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The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk
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“These data also suggest that, similar to carcinogenesis, driver mutations alone may not be sufficient to accelerate aging because they require a permissive microenvironment created by non-mutagenic promoting factors to become penetrant 10 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [10]
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Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660
High burden and pervasive positive selection of somatic mutations in normal human skin
Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770
Age-related remodelling of oesophageal epithelia by mutated cancer drivers
Yokoyama, A., Kakiuchi, N., Yoshizato, T., Nannya, Y., Suzuki, H., Takeuchi, Y., Shiozawa, Y., Sato, Y., Aoki, K., Kim, S. K., et al. (2019) · Nature · doi:10.1038/s41586-018-0811-x · Cited by 628
Aging and Genome Maintenance: Lessons from the Mouse?
Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553
The mutational landscape of normal human endometrial epithelium
Moore, L., Leongamornlert, D., Coorens, T. H. H., Sanders, M. A., Ellis, P., Dentro, S. C., Dawson, K. J., Butler, T., Rahbari, R., Mitchell, T. J., et al. (2020) · Nature · doi:10.1038/s41586-020-2214-z · Cited by 499
McMahon, C. M., Ferng, T., Canaani, J., Wang, E. S., Morrissette, J. J. D., Eastburn, D. J., Pellegrino, M., Durruthy-Durruthy, R., Watt, C. D., Asthana, S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1453 · Cited by 446
Suda, K., Nakaoka, H., Yoshihara, K., Ishiguro, T., Tamura, R., Mori, Y., Yamawaki, K., Adachi, S., Takahashi, T., Kase, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.037 · Cited by 414
Research works printed but not linked: 41
- Odegard, V. H. & Schatz, D. G. Targeting of somatic hypermutation. Nat. Rev. Immunol. 6, 573–583 (2006). · DOI
- Martincorena, I. et al. Somatic mutant clones colonize the human esophagus with age. Science 362, 911–917 (2018). · DOI · Paper page
- Lee-Six, H. et al. The landscape of somatic mutation in normal colorectal epithelial cells. Nature 574, 532–537 (2019). · DOI · Paper page
- Brunner, S. F. et al. Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Nature 574, 538–542 (2019). · DOI · Paper page
- Yoshida, K. et al. Tobacco smoking and somatic mutations in human bronchial epithelium. Nature 578, 266–272 (2020). · DOI
- Kim, S. K. et al. Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis. J. Gastroenterol. 54, 628–640 (2019). · DOI
- Zhu, M. et al. Somatic mutations increase hepatic clonal fitness and regeneration in chronic liver disease. Cell 177, 608–621.e12 (2019). · DOI · Paper page
- Nik-Zainal, S. & Hall, B. A. Cellular survival over genomic perfection. Science 366, 802–803 (2019). · DOI · Paper page
- Brown, K., Strathdee, D., Bryson, S., Lambie, W. & Balmain, A. The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr. Biol. 23, 516–24 (1998). · DOI
- Yamagiwa, K. & Ichikawa, K. Über die künstliche Erzeugung von Papillom. Verh Jap Path Ges. 5, 142–148 (1915).
- Berenblum, I. & Shubik, P. The role of croton oil applications, associated with a single painting of a carcinogen, in tumour induction of the mouse’s skin. Br. J. Cancer 1, 379–382 (1947). · DOI
- Balmain, A. & Pragnell, I. B. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature 303, 72–74 (1983). · DOI
- Quintanilla, M., Brown, K., Ramsden, M. & Balmain, A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322, 78–80 (1986). · DOI
- McCreery, M. Q. & Balmain, A. Chemical carcinogenesis models of cancer: back to the future. Annu. Rev. Cancer Biol. 1, 295–312 (2017). · DOI
- Berenblum, I. & Shubik, P. The persistence of latent tumour cells induced in the mouse’s skin by a single application of 9:10-dimethyl-1:2-benzanthracene. Br. J. Cancer 3, 384–386 (1949). · DOI
- Stenbäck, F., Peto, R. & Shubik, P. Initiation and promotion at different ages and doses in 2200 mice. Br. J. Cancer 44, 1–14 (1981). · DOI
- Loehrke, H. et al. On the persistence of tumor initiation in two-stage carcinogenesis on mouse skin. Carcinogenesis 4, 771–775 (1983). · DOI
- Goerttler, K., Loehrke, H., Schweizer, J. & Hesse, B. Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate. J. Cancer Res. Clin. Oncol. 98, 267–275 (1980). · DOI
- Goerttler, K., Loehrke, H., Hesse, B., Milz, A. & Schweizer, J. Diaplacental initiation of NMRI mice with 7,12-dimethylbenz[a]anthracene during gestation days 6–20 and postnatal treatment of the F1-generation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate: tumor incidence in organs other than the skin. Carcinogenesis 2, 1087–1094 (1981). · DOI
- McCreery, M. Q. et al. Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. Nat. Med. 21, 1514–1520 (2015). · DOI
- Nassar, D., Latil, M., Boeckx, B., Lambrechts, D. & Blanpain, C. Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma. Nat. Med. 21, 946–954 (2015). · DOI
- Binder, R. L. et al. Squamous cell hyperplastic foci: precursors of cutaneous papillomas induced in SENCAR mice by a two-stage carcinogenesis regimen. Cancer Res. 58, 4314–4323 (1998).
- Bauer, A. K., Dwyer-Nield, L. D., Keil, K., Koski, K. & Malkinson, A. M. Butylated hydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion. Exp. Lung Res. 27, 197–216 (2001). · DOI
- Snider, A. J. et al. Murine model for colitis-associated cancer of the colon. Methods Mol. Biol. 1438, 245–254 (2016). · DOI
- Diwan, B. A., Rice, J. M. & Ward, J. M. Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice. Prog. Clin. Biol. Res. 331, 69–83 (1990).
- Guerra, C. et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11, 291–302 (2007). · DOI · Paper page
- Rapozo, D. C. M. et al. Recurrent acute thermal lesion induces esophageal hyperproliferative premalignant lesions in mice esophagus. Exp. Mol. Pathol. 100, 325–331 (2016). · DOI
- Tomasetti, C. & Vogelstein, B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347, 78–81 (2015). · DOI · Paper page
- Wu, S., Powers, S., Zhu, W. & Hannun, Y. A. Substantial contribution of extrinsic risk factors to cancer development. Nature 529, 43–47 (2016). · DOI
- Wild, C. et al. Cancer risk: role of chance overstated. Science 347, 728 (2015). · DOI
- Schaal, C. & Chellappan, S. P. Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol. Cancer Res. 12, 14–23 (2014). · DOI
- Dérijard, B. et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025–1037 (1994). · DOI · Paper page
- Fu, T. et al. FXR regulates intestinal cancer stem cell proliferation. Cell 176, 1098–1112.e18 (2019). · DOI
- Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860–867 (2002). · DOI · Paper page
- Dolberg, D. S., Hollingsworth, R., Hertle, M. & Bissell, M. J. Wounding and its role in RSV-mediated tumor formation. Science 230, 676–678 (1985). · DOI
- Weinberg, R. A. Oncogenes and the molecular basis of cancer. Harvey Lect. 80, 129–136 (1984). -1985–1985.
- Murphy, G. et al. International cancer seminars: a focus on esophageal squamous cell carcinoma. Ann. Oncol. 28, 2086–2093 (2017). · DOI
- Rose, Li,Y. et al. Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice. Nat. Commun. 11, 394 (2020). · DOI
- Riva, L. et al. The mutational signature profile of known and suspected human carcinogens in mice. Nat. Genet. https://doi.org/10.1038/s41588-020-0692-4 (2020). · DOI
- Salk, J. J., Schmitt, M. W. & Loeb, L. A. Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations. Nat. Rev. Genet. 19, 269–285 (2018). · DOI
- Li, S., MacAlpine, D. M. & Counter, C. M. Capturing the primordial Kras mutation initiating urethane carcinogenesis. Nat. Commun. 11, 1800 (2020). · DOI
Cited by
Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529
Metadata
- Authors
- Balmain, A.
- ORCID
- Balmain, Allan
- Venue
- Nature Genetics
- Published
- 2020-10-26
- Volume
- 52
- Issue
- 11
- Pages
- 1139-1143
- ISSN
- 1061-4036
- 1546-1718
- PMC
- PMC8360498
- Cited by
- 152
- References
- 7
- Language
- en
- Funders
- Cancer Research UK (C98/A24032)
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (R35CA210018, UO1CA176287)
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