r56ag065986-01, P40OD018537)
- National Institute on Aging (R56AG065986, R01AG045842)
- National Institute of General Medical Sciences (R01GM117407, T32GM007088, R01GM105775, R35GM127049, T32GM141882, R01GM130764)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- circadian rhythm, autophagy, lifespan extension, aging, Drosophila, feeding timing, muscle aging, ad libitum feeding
- MeSH terms
- Aging, Animals, Autophagy, Circadian Rhythm, Darkness, Drosophila melanogaster, Feeding Behavior, Female, Longevity, Male, Time Factors, Biomarkers, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
