The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Gut microbial carbohydrate metabolism contributes to insulin resistance
Open accessAbstract
Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes 1,2. Previous metagenomic studies have described the characteristics of gut microbiota and their roles in metabolizing major nutrients in insulin resistance 3–9. In particular, carbohydrate metabolism of commensals has been proposed to contribute up to 10% of the host’s overall energy extraction 10, thereby playing a role in the pathogenesis of obesity and prediabetes 3,4,6. Nevertheless, the underlying mechanism remains unclear. Here we investigate this relationship using a comprehensive multi-omics strategy in humans. We combine unbiased faecal metabolomics with metagenomics, host metabolomics and transcriptomics data to profile the involvement of the microbiome in insulin resistance. These data reveal that faecal carbohydrates, particularly host-accessible monosaccharides, are increased in individuals with insulin resistance and are associated with microbial carbohydrate metabolisms and host inflammatory cytokines. We identify gut bacteria associated with insulin resistance and insulin sensitivity that show a distinct pattern of carbohydrate metabolism, and demonstrate that insulin-sensitivity-associated bacteria ameliorate host phenotypes of insulin resistance in a mouse model. Our study, which provides a comprehensive view of the host–microorganism relationships in insulin resistance, reveals the impact of carbohydrate metabolism by microbiota, suggesting a potential therapeutic target for ameliorating insulin resistance.
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Diet rapidly and reproducibly alters the human gut microbiome
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A core gut microbiome in obese and lean twins
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A metagenome-wide association study of gut microbiota in type 2 diabetes
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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Cited by
Funayama, E., Hosonuma, M., Tajima, K., Isobe, J., Baba, Y., Murayama, M., Narikawa, Y., Toyoda, H., Tsurui, T., Maruyama, Y., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117749 · Cited by 9
Metadata
- Authors
- Takeuchi, T., Kubota, T., Nakanishi, Y., Tsugawa, H., Suda, W., Kwon, A. T.-J., Yazaki, J., Ikeda, K., Nemoto, S., Mochizuki, Y., Kitami, T., Yugi, K., Mizuno, Y., Yamamichi, N., Yamazaki, T., Takamoto, I., Kubota, N., Kadowaki, T., Arner, E., Carninci, P., Ohara, O., Arita, M., Hattori, M., Koyasu, S., & Ohno, H.
- Venue
- Nature
- Published
- 2023-08-30
- Volume
- 621
- Issue
- 7978
- Pages
- 389-395
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W4386282944
- Cited by
- 438
- References
- 69
- FWCI
- 32.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Takeuchi, T., Kubota, T., Nakanishi, Y., Tsugawa, H., Suda, W., Kwon, A. T.-J., Yazaki, J., Ikeda, K., Nemoto, S., Mochizuki, Y., Kitami, T., Yugi, K., Mizuno, Y., Yamamichi, N., Yamazaki, T., Takamoto, I., Kubota, N., Kadowaki, T., Arner, E., . . . Ohno, H. (2023). Gut microbial carbohydrate metabolism contributes to insulin resistance. Nature. https://doi.org/10.1038/s41586-023-06466-x
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