The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Petabase-scale sequence alignment catalyses viral discovery
Open accessAbstract
Abstract Public databases contain a planetary collection of nucleic acid sequences, but their systematic exploration has been inhibited by a lack of efficient methods for searching this corpus, now exceeding multiple petabases and growing exponentially [1, 2]. We developed a cloud computing infrastructure, Serratus , to enable ultra-high throughput sequence alignment at the petabase scale. We searched 5.7 million biologically diverse samples (10.2 petabases) for the hallmark gene RNA dependent RNA polymerase, identifying well over 10 5 novel RNA viruses and thereby expanding the number of known species by roughly an order of magnitude. We characterised novel viruses related to coronaviruses and to hepatitis δ virus, respectively and explored their environmental reservoirs. To catalyse a new era of viral discovery, we established a free and comprehensive database of these data and tools. Expanding the known sequence diversity of viruses can reveal the evolutionary origins of emerging pathogens and improve pathogen surveillance for the anticipation and mitigation of future pandemics.
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Cites
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Camargo, A. P., Nayfach, S., Chen, I.-M. A., Palaniappan, K., Ratner, A., Chu, K., Ritter, S. J., Reddy, T. B. K., Mukherjee, S., Schulz, F., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkac1037 · Cited by 446
Using artificial intelligence to document the hidden RNA virosphere
Hou, X., He, Y., Fang, P., Mei, S.-Q., Xu, Z., Wu, W.-C., Tian, J.-H., Zhang, S., Zeng, Z.-Y., Gou, Q.-Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.09.027 · Cited by 162
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Camargo, A. P., Call, L., Roux, S., Nayfach, S., Huntemann, M., Palaniappan, K., Ratner, A., Chu, K., Mukherjeep, S., Reddy, T. B. K., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkad964 · Cited by 87
Metadata
- Authors
- Edgar, R. C., Taylor, B., Lin, V., Altman, T., Barbera, P., Meleshko, D., Lohr, D., Novakovsky, G., Buchfink, B., Al-Shayeb, B., Banfield, J. F., de la Peña, M., Korobeynikov, A., Chikhi, R., & Babaian, A.
- Venue
- Nature
- Published
- 2022-01-26
- Volume
- 602
- Issue
- 7895
- Pages
- 142-147
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W4221049439
- Cited by
- 498
- References
- 103
- FWCI
- 28.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Edgar, R. C., Taylor, B., Lin, V., Altman, T., Barbera, P., Meleshko, D., Lohr, D., Novakovsky, G., Buchfink, B., Al-Shayeb, B., Banfield, J. F., de la Peña, M., Korobeynikov, A., Chikhi, R., & Babaian, A. (2022). Petabase-scale sequence alignment catalyses viral discovery. Nature. https://doi.org/10.1038/s41586-021-04332-2
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