JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Abstract
The ultraviolet (UV) response of mammalian cells is characterized by a rapid and selective increase in gene expression mediated by AP-1 and NF-kappa B. The effect on AP-1 transcriptional activity results, in part, from enhanced phosphorylation of the c-Jun NH2-terminal activation domain. Here, we describe the molecular cloning and characterization of JNK1, a distant relative of the MAP kinase group that is activated by dual phosphorylation at Thr and Tyr during the UV response. Significantly, Ha-Ras partially activates JNK1 and potentiates the activation caused by UV. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. Thus, JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation. These properties indicate that JNK1 activation may play an important role in tumor promotion.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The transcriptional activity of c-Jun is increased following phosphorylation on Ser-63 and -73 by JNK.
“The transcriptional activity of c-Jun is increased following phosphorylation on Ser-63 and -73 by JNK (34,46).”
From c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor (1999) · cites this paper as [46]
Usually, the transcriptional activity of c-Jun is increased following phosphorylation on Ser-63 and -73 by JNK.
“Usually, the transcriptional activity of c-Jun is increased following phosphorylation on Ser-63 and -73 by JNK (34,46).”
From c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor (1999) · cites this paper as [46]
UV light is a well-established inducer of JNK signaling.
“UV light, a well-established inducer of JNK signaling43,44”
From LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers (2025) · cites this paper as [43]
Cites
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., & Pease, L. R. (1989) · Gene · doi:10.1016/0378-1119(89)90358-2 · Cited by 7,354 · see citing works
Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,974 · see citing works
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
Angel, P. E., & Karin, M. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90011-9 · Cited by 3,390 · see citing works
Self-citationProoxidant States and Tumor Promotion
Cerutti, P. (1985) · Science · doi:10.1126/science.2981433 · Cited by 2,513 · see citing works
The mitogen-activated protein kinase signal transduction pathway
Davis, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82362-6 · Cited by 2,112 · see citing works
Self-citationHibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886 · see citing works
Self-citationBoulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radzlejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., & Yancopoulos, G. D. (1991) · Cell · doi:10.1016/0092-8674(91)90098-j · Cited by 1,876 · see citing works
Phosphorylation of c-jun mediated by MAP kinases
Pulverer, B., Kyriakis, J. M., Avruch, J., Nikolakaki, E., & Woodgett, J. R. (1991) · Nature · doi:10.1038/353670a0 · Cited by 1,470 · see citing works
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
Marais, R., Wynne, J., & Treisman, R. (1993) · Cell · doi:10.1016/0092-8674(93)90237-k · Cited by 1,275 · see citing works
The regulation of transcription by phosphorylation
Hunter, T. R., & Karin, M. (1992) · Cell · doi:10.1016/0092-8674(92)90162-6 · Cited by 1,273 · see citing works
Self-citationAn Osmosensing Signal Transduction Pathway in Yeast
Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993) · Science · doi:10.1126/science.7681220 · Cited by 1,248 · see citing works
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239 · see citing works
Self-citationAndersson, S., Davis, D. L., Dahlbäck, H., Jörnvall, H., & Russell, D. W. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83172-6 · Cited by 1,229 · see citing works
Payne, D. M., Rossomando, A. J., Martino, P. A., Erickson, A. K., Her, J. H., Shabanowitz, J., Hunt, D. F., Weber, M. J., & Sturgill, T. W. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08021.x · Cited by 1,041 · see citing works
Boyle, W. J., Smeal, T., Defize, L. H. K., Angel, P. E., Woodgett, J. R., Karin, M., & Hunter, T. R. (1991) · Cell · doi:10.1016/0092-8674(91)90241-p · Cited by 1,036 · see citing works
Self-citationGille, H., Sharrocks, A. D., & Shaw, P. E. (1992) · Nature · doi:10.1038/358414a0 · Cited by 966 · see citing works
SH2 and SH3 domains: From structure to function
Pawson, T. J., & Gish, G. D. (1992) · Cell · doi:10.1016/0092-8674(92)90504-6 · Cited by 949 · see citing works
The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product
Crews, C. M., Alessandrini, A., & Erikson, R. L. (1992) · Science · doi:10.1126/science.1411546 · Cited by 930 · see citing works
The mammalian ultraviolet response is triggered by activation of src tyrosine kinases
Devary, Y., Gottlieb, R. A., Smeal, T., & Karin, M. (1992) · Cell · doi:10.1016/s0092-8674(05)80058-3 · Cited by 852 · see citing works
Self-citationSmeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature · doi:10.1038/354494a0 · Cited by 789 · see citing works
Self-citationProlonged activation of jun and collagenase genes by tumour necrosis factor-α
Brenner, D. A., O'Hara, M., Angel, P. E., Chojkier, M., & Karin, M. (1989) · Nature · doi:10.1038/337661a0 · Cited by 717 · see citing works
Self-citationAn Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control
Boulton, T. G., Yancopoulos, G. D., Gregory, J. S., Slaughter, C. A., Moomaw, C. R., Hsu, J., & Cobb, M. H. (1990) · Science · doi:10.1126/science.2164259 · Cited by 707 · see citing works
Rapid and Preferential Activation of the c- jun Gene during the Mammalian UV Response
Devary, Y., Gottlieb, R. A., Lau, L. F., & Karin, M. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.5.2804 · Cited by 667 · see citing works
Self-citationNF-kappa B activation by ultraviolet light not dependent on a nuclear signal
Devary, Y., Rosette, C., DiDonato, J. A., & Karin, M. (1993) · Science · doi:10.1126/science.8367725 · Cited by 637 · see citing works
Self-citationHa-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
Binétruy, B., Smeal, T., & Karin, M. (1991) · Nature · doi:10.1038/351122a0 · Cited by 598 · see citing works
Self-citationAlvarez, E., Northwood, I. C., Gonzalez, F. A., Latour, D. A., Seth, A., Abate, C., Curran, T., & Davis, R. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98613-8 · Cited by 472 · see citing works
Self-citationIdentification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.
Gonzalez, F. A., Raden, D. L., & Davis, R. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54548-8 · Cited by 454 · see citing works
Self-citationTreisman, R. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90013-y · Cited by 452 · see citing works
FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation
Elion, E. A., Grisafi, P. L., & Fink, G. R. (1990) · Cell · doi:10.1016/0092-8674(90)90668-5 · Cited by 433 · see citing works
Sturgill, T. W., & Wu, J. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)90012-4 · Cited by 430 · see citing works
Inflammation and Oxidative Stress in Carcinogenesis
Cerutti, P., & Amstad, P. (1993) · Springer eBooks · doi:10.1007/978-1-4615-3520-1_75 · Cited by 409 · see citing works
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity
Lin, A., Frost, J. A., Deng, T., Smeal, T., Al-Alawi, N., Kikkawa, U., Hunter, T. R., Brenner, D. A., & Karin, M. (1992) · Cell · doi:10.1016/0092-8674(92)90311-y · Cited by 378 · see citing works
Self-citationA Yeast Mitogen-Activated Protein Kinase Homolog (Mpk1p) Mediates Signalling by Protein Kinase C
Lee, K. S., Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K., & Levin, D. E. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.3067 · Cited by 377 · see citing works
van Dam, H., Duyndam, M., Rottier, R., Bosch, A., de Vries‐Smits, L., Herrlich, P., Zantema, A., Angel, P., & van der Eb, A. J. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05680.x · Cited by 375 · see citing works
An overview of the relationship between oxidative stress and chemical carcinogenesis
Trush, M. A., & Kensler, T. W. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90077-g · Cited by 374 · see citing works
POTENTIAL INVOLVEMENT OF FREE RADICAL REACTIONS IN ULTRAVIOLET LIGHT‐MEDIATED CUTANEOUS DAMAGE*
Black, H. S. (1987) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1987.tb04759.x · Cited by 344 · see citing works
Smeal, T., Binétruy, B., Mercola, D., Grover-Bardwick, A., Heidecker, G., Rapp, U. R., & Karin, M. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3507 · Cited by 335 · see citing works
Self-citationDeng, T., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.3.479 · Cited by 328 · see citing works
Self-citationjun:Oncogene and Transcription Factor
Vogt, P. K., & Bos, T. J. (1990) · Advances in cancer research · doi:10.1016/s0065-230x(08)60466-2 · Cited by 326 · see citing works
A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae
Courchesne, W. E., Kunisawa, R., & Thorner, J. W. (1989) · Cell · doi:10.1016/0092-8674(89)90509-6 · Cited by 295 · see citing works
The mitogen-activated protein kinase activator
Ahn, N. G., Seger, R., & Krebs, E. G. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90131-u · Cited by 284 · see citing works
Kyriakis, J. M., & Avruch, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44910-6 · Cited by 262 · see citing works
Cell-free activation of a DNA-binding protein by epidermal growth factor
Sadowski, H. B., & Gilman, M. Z. (1993) · Nature · doi:10.1038/362079a0 · Cited by 258 · see citing works
UV‐induced activation of AP‐1 involves obligatory extranuclear steps including Raf‐1 kinase.
Radler‐Pohl, A., Sachsenmaier, C., Gebel, S., Auer, H. P., Bruder, J. T., Rapp, U. R., Angel, P. E., Rahmsdorf, H. J., & Herrlich, P. A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05741.x · Cited by 251 · see citing works
Lautier, D., Lüscher, P., & Tyrrell, R. M. (1992) · Carcinogenesis · doi:10.1093/carcin/13.2.227 · Cited by 216 · see citing works
A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants
Torres, L., Martı́n, H., García-Sáez, M. I., Arroyo, J., Molina, M., Sánchez, M., & Nombela, C. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb01993.x · Cited by 191 · see citing works
Response to adversity: molecular control of gene activation following genotoxic stress.
Nj, H., & Fornace, A. J. (1991) · PubMed · Cited by 184 · see citing works
DNA damage-induced gene expression: Signal transduction and relation to growth factor signaling
Herrlich, P. A., Ponta, H., & Rahmsdorf, H. J. (1992) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/3540551921_7 · Cited by 180 · see citing works
ERKs, extracellular signal-regulated MAP-2 kinases
Cobb, M. H., Robbins, D. J., & Boulton, T. G. (1991) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(91)90124-h · Cited by 143 · see citing works
Adler, V., Franklin, C. C., & Kraft, A. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5341 · Cited by 140 · see citing works
Alani, R. M., Brown, P. H., Binétruy, B., Dosaka, H., Rosenberg, R. K., Angel, P. E., Karin, M., & Birrer, M. J. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.12.6286 · Cited by 128 · see citing works
Self-citationBaker, S. J., Kerppola, T. K., Luk, D. C., Vandenberg, M. T., Marshak, D. R., Curran, T., & Abate, C. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4694 · Cited by 124 · see citing works
Kyriakis, J. M., Brautigan, D. L., Ingebritsen, T. S., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99183-0 · Cited by 108 · see citing works
Abdel-Hafiz, H. A.-M., Heasley, L. E., Kyriakis, J. M., et al. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.12.1337144 · Cited by 103 · see citing works
Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.
Chou, S. Y., Baichwal, V. R., & Ferrell, J. E. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.10.1117 · Cited by 76 · see citing works
Genes and Signal Transduction in Multistage Carcinogenesis
Smith, G. (1990) · Pathology · doi:10.1016/s0031-3025(16)36251-1 · Cited by 67 · see citing works
Pulverer, B., Hughes, K., Franklin, C. C., Kraft, A. S., Leevers, S. J., & Woodgett, J. R. (1993) · PubMed · Cited by 65 · see citing works
Hunter, T. (1993) · Nature · doi:10.1038/366114a0 · Cited by 64 · see citing works
The role of ultraviolet radiation in the induction of melanocytic skin tumors in inbred mice.
Ca, R., Lc, S., BUCANA, C. D., et al. (1989) · PubMed · Cited by 55 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works
Self-citationActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274 · see citing works
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961 · see citing works
Self-citationA landscape of driver mutations in melanoma
Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J.-P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.024 · Cited by 2,610 · see citing works
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558 · see citing works
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937 · see citing works
Self-citationMitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600 · see citing works
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555 · see citing works
Self-citationWhitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543 · see citing works
Self-citationAguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487 · see citing works
Self-citationMitogen-activated protein kinases in apoptosis regulation
Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432 · see citing works
Transcription factors as targets for cancer therapy
Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194 · see citing works
Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m101521200 · Cited by 1,010 · see citing works
c-Jun overexpression in CAR T cells induces exhaustion resistance
Lynn, R. C., Weber, E. W., Sotillo, E., Gennert, D., Xu, P., Good, Z., Anbunathan, H., Lattin, J., Jones, R., Tieu, V., et al. (2019) · Nature · doi:10.1038/s41586-019-1805-z · Cited by 891 · see citing works
The Role of Oxidative Stress in Noise-Induced Hearing Loss
Henderson, D., Bielefeld, E. C., Harris, K. C., & Hu, B. H. (2006) · Ear & Hearing · doi:10.1097/01.aud.0000191942.36672.f3 · Cited by 879 · see citing works
The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation
Chen, Y.-R., Wang, X., Templeton, D., Davis, R. J., & Tan, T.-H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31929 · Cited by 867 · see citing works
Self-citationDNA damage induces phosphorylation of the amino terminus of p53
Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B. (1997) · Genes & Development · doi:10.1101/gad.11.24.3471 · Cited by 818 · see citing works
Gutkind, J. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1839 · Cited by 812 · see citing works
Redox regulation of FoxO transcription factors
Klotz, L.-O., Sánchez-Ramos, C., Prieto-Arroyo, I., Urbánek, P., Steinbrenner, H., & Monsalve, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.019 · Cited by 747 · see citing works
Mitogen-activated protein kinase cascades and regulation of gene expression
Su, B., & Karin, M. (1996) · Current Opinion in Immunology · doi:10.1016/s0952-7915(96)80131-2 · Cited by 747 · see citing works
Self-citationActivation mechanism of the MAP kinase ERK2 by dual phosphorylation
Canagarajah, B. J., Khokhlatchev, A., Cobb, M. H., & Goldsmith, E. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80351-7 · Cited by 729 · see citing works
Inhibition of JNK activation through NF-κB target genes
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721 · see citing works
Self-citationKasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., & Green, D. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80054-4 · Cited by 721 · see citing works
A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway
Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., & Davis, R. J. (1997) · Science · doi:10.1126/science.277.5326.693 · Cited by 675 · see citing works
Self-citationRecent advances torwards understanding redox mechanisms in the activation of nuclear factor κb
Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00218-5 · Cited by 666 · see citing works
A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation
Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J. (1998) · Science · doi:10.1126/science.281.5383.1671 · Cited by 652 · see citing works
Self-citationKallunki, T., Su, B., Tsigelny, I., Sluss, H. K., Dérijard, B., Moore, G., Davis, R., & Karin, M. (1994) · Genes & Development · doi:10.1101/gad.8.24.2996 · Cited by 642 · see citing works
Self-citationThe JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins
Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., & Davis, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7245 · Cited by 458 · see citing works
Self-citationTranslocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage
Kharbanda, S., Saxena, S., Yoshida, K., Pandey, P., Kaneki, M., Wang, Q., Cheng, K., Chen, Y.-N., Campbell, A., Sudha, T., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.322 · Cited by 429 · see citing works
Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways
Igarashi, M., Wakasaki, H., Takahara, N., Ishii, H., Jiang, Z.-Y., Yamauchi, T., Kuboki, K., Meier, M., Rhodes, C. J., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3326 · Cited by 386 · see citing works
Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway
Chow, C.-W., Rincón, M., Cavanagh, J., Dickens, M., & Davis, R. J. (1997) · Science · doi:10.1126/science.278.5343.1638 · Cited by 357 · see citing works
Self-citationActivation and Association of Stat3 with Src in v-Src-Transformed Cell Lines
Cao, X., Tay, A., Guy, G. R., & Tan, Y. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1595 · Cited by 359 · see citing works
Yang, B.-S., Hauser, C. A., Henkel, G., Colman, M. S., Beveren, C. V., Stacey, K. J., Hume, D. A., Maki, R. A., & Ostrowski, M. C. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.2.538 · Cited by 333 · see citing works
Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase
Rogatsky, I., Logan, S. K., & Garabedian, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2050 · Cited by 297 · see citing works
Cellular Transformation and Malignancy Induced by ras Require c-jun
Johnson, R., Spiegelman, B., Hanahan, D., & Wisdom, R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4504 · Cited by 282 · see citing works
c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer
Vleugel, M. M., Greijer, A. E., Bos, R., van der Wall, E., & van Diest, P. J. (2006) · Human Pathology · doi:10.1016/j.humpath.2006.01.022 · Cited by 250 · see citing works
Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., & Yamamoto, K.-I. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7539 · Cited by 279 · see citing works
Self-citationInteraction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1030-1043.2000 · Cited by 281 · see citing works
The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution
Wang, Z., Harkins, P. C., Ulevitch, R. J., Han, J., Cobb, M. H., & Goldsmith, E. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2327 · Cited by 275 · see citing works
Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors
Yang, S.-H., Galanis, A., & Sharrocks, A. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4028 · Cited by 244 · see citing works
Requirement of the JIP1 scaffold protein for stress-induced JNK activation
Whitmarsh, A. J., Kuan, C.-Y., Kennedy, N. J., Kelkar, N., Haydar, T. F., Mordes, J. P., Appel, M., Rossini, A. A., Jones, S. N., Flavell, R. A., et al. (2001) · Genes & Development · doi:10.1101/gad.922801 · Cited by 238 · see citing works
Self-citationMgrditchian, T., Arakelian, T., Paggetti, J., Noman, M. Z., Viry, E., Moussay, E., Van Moer, K., Kreis, S., Guerin, C., Buart, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703921114 · Cited by 226 · see citing works
Nagata, Y., & Todokoro, K. (1999) · Blood · doi:10.1182/blood.v94.3.853.415a12_853_863 · Cited by 218 · see citing works
PPARs and lipid ligands in inflammation and metabolism
Harmon, G. S., Lam, M. T., & Glass, C. K. (2011) · Chemical Reviews · doi:10.1021/cr2001355 · Cited by 216 · see citing works
Identification of the Critical Features of a Small Peptide Inhibitor of JNK Activity
Barr, R. K., Kendrick, T. S., & Bogoyevitch, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107565200 · Cited by 211 · see citing works
Role of p38/MAPKs in Alzheimer's Disease: Implications for Amyloid Beta Toxicity Targeted Therapy
Kheiri, G., Dolatshahi, M., Rahmani, F., & Rezaei, N. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0008 · Cited by 211 · see citing works
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis
Xie, X., Gu, Y., Fox, T., Coll, J. T., Fleming, M. A., Markland, W., Caron, P. R., Wilson, K. P., & Su, M. S.-S. (1998) · Structure · doi:10.1016/s0969-2126(98)00100-2 · Cited by 198 · see citing works
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
Kaneto, H., Matsuoka, T.-A., Nakatani, Y., Kawamori, D., Miyatsuka, T., Matsuhisa, M., & Yamasaki, Y. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0640-x · Cited by 193 · see citing works
Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8066 · Cited by 191 · see citing works
Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove
Garai, Á., Zeke, A., Gógl, G., Törő, I., Fördős, F., Blankenburg, H., Bárkai, T., Varga, J., Alexa, A., Emig, D., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2003004 · Cited by 177 · see citing works
Gao, Z., Zhang, J., Kheterpal, I., Kennedy, N., Davis, R. J., & Ye, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228874 · Cited by 187 · see citing works
Self-citationIdentification of a new JNK inhibitor targeting the JNK-JIP interaction site
Stebbins, J. L., De, S. K., Machleidt, T., Becattini, B., Vazquez, J., Kuntzen, C., Chen, L.-H., Cellitti, J. F., Riel-Mehan, M., Emdadi, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805677105 · Cited by 186 · see citing works
Self-citationc-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor
Behre, G., Whitmarsh, A. J., Coghlan, M. P., Hoang, T., Carpenter, C. L., Zhang, D.-E., Davis, R. J., & Tenen, D. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4939 · Cited by 183 · see citing works
Self-citationCorazzari, M., Rapino, F., Ciccosanti, F., Giglio, P., Antonioli, M., Conti, B., Fimia, G. M., Lovat, P. E., & Piacentini, M. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.183 · Cited by 162 · see citing works
López-Camarillo, C., Aréchaga Ocampo, E., López Casamichana, M., Pérez-Plasencia, C., Álvarez-Sánchez, E., & Marchat, L. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms13010142 · Cited by 165 · see citing works
Yang, L.-C., Zhang, Q.-G., Zhou, C.-F., Yang, F., Zhang, Y.-D., Wang, R.-M., & Brann, D. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009851 · Cited by 163 · see citing works
JunB can substitute for Jun in mouse development and cell proliferation
Passegué, E., Jochum, W., Behrens, A., Ricci, R., & Wagner, E. F. (2002) · Nature Genetics · doi:10.1038/ng790 · Cited by 162 · see citing works
A role for NF-κB–dependent gene transactivation in sunburn
Abeyama, K., Eng, W., Jester, J. V., Vink, A. A., Edelbaum, D., Cockerell, C. J., Bergstresser, P. R., & Takashima, A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9745 · Cited by 160 · see citing works
Tanaka, T., Kurokawa, M., Ueki, K., Tanaka, K., Imai, Y., Mitani, K., Okazaki, K., Sagata, N., Yazaki, Y., Shibata, Y., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3967 · Cited by 152 · see citing works
Bitomsky, N., Böhm, M., & Klempnauer, K.-H. (2004) · Oncogene · doi:10.1038/sj.onc.1208064 · Cited by 134 · see citing works
Zheng, C., Xiang, J., Hunter, T., & Lin, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28966 · Cited by 110 · see citing works
Antosiewicz, J., Ziolkowski, W., Kaczor, J. J., & Herman-Antosiewicz, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.023 · Cited by 102 · see citing works
Sudbeck, B. D., Parks, W. C., Welgus, H. G., & Pentland, A. P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43983-x · Cited by 93 · see citing works
Wang, Y., Su, W., Zhang, C., Xue, C., Chang, Y., Wu, X., Tang, Q., & Wang, J. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.028 · Cited by 92 · see citing works
Shin, T. H., Paterson, A. J., & Kudlow, J. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4694 · Cited by 78 · see citing works
Targeting MAPK Signaling in Age-Related Macular Degeneration
Kyosseva, S. V. (2016) · Ophthalmology and Eye Diseases · doi:10.4137/oed.s32200 · Cited by 74 · see citing works
Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells
Ito, Y., Mishra, N. C., Yoshida, K., Kharbanda, S., Saxena, S., & Kufe, D. (2001) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400886 · Cited by 62 · see citing works
Delgado, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00283-8 · Cited by 53 · see citing works
Rieske, P., & Pongubala, J. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007482200 · Cited by 53 · see citing works
Bruck, N., Bastien, J., Bour, G., Tarrade, A., Plassat, J.-L., Bauer, A., Adam-Stitah, S., & Rochette-Egly, C. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.006 · Cited by 52 · see citing works
Mathiasen, D. P., Egebjerg, C., Andersen, S. H., Rafn, B., Puustinen, P., Khanna, A., Daugaard, M., Valo, E., Tuomela, S., Bøttzauw, T., et al. (2012) · Oncogene · doi:10.1038/onc.2011.230 · Cited by 44 · see citing works
Understanding the specificity of a docking interaction between JNK1 and the scaffolding protein JIP1
Yan, C., Kaoud, T., Lee, S., Dalby, K. N., & Ren, P. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp1073522 · Cited by 36 · see citing works
Callaway, K., Rainey, M. A., & Dalby, K. N. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.11.002 · Cited by 26 · see citing works
Phospholipase Cγ2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis
Chen, Y., Wang, X., Di, L., Fu, G., Chen, Y., Bai, L., Liu, J., Feng, X., McDonald, J. M., Michalek, S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802493200 · Cited by 27 · see citing works
Cho, H., & Hah, J.-M. (2021) · Biomedicines · doi:10.3390/biomedicines9101431 · Cited by 27 · see citing works
LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
Li, C., Syed, M. U., Nimbalkar, A., Shen, Y., Vieira, M. D., Fraser, C., Inde, Z., Qin, X., Ouyang, J., Kreuzer, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58753-y · Cited by 11 · see citing works
“Upon exposure of H2030 EV or LKB1 cells to UV light, a well-established inducer of JNK signaling 43,44 , weobservedanincreaseinphospho-JNKinH2030EVcellsthatpeaked within 60min (Fig.”
- Authors
- Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Massachusetts Chan Medical School (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 76
- Issue
- 6
- Pages
- 1025-1037
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1984903682
- Cited by
- 3,188
- References
- 59
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 22 · 2023: 13 · 2022: 22 · 2021: 17 · 2020: 25 · 2019: 28 · 2018: 30 · 2017: 36 · 2016: 36 · 2015: 48 · 2014: 47 · 2013: 63 · 2012: 58
- FWCI
- 92.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm037845-08, 5r01ca058396-09, 5p01ca050528-07)
- National Cancer Institute (CA 58396, CA50528)
- National Institute of General Medical Sciences (GM37845)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- JNK1, c-Jun N-terminal kinase, ultraviolet response, Ha-ras, mitogen-activated protein kinase, AP-1 transcription, signal transduction, tumor promotion, oncoprotein, dual phosphorylation
- MeSH terms
- Amino Acid Sequence, Base Sequence, Binding Sites, Cell Line, Enzyme Activation, Humans, Molecular Sequence Data, Phosphorylation, Protein Binding, Substrate Specificity, Ultraviolet Rays, Transcriptional Activation, Oncogene Protein p21(ras), Proto-Oncogene Proteins c-jun, Protein Serine-Threonine Kinases, Sequence Homology, Amino Acid, Calcium-Calmodulin-Dependent Protein Kinases, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review