The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
Open accessAbstract
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). We demonstrated that conditional inactivation of Pml in the mouse prostate morphs indolent Pten-null tumors into lethal metastatic disease. We identified MAPK reactivation, subsequent hyperactivation of an aberrant SREBP prometastatic lipogenic program, and a distinctive lipidomic profile as key characteristic features of metastatic Pml and Pten double-null CaP. Furthermore, targeting SREBP in vivo by fatostatin blocked both tumor growth and distant metastasis. Importantly, a high-fat diet (HFD) induced lipid accumulation in prostate tumors and was sufficient to drive metastasis in a nonmetastatic Pten-null mouse model of CaP, and an SREBP signature was highly enriched in metastatic human CaP. Thus, our findings uncover a prometastatic lipogenic program and lend direct genetic and experimental support to the notion that a Western HFD can promote metastasis. This study shows that inactivation of Pml in the mouse prostate turns indolent Pten-null tumors into lethal metastatic disease. The authors identify an aberrant SREBP prometastatic lipogenic program and show that a high-fat diet induces lipid accumulation in prostate tumors and is sufficient to drive metastasis.
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The functions and regulation of the PTEN tumour suppressor: new modes and prospects
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Self-citationLipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
Butler, L. M., Perone, Y., Dehairs, J., Lupien, L. E., de Laat, V., Talebi, A., Loda, M., Kinlaw, W. B., & Swinnen, J. V. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.013 · Cited by 589
Papa, A., & Pandolfi, P. P. (2019) · Biomolecules · doi:10.3390/biom9040153 · Cited by 303
Self-citationLabbé, D. P., Zadra, G., Yang, M., Reyes, J. M., Lin, C. Y., Cacciatore, S., Ebot, E. M., Creech, A. L., Giunchi, F., Fiorentino, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12298-z · Cited by 174
Metadata
- Authors
- Chen, M., Zhang, J., Sampieri, K., Clohessy, J. G., Mendez, L., Gonzalez-Billalabeitia, E., Liu, X.-S., Lee, Y.-R., Fung, J., Katon, J. M., Menon, A. V., Webster, K. A., Ng, C., Palumbieri, M. D., Diolombi, M. S., Breitkopf, S. B., Teruya-Feldstein, J., Signoretti, S., Bronson, R. T., Asara, J. M., Castillo-Martin, M., Cordon-Cardo, C., & Pandolfi, P. P.
- Venue
- Nature Genetics
- Published
- 2018-01-15
- Volume
- 50
- Issue
- 2
- Pages
- 206-218
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2783366082
- Cited by
- 293
- References
- 77
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, M., Zhang, J., Sampieri, K., Clohessy, J. G., Mendez, L., Gonzalez-Billalabeitia, E., Liu, X.-S., Lee, Y.-R., Fung, J., Katon, J. M., Menon, A. V., Webster, K. A., Ng, C., Palumbieri, M. D., Diolombi, M. S., Breitkopf, S. B., Teruya-Feldstein, J., Signoretti, S., Bronson, R. T., . . . Pandolfi, P. P. (2018). An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nature Genetics. https://doi.org/10.1038/s41588-017-0027-2
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