The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Spatial multiomics map of trophoblast development in early pregnancy
Open accessAbstract
The relationship between the human placenta—the extraembryonic organ made by the fetus, and the decidua—the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate the decidua, transforming the maternal arteries into high-conductance vessels 1. Defects in trophoblast invasion and arterial transformation established during early pregnancy underlie common pregnancy disorders such as pre-eclampsia 2. Here we have generated a spatially resolved multiomics single-cell atlas of the entire human maternal–fetal interface including the myometrium, which enables us to resolve the full trajectory of trophoblast differentiation. We have used this cellular map to infer the possible transcription factors mediating EVT invasion and show that they are preserved in in vitro models of EVT differentiation from primary trophoblast organoids 3,4 and trophoblast stem cells 5. We define the transcriptomes of the final cell states of trophoblast invasion: placental bed giant cells (fused multinucleated EVTs) and endovascular EVTs (which form plugs inside the maternal arteries). We predict the cell–cell communication events contributing to trophoblast invasion and placental bed giant cell formation, and model the dual role of interstitial EVTs and endovascular EVTs in mediating arterial transformation during early pregnancy. Together, our data provide a comprehensive analysis of postimplantation trophoblast differentiation that can be used to inform the design of experimental models of the human placenta in early pregnancy.
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Self-citationSlingshot: cell lineage and pseudotime inference for single-cell transcriptomics
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Single-cell reconstruction of the early maternal–fetal interface in humans
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chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
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Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
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Self-citationMüller-Dott, S., Tsirvouli, E., Vazquez, M., Ramirez Flores, R. O., Badia-i-Mompel, P., Fallegger, R., Türei, D., Lægreid, A., & Saez-Rodriguez, J. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad841 · Cited by 380
A tridimensional atlas of the developing human head
Blain, R., Couly, G., Shotar, E., Blévinal, J., Toupin, M., Favre, A., Abjaghou, A., Inoue, M., Hernández-Garzón, E., Clarençon, F., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.013 · Cited by 35
Metadata
- Authors
- Arutyunyan, A., Roberts, K., Troulé, K., Wong, F. C. K., Sheridan, M. A., Kats, I., Garcia-Alonso, L., Velten, B., Hoo, R., Ruiz-Morales, E. R., Sancho-Serra, C., Shilts, J., Handfield, L.-F., Marconato, L., Tuck, E., Gardner, L., Mazzeo, C. I., Li, Q., Kelava, I., Wright, G. J., Prigmore, E., Teichmann, S. A., Bayraktar, O. A., Moffett, A., Stegle, O., Turco, M. Y., & Vento-Tormo, R.
- Venue
- Nature
- Published
- 2023-03-29
- Volume
- 616
- Issue
- 7955
- Pages
- 143-151
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W4361285167
- Cited by
- 303
- References
- 73
- FWCI
- 83.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Arutyunyan, A., Roberts, K., Troulé, K., Wong, F. C. K., Sheridan, M. A., Kats, I., Garcia-Alonso, L., Velten, B., Hoo, R., Ruiz-Morales, E. R., Sancho-Serra, C., Shilts, J., Handfield, L.-F., Marconato, L., Tuck, E., Gardner, L., Mazzeo, C. I., Li, Q., Kelava, I., . . . Vento-Tormo, R. (2023). Spatial multiomics map of trophoblast development in early pregnancy. Nature. https://doi.org/10.1038/s41586-023-05869-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
