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The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Stroke genetics informs drug discovery and risk prediction across ancestries

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Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, The COMPASS Consortium, Bis, Joshua C., Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F., Chen, Wei Min, Sale, Michèle M., Zonderman, Alan B., Evans, Michele K., Wilson, James G., Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M., Carty, Cara L., Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D., Gottesman, Rebecca F., Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A., Furie, Karen L., Arnett, Donna K., Benavente, Oscar R., Grewal, Raji P., Peddareddygari, Leema Reddy, The INVENT Consortium, Kooperberg, Charles, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A., Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rebecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., McCauley, Bryan M., Taylor, Kent D., Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O’Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, The Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group, van Dijk, Ewoud J., Koudstaal, Peter J., Luijckx, Gert-Jan, Nederkoorn, Paul J., van Oostenbrugge, Robert J., Visser, Marieke C., Wermer, Marieke J. H., Kappelle, L. Jaap, The Estonian Biobank, Esko, Tõnu, Metspalu, Andres, Mägi, Reedik, Nelis, Mari, The PRECISE4Q Consortium, The FinnGen Consortium, The NINDS Stroke Genetics Network (SiGN), Irvin, Marguerite R., de Leeuw, Frank-Erik, Levi, Christopher R., Maguire, Jane, Jiménez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie L. M., Rannikmäe, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent N. S., Lindgren, Arne G., Ilinca, Andreea, Melander, Olle, Engström, Gunnar, Rexrode, Kathryn M., Rothwell, Peter M., Stanne, Tara M., Johnson, Julie A., Danesh, John, Butterworth, Adam S., Heitsch, Laura, Boncoraglio, Giorgio B., Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Jackson, Rebecca D., Ross, Owen A., Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W., Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, The MEGASTROKE Consortium, Anderson, Christopher D., Lopez, Oscar L., Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibañez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muiño, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Giese, Anne-Katrin, Gretarsdottir, Solveig, Rost, Natalia S., Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D., Carrera, Caty, Buring, Julie E., Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul I. W., DeStefano, Anita L., den Hoed, Marcel, Duan, Qing, Engelter, Stefan T., Falcone, Guido J., Gottesman, Rebecca F., Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G., Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B., Kissela, Brett M., Kleindorfer, Dawn O., Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K., McArdle, Patrick F., Pulit, Sara L., Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R., Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M., Walters, Matthew, Wareham, Nicholas J., Amin, Najaf, Aparicio, Hugo J., Attia, John, Beiser, Alexa S., Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-François, Delavaran, Hossein, Dörr, Marcus, Ford, Ian, Gurpreet, Wander S., Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L., Laurie, Cathy C., Li, Linxin, Lind, Lars, Lindgren, Cecilia M., Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P., Müller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A., Pedersen, Nancy L., Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribasés, Marta, Romero, Jose R., Rudd, Anthony G., Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Ásgeir, Smith, Albert, Stine, O. Colin, Stott, David J., Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G., Valdimarsson, Einar M., van der Lee, Sven J., Wakai, Kenji, Williams, Stephen R., Wolfe, Charles D. A., Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K., Stefansson, Kari, Taylor, Kent D., Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tárraga, Carolina, Völzke, Henry, The SIREN Consortium, Akpa, Onoja, Sarfo, Fred S., Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M., Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G., Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J., The China Kadoorie Biobank Collaborative Group, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, The VA Million Veteran Program, The International Stroke Genetics Consortium (ISGC), Le Grand, Quentin, Ferreira, Leslie E., The Biobank Japan, Nagai, Akiko, Murakami, Yoishinori, The CHARGE Consortium, Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, van Vugt, Marion, Gottesman, Rebecca F., Shiroma, Eric J., Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Beiser, Alexa S., Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K., Völker, Uwe, The GIGASTROKE Consortium, de Jager, Phil L., de Cid, Rafael, Nordestgaard, Børge G., Sargurupremraj, Muralidharan, Verma, Shefali S., Regeneron Genetics Center, The ODYSSEY Study, de Laat, Karlijn F., van Norden, Anouk G. W., de Kort, Paul L., Vermeer, Sarah E., Brouwers, Paul J. A. M., Gons, Rob A. R., Nederkoorn, Paul J., den Heijer, Tom, van Dijk, Gert W., van Rooij, Frank G. W., HUNT All-In Stroke, Aamodt, Anne H., Skogholt, Anne H., Brumpton, Ben M., Willer, Cristen J., Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G., Pedersen, Linda M., Gabrielsen, Maiken E., Ellekjær, Hanne, Zhou, Wei, Martinsen, Amy E., Kristoffersen, Espen S., Nielsen, Jonas B., Hveem, Kristian, Thomas, Laurent F., The SICFAIL Study, Kleinschnitz, Christoph, Frantz, Stefan, Ungethüm, Kathrin, The Generacion Study, Gallego-Fabrega, Cristina, Lledós, Miquel, Llucià-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, José, Freijó, Marimar, Arenillas, Juan Francisco, Obach, Victor, Álvarez-Sabín, José, Molina, Carlos A., Ribó, Marc, Muñoz-Narbona, Lucia, Lopez-Cancio, Elena, Millán, Mònica, Diaz-Navarro, Rosa, Vives-Bauza, Cristòfol, Serrano-Heras, Gemma, Segura, Tomás, Delgado, Pilar, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sánchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Martí-Fàbregas, Joan, The Copenhagen City Heart Study, Schnohr, Peter, Jensen, Gorm B., Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R., The SMART Study, van Setten, Jessica, van der Laan, Sander W., Vonk, Jet M. J., Clinical Research Collaboration for Stroke in Korea (CRCS-K) and Korea Biobank Array (KBA) Project, Kim, Bong-Jo, Helsinki Stroke Project, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Follow-up Studies, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, EPIC-CVD, Onland-Moret, N. Charlotte, Heath, Alicia K., Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie·2022·Nature
DOI 10.1038/s41586-022-05165-3
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Abstract

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry 1,2 . Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated ( P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis 3 , and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN ) and variants (such as at GRK5 and NOS3 ). Using a three-pronged approach 4 , we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry 5 . Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.

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Mishra, A., Malik, R., Hachiya, T., Jürgenson, T., Namba, S., Posner, D. C., Kamanu, F. K., Koido, M., Le Grand, Q., Shi, M., He, Y., Georgakis, M. K., Caro, I., Krebs, K., Liaw, Y.-C., Vaura, F. C., Lin, K., Winsvold, B. S., Srinivasasainagendra, V., Parodi, L., Bae, H.-J., Chauhan, G., Chong, M. R., Tomppo, L., Akinyemi, R., Roshchupkin, G. V., Habib, N., Jee, Y. H., Thomassen, J. Q., Abedi, V., Cárcel-Márquez, J., Nygaard, M., Leonard, H. L., Yang, C., Yonova-Doing, E., Knol, M. J., Lewis, A. J., Judy, R. L., Ago, T., Amouyel, P., Armstrong, N. D., Bakker, M. K., Bartz, T. M., Bennett, D. A., Bis, J. C., Bordes, C., Børte, S., Cain, A., Ridker, P. M., Cho, K., Chen, Z., Cruchaga, C., Cole, J. W., de Jager, P. L., de Cid, R., Endres, M., Ferreira, L. E., Geerlings, M. I., Gasca, N. C., Gudnason, V., Hata, J., He, J., Heath, A. K., Ho, Y.-L., Havulinna, A. S., Hopewell, J. C., Hyacinth, H. I., Inouye, M., Jacob, M. A., Jeon, C. E., Jern, C., Kamouchi, M., Keene, K. L., Kitazono, T., Kittner, S. J., Konuma, T., Kumar, A., Lacaze, P., Launer, L. J., Lee, K.-J., Lepik, K., Li, J., Li, L., Manichaikul, A., Markus, H. S., Marston, N. A., Meitinger, T., Mitchell, B. D., Montellano, F. A., Morisaki, T., Mosley, T. H., Nalls, M. A., Nordestgaard, B. G., O’Donnell, M. J., Okada, Y., Onland-Moret, N. C., Ovbiagele, B., Peters, A., Psaty, B. M., Rich, S. S., Rosand, J., Sabatine, M. S., Sacco, R. L., Saleheen, D., Sandset, E. C., Salomaa, V., Sargurupremraj, M., Sasaki, M., Satizabal, C. L., Schmidt, C. O., Shimizu, A., Smith, N. L., Sloane, K. L., Sutoh, Y., Sun, Y. V., Tanno, K., Tiedt, S., Tatlisumak, T., Torres-Aguila, N. P., Tiwari, H. K., Trégouët, D.-A., Trompet, S., Tuladhar, A. M., Tybjærg-Hansen, A., van Vugt, M., Vibo, R., Verma, S. S., Wiggins, K. L., Wennberg, P., Woo, D., Wilson, P. W. F., Xu, H., Yang, Q., Yoon, K., The COMPASS Consortium, Bis, J. C., Lee, J.-M., Cheng, Y.-C., Meschia, J. F., Chen, W. M., Sale, M. M., Zonderman, A. B., Evans, M. K., Wilson, J. G., Correa, A., Traylor, M., Lewis, C. M., Carty, C. L., Reiner, A., Haessler, J., Langefeld, C. D., Gottesman, R. F., Yaffe, K., Liu, Y. M., Kooperberg, C., Lange, L. A., Furie, K. L., Arnett, D. K., Benavente, O. R., Grewal, R. P., Peddareddygari, L. R., The INVENT Consortium, Kooperberg, C., Hveem, K., Lindstrom, S., Wang, L., Smith, E. N., Gordon, W., van Hylckama Vlieg, A., de Andrade, M., Brody, J. A., Pattee, J. W., Haessler, J., Brumpton, B. M., Suchon, P., Chen, M.-H., Frazer, K. A., Turman, C., Germain, M., MacDonald, J., Braekkan, S. K., Armasu, S. M., Pankratz, N., Jackson, R. D., Nielsen, J. B., Giulianini, F., Puurunen, M. K., Ibrahim, M., Heckbert, S. R., Bammler, T. K., McCauley, B. M., Taylor, K. D., Pankow, J. S., Reiner, A. P., Gabrielsen, M. E., Deleuze, J.-F., O’Donnell, C. J., Kim, J., McKnight, B., Kraft, P., Hansen, J.-B., Rosendaal, F. R., Heit, J. A., Tang, W., Morange, P.-E., Johnson, A. D., Kabrhel, C., The Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group, van Dijk, E. J., Koudstaal, P. J., Luijckx, G.-J., Nederkoorn, P. J., van Oostenbrugge, R. J., Visser, M. C., Wermer, M. J. H., Kappelle, L. J., Biobank, T. E., Esko, T., Metspalu, A., Mägi, R., Nelis, M., The PRECISE4Q Consortium, The FinnGen Consortium, The NINDS Stroke Genetics Network (SiGN), Irvin, M. R., de Leeuw, F.-E., Levi, C. R., Maguire, J., Jiménez-Conde, J., Sharma, P., Sudlow, C. L. M., Rannikmäe, K., Schmidt, R., Slowik, A., Pera, J., Thijs, V. N. S., Lindgren, A. G., Ilinca, A., Melander, O., Engström, G., Rexrode, K. M., Rothwell, P. M., Stanne, T. M., Johnson, J. A., Danesh, J., Butterworth, A. S., Heitsch, L., Boncoraglio, G. B., Kubo, M., Pezzini, A., Rolfs, A., Giese, A.-K., Weir, D., Jackson, R. D., Ross, O. A., Lemmons, R., Soderholm, M., Cushman, M., Jood, K., McDonough, C. W., Bell, S., Linkohr, B., Lee, T.-H., Putaala, J., The MEGASTROKE Consortium, Anderson, C. D., Lopez, O. L., Jian, X., Schminke, U., Cullell, N., Delgado, P., Ibañez, L., Krupinski, J., Lioutas, V., Matsuda, K., Montaner, J., Muiño, E., Roquer, J., Sarnowski, C., Sattar, N., Sibolt, G., Teumer, A., Rutten-Jacobs, L., Kanai, M., Giese, A.-K., Gretarsdottir, S., Rost, N. S., Yusuf, S., Almgren, P., Ay, H., Bevan, S., Brown, R. D., Carrera, C., Buring, J. E., Chen, W.-M., Cotlarciuc, I., de Bakker, P. I. W., DeStefano, A. L., den Hoed, M., Duan, Q., Engelter, S. T., Falcone, G. J., Gottesman, R. F., Gustafsson, S., Hassan, A., Holliday, E. G., Howard, G., Hsu, F.-C., Ingelsson, E., Harris, T. B., Kissela, B. M., Kleindorfer, D. O., Langenberg, C., Lemmens, R., Leys, D., Lin, W.-Y., Lorentzen, E., Magnusson, P. K., McArdle, P. F., Pulit, S. L., Rice, K., Sakaue, S., Sapkota, B. R., Tanislav, C., Thorleifsson, G., Thorsteinsdottir, U., Tzourio, C., van Duijn, C. M., Walters, M., Wareham, N. J., Amin, N., Aparicio, H. J., Attia, J., Beiser, A. S., Berr, C., Bustamante, M., Caso, V., Choi, S. H., Chowhan, A., Dartigues, J.-F., Delavaran, H., Dörr, M., Ford, I., Gurpreet, W. S., Hamsten, A., Hozawa, A., Ingelsson, M., Iwasaki, M., Kaffashian, S., Kalra, L., Kjartansson, O., Kloss, M., Labovitz, D. L., Laurie, C. C., Li, L., Lind, L., Lindgren, C. M., Makoto, H., Minegishi, N., Morris, A. P., Müller-Nurasyid, M., Norrving, B., Ogishima, S., Parati, E. A., Pedersen, N. L., Perola, M., Jousilahti, P., Pileggi, S., Rabionet, R., Riba-Llena, I., Ribasés, M., Romero, J. R., Rudd, A. G., Sarin, A.-P., Sarju, R., Satoh, M., Sawada, N., Sigurdsson, Á., Smith, A., Stine, O. C., Stott, D. J., Strauch, K., Takai, T., Tanaka, H., Touze, E., Tsugane, S., Uitterlinden, A. G., Valdimarsson, E. M., van der Lee, S. J., Wakai, K., Williams, S. R., Wolfe, C. D. A., Wong, Q., Yamaji, T., Sanghera, D. K., Stefansson, K., Taylor, K. D., Martinez-Majander, N., Sobue, K., Soriano-Tárraga, C., Völzke, H., The SIREN Consortium, Akpa, O., Sarfo, F. S., Akpalu, A., Obiako, R., Wahab, K., Osaigbovo, G., Owolabi, L., Komolafe, M., Jenkins, C., Arulogun, O., Ogbole, G., Adeoye, A. M., Akinyemi, J., Agunloye, A., Fakunle, A. G., Uvere, E., Olalere, A., Adebajo, O. J., The China Kadoorie Biobank Collaborative Group, Chen, J., Clarke, R., Collins, R., Guo, Y., Wang, C., Lv, J., Peto, R., Chen, Y., Fairhurst-Hunter, Z., Hill, M., Pozarickij, A., Schmidt, D., Stevens, B., Turnbull, I., Yu, C., Program, T. V. M. V., The International Stroke Genetics Consortium (ISGC), Le Grand, Q., Ferreira, L. E., Japan, T. B., Nagai, A., Murakami, Y., The CHARGE Consortium, Geerlings, M. I., Gasca, N. C., Gudnason, V., van Vugt, M., Gottesman, R. F., Shiroma, E. J., Sigurdsson, S., Ghanbari, M., Boerwinkle, E., Beiser, A. S., Fongang, B., Wang, R., Ikram, M. K., Völker, U., The GIGASTROKE Consortium, de Jager, P. L., de Cid, R., Nordestgaard, B. G., Sargurupremraj, M., Verma, S. S., Regeneron Genetics Center, Study, T. O., de Laat, K. F., van Norden, A. 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J., Fornage, M., Liaw, Y.-P., Seshadri, S., Fernández-Cadenas, I., Walters, R. G., Ruff, C. T., Owolabi, M. O., Huffman, J. E., Milani, L., Kamatani, Y., Dichgans, M., & Debette, S.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2022-09-30
Volume
611
Issue
7934
Pages
115-123
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/s41586-022-05165-3
OpenAlex
W4298138773
Cited by
600
References
137
FWCI
65.02
Type
journal article
Language
en
Open access
hybrid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Stroke genetics informs drug discovery and risk prediction across ancestries. https://app.cochat.ai/papers/10.1038/s41586-022-05165-3
The paper
Mishra, A., Malik, R., Hachiya, T., Jürgenson, T., Namba, S., Posner, D. C., Kamanu, F. K., Koido, M., Le Grand, Q., Shi, M., He, Y., Georgakis, M. K., Caro, I., Krebs, K., Liaw, Y.-C., Vaura, F. C., Lin, K., Winsvold, B. S., Srinivasasainagendra, V., . . . Debette, S. (2022). Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. https://doi.org/10.1038/s41586-022-05165-3

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.