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Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants

Chandra, Vivek, Bhattacharyya, Sourya, Schmiedel, Benjamin J., Madrigal, Ariel, Gonzalez-Colin, Cristian, Fotsing, Stephanie, Crinklaw, Austin, Seumois, Gregory +5 more·2021·Nature Genetics
DOI 10.1038/s41588-020-00745-3PMC PMC8053422
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  • We limited this analysis to SNPs within 50 Kb of miRNA genes to reduce confounding between distance to nearest gene and probability that a genomic region harbors a promoter.

    “We limited this analysis to SNPs within 50 Kb of miRNA genes because doing so reduces the potential effect of confounding between distance to nearest gene and probability that a genomic region harbors a promoter60.”

    From Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions (2024) · cites this paper as [60]

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Research works printed but not linked: 34

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Cited by

Sorted by citations

Authors
Chandra, V., Bhattacharyya, S., Schmiedel, B. J., Madrigal, A., Gonzalez-Colin, C., Fotsing, S., Crinklaw, A., Seumois, G., Mohammadi, P., Kronenberg, M., Peters, B., Ay, F., & Vijayanand, P.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2020-12-21
Volume
53
Issue
1
Pages
110-119
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/s41588-020-00745-3
PMC
PMC8053422
Cited by
123
References
13
Language
en
Licence
Funders
  • U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (R24-AI108564)
  • U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (R01-HL114093)
  • U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35-GM128938)
  • U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (UL1-TR002550)

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